EKS-SUS-00344

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00344

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.0	5.3E-97	1239	1503	265

Status

Unreviewed

Ensembl Protein

ENSSSCP00000017927

UniProt Accession

F1SLK9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000016918	ENSSSCP00000017927	ENSSSCT00000018424

Organism

Sus scrofa

Functional Description

Protein Length

1508

Protein Sequence
(FASTA)

MAAAAGNRAS SSGFPGAGAA SPEAGGGGGA LKAGSAPAAA AGLLREAGSG GRERADWRRR 60

QLRKVRSVEL DQLPEPPLFL AASPPSSSTS PSPEPADAPA SGSSFQPVAV PPPHGAGSRG 120

GAHPAEPAAA PDSGAPSTAG AEPGEKRMPA AEPPSTAAPV GREMENKETL KGLHKMDDRP 180

EERMIREKLK ATCMPAWKHE WLERRNRRGP VVVKPIPIKG DGSEINNLAA ESQGDGQASV 240

ASPAPKGRRS PSPGSSPSGR TVKSESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS 300

PEETSRRVNK VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCG RGTFCIHLLF 360

VMLRVFQLEP SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK FVSRMSNSHT 420

LSSSSTSTSS SENSIKDEEE QMCPICLLGM LDEESLTVCE DGCRNKLHHH CMSIWAEECR 480

RNREPLICPL CRSKWRSHDF YSHELSSPVD SPSSLRAAQQ QTTQQHPLAG SQRRNQESNF 540

NLTHYGTQQI PPAYKDLAEP WIQVFGMELV GCLFSRNWNV REMALRRLSH DVSGALLLAN 600

GESTGHSGSN GGSSPSAGAT SGSSQTSISG DVVEACCNIL SMVCADPVYK VYVAALKTLR 660

AMLVYTPCHS LAERIKLQRL LRPVVDTILV KCADANSRTS QLSISTLLEL CKGQAGELAV 720

GREILKAGSI GIGGVDYVLN CILGNQTESN NWQELLGRLC LIDRLLLEFP AEFYPHIVST 780

DVSQAEPVEV RYKKLLSLLT FALQSIDNSH SMVGKLSRRI YLSSARMVTA VPHVFSKLLE 840

MLNVSSSTHF TRMRRRLMAI ADEVEIAEAI QLGIDETLDG RHDSFLQAPV PNNYPEATEN 900

SSLERTDHLE KTGKGLCATK LSASSEDISD RLASISVGLP SSATMEQPKP MVQTKGRPHS 960

QCLNSSPLSH HSQLMFPALS TPTSSVPSVP AGTVTDVSKH RPQGFVPCKI PSASPQTQRK 1020

FSLQFQRNCS ENKDSDKLSP IFTQSRPLPS SNIHRPKPSR PAPSNTSKQG DASKNSMTLD 1080

LNSSSKCDDS FGSSSNGSNA VIPSDETVFT PVEEKCRLDV NTELNSSIED LLEASMPSSD 1140

TTVTFKSEVA VLSPEKDEND DTYKDDVNHN QKCKEKMEAE EEEALAIAMA MSASQDALPI 1200

VPQLQVENGE DIIIIQQDTP ETLPGHTKAK QPYREDTEWL KGQQIGLGAF SSCYQAQDVG 1260

TGTLMAVKQV TYVRNTSSEQ EEVVEALREE IRMMSHLNHP NIIRMLGATC EKSNYNLFIE 1320

WMAGGSVAHL LSKYGAFKES VVINYTEQLL RGLSYLHENQ IIHRDVKGAN LLIDSTGQRL 1380

RIADFGAAAR LASKGTGAGE FQGQLLGTIA FMAPEVLRGQ QYGRSCDVWS VGCAIIEMAC 1440

AKPPWNAEKH SNHLALIFKI ASATTAPSIP SHLSPGLRDV ALRCLELQPQ DRPPSRELLK 1500

HPVFRTTW 1508

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGGGAA TCGCGCCTCG TCCTCGGGAT TCCCGGGCGC CGGGGCGGCG 60

AGCCCCGAAG CGGGCGGCGG CGGAGGGGCC CTCAAGGCCG GCAGCGCGCC CGCGGCAGCC 120

GCGGGGCTGC TGCGGGAGGC GGGCAGCGGG GGCCGCGAGC GGGCAGACTG GAGGCGGCGG 180

CAACTGCGCA AAGTGCGGAG TGTGGAGCTG GACCAGCTGC CGGAGCCGCC GCTTTTCCTC 240

GCCGCCTCTC CGCCGTCCTC CTCCACTTCC CCGTCGCCAG AGCCGGCGGA CGCTCCTGCG 300

AGTGGGAGTA GTTTCCAGCC TGTGGCGGTA CCACCGCCCC ACGGAGCCGG GAGCCGAGGC 360

GGCGCCCATC CTGCAGAGCC GGCGGCCGCC CCAGACAGCG GCGCCCCGAG CACCGCGGGG 420

GCCGAGCCCG GGGAGAAGCG GATGCCCGCC GCAGAGCCAC CTTCTACTGC GGCCCCTGTC 480

GGTCGCGAGA TGGAGAATAA AGAAACACTC AAGGGGTTGC ACAAGATGGA TGATCGCCCA 540

GAAGAACGGA TGATCAGGGA GAAACTGAAG GCAACCTGTA TGCCAGCCTG GAAGCACGAA 600

TGGCTGGAAA GGCGAAACAG GAGAGGCCCT GTGGTGGTAA AACCAATCCC TATTAAAGGA 660

GATGGATCTG AAATTAATAA CTTGGCAGCT GAGTCTCAAG GAGACGGCCA GGCGAGTGTT 720

GCTTCCCCAG CTCCCAAAGG CCGACGCAGT CCTTCCCCTG GCAGCTCCCC ATCTGGTCGC 780

ACAGTGAAAT CAGAATCTCC AGGAGTAAGG AGAAAAAGAG TTTCCCCGGT ACCTTTTCAG 840

AGCGGGAGAA TCACACCACC TCGAAGAGCC CCTTCACCAG ATGGCTTTTC ACCATATAGC 900

CCTGAGGAAA CAAGCCGCCG AGTAAACAAA GTGATGCGGG CCAGGCTGTA CTTACTGCAG 960

CAAATAGGAC CTAACTCCTT CCTGATTGGA GGAGACAGCC CAGACAACAA ATACCGGGTG 1020

TTTATTGGGC CGCAGAACTG CAGCTGTGGG CGTGGAACAT TTTGTATTCA TCTGCTATTT 1080

GTTATGCTCC GGGTGTTTCA GCTAGAACCT TCAGACCCGA TGTTATGGAG AAAAACTTTA 1140

AAGAATTTTG AGGTTGAGAG TTTGTTCCAG AAATATCACA GTAGGCGTAG CTCAAGGATC 1200

AAAGCTCCAT CTCGTAACAC CATCCAGAAG TTTGTTTCAC GCATGTCAAA TTCCCATACA 1260

TTGTCATCAT CTAGCACTTC TACATCTAGT TCAGAAAACA GTATAAAAGA TGAAGAGGAA 1320

CAGATGTGTC CTATTTGCTT GTTGGGTATG CTTGATGAAG AAAGTCTTAC AGTGTGTGAA 1380

GATGGCTGCA GGAACAAGCT GCACCACCAC TGCATGTCAA TCTGGGCAGA AGAATGTAGA 1440

AGAAATAGAG AACCTTTAAT ATGCCCCCTT TGTAGGTCTA AGTGGAGATC CCATGATTTT 1500

TACAGCCATG AGTTGTCAAG CCCTGTGGAT TCCCCTTCTT CCCTGCGAGC TGCACAGCAG 1560

CAAACCACAC AGCAGCATCC CTTAGCTGGA TCACAACGAA GGAATCAGGA GAGCAATTTT 1620

AACCTTACTC ATTATGGAAC TCAGCAGATC CCTCCTGCTT ATAAAGATTT AGCTGAGCCA 1680

TGGATTCAGG TATTTGGAAT GGAACTCGTT GGCTGCTTAT TTTCTAGAAA CTGGAATGTA 1740

AGAGAGATGG CTCTCAGGCG TCTTTCCCAC GATGTTAGTG GGGCTCTGCT ATTGGCAAAT 1800

GGGGAGAGCA CTGGACATTC TGGGAGCAAC GGTGGAAGCA GTCCGAGTGC TGGAGCCACT 1860

AGTGGGTCTT CCCAGACCAG TATCTCAGGA GATGTGGTGG AGGCGTGCTG CAACATTTTG 1920

TCAATGGTCT GTGCTGACCC TGTCTACAAA GTGTACGTTG CTGCTTTAAA AACGTTGAGA 1980

GCCATGTTAG TATATACTCC TTGCCATAGT TTGGCAGAAA GAATCAAGCT GCAGAGACTT 2040

CTCCGGCCAG TTGTAGACAC CATCCTTGTC AAGTGTGCAG ATGCCAATAG TCGCACAAGT 2100

CAGCTGTCTA TATCAACGCT ATTGGAATTG TGCAAAGGCC AAGCAGGAGA GTTGGCAGTT 2160

GGCAGAGAAA TACTTAAAGC TGGATCCATT GGCATCGGCG GTGTTGATTA TGTCTTAAAT 2220

TGTATTCTTG GAAACCAAAC TGAATCAAAC AACTGGCAAG AACTTCTGGG CCGCCTTTGT 2280

CTCATAGATA GACTGCTGTT GGAATTTCCT GCTGAATTTT ACCCTCATAT TGTTAGTACT 2340

GATGTTTCAC AAGCTGAGCC TGTTGAAGTC AGGTATAAGA AGCTGCTGTC CCTCTTAACC 2400

TTTGCTCTGC AGTCCATTGA TAATTCCCAC TCAATGGTTG GTAAACTCTC CCGAAGGATA 2460

TATTTGAGTT CTGCAAGAAT GGTTACTGCA GTACCCCATG TATTTTCAAA ACTGTTAGAA 2520

ATGCTGAATG TTTCCAGTTC CACTCATTTT ACCAGGATGC GTCGTCGTTT GATGGCTATT 2580

GCAGATGAGG TGGAAATTGC TGAGGCCATC CAGCTGGGCA TAGACGAGAC TTTGGATGGT 2640

CGACATGACA GCTTTTTGCA GGCACCTGTG CCTAACAACT ATCCAGAAGC CACAGAGAAC 2700

AGTTCCCTTG AGCGCACAGA CCATTTAGAG AAAACTGGAA AAGGATTGTG TGCTACAAAA 2760

TTGAGTGCCA GTTCAGAGGA CATTTCTGAC CGACTGGCCA GCATTTCAGT AGGACTTCCT 2820

AGTTCAGCAA CAATGGAGCA ACCAAAGCCA ATGGTTCAAA CAAAAGGCAG ACCCCACAGT 2880

CAGTGTTTGA ACTCCTCTCC TTTATCTCAT CATTCCCAGT TAATGTTCCC AGCCTTGTCA 2940

ACTCCTACTT CCTCTGTCCC ATCTGTACCA GCTGGCACCG TAACAGATGT CTCTAAGCAT 3000

AGACCTCAGG GATTTGTTCC CTGCAAAATA CCTTCTGCAT CTCCTCAAAC ACAGCGCAAG 3060

TTTTCTCTAC AGTTCCAGAG AAACTGTTCT GAAAACAAAG ACTCAGATAA ACTCTCCCCA 3120

ATCTTTACTC AGTCAAGACC CCTGCCCTCC AGTAATATAC ACAGGCCAAA GCCATCTCGA 3180

CCTGCTCCAA GTAATACAAG TAAACAGGGA GATGCCTCAA AAAATAGCAT GACACTTGAT 3240

TTGAACAGTA GTTCCAAATG TGATGACAGC TTTGGCAGTA GCAGCAATGG TAGTAATGCT 3300

GTTATACCCA GCGATGAGAC AGTGTTCACC CCAGTAGAGG AGAAATGCAG ATTAGATGTC 3360

AATACAGAGC TCAACTCCAG TATTGAGGAC CTTCTTGAAG CATCTATGCC TTCAAGTGAC 3420

ACAACAGTAA CTTTTAAGTC AGAAGTTGCT GTGCTCTCTC CTGAGAAGGA TGAAAATGAT 3480

GATACCTATA AAGATGATGT AAATCATAAT CAAAAGTGCA AAGAAAAGAT GGAAGCTGAA 3540

GAAGAAGAAG CTTTAGCAAT TGCCATGGCA ATGTCAGCGT CTCAGGATGC CCTCCCCATA 3600

GTTCCTCAGT TACAGGTTGA AAATGGAGAA GATATCATCA TTATTCAACA GGATACACCA 3660

GAGACTCTAC CAGGACATAC CAAAGCAAAA CAGCCTTATA GAGAAGACAC CGAATGGCTG 3720

AAAGGTCAGC AAATAGGCCT TGGAGCATTT TCTTCTTGTT ACCAAGCTCA AGATGTGGGA 3780

ACTGGAACTT TAATGGCCGT TAAACAGGTG ACATATGTCA GAAATACATC TTCTGAGCAA 3840

GAAGAAGTAG TAGAAGCATT AAGAGAAGAG ATAAGAATGA TGAGCCATCT GAATCATCCA 3900

AACATCATTA GGATGTTAGG AGCCACATGT GAGAAGAGCA ATTATAATCT CTTCATTGAG 3960

TGGATGGCAG GGGGATCTGT GGCTCATTTG CTTAGTAAAT ATGGAGCCTT CAAGGAATCA 4020

GTAGTTATTA ACTACACTGA ACAGTTACTT CGTGGCCTTT CGTATCTCCA TGAAAACCAG 4080

ATTATTCACA GAGATGTCAA AGGTGCCAAT TTGCTAATTG ACAGCACAGG TCAGAGACTG 4140

AGAATTGCTG ATTTTGGAGC TGCAGCCAGG TTGGCATCAA AAGGAACTGG TGCGGGAGAG 4200

TTTCAAGGAC AGTTGTTGGG GACGATTGCA TTTATGGCAC CTGAGGTCCT AAGAGGTCAG 4260

CAGTATGGTA GGAGCTGTGA TGTATGGAGT GTTGGCTGTG CTATTATAGA AATGGCTTGT 4320

GCTAAACCAC CTTGGAATGC AGAAAAACAC TCCAATCATC TTGCTTTGAT ATTTAAGATT 4380

GCCAGTGCAA CTACTGCTCC ATCAATCCCG TCACATCTGT CTCCTGGTTT ACGAGATGTG 4440

GCGCTTCGTT GTTTAGAACT TCAACCTCAG GACAGACCTC CGTCGAGAGA GCTACTGAAG 4500

CATCCAGTCT TCCGTACTAC ATGGTAG 4527

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1239  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1298

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1299  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1358

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1359  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1418

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1419  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1476

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1477  LRDVALRCLELQPQDRPPSRELLKHPV  1503

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

ssc:396617

;

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013