EKS-SUS-00136

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00136

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.6	4.7E-188	438	717	280

Status

Unreviewed

Ensembl Protein

ENSSSCP00000018335

UniProt Accession

F1RRU6;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000017301	ENSSSCP00000018335	ENSSSCT00000018837

Organism

Sus scrofa

Functional Description

Protein Length

748

Protein Sequence
(FASTA)

QGPLNSESSN QSLCSVGSLS DKEVETPEKK QNDQRNRKRK AEPYETSQGK GTPRGHKISD 60

YFEFAGGSGP GTSPGRSVPP VARSSPQHSL SNPLPRRVEQ PLYGLDGSAA KEVSEEQSAL 120

PTLMSVMLAK PRLDTEQLAQ RGAGLCFTFV SAQQNSPSST GSGNTEHSCS SQKQISIQHR 180

QTQSDLTIEK ISALENSKNS DLEKKEGRID DLLRANCDLR RQIDEQQKML EKYKERLNRC 240

VTMSKKLLIE KSKQEKMACR DKSMQDRLRL GHFTTVRHGA SFTEQWTDGY AFQNLIKQQE 300

RINSQREEIE RQRKMLAKRK PPAMGQAPPA TNEQKQRKSK TNGAENETDS PSTVTQKLLN 360

FRPVVCHNSF LRLTLAEYHE QEEIFKLRLG HLKKEEAEIQ AELERLERVR NLHIRELKRI 420

HNEDNSQFKD HPTLNDRYLL LHLLGRGGFS EVYKAFDLTE QRYVAVKIHQ LNKNWRDEKK 480

ENYHKHACRE YRIHKELDHP RIVKLYDYFS LDTDSFCTVL EYCEGNDLDF YLKQHKLMSE 540

KEARSIIMQI VNALKYLNEI KPPIIHYDLK PGNILLVNGT ACGEIKITDF GLSKIMDDDS 600

YNSVDGMELT SQGAGTYWYL PPECFVVGKE PPKISNKVDV WSVGVIFYQC LYGRKPFGHN 660

QSQQDILQEN TILKATEVQF PPKPVVTPEA KAFIRRCLAY RKEDRIDVQQ LACDPYLLPH 720

IRKSVSTSSP AGAAIASTSG ASNNSSSN 748

Nucleotide Sequence
(FASTA)

CAGGGGCCAC TCAATAGTGA GTCTTCCAAC CAGAGCTTGT GCAGCGTGGG GTCCTTGAGT 60

GATAAGGAGG TAGAGACTCC TGAGAAGAAA CAGAATGACC AGCGAAACCG GAAAAGAAAA 120

GCTGAACCGT ATGAAACTAG CCAAGGGAAA GGCACTCCTA GGGGACATAA AATTAGTGAT 180

TACTTTGAGT TTGCTGGGGG AAGCGGGCCA GGAACCAGCC CTGGCAGAAG TGTTCCACCA 240

GTTGCACGAT CCTCACCGCA ACATTCCTTA TCCAATCCCT TACCGCGGCG AGTAGAGCAG 300

CCCCTCTATG GTTTAGATGG CAGTGCTGCA AAGGAGGTAT CTGAGGAGCA GTCTGCTCTG 360

CCAACCCTGA TGTCAGTGAT GCTAGCAAAA CCTCGGCTCG ACACAGAGCA GCTGGCACAG 420

AGGGGAGCTG GCCTCTGTTT CACTTTTGTT TCAGCTCAGC AAAACAGTCC CTCGTCTACG 480

GGATCTGGCA ACACAGAGCA TTCCTGCAGC TCCCAAAAAC AGATCTCCAT TCAGCACAGA 540

CAGACGCAGT CTGACCTCAC AATAGAAAAA ATATCTGCAC TAGAAAATAG TAAGAATTCT 600

GACTTAGAGA AAAAGGAAGG AAGAATAGAT GATTTGTTAA GAGCCAACTG TGATTTGAGA 660

CGGCAGATTG ATGAACAGCA AAAGATGTTA GAGAAATATA AAGAACGATT AAATCGATGT 720

GTGACAATGA GCAAGAAACT CCTTATAGAA AAGTCAAAAC AAGAGAAGAT GGCGTGTAGA 780

GATAAAAGCA TGCAAGATCG CTTGAGATTG GGCCACTTTA CCACTGTCCG ACATGGGGCC 840

TCATTCACTG AACAGTGGAC AGATGGTTAT GCTTTCCAGA ACCTTATCAA GCAACAGGAA 900

AGGATAAATT CACAGAGGGA AGAGATAGAA AGACAACGAA AAATGTTAGC AAAGCGGAAA 960

CCTCCTGCCA TGGGACAGGC CCCTCCAGCA ACCAATGAGC AGAAACAGCG AAAAAGCAAG 1020

ACCAACGGAG CTGAGAATGA AACGGACTCT CCTTCCACTG TTACTCAGAA ATTGCTTAAT 1080

TTTAGGCCAG TAGTGTGTCA CAATAGTTTT TTAAGGTTAA CGTTAGCCGA ATACCATGAA 1140

CAAGAAGAAA TCTTCAAACT CAGATTAGGT CATCTTAAAA AGGAGGAAGC AGAGATCCAG 1200

GCGGAGCTGG AAAGGCTAGA AAGGGTTAGA AATCTACATA TCAGGGAACT AAAAAGGATA 1260

CATAATGAAG ATAATTCACA ATTTAAAGAC CATCCAACGC TAAATGACAG ATATTTGTTG 1320

TTACATCTTT TGGGTAGAGG AGGTTTCAGT GAAGTTTACA AGGCATTTGA TCTAACAGAA 1380

CAAAGATATG TAGCTGTGAA AATTCACCAG TTAAATAAAA ACTGGAGAGA TGAGAAAAAG 1440

GAGAATTACC ACAAGCATGC ATGTAGGGAA TACCGGATTC ACAAAGAACT GGATCATCCC 1500

AGAATAGTTA AGCTGTATGA TTACTTTTCA CTGGACACTG ACTCGTTTTG TACAGTATTA 1560

GAATACTGTG AGGGAAATGA TCTGGACTTC TACCTGAAAC AGCACAAATT AATGTCGGAG 1620

AAGGAGGCTC GATCCATTAT CATGCAGATT GTGAATGCTT TAAAGTATTT AAATGAAATA 1680

AAACCTCCCA TCATACACTA TGACCTCAAA CCAGGTAATA TTCTTTTAGT AAATGGTACA 1740

GCATGTGGAG AGATAAAAAT CACAGATTTT GGTCTTTCCA AGATCATGGA TGATGATAGC 1800

TACAATTCAG TGGATGGCAT GGAGCTAACA TCACAAGGTG CTGGTACTTA TTGGTATTTA 1860

CCACCAGAGT GTTTTGTGGT TGGGAAAGAA CCACCAAAGA TCTCAAATAA AGTTGACGTC 1920

TGGTCCGTGG GTGTGATCTT CTACCAGTGT CTCTATGGAA GGAAGCCTTT TGGTCATAAC 1980

CAGTCCCAGC AAGACATTCT ACAAGAAAAT ACTATTCTCA AAGCTACTGA GGTGCAGTTC 2040

CCACCAAAGC CAGTAGTAAC ACCTGAAGCA AAGGCGTTTA TTCGACGATG CTTGGCCTAC 2100

CGAAAGGAGG ACCGCATCGA CGTCCAGCAG CTGGCCTGTG ACCCCTACTT GCTTCCTCAC 2160

ATCCGAAAGT CAGTCTCCAC AAGTAGCCCT GCTGGAGCTG CTATTGCATC AACCTCTGGG 2220

GCGTCCAATA ACAGTTCTTC GAATTGA 2247

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 438   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  497

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 498   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  557

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 558   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  617

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 618   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  677

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 678   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  717

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013