EKS-SUS-00042
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00042
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF413.07.6E-124452708257
StatusUnreviewed
Ensembl ProteinENSSSCP00000017476
UniProt AccessionF1SRQ1;
Protein Name
Protein Synonyms/Alias
Gene NameBRAF
Gene Synonyms/Alias BRAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000016494ENSSSCP00000017476ENSSSCT00000017958
OrganismSus scrofa
Functional Description
Protein Length754
Protein Sequence
(FASTA)
VWNIKQMIKL TQEHIEALLD KFGGEHNPPS IYLEAYEEYT SKLDALQQRE QQLLESLGNG 60
TDFSVSSSAS TDTVTSSSSS SLSVLPSSLS VFQNPTDASR SNPKSPQKPI VRVFLPNKQR 120
TVVPARCGVT VRDSLKKALM MRGLIPECCA VYRIQDGEKK PIGWDTDISW LTGEELHVEV 180
LENVPLTTHN FVRKTFFTLA FCDFCRKLLF QGFRCQTCGY KFHQRCSTEV PLMCVNYDQL 240
DLLFVSKFFE HHPIPQEEAS LAETALTSGS SPSAPPSDSL GPQILTSPSP SKSIPIPQPF 300
RPADEDHRNQ FGQRDRSSSA PNVHINTIEP VNIDDLIRDQ GFRSDGAPLN QLMRCLRKYQ 360
SRTPSPLLHS VPSEIVFDFE PGPVFRGSTT GLSATPPASL PGSLTNVKAL QKSPGPQRER 420
KSSSSSEDRN RMKTLGRRDS SDDWEIPDGQ ITVGQRIGSG SFGTVYKGKW HGDVAVKMLN 480
VTAPTPQQLQ AFKNEVGVLR KTRHVNILLF MGYSTKPQLA IVTQWCEGSS LYHHLHIIET 540
KFEMIKLIDI ARQTAQGMDY LHAKSIIHRD LKSNNIFLHE DLTVKIGDFG LATVKSRWSG 600
SHQFEQLSGS ILWMAPEVIR MQDKNPYSFQ SDVYAFGIVL YELMTGQLPY SNINNRDQII 660
FMVGRGYLSP DLSKVRSNCP KAMKRLMAEC LKKKRDERPL FPQILASIEL LARSLPKIHR 720
SASEPSLNRA GFQTEDFSLY ACASPKTPIQ AGGY 754
Nucleotide Sequence
(FASTA)
GTATGGAATA TCAAACAAAT GATTAAATTG ACACAAGAAC ATATAGAGGC CCTATTGGAC 60
AAATTTGGTG GGGAGCATAA TCCACCTTCA ATATATCTGG AGGCCTATGA AGAATACACC 120
AGCAAGCTAG ATGCCCTCCA GCAAAGAGAA CAGCAGTTAT TGGAATCCCT GGGGAATGGA 180
ACTGATTTTT CTGTTTCTAG TTCTGCATCA ACGGACACCG TTACATCTTC TTCCTCTTCT 240
AGCCTTTCTG TGCTGCCTTC ATCTCTTTCA GTTTTTCAAA ATCCCACAGA TGCATCACGG 300
AGCAACCCCA AGTCACCACA AAAACCTATT GTTAGAGTCT TCCTGCCCAA TAAACAGAGG 360
ACAGTGGTAC CTGCAAGGTG TGGCGTTACA GTCCGGGACA GTCTAAAGAA AGCGCTGATG 420
ATGAGAGGTC TAATCCCAGA GTGCTGCGCT GTTTACAGAA TTCAGGATGG AGAGAAGAAA 480
CCAATTGGCT GGGACACTGA TATTTCCTGG CTTACAGGAG AGGAATTGCA TGTAGAAGTG 540
TTGGAGAATG TTCCACTTAC AACCCACAAC TTTGTACGGA AAACTTTTTT CACCTTAGCA 600
TTTTGTGACT TCTGTCGAAA GCTGCTTTTC CAGGGGTTCC GCTGTCAAAC ATGTGGTTAT 660
AAATTTCACC AGCGTTGTAG TACAGAGGTT CCACTGATGT GTGTTAATTA TGATCAACTT 720
GATTTGCTGT TTGTCTCCAA GTTCTTTGAA CACCACCCAA TACCACAGGA GGAGGCCTCC 780
TTAGCAGAGA CTGCCCTTAC GTCTGGATCA TCCCCTTCTG CACCCCCCTC CGATTCCCTT 840
GGGCCCCAAA TTCTCACCAG TCCGTCTCCT TCAAAATCCA TTCCAATCCC ACAGCCTTTC 900
CGACCAGCAG ATGAAGATCA TCGAAATCAG TTTGGACAGA GAGACCGGTC CTCATCAGCT 960
CCAAATGTGC ATATAAACAC AATAGAACCC GTCAATATTG ATGACTTGAT TAGAGACCAA 1020
GGGTTTCGTA GTGATGGAGC CCCTTTGAAC CAGCTGATGC GCTGTCTTCG GAAATACCAA 1080
TCCCGGACTC CCAGTCCCCT CCTACATTCT GTCCCCAGTG AAATAGTGTT TGATTTTGAG 1140
CCTGGCCCAG TGTTCAGAGG ATCCACCACA GGTTTGTCTG CCACGCCCCC TGCCTCATTA 1200
CCTGGCTCAC TCACTAATGT GAAAGCATTA CAGAAATCTC CAGGACCTCA GCGAGAGAGG 1260
AAGTCATCTT CATCCTCAGA AGACAGGAAT CGAATGAAAA CACTTGGTAG ACGGGATTCA 1320
AGTGATGATT GGGAGATTCC TGATGGGCAG ATCACAGTGG GACAAAGAAT TGGATCTGGG 1380
TCGTTTGGGA CAGTCTACAA GGGAAAGTGG CATGGTGATG TGGCAGTGAA AATGTTGAAT 1440
GTGACAGCAC CCACACCTCA GCAGTTACAG GCCTTCAAAA ATGAAGTAGG AGTACTCAGG 1500
AAAACTCGAC ATGTGAATAT CCTACTCTTC ATGGGTTATT CAACAAAGCC ACAACTGGCT 1560
ATTGTTACCC AGTGGTGTGA GGGCTCCAGC TTATATCATC ATCTCCACAT CATTGAGACC 1620
AAATTCGAGA TGATCAAACT TATAGATATT GCACGGCAGA CTGCACAGGG CATGGATTAC 1680
TTACACGCCA AGTCAATCAT CCACAGAGAC CTCAAGAGTA ATAATATTTT TCTTCATGAA 1740
GACCTCACAG TAAAAATAGG TGATTTTGGT CTAGCCACAG TGAAATCTCG ATGGAGTGGG 1800
TCCCATCAAT TTGAACAGTT GTCTGGATCC ATTTTGTGGA TGGCGCCAGA AGTAATCAGA 1860
ATGCAAGACA AAAACCCGTA TAGCTTTCAG TCAGACGTAT ATGCTTTTGG TATTGTTCTG 1920
TATGAATTGA TGACTGGACA GTTACCTTAT TCAAACATCA ACAACAGGGA CCAGATAATT 1980
TTTATGGTGG GACGAGGATA TCTATCTCCA GATCTCAGTA AGGTACGGAG TAACTGTCCA 2040
AAGGCCATGA AGAGATTAAT GGCAGAGTGC CTAAAAAAGA AGAGAGATGA GAGACCACTC 2100
TTTCCCCAAA TTCTCGCCTC TATTGAGCTG TTGGCCCGCT CATTGCCAAA AATTCACCGC 2160
AGTGCATCAG AACCCTCCTT GAATCGGGCT GGCTTCCAAA CAGAGGATTT TAGTCTATAT 2220
GCTTGTGCTT CTCCAAAAAC ACCCATCCAG GCAGGGGGAT AT 2262
Domain Profile
S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61
         +++++iGsG+fGtvy+gkwhGdvavk+lnv++++++ql+aFk+ev +++ktRh+ni+LFm
Q: 452   TVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM  511
         7899********************************************************
S: 62    GyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkDl  121
         Gy +kp+laivt++c+gssLy++lh  etk+++ klidiarq+aqgmdYLhak+i+h+Dl
Q: 512   GYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDL  571
         ************************************************************
S: 122   ksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleqd  181
         ks+ni+l+e+l+v+i+DFgl++vk+++sg  ++q+e+ +g+il++apevir+      qd
Q: 572   KSNNIFLHEDLTVKIGDFGLATVKSRWSG--SHQFEQLSGSILWMAPEVIRM------QD  623
         *****************************..*********************......**
S: 182   elpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpkel  239
         ++p+s++sDvyafGivlyel++++lpy++ +++dqi+f+vgrG l+pdlskv+s++pk++
Q: 624   KNPYSFQSDVYAFGIVLYELMTGQLPYSNiNNRDQIIFMVGRGyLSPDLSKVRSNCPKAM  683
         ************************************************************
S: 240   kellleClkfekeeRPlftqilkkl  264
         k+l++eClk++++eRPlf+qil+++
Q: 684   KRLMAECLKKKRDERPLFPQILASI  708
         *********************9875
Domain Sequence
(FASTA)
TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRK TRHVNILLFM 60
GYSTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL HAKSIIHRDL 120
KSNNIFLHED LTVKIGDFGL ATVKSRWSGS HQFEQLSGSI LWMAPEVIRM QDKNPYSFQS 180
DVYAFGIVLY ELMTGQLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK AMKRLMAECL 240
KKKRDERPLF PQILASI 257
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00046
EKS-ANC-00043
EKS-BOT-00051
EKS-CAE-00039
EKS-CAJ-00051
EKS-CAF-00052
EKS-CAP-00053
EKS-CII-00019
EKS-DAR-00064
EKS-DRM-00019
EKS-EQC-00048
EKS-FEC-00048
EKS-GAG-00041
EKS-GAA-00067
EKS-GOG-00049
EKS-HOS-00052
EKS-ICT-00047
EKS-LAC-00057
EKS-LOA-00051
EKS-MEG-00042
EKS-MOD-00052
EKS-MUM-00052
EKS-MUP-00052
EKS-MYL-00057
EKS-NOL-00048
EKS-ORA-00043
EKS-ORC-00046
EKS-ORL-00064
EKS-OTG-00053
EKS-PAT-00046
EKS-PES-00045
EKS-PEM-00028
EKS-POA-00047
EKS-RAN-00051
EKS-SAH-00050
EKS-TAG-00045
EKS-TAR-00070
EKS-TEN-00073
EKS-VIP-00024
EKS-XET-00051
EKS-XIM-00072
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005509; F:calcium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0071277; P:cellular response to calcium ion
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0010628; P:positive regulation of gene expression
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0070849; P:response to epidermal growth factor stimulus
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013