EKS-SUS-00151
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00151
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC383.01.0E-114250447198
StatusUnreviewed
Ensembl ProteinENSSSCP00000018296
UniProt AccessionF1RV14;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCA
Gene Synonyms/Alias PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000017268ENSSSCP00000018296ENSSSCT00000018798
OrganismSus scrofa
Functional Description
Protein Length461
Protein Sequence
(FASTA)
PKGNGPKDPR SKHKFKIHTY GSPTFCDHCG SLLYGLIHQG MKCDTCDMNV HKQCVINVPS 60
LCGMDHTEKR GRIYLKAEVT DEKLHVTVRD AKNLIPMDPN GLSDPYVKLK LIPDPKNESK 120
QKTKTIRSTL NPQWNESFTF KLKPSDKDRR LSVEIWDWDR TTRNDFMGSL SFGVSELMKM 180
PASGWYKLLN QEEGEYYNVP IPEGDEEGNV ELRQKFEKAK LGPAGNKVIS PSEDRRQPSN 240
NLDRVKLTDF NFLMVLGKGS FGKVMLADRK GTEELYAIKI LKKDVVIQDD DVECTMVEKR 300
VLALLDKPPF LTQLHSCFQT VDRLYFVMEY VNGGDLMYHI QQVGKFKEPQ AVFYAAEISI 360
GLFFLHKRGI IYRDLKLDNV MLDSEGHIKI ADFGMCKEHM MDGVTTRTFC GTPDYIAPEI 420
IAYQPYGKSV DWWAYGVLLY EMLAGQVMLP RGFLLVGHPI A 461
Nucleotide Sequence
(FASTA)
CCAAAAGGAA ATGGACCAAA AGACCCCCGG AGCAAGCACA AGTTTAAGAT CCACACGTAT 60
GGAAGCCCCA CCTTCTGCGA CCACTGCGGG TCCTTGCTGT ATGGACTTAT CCATCAAGGG 120
ATGAAATGTG ACACCTGTGA CATGAACGTG CACAAGCAGT GTGTGATCAA CGTCCCCAGC 180
CTCTGCGGCA TGGACCACAC GGAGAAGAGG GGGCGCATCT ACCTGAAAGC CGAGGTCACC 240
GACGAGAAGC TCCACGTCAC AGTACGAGAC GCAAAAAATC TAATCCCTAT GGATCCAAAT 300
GGGCTCTCAG ATCCTTATGT GAAGCTGAAA CTTATTCCTG ATCCCAAGAA CGAAAGCAAA 360
CAAAAAACCA AGACCATCCG CTCTACACTC AACCCCCAGT GGAACGAGTC CTTCACATTC 420
AAATTAAAAC CTTCAGATAA AGACCGACGA CTGTCTGTAG AAATCTGGGA CTGGGACCGA 480
ACAACAAGGA ACGACTTCAT GGGCTCCCTT TCCTTCGGAG TTTCGGAGCT GATGAAGATG 540
CCGGCCAGCG GATGGTACAA GTTGCTCAAC CAGGAAGAAG GTGAGTACTA CAATGTGCCC 600
ATTCCAGAAG GAGACGAAGA AGGAAACGTG GAGCTCAGGC AGAAATTTGA GAAAGCCAAG 660
CTGGGCCCTG CCGGTAACAA AGTGATCAGT CCTTCTGAAG ACAGGAGACA GCCTTCCAAC 720
AACCTTGACC GAGTGAAGCT CACCGACTTC AATTTCCTCA TGGTGCTGGG GAAGGGCAGT 780
TTCGGGAAGG TGATGCTCGC CGACAGGAAG GGAACGGAAG AACTGTATGC CATCAAAATC 840
CTGAAGAAGG ACGTGGTGAT TCAAGACGAC GACGTGGAGT GCACCATGGT GGAGAAGCGC 900
GTACTGGCCC TGCTGGATAA GCCTCCGTTC CTGACGCAGC TACACTCCTG CTTCCAGACG 960
GTGGACCGGC TGTACTTCGT CATGGAATAT GTCAATGGAG GGGACCTCAT GTACCACATT 1020
CAGCAAGTAG GAAAATTTAA GGAACCGCAA GCCGTATTCT ATGCAGCAGA AATTTCCATC 1080
GGGCTGTTCT TCCTTCATAA AAGAGGAATC ATTTATAGGG ACCTGAAGTT GGATAACGTC 1140
ATGCTGGATT CGGAGGGCCA CATCAAGATT GCCGATTTTG GGATGTGTAA GGAGCACATG 1200
ATGGATGGGG TCACGACCAG GACCTTCTGC GGGACCCCAG ATTACATCGC CCCGGAGATC 1260
ATCGCCTATC AGCCGTATGG GAAATCCGTG GACTGGTGGG CCTATGGCGT CCTGTTATAT 1320
GAAATGCTGG CCGGACAGGT AATGCTTCCC CGTGGTTTCC TACTGGTGGG TCACCCTATA 1380
GCA 1383
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 250   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  309
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 310   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  369
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks
Q: 370   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  429
         ************************************************************
S: 181   vdwwalGvllyemlagqs  198
         vdwwa+Gvllyemlagq 
Q: 430   VDWWAYGVLLYEMLAGQV  447
         ****************95
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQV 198
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Equus caballus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Sarcophilus harrisii"; ?>
EKS-BOT-00169
EKS-CAJ-00173
EKS-EQC-00167
EKS-GOG-00167
EKS-ICT-00164
EKS-MYL-00178
EKS-ORA-00149
EKS-ORC-00155
EKS-SAH-00163
Gene Ontology
GO:0005829; C:cytosol
GO:0030425; C:dendrite
GO:0005783; C:endoplasmic reticulum
GO:0005739; C:mitochondrion
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0001750; C:photoreceptor outer segment
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004698; F:calcium-dependent protein kinase C activity
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0046872; F:metal ion binding
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0002062; P:chondrocyte differentiation
GO:0000188; P:inactivation of MAPK activity
GO:0050930; P:induction of positive chemotaxis
GO:0035556; P:intracellular signal transduction
GO:0008285; P:negative regulation of cell proliferation
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0030593; P:neutrophil chemotaxis
GO:0045766; P:positive regulation of angiogenesis
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0045785; P:positive regulation of cell adhesion
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0050729; P:positive regulation of inflammatory response
GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0001934; P:positive regulation of protein phosphorylation
GO:0006937; P:regulation of muscle contraction
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0090330; P:regulation of platelet aggregation
GO:0002026; P:regulation of the force of heart contraction
GO:0070555; P:response to interleukin-1
KEGG
InterPros
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00168; C2; 1.
PF00069; Pkinase; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
Prosites
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013