EKS-SUS-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.5	3.1E-111	728	1021	294

Status

Unreviewed

Ensembl Protein

ENSSSCP00000018551

UniProt Accession

F1RWL3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000017504	ENSSSCP00000018551	ENSSSCT00000019057

Organism

Sus scrofa

Functional Description

Protein Length

1492

Protein Sequence
(FASTA)

MPNPERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 60

APLGTIIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GTDRSDRLHK HRHHQHRRSR 120

DLLKTKQTEK EKNLETFSKS GSMKDRVSGT SKRSNEENDD HGKAQISKSS SNKESRSSKL 180

HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWLD SPKQDDSPSG 240

ASYGQDYDLS PPRSHTSSNY DSYKKSPGST SRRQSVSPPY KEPSAYQSST RSPSPYSRRQ 300

RSVSPYSRRR SSSYERSGSY SGRSPSPYGR RRSSSPFLSK RSLSRSPLPS RKSMKSRSRS 360

PVYSRHSSSH SKKKRSGSRS RHSSISPVRL PLNSSLGAEL SRKKKERAAA AAAAKMDGKE 420

SKGSPIFLPR KENSSVEAKD SGLESKKLPR GVKLEKSAPD TELVNVTHLN TEVKNSLDTG 480

KVKSDENSEK HPVLKDLKVQ ATKDSKPVAL KEEIVTPKET ETSEKEILPP LPTVTSPPPL 540

PTTTPPPQTP PLPPLPPLPA IPQQPPLPPP QPAFSQVLAS STSTLPPSTH PRTSTLSSQA 600

NSQPPVQVSV KTQVSVTAAI PHLKTSTLPP LPLPPLLPGD DDMDSPKETL PSKPVKKEKE 660

QRPRHLLTDL PLPPELPGGD PSPPDSPEPK AITPPQQPYK KRPKICCPRY GERRQTESDW 720

GKRCVDKFDI IGIIGEGTYG QVYKAKDKDT GELVALKKVR LDNEKEGFPI TAIREIKILR 780

QLIHRSVVNM KEIVTDKQDA LDFKKDKGAF YLVFEYMDHD LMGLLESGLV HFSEDHIKSF 840

MKQLMEGLDY CHKKNFLHRD IKCSNILLNN SGQIKLADFG LARLYNSEES RPYTNKVITL 900

WYRPPELLLG EERYTPAIDV WSCGCILGEL FTKKPIFQAN LELAQLELIS RLCGSPCPAV 960

WPDVIKLPYF NTMKPKKQYR RRLREEFSFI PSAALDLLDH MLTLDPSKRC TAEQTLQSDF 1020

LKDVELSKMD PPDLPHWQDC HELWSKKRRR QRQSGVLVEE PPPPKASRKE TISGTSAEPV 1080

KNSSPAPPQP APGKMEPGAG DAIGLGDITQ QLNQSELAVL LNLLQSQTDL SIPQMAQLLN 1140

IHSNPEIQQQ LEALNQSISA LTEAASQQQD SESIVPEESL KEAPPAPVVQ PSAEQTTPEA 1200

SSTPADMQNM LAVLLGQLMK TQEPAGNLEE NNSDNKNSGP QGPRRTPTMP QEEAAACPPH 1260

ILPPEKRPPE PPGPPPPPPP PPLVEGDLSS APQELNPAVT AALLQLLSQP EAEPPGHLPH 1320

EHQALRPMDY STRPHPTRTY GNTDGPETGF SATDTDERNS GPALTESLAQ TLVKNRTFSG 1380

SVSHLGESSS YQGTGSVQFP GDQDLRFARV PLALHSVVGQ PFLKAEGSSN SVVHAETKLQ 1440

NYGELGPGTT GASSSGAGLN WGAPAQSSAY GKLYRGPTRV PPRGGRGRGV PY 1492

Nucleotide Sequence
(FASTA)

ATGCCCAATC CAGAGAGACA TGGGGGCAAG AAGGACGGGA GCGGAGGAGC TTCTGGAACT 60

TTGCAGCCGT CATCGGGAGG TGGCAGCTCC AACAGCAGAG AGCGTCACCG CTTGGTGTCG 120

AAGCACAAGC GGCATAAGTC CAAGCACTCC AAAGACATGG GGTTGGTGAC CCCCGAAGCA 180

GCACCTTTGG GTACAATTAT CAAACCTTTG GTGGAGTATG ATGACATTAG CTCAGATTCT 240

GATACCTTCT CTGACGACAT GGCCTTCAAA CTGGACAGGA GGGAGAATGA TGAACGTCGC 300

GGGACTGATC GGAGTGACCG ACTGCACAAA CACCGTCACC ATCAGCACAG ACGTTCCCGG 360

GACTTACTAA AAACTAAACA GACAGAGAAA GAAAAAAACC TGGAAACCTT TAGCAAGTCG 420

GGATCGATGA AGGACCGGGT ATCAGGAACT TCGAAGCGTT CAAATGAGGA GAATGATGAC 480

CATGGGAAGG CGCAGATCTC CAAAAGCAGC AGCAACAAGG AATCCAGGTC ATCCAAACTC 540

CATAAGGAGA AGACCCGGAA AGAACGTGAG TTGAAGTCTG GGCACAAAGA CCGGAGTAAA 600

AGTCATCGGA AAAGGGAAAC ACCCAAAAGT TACAAAACAG TGGACAGCCC CAAACGGAGG 660

TCCAGGAGTC CCCACCGGAA ATGGTTGGAT AGCCCCAAGC AAGATGATAG CCCGTCAGGA 720

GCTTCTTATG GCCAAGATTA TGACCTTAGT CCCCCAAGAT CTCACACTTC TAGCAATTAT 780

GACTCCTACA AGAAGAGTCC GGGAAGTACC TCAAGAAGGC AGTCCGTCAG CCCACCTTAC 840

AAGGAGCCTT CGGCCTACCA ATCCAGCACC CGGTCACCCA GTCCCTACAG TAGAAGACAG 900

AGGTCCGTGA GTCCCTATAG CCGGCGACGT TCATCCAGCT ATGAAAGGAG TGGCTCTTAC 960

AGTGGGAGAT CACCAAGCCC TTACGGTCGA AGGCGGTCCA GCAGCCCATT CCTGAGCAAG 1020

CGGTCTCTGA GCCGGAGTCC TCTCCCCAGT AGAAAATCCA TGAAGTCTAG AAGTAGAAGT 1080

CCTGTGTATT CAAGACACTC ATCTTCCCAT AGTAAAAAGA AGAGATCCGG GTCACGCAGT 1140

CGACATTCCA GTATCTCACC TGTCAGGCTT CCGTTGAACT CCAGCTTGGG AGCTGAACTC 1200

AGTAGGAAAA AGAAGGAAAG AGCAGCAGCT GCTGCTGCAG CAAAAATGGA TGGAAAGGAA 1260

TCCAAGGGTT CACCTATATT TTTGCCTAGA AAAGAGAACA GTTCAGTAGA AGCTAAGGAT 1320

TCAGGCTTGG AGTCTAAAAA GTTACCCAGG GGTGTAAAAT TGGAAAAATC TGCCCCAGAT 1380

ACTGAACTGG TGAATGTAAC ACATCTAAAC ACAGAGGTCA AAAATTCTTT AGACACAGGG 1440

AAAGTAAAGT CGGATGAGAA CTCTGAGAAG CATCCTGTCC TAAAAGATTT GAAAGTACAG 1500

GCAACGAAAG ACTCTAAACC TGTAGCACTG AAAGAGGAGA TTGTTACTCC AAAAGAGACA 1560

GAGACGTCTG AAAAGGAGAT CCTTCCACCT CTCCCCACAG TTACTTCTCC ACCTCCTTTA 1620

CCAACTACTA CCCCTCCACC TCAGACACCC CCCTTGCCAC CTTTGCCTCC ACTACCAGCT 1680

ATTCCACAGC AACCACCTCT GCCTCCTCCC CAACCAGCAT TTAGTCAGGT TCTTGCTTCT 1740

AGTACTTCAA CTTTGCCCCC TTCTACTCAC CCACGGACAT CTACTCTGTC CTCTCAGGCA 1800

AATTCTCAGC CCCCTGTACA GGTTTCTGTG AAGACTCAAG TATCTGTAAC AGCTGCTATT 1860

CCACATCTAA AAACTTCAAC GTTGCCTCCT CTGCCTCTCC CACCCTTATT ACCTGGAGAT 1920

GATGACATGG ATAGTCCAAA AGAAACCCTA CCTTCAAAAC CTGTAAAGAA AGAGAAGGAA 1980

CAAAGGCCAC GTCACCTACT CACAGACCTC CCTCTCCCTC CAGAGCTCCC TGGTGGGGAT 2040

CCATCTCCCC CAGACTCTCC AGAACCAAAG GCAATCACAC CACCTCAGCA ACCATACAAA 2100

AAGAGACCAA AAATTTGTTG TCCTCGTTAC GGAGAAAGAA GACAAACAGA AAGTGACTGG 2160

GGGAAACGCT GTGTGGACAA GTTTGACATT ATTGGGATTA TTGGAGAGGG AACCTATGGC 2220

CAAGTATATA AAGCCAAGGA CAAAGATACA GGAGAGCTAG TAGCTCTGAA GAAGGTGAGA 2280

CTGGACAATG AAAAAGAGGG CTTCCCAATC ACAGCCATTC GTGAGATCAA AATCCTTCGC 2340

CAGCTAATCC ACCGAAGTGT TGTTAACATG AAGGAAATTG TCACAGATAA GCAAGATGCA 2400

CTGGACTTCA AGAAGGACAA AGGAGCCTTT TACCTTGTGT TTGAGTATAT GGACCATGAC 2460

TTAATGGGAC TGTTGGAATC TGGTTTGGTG CACTTTTCTG AGGACCATAT CAAGTCATTC 2520

ATGAAACAGC TGATGGAAGG ATTGGATTAC TGTCACAAAA AGAATTTCCT GCATCGGGAT 2580

ATTAAGTGTT CTAACATTTT GCTGAACAAC AGTGGGCAGA TCAAACTAGC AGATTTTGGA 2640

CTTGCTCGGC TCTATAATTC TGAAGAGAGT CGTCCTTATA CAAACAAAGT CATTACTCTG 2700

TGGTACCGAC CTCCAGAACT TCTGCTGGGA GAAGAGCGTT ATACACCAGC AATAGATGTT 2760

TGGAGCTGTG GATGCATCCT TGGGGAACTG TTCACAAAGA AGCCTATTTT TCAAGCCAAT 2820

CTGGAACTGG CTCAGCTAGA ACTGATCAGT CGACTCTGTG GTAGCCCTTG TCCAGCTGTG 2880

TGGCCTGATG TTATCAAGCT GCCCTATTTC AATACAATGA AACCGAAGAA GCAGTATAGA 2940

AGGCGCCTAC GAGAAGAATT CTCTTTCATT CCTTCAGCAG CACTTGATTT ACTGGACCAC 3000

ATGCTGACAC TAGATCCTAG CAAACGTTGT ACAGCTGAAC AGACCCTACA GAGTGACTTC 3060

CTTAAAGATG TCGAGCTCAG CAAAATGGAT CCTCCAGACC TACCCCACTG GCAGGATTGC 3120

CATGAATTAT GGAGTAAGAA AAGGCGACGG CAGCGACAAA GTGGTGTATT GGTCGAAGAG 3180

CCACCTCCAC CTAAAGCCTC TCGAAAAGAA ACTATCTCAG GGACAAGTGC TGAGCCTGTG 3240

AAGAACAGCA GCCCAGCACC ACCTCAGCCT GCTCCTGGCA AGATGGAGCC TGGGGCTGGG 3300

GATGCAATAG GCCTTGGTGA CATCACACAG CAGTTGAATC AAAGCGAATT GGCAGTGTTA 3360

TTAAACCTGC TGCAGAGCCA AACCGACCTG AGCATTCCTC AAATGGCACA GCTGCTTAAC 3420

ATCCACTCCA ACCCAGAGAT ACAACAGCAG CTGGAGGCCC TGAACCAGTC TATCAGTGCC 3480

CTAACGGAAG CTGCTTCCCA GCAGCAGGAC TCAGAGTCCA TAGTCCCAGA GGAGTCTTTA 3540

AAGGAGGCAC CCCCTGCCCC AGTGGTCCAG CCTTCAGCAG AACAGACAAC CCCTGAAGCT 3600

TCAAGCACAC CAGCTGACAT GCAGAATATG TTGGCAGTTC TCTTGGGTCA ACTGATGAAA 3660

ACCCAGGAGC CAGCAGGCAA CCTGGAGGAA AACAACAGTG ACAACAAGAA CAGTGGGCCA 3720

CAGGGGCCCC GAAGAACTCC CACAATGCCA CAGGAGGAGG CAGCAGCATG TCCTCCTCAC 3780

ATTCTTCCAC CAGAGAAGAG GCCCCCTGAG CCCCCCGGAC CTCCACCGCC GCCACCTCCA 3840

CCCCCTCTGG TTGAAGGCGA TCTTTCCAGC GCCCCCCAGG AGTTGAACCC AGCTGTGACA 3900

GCCGCCTTGC TGCAACTTTT ATCCCAGCCT GAAGCAGAGC CTCCTGGCCA CCTGCCACAT 3960

GAGCACCAGG CCTTGAGACC AATGGATTAC TCCACCCGAC CCCATCCCAC CAGGACTTAC 4020

GGAAACACTG ATGGGCCTGA AACAGGGTTC AGTGCCACTG ACACTGATGA ACGCAACTCT 4080

GGTCCAGCCT TGACAGAATC CTTGGCCCAG ACCCTGGTGA AGAACAGGAC CTTCTCCGGC 4140

TCTGTGAGCC ACCTTGGGGA GTCCAGCAGT TACCAGGGCA CAGGGTCAGT GCAGTTCCCA 4200

GGGGACCAGG ACCTCCGTTT TGCCAGGGTC CCCTTAGCAT TACACTCGGT GGTCGGGCAA 4260

CCATTCCTGA AGGCTGAGGG AAGCAGCAAC TCTGTGGTAC ATGCAGAGAC CAAATTGCAA 4320

AACTATGGGG AGCTGGGGCC AGGAACTACT GGGGCCAGCA GTTCAGGAGC AGGCCTTAAT 4380

TGGGGGGCCC CAGCTCAGTC TTCTGCTTAT GGAAAACTCT ATCGGGGGCC TACAAGAGTC 4440

CCTCCAAGAG GGGGAAGAGG GAGAGGAGTT CCTTACTAA 4479

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 728   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  787

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 788   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  846

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 847   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  906

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 907   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  966

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a+++lq++++

Q: 967   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  1021

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain
GO:0046777	; P:protein autophosphorylation
GO:0043405	; P:regulation of MAP kinase activity

KEGG

ssc:100513815

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013