EKS-SUS-00262

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00262

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	446.0	5.0E-134	696	956	261

Status

Unreviewed

Ensembl Protein

ENSSSCP00000018545

UniProt Accession

F1RWM5;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100516641

Gene Synonyms/Alias

LOC100516641;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000017497	ENSSSCP00000029249	ENSSSCT00000034730
ENSSSCG00000017497	ENSSSCP00000030723	ENSSSCT00000033442
ENSSSCG00000017497	ENSSSCP00000018545	ENSSSCT00000019050
ENSSSCG00000017497	ENSSSCP00000029204	ENSSSCT00000034784
ENSSSCG00000017497	ENSSSCP00000029843	ENSSSCT00000034555

Organism

Sus scrofa

Functional Description

Protein Length

1234

Protein Sequence
(FASTA)

VCTGTDMKLQ LPASPETHLD MLRHLYQGCQ VVQGNLELTY LPANANLFFL QEIQEVQGYV 60

LIAHNRVSWV PLQRLRIVRG TQLFEDRYAL AVLDNGDLLE SATPAAGAAA EGLQELQLQS 120

LTEILKGGVL IQRNPQLCHQ DTILWKDIFH KNNPLTTVAV EANRSRACPP CSPACKASHC 180

WGESSKDCQS LTRTICAGGC ARCKGPLPTD CCHEQCAAGC TGPKHSDCLA CFHFNHSGIC 240

ELHCPALVTY NTDTFESMPN PEGRYTFGAS CVTACPYNYL STDVGSCTLV CPPNNQEVTA 300

EDGTQRCEKC SKPCAQVCYG LGIEHLREVR AVTSANIQEF AGCRKIFGSL AFLPESFEGD 360

PASSTAPLQP EQLRVFETLE EITGYLYISA WPDSLPDLSV FQNLRVIRGR VLHDGAYSLT 420

LQGLGISSLG LRSLRELGSG LALIHRNARL CFVHTVPWDQ LFRNPHQALL HSANRPEEEC 480

VGEGLTCYQL CAHGHCWGPG PTQCVNCSQF LRGQECVKEC RVQQGHPREY VKDRYCLPCH 540

PECQPQNGSD TCFGSEADQC VACAHYKDPP FCVARCPSGV KPDLSFMPIW KFPDEDGMCQ 600

PCPINCTHSC VDLDDKGCPA EQRASPASSI IAGVVGVLLA AVIGVVFGTL IKRRRQKIRK 660

YTMRRLLQET ELVEPLTPSG AMPNQAQMRI LKETELRKVK VLGSGAFGTV YKVRGGAKVR 720

GGRSQRTRAQ LDVLRENTSP KANKEILDEA YVMAGVGSPY VSRLLGICLT STVQLVTQLM 780

PYGCLLDHVR EHRGRLGSQD LLNWCVQIAK GMSYLEDVRL VHRDLAARNV LVKSPNHVKI 840

TDFGLARLLD IDETEYHADG GKVPIKWMAL ESILRRRFTH QSDVWSYGVT VWELMTFGAK 900

PYDGIPAREI PDLLEKGERL PQPPICTIDV YMIMVKCWMI DSECRPRFRE LVAEFSRMAR 960

DPQRFVVIQN EDLGPASPLD STFYRSLLED DDMGDLVDAE EYLVPQQGFF CPDPAPGAGG 1020

TAHRRHRSTS TRSGGGELTL GLEASEEEPP KSPLAPSEGA GSDVFDGDLG MGAAKGLQNL 1080

PQHDSSPLQR YSEDPTVPLP PETDGYVAPL TCSPQPEYVN QPEVRPQPPS PLEGPLPPPR 1140

PTGATLERPK TLSPGRNGVV KDVFAFGAAV ENPEYLAPRG RAPSQNHPSP AFSPAFDNLY 1200

YWDQDPSDRG ALPSTFEGTP TAENPEYLGL DVPV 1234

Nucleotide Sequence
(FASTA)

GTGTGCACCG GCACAGACAT GAAGCTGCAG CTGCCAGCCA GTCCTGAGAC CCACCTGGAC 60

ATGCTCCGCC ACCTCTACCA GGGCTGTCAG GTGGTACAGG GTAACCTGGA GCTCACCTAC 120

CTGCCGGCTA ATGCCAACCT CTTCTTCTTG CAGGAGATCC AGGAGGTGCA GGGCTACGTG 180

CTTATCGCTC ACAACCGAGT GAGTTGGGTC CCGCTGCAGA GGCTGCGAAT CGTGCGAGGT 240

ACCCAGCTCT TTGAAGACAG ATATGCCCTG GCTGTGCTGG ACAATGGAGA CCTTCTGGAA 300

AGTGCCACCC CTGCTGCGGG TGCTGCCGCA GAAGGGCTGC AGGAGCTGCA GCTGCAAAGC 360

CTCACAGAGA TCCTGAAGGG AGGAGTCTTG ATCCAGCGGA ACCCCCAGCT CTGCCACCAG 420

GACACGATTC TGTGGAAGGA CATCTTCCAC AAGAACAACC CCCTGACCAC AGTGGCGGTA 480

GAAGCCAACC GCTCCCGGGC CTGCCCACCC TGTTCTCCAG CTTGTAAAGC TTCCCACTGC 540

TGGGGAGAAA GTTCCAAGGA CTGTCAGAGC TTGACGCGAA CCATCTGTGC CGGTGGCTGT 600

GCCCGCTGTA AGGGCCCGCT GCCCACCGAC TGCTGCCATG AGCAGTGTGC TGCCGGCTGC 660

ACGGGCCCCA AGCACTCTGA CTGCCTGGCC TGCTTCCACT TCAACCACAG CGGCATCTGT 720

GAGCTGCATT GCCCGGCCCT GGTCACCTAC AACACAGACA CCTTCGAGTC CATGCCCAAC 780

CCCGAGGGCC GTTACACCTT TGGCGCCAGC TGCGTGACCG CCTGTCCTTA CAACTACCTG 840

TCTACGGACG TGGGATCCTG CACCCTGGTT TGTCCCCCGA ACAACCAAGA GGTGACAGCT 900

GAGGACGGAA CGCAGCGGTG TGAGAAATGC AGCAAGCCCT GTGCCCAAGT GTGCTACGGT 960

CTGGGCATAG AACACCTGCG GGAGGTGAGG GCGGTCACCA GCGCCAATAT CCAGGAGTTT 1020

GCTGGCTGCA GGAAGATCTT TGGGAGCCTG GCATTTCTGC CAGAGAGCTT TGAGGGGGAC 1080

CCAGCCTCCA GCACTGCCCC CCTACAGCCT GAGCAGCTCA GAGTGTTTGA GACTCTGGAG 1140

GAGATCACAG GTTACCTGTA CATCTCCGCT TGGCCAGATA GCCTGCCTGA CCTCAGTGTT 1200

TTCCAGAACC TGCGAGTAAT CCGGGGACGA GTTCTGCATG ATGGTGCCTA CTCGCTGACC 1260

CTGCAAGGGC TGGGCATCAG CTCGCTGGGG CTGCGCTCGC TGCGGGAGCT GGGCAGCGGG 1320

CTGGCCCTCA TCCACCGCAA CGCCCGCCTC TGCTTCGTGC ATACGGTGCC CTGGGACCAG 1380

CTCTTCCGGA ACCCTCACCA GGCCCTGCTC CACAGTGCCA ACCGGCCAGA GGAGGAGTGC 1440

GTGGGCGAGG GCCTGACCTG CTACCAGCTG TGCGCACACG GGCACTGCTG GGGTCCAGGG 1500

CCCACCCAGT GCGTAAACTG CAGCCAGTTC CTTCGGGGCC AAGAGTGCGT GAAGGAGTGC 1560

CGAGTACAGC AGGGGCACCC CCGGGAGTAC GTGAAGGACA GGTACTGTCT GCCGTGCCAC 1620

CCCGAGTGTC AGCCCCAGAA TGGCTCCGAC ACCTGCTTTG GCTCGGAGGC TGACCAGTGT 1680

GTGGCTTGCG CCCACTACAA GGATCCCCCC TTCTGCGTGG CTCGTTGCCC CAGTGGTGTG 1740

AAGCCTGACC TCTCCTTCAT GCCCATCTGG AAGTTCCCGG ATGAGGATGG CATGTGCCAG 1800

CCGTGCCCCA TCAACTGCAC CCACTCCTGT GTGGACCTGG ACGACAAGGG CTGCCCTGCA 1860

GAGCAGAGAG CCAGCCCCGC GTCGTCCATC ATTGCCGGCG TGGTGGGCGT TCTGCTGGCC 1920

GCCGTCATAG GGGTGGTCTT TGGCACCCTA ATCAAACGAA GGCGACAGAA GATCCGCAAG 1980

TACACGATGC GGAGGCTGCT GCAGGAAACG GAGCTGGTGG AGCCCCTGAC GCCCAGCGGG 2040

GCGATGCCTA ATCAGGCTCA GATGCGCATC TTGAAAGAGA CGGAGCTGAG GAAGGTGAAG 2100

GTGCTTGGAT CTGGCGCTTT TGGCACAGTC TACAAGGTCA GGGGCGGGGC CAAAGTCCGG 2160

GGTGGGCGGT CCCAGAGGAC GCGTGCGCAG TTGGATGTGT TGAGGGAAAA CACGTCCCCC 2220

AAAGCCAACA AAGAAATCTT GGACGAAGCA TATGTGATGG CTGGTGTAGG CTCCCCGTAT 2280

GTGTCCCGCC TCCTGGGCAT CTGCCTGACA TCCACGGTGC AGCTGGTGAC ACAGCTTATG 2340

CCCTATGGCT GCCTCCTAGA CCACGTCCGA GAACACCGCG GGCGCCTGGG CTCCCAGGAC 2400

CTGCTGAACT GGTGTGTGCA GATTGCCAAG GGCATGAGCT ACTTGGAGGA CGTGCGGCTT 2460

GTGCACAGGG ACCTGGCTGC CCGCAACGTG CTGGTCAAGA GTCCCAACCA TGTCAAGATT 2520

ACGGACTTCG GGCTGGCTCG GCTGCTGGAC ATTGACGAGA CGGAGTACCA TGCGGATGGG 2580

GGCAAGGTGC CCATCAAGTG GATGGCATTG GAGTCCATTC TCCGCCGGCG GTTCACCCAC 2640

CAGAGTGATG TCTGGAGCTA TGGTGTGACT GTGTGGGAGC TGATGACTTT TGGGGCCAAA 2700

CCTTATGATG GGATCCCAGC CCGGGAGATT CCTGACCTGC TGGAGAAGGG GGAACGGCTG 2760

CCTCAGCCCC CCATCTGCAC CATTGATGTC TACATGATCA TGGTCAAATG TTGGATGATT 2820

GACTCTGAAT GTCGGCCGAG GTTCCGGGAG TTGGTGGCCG AATTCTCCCG GATGGCCAGG 2880

GACCCCCAGC GCTTTGTGGT CATCCAGAAT GAGGACTTGG GCCCGGCCAG CCCCTTGGAC 2940

AGCACCTTCT ACCGCTCGCT GCTGGAGGAT GACGACATGG GGGACCTGGT GGATGCTGAG 3000

GAGTACCTGG TACCCCAGCA GGGCTTCTTC TGCCCAGACC CTGCCCCGGG CGCTGGGGGC 3060

ACAGCCCACC GCAGGCACCG CAGCACATCC ACCAGGAGTG GCGGTGGTGA GCTGACGCTG 3120

GGGCTGGAGG CCTCTGAGGA GGAGCCCCCC AAGTCTCCAC TGGCACCTTC CGAAGGGGCC 3180

GGCTCTGACG TGTTCGACGG CGACCTGGGC ATGGGGGCAG CCAAGGGGCT GCAGAACCTC 3240

CCCCAACACG ACTCTAGCCC TCTACAGCGG TACAGTGAGG ACCCCACAGT ACCCCTGCCT 3300

CCTGAAACTG ATGGCTACGT TGCCCCCCTG ACCTGCAGCC CCCAGCCCGA ATACGTGAAC 3360

CAGCCGGAGG TTCGGCCACA GCCCCCCTCG CCCCTAGAGG GTCCTCTGCC TCCTCCTCGA 3420

CCTACTGGAG CCACCCTGGA AAGGCCCAAG ACGCTCTCCC CTGGAAGGAA CGGGGTTGTC 3480

AAGGACGTTT TTGCCTTTGG TGCTGCAGTG GAGAATCCAG AGTACTTGGC ACCCCGGGGC 3540

AGGGCTCCCT CTCAGAACCA CCCTTCTCCG GCCTTCAGCC CAGCCTTTGA CAACCTCTAT 3600

TACTGGGACC AGGACCCATC AGACCGGGGC GCTCTACCCA GCACCTTTGA AGGGACCCCG 3660

ACTGCAGAGA ACCCCGAATA CCTGGGTCTG GATGTGCCAG TATGA 3705

Domain Profile

S: 1     lkklkvlGsGafGtvyk...Giwipegenvkipvaikvleektgkkankelldealvlas  57

         l+k+kvlGsGafGtvyk   G  +  g++ +    + vl+e+t++kanke+ldea+v+a

Q: 696   LRKVKVLGSGAFGTVYKvrgGAKVRGGRSQRTRAQLDVLRENTSPKANKEILDEAYVMAG  755

         69**************9887899999**********************************

S: 58    ldhanlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyl  117

         + +++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyl

Q: 756   VGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYL  815

         ************************************************************

S: 118   eekrlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilk  177

         e+ rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+

Q: 816   EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILR  875

         ************************************************************

S: 178   rkythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlv  237

         r++thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++v

Q: 876   RRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV  935

         ************************************************************

S: 238   kcwmidaesrpkfkelaeefs  258

         kcwmid+e+rp+f+el++efs

Q: 936   KCWMIDSECRPRFRELVAEFS  956

         *******************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKVRG GAKVRGGRSQ RTRAQLDVLR ENTSPKANKE ILDEAYVMAG 60

VGSPYVSRLL GICLTSTVQL VTQLMPYGCL LDHVREHRGR LGSQDLLNWC VQIAKGMSYL 120

EDVRLVHRDL AARNVLVKSP NHVKITDFGL ARLLDIDETE YHADGGKVPI KWMALESILR 180

RRFTHQSDVW SYGVTVWELM TFGAKPYDGI PAREIPDLLE KGERLPQPPI CTIDVYMIMV 240

KCWMIDSECR PRFRELVAEF S 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013