EKS-SUS-00226

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00226

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.0	1.6E-128	82	334	253

Status

Unreviewed

Ensembl Protein

ENSSSCP00000017934

UniProt Accession

F1SLJ2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000016925	ENSSSCP00000017934	ENSSSCT00000018432

Organism

Sus scrofa

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

MELLRTITYQ PAASTKMCEQ ALGKACGGDS KKKRPQPPPE EPQQPQPQAQ VQPVAPHHHH 60

HHSHSGAEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 120

PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 180

EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 240

CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 300

SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HEFFLQGFTP DRLSSSCCHT VPDFHLSSPA 360

KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEEIYKLRH DLKKTSITQQ PSKHRTDEEL 420

QPPTTTVARS GTPAVENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR 480

GCLENMPEAD CIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD 540

KKTVHYYAEL GQCSVFPATD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDVRRPRL 600

YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL 660

LMSGCSLELK NRMEYALNML LQRCN 685

Nucleotide Sequence
(FASTA)

ATGGAGCTCT TGCGGACTAT CACCTACCAG CCGGCCGCCA GCACCAAGAT GTGCGAGCAG 60

GCTCTGGGCA AGGCTTGCGG CGGGGACTCG AAGAAGAAGC GGCCGCAGCC GCCCCCCGAG 120

GAGCCGCAGC AGCCGCAGCC CCAGGCTCAA GTGCAGCCGG TGGCTCCGCA CCACCATCAC 180

CACCACTCGC ACTCGGGGGC GGAGATCTCT CGGATTATCG TCGATCCCAC GACGGGGAAG 240

CGCTACTGCC GCGGCAAAGT GCTGGGAAAG GGTGGCTTTG CAAAATGTTA CGAGATGACA 300

GATTTGACAA ACAACAAAGT CTACGCTGCA AAAATTATTC CTCACAGCAG AGTAGCTAAA 360

CCTCATCAAA GGGAAAAGAT CGACAAAGAA ATAGAGCTTC ACAGAATTCT CCATCATAAG 420

CATGTAGTGC AGTTTTATCA CTACTTTGAA GACAAAGAAA ACATTTATAT TCTCTTGGAA 480

TATTGCAGTA GAAGGTCCAT GGCTCATATC TTGAAAGCAA GGAAGGTATT GACAGAGCCA 540

GAAGTCCGAT ACTACCTCAG GCAGATTGTG TCTGGACTAA AGTACCTTCA TGAGCAAGAA 600

ATCTTGCACA GAGATCTCAA ACTAGGGAAT TTCTTTATTA ATGAAGCCAT GGAACTGAAA 660

GTCGGGGACT TTGGTTTGGC TGCCAGGCTG GAGCCCTTAG AACACAGAAG GAGGACGATA 720

TGTGGTACCC CAAATTATCT TTCTCCTGAA GTCCTCAACA AACAGGGACA TGGCTGTGAA 780

TCAGACATCT GGGCCTTAGG CTGTGTAATG TACACAATGT TACTAGGAAG ACCCCCATTT 840

GAAACTACAA ATCTGAAAGA AACTTACAGG TGCATAAGAG AAGCAAGGTA TACAATGCCC 900

TCATCCTTGT TGGCTCCTGC TAAGCACCTA ATAGCTAGCA TGTTGTCGAA AAATCCAGAG 960

GACCGCCCCA GTTTGGATGA CATCATTCGA CATGAATTTT TTTTGCAGGG TTTCACACCA 1020

GACAGACTCT CTTCTAGCTG TTGTCATACA GTTCCCGATT TCCACTTGTC AAGCCCAGCT 1080

AAGAATTTCT TTAAGAAGGC AGCTGCTGCT CTTTTTGGTG GCAAAAAAGA CAAAGCCAGA 1140

TATATTGACA CACATAATAG AGTGTCTAAA GAAGATGAAG AAATATACAA GCTTAGGCAT 1200

GATTTGAAAA AGACTTCAAT AACTCAGCAA CCCAGCAAAC ATAGGACAGA TGAGGAACTC 1260

CAGCCACCTA CCACTACCGT TGCCAGATCT GGAACACCCG CAGTAGAAAA CAAGCAGCAG 1320

ATTGGAGATG CTATTCGGAT GATAGTCAGA GGAACTCTTG GCAGCTGCAG CAGTAGCAGC 1380

GAATGTCTCG AGGACAGTAC CATGGGAAGT GTTGCCGACA CAGTGGCCAG AGTCCTTCGA 1440

GGATGTCTAG AAAACATGCC AGAAGCTGAC TGTATTCCCA AAGAGCAGCT GAGCACTTCC 1500

TTTCAGTGGG TCACCAAATG GGTCGATTAC TCCAACAAAT ATGGCTTCGG GTACCAGCTC 1560

TCAGACCACA CTGTAGGCGT CCTTTTCAAC AATGGTGCTC ATATGAGCCT GCTTCCAGAC 1620

AAAAAAACAG TTCACTATTA TGCAGAGCTT GGCCAGTGCT CTGTTTTCCC AGCAACAGAT 1680

GCCCCTGAAC AATTCATCAG TCAAGTGACG GTGCTGAAAT ACTTCTCTCA TTACATGGAG 1740

GAGAACCTCA TGGATGGTGG AGATCTGCCT AGTGTTACTG ATGTTCGAAG ACCTCGGCTC 1800

TACCTCCTTC AGTGGCTAAA ATCTGATAAG GCCTTAATGA TGCTCTTCAA TGACGGCACC 1860

TTTCAGGTGA ATTTCTACCA TGATCATACG AAAATAATCA TCTGTAGCCA AAATGAAGAA 1920

TACCTTCTCA CTTACATCAA CGAGGACAGG ATATCTACAA CGTTTAGGCT GACGACTCTG 1980

CTGATGTCTG GCTGTTCATT AGAATTAAAA AACCGAATGG AATATGCTCT GAACATGCTC 2040

TTACAGAGAT GTAACTGA 2058

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 82    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  141

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 142   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  201

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 202   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  261

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 262   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  321

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl++++++ef+

Q: 322   RPSLDDIIRHEFF  334

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPSLDDIIRH EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0007613	; P:memory
GO:0007093	; P:mitotic cell cycle checkpoint
GO:0007052	; P:mitotic spindle organization
GO:0043066	; P:negative regulation of apoptotic process
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599	; P:regulation of centriole replication
GO:0048167	; P:regulation of synaptic plasticity

KEGG

ssc:397251

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013