EKS-SUS-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	359.5	1.5E-107	12	295	284

Status

Unreviewed

Ensembl Protein

ENSSSCP00000017970

UniProt Accession

C9K505;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 7;

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000016961	ENSSSCP00000017970	ENSSSCT00000018470

Organism

Sus scrofa

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

MAVDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 120

TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 240

CSLPDFVTFK SFPGIPLQHI FIAAGDDLLD LIQGLFLFNP CTRITATQAL KTKYFSNRPG 300

PTPGCQLPRP NCPVEALKEQ SNPAVATKRK RTEALEQGGL PKKLIF 346

Nucleotide Sequence
(FASTA)

ATGGCTGTGG ACGTGAAGTC GCGAGCAAAG CGTTATGAAA AGCTGGACTT CCTCGGGGAG 60

GGACAGTTTG CCACGGTTTA CAAGGCCAGA GACAAGAACA CCAACCAAAT TGTCGCCATT 120

AAGAAAATCA AACTTGGACA TAGATCAGAA GCTAAAGATG GTATAAACAG AACAGCCTTA 180

AGAGAGATAA AATTGTTACA GGAGCTAAGT CATCCAAATA TAATTGGTCT CCTTGATGCT 240

TTTGGACATA AATCTAATAT TAGCCTTGTC TTTGATTTTA TGGAAACTGA CCTAGAGGTT 300

ATAATAAAGG ATAACAGTCT TGTGCTAACA CCATCACACA TCAAAGCCTA CATGTTGATG 360

ACTCTTCAAG GATTAGAATA TTTGCACCAA CATTGGATTC TACATAGGGA TCTAAAACCA 420

AACAACTTGT TGCTAGATGA AAATGGAGTT CTAAAACTGG CAGATTTTGG CTTGGCAAAA 480

TCATTTGGGA GCCCTAATAG AGCTTATACA CATCAGGTTG TAACCAGATG GTATCGGGCT 540

CCTGAGCTAC TATTTGGAGC TAGAATGTAC GGTGTAGGTG TGGACATGTG GGCTGTTGGC 600

TGTATATTGG CAGAGTTGCT TCTAAGGGTT CCATTTTTGC CGGGAGATTC AGACCTTGAT 660

CAACTAACAA GAATATTTGA AACTTTGGGC ACACCAACTG AAGAACAGTG GCCTGACATG 720

TGTAGTCTTC CAGATTTCGT GACGTTTAAG AGTTTCCCTG GAATCCCGCT ACAACATATC 780

TTCATTGCAG CAGGAGATGA CTTGCTAGAT CTCATACAAG GCTTATTCTT ATTTAATCCA 840

TGTACTCGAA TTACAGCCAC ACAGGCATTG AAAACTAAGT ATTTCAGCAA TCGGCCAGGG 900

CCAACACCTG GATGTCAGCT GCCAAGACCA AACTGTCCAG TGGAAGCTTT AAAGGAACAG 960

TCCAATCCTG CTGTGGCAAC AAAACGGAAG AGAACAGAGG CCTTGGAACA AGGAGGATTA 1020

CCCAAGAAGC TAATTTTTTA G 1041

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  129

         ***********.99**********************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 130   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp++  +

Q: 190   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDFV-T  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ + ++ ++ ldl++ l+ ++p +Ri+a++al++kyf

Q: 249   FKSFPGIPLQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYF  295

         9999999******99999****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDFVTFKS 240

FPGIPLQHIF IAAGDDLLDL IQGLFLFNPC TRITATQALK TKYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

ssc:100310797

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013