EKS-SUS-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	356.2	1.3E-106	15	279	265

Status

Unreviewed

Ensembl Protein

ENSSSCP00000018973

UniProt Accession

F1RFV9;

Protein Name

Protein Synonyms/Alias

Gene Name

MINK1

Gene Synonyms/Alias

MINK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000017917	ENSSSCP00000018973	ENSSSCT00000019491

Organism

Sus scrofa

Functional Description

Protein Length

1323

Protein Sequence
(FASTA)

DPCSFSLPQD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE DEEEEIKQEI 60

NMLKKYSHHR NIATYYGAFI KKSPPGNDDQ LWLVMEFCGA GSVTDLVKNT KGNALKEDCI 120

AYICREILRG LAHLHAHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG 180

TPYWMAPEVI ACDENPDATY DYRSDIWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 240

PRLKSKKWSK KFIDFIDTCL IKTYLSRPPT EQLLKFPFIR DQPTERQVRI QLKDHIDRSR 300

KKRGEKEETE YEYSGSEEED DSHGEEGEPS SIMNVPGEST LRREFLRLQQ ENKSNSEALK 360

QQQQLQQQQQ RDPEAHIKHL LHQRQRRIEE QKEERRRVEE QQRREREQRK LQEKEQQRRL 420

EDMQALRREE ERRQAEREQE YKRKQLEEQR QSERLQRQLQ QEHAYLKSLQ QQQQQQQQLQ 480

KQQQQQILPG DRKPLYHYGR GINPADKPAW AREVEERTRM NKQQNSPLAK TKPGSSGPEP 540

PGPQASPGPP GPLSQTPPMQ RPVEPQEGPH KSLVAHRVPL KPYAAPVPRS QSLQDQPTRN 600

LAAFPAAHDP DPAVPAPTAT PSARGAVIRQ NSDPTSEGPG PSPSPPAWVR PDNEAPPKVP 660

QRTSSIATAL NTSGARGARP AQAVRARPRS NSAWQIYLQR RAERGTPKPP GPPAQPPGPP 720

SACSNPDLRR SDPGWERSDS VLPASHGHLP QAGSLERNRV GASSKLDSSP VLSPGNKAKP 780

DDHRSRPGRP ADFVLLKERT LDEAPRPPKK AMDYSSSSEE VESSEDDEEE SNGEPSQGSR 840

DTPGARSDGD TDSVSTMVVH DVEEVAGTQT PYGGGTMVVQ RTPEEERSLL HADSNGYTNL 900

PDVVQPSHSP TESSKGQSPP LKDGGSDYQS RGLVKAPGQS SFTMFVDLGI YQSGGSGDTI 960

PITALLGGEG GRLDQLQLDV RKGSVVNVNP TTTRAHSETP EIRKYKKRFN SEILCAALWG 1020

VNLLVGTENG LMLLDRSGQG KVYGLIGRRR FQQMDVLEGL NLLITISGKR NKLRVYYLSW 1080

LRNKILHNDP EVEKKQGWTT VGDMEGCGHY RVVKYERIKF LVIALKNSVE VYAWAPKPYH 1140

KFMAFKSFAD LPHRPLLVDL TVEEGQRLKV IYGSSAGFHA VDVDSGNSYD IYIPVHIQSQ 1200

ITPHAIIFLP NTDGMEMLLC YEDEGVYVNT YGRIIKDVVL QWGEMPTSVA YICSNQIMGW 1260

GEKAIEIRSV ETGHLDGVFM HKRAQRLKFL CERNDKVFFA SVRSGGSSQV YFMTLNRNCI 1320

MNW 1323

Nucleotide Sequence
(FASTA)

GACCCCTGTT CTTTCTCCCT CCCCCAGGAT CCTGCTGGAA TCTTCGAGCT GGTGGAGGTG 60

GTCGGCAATG GAACCTACGG ACAGGTGTAC AAGGGTCGGC ATGTCAAGAC CGGGCAGCTG 120

GCTGCCATCA AGGTCATGGA TGTCACGGAG GATGAGGAGG AAGAGATCAA GCAGGAGATC 180

AACATGCTGA AAAAATACTC TCACCACCGC AACATCGCCA CCTACTACGG GGCCTTCATC 240

AAGAAGAGCC CCCCTGGGAA CGACGACCAG CTCTGGCTGG TCATGGAGTT CTGTGGTGCC 300

GGTTCCGTGA CGGACCTGGT GAAGAACACG AAGGGCAACG CCCTGAAGGA GGACTGCATC 360

GCCTACATCT GCCGCGAGAT CCTCCGGGGT CTGGCCCACC TCCACGCCCA CAAGGTCATC 420

CACCGGGACA TCAAGGGGCA GAATGTGCTG CTGACAGAGA ATGCCGAGGT CAAGCTAGTG 480

GACTTCGGGG TGAGCGCTCA GCTGGACCGC ACGGTGGGCA GGCGCAACAC CTTCATCGGG 540

ACCCCCTACT GGATGGCCCC CGAGGTCATC GCCTGTGATG AGAACCCCGA CGCCACCTAC 600

GATTACAGGA GTGACATTTG GTCTTTAGGA ATCACAGCCA TCGAGATGGC AGAGGGAGCC 660

CCCCCTCTGT GTGACATGCA CCCCATGCGA GCCCTCTTCC TCATCCCCCG CAATCCGCCA 720

CCCAGGCTCA AGTCCAAGAA ATGGTCTAAG AAGTTCATCG ACTTCATTGA CACGTGTCTC 780

ATCAAGACGT ACCTGAGCCG CCCGCCGACG GAGCAGCTGC TCAAGTTCCC CTTCATCCGA 840

GACCAGCCCA CCGAGCGGCA GGTCCGCATC CAGCTCAAGG ACCACATCGA CCGATCGCGC 900

AAGAAGCGAG GCGAGAAAGA GGAGACAGAG TATGAGTACA GCGGCAGCGA AGAGGAAGAC 960

GACAGCCACG GCGAGGAAGG AGAGCCAAGC TCCATCATGA ACGTGCCAGG GGAGTCGACC 1020

CTCCGCCGGG AATTCCTCCG GCTCCAGCAG GAGAACAAGA GCAACTCGGA AGCTTTAAAG 1080

CAGCAACAGC AGCTGCAGCA GCAGCAACAG CGAGACCCCG AGGCGCACAT CAAGCACCTC 1140

CTGCACCAGC GACAGCGGCG CATTGAGGAG CAGAAGGAGG AGCGGCGGCG TGTTGAAGAG 1200

CAACAGCGGC GGGAGCGGGA GCAGCGGAAG CTGCAGGAGA AGGAGCAGCA GCGGCGGCTG 1260

GAGGACATGC AGGCCCTGCG GCGGGAGGAG GAGAGGCGGC AGGCCGAGCG GGAGCAGGAA 1320

TACAAGCGGA AGCAGCTGGA GGAGCAGCGG CAGTCGGAGC GCCTGCAGAG GCAGCTGCAG 1380

CAGGAGCATG CCTACCTCAA GTCCCTGCAG CAGCAGCAGC AGCAGCAGCA GCAGCTTCAG 1440

AAGCAGCAGC AGCAGCAAAT CCTGCCCGGG GACAGGAAGC CCCTGTATCA TTACGGTCGG 1500

GGCATTAACC CCGCTGACAA ACCAGCCTGG GCCCGAGAGG TGGAAGAGAG GACAAGGATG 1560

AACAAGCAGC AGAACTCTCC CCTGGCCAAG ACCAAGCCAG GCAGCTCGGG GCCTGAGCCC 1620

CCGGGCCCCC AGGCCTCCCC TGGGCCCCCA GGCCCCCTTT CCCAGACTCC TCCTATGCAG 1680

AGGCCGGTGG AGCCCCAGGA GGGACCGCAC AAGAGCCTGG TGGCACACCG GGTCCCACTG 1740

AAGCCATATG CAGCGCCTGT ACCCCGATCC CAGTCCCTGC AGGACCAGCC CACCCGAAAC 1800

CTGGCTGCCT TCCCAGCGGC CCACGACCCC GACCCCGCCG TCCCCGCCCC CACTGCCACG 1860

CCCAGTGCCC GAGGAGCCGT CATCCGCCAG AACTCAGACC CCACTTCCGA AGGGCCTGGC 1920

CCCAGCCCCA GCCCTCCAGC CTGGGTCCGG CCTGACAACG AGGCCCCTCC CAAGGTGCCG 1980

CAGAGAACCT CCTCCATCGC CACTGCCCTT AACACCAGTG GGGCCCGAGG GGCCCGGCCG 2040

GCCCAGGCTG TCCGCGCCAG ACCTCGCAGC AACTCCGCCT GGCAAATCTA CCTGCAAAGG 2100

CGGGCAGAGC GGGGCACCCC CAAGCCTCCA GGGCCCCCTG CTCAGCCCCC TGGCCCGCCC 2160

AGCGCCTGTA GTAACCCTGA CCTCAGGAGG AGCGACCCTG GCTGGGAGCG CTCGGACAGC 2220

GTCCTGCCCG CCTCGCACGG GCACCTCCCC CAGGCTGGCT CGCTGGAGCG GAACCGTGTG 2280

GGAGCCTCCT CCAAACTGGA CAGCTCGCCC GTGCTCTCCC CTGGCAACAA AGCCAAGCCT 2340

GATGACCACC GCTCGCGGCC CGGCAGGCCC GCAGACTTCG TGCTGCTCAA AGAGCGGACT 2400

CTGGACGAGG CCCCCCGGCC TCCCAAGAAG GCCATGGACT ACTCCTCGTC CAGCGAGGAG 2460

GTGGAGAGCA GCGAGGACGA TGAGGAGGAG AGCAACGGCG AGCCTTCCCA GGGGAGCAGA 2520

GACACCCCCG GGGCCCGCAG CGACGGCGAC ACCGACAGCG TCAGCACCAT GGTGGTCCAC 2580

GACGTGGAGG AGGTGGCCGG GACCCAGACT CCCTACGGGG GCGGCACCAT GGTGGTCCAG 2640

CGTACCCCGG AAGAGGAGCG AAGCCTGCTA CACGCCGACA GCAACGGCTA CACGAACCTG 2700

CCAGACGTGG TCCAGCCCAG CCACTCGCCC ACTGAGAGCA GCAAAGGCCA AAGCCCCCCC 2760

TTGAAGGATG GCGGCAGTGA CTACCAGTCT CGTGGGCTGG TGAAGGCCCC GGGCCAGAGC 2820

TCGTTTACCA TGTTTGTGGA CCTGGGGATC TACCAGTCCG GAGGCAGTGG GGATACCATC 2880

CCCATCACAG CCCTGCTGGG TGGAGAGGGC GGCCGGCTCG ACCAGCTCCA GTTGGACGTG 2940

AGGAAAGGCT CTGTGGTCAA CGTGAACCCC ACCACCACCC GGGCCCACAG CGAGACCCCC 3000

GAGATCCGGA AGTACAAGAA GCGGTTCAAC TCCGAGATCC TCTGTGCGGC CCTTTGGGGG 3060

GTCAACCTGC TGGTGGGCAC GGAGAACGGG CTGATGCTGC TGGACCGCAG CGGGCAGGGC 3120

AAGGTGTACG GGCTCATCGG GCGCCGCCGC TTCCAGCAGA TGGACGTGCT GGAGGGACTC 3180

AACCTGCTCA TCACCATCTC AGGGAAAAGG AACAAACTGC GGGTGTACTA CCTGTCCTGG 3240

CTCCGGAACA AGATCCTGCA CAACGACCCG GAAGTGGAGA AGAAGCAGGG CTGGACCACC 3300

GTCGGGGACA TGGAGGGCTG CGGCCACTAC CGCGTTGTGA AGTACGAACG CATCAAGTTC 3360

CTGGTCATCG CCCTGAAGAA CTCGGTGGAG GTGTATGCCT GGGCCCCCAA ACCGTACCAC 3420

AAATTCATGG CTTTCAAGTC CTTTGCGGAC CTCCCGCACC GCCCTCTGCT GGTGGACCTG 3480

ACGGTGGAGG AGGGGCAGCG GCTCAAGGTC ATCTACGGCT CCAGCGCCGG CTTCCACGCG 3540

GTGGACGTCG ACTCGGGGAA CAGCTACGAC ATCTACATCC CCGTGCACAT CCAGAGCCAG 3600

ATCACGCCCC ACGCCATCAT CTTCCTCCCC AACACGGACG GCATGGAGAT GCTGCTGTGC 3660

TACGAGGACG AGGGCGTCTA CGTCAACACG TACGGGCGCA TCATCAAGGA CGTGGTGCTG 3720

CAGTGGGGAG AGATGCCCAC CTCTGTGGCC TACATCTGCT CCAACCAGAT CATGGGCTGG 3780

GGTGAGAAAG CCATTGAGAT CCGCTCGGTG GAGACGGGCC ACCTGGACGG CGTCTTCATG 3840

CACAAGCGAG CCCAGAGGCT CAAGTTCCTG TGCGAGCGGA ACGACAAGGT GTTTTTTGCC 3900

TCCGTCCGCT CCGGGGGCAG CAGCCAAGTT TACTTCATGA CGCTGAACCG TAACTGCATC 3960

ATGAACTGGT GA 3972

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee+++ei++lkk++h +ni

Q: 15    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKKYSHhRNIA  73

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ + lkE+ iayi+re+l++L++

Q: 74    TYYGAFIKksppgnDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAH  133

         *************99*********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 134   LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  193

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd+++DiwslGItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f

Q: 194   enpDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  252

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

          +f+++cl k + +Rp +++llk +F+

Q: 253   IDFIDTCLIKTYLSRPPTEQLLKFPFI  279

         *************************97

Domain Sequence
(FASTA)

FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKSP PGNDDQLWLV MEFCGAGSVT DLVKNTKGNA LKEDCIAYIC REILRGLAHL 120

HAHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDYRS DIWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFID 240

FIDTCLIKTY LSRPPTEQLL KFPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0045060	; P:negative thymic T cell selection
GO:0046330	; P:positive regulation of JNK cascade
GO:0046777	; P:protein autophosphorylation
GO:0030334	; P:regulation of cell migration
GO:0022407	; P:regulation of cell-cell adhesion
GO:0001952	; P:regulation of cell-matrix adhesion

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013