EKS-SUS-00263
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00263
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR367.25.4E-1102206205
StatusUnreviewed
Ensembl ProteinENSSSCP00000019799
UniProt AccessionI3L6Z7;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000020725ENSSSCP00000019799ENSSSCT00000027288
OrganismSus scrofa
Functional Description
Protein Length578
Protein Sequence
(FASTA)
MLAIGSLDHA HIVRLLGLCP GSSLQLVTQY LPLGSLLDHV RQHRGVLGPQ LLLNWGVQIA 60
KGMYYLEEHG MVHRNLAARN VLLKSPSQVQ VADFGVADLL PPDDKQLLHS EAKTPIKWMA 120
LESIHFGKYT HQSDVWSYGV TVWELMTFGA EPYAGLRLAE VPDLLEKGER LAQPQICTID 180
VYMVMVKCWM IDENIRPTFK ELANEFTRMA RDPPRYLVIK RESGPGIPPG AEPPALTNKE 240
LEEVELEPEL DLDLELEAEE DNLAPTLGSA LSLPLGTLNR PRASQSLVSP SSGYMPMNQG 300
NLGEACQEPA VCRGSERCPR PASLHPVPRG RLTSESSEGH VTGSEAELQE KVSMCRSRSR 360
SPRPRGDSAY HSQRHSLLTP VTPQSPPGLE EEDVNGYVMP DAHLKGTSSR EGTLSSVGLS 420
SVLGTEEEEE DEEYEYMNRR RRCSPARPPR PSSLEELGYE YMDVGSDLSA SLGSTQSCPL 480
NPVPTMPNAS TTPDEDYEYM NRRRGGGGPG GDYAAMEACP AAEQGYEEMR AFQGPGHHGP 540
QVHYARLKTR SLEATDSAFD NPDYWHSRLF PKANAQRT 578
Nucleotide Sequence
(FASTA)
ATGCTGGCCA TTGGCAGCCT CGACCACGCC CACATTGTAC GGCTGCTGGG ACTGTGCCCA 60
GGGTCATCTC TGCAGCTCGT CACGCAGTAC TTGCCTCTGG GCTCCCTGCT GGATCATGTG 120
AGACAACACC GGGGGGTACT GGGGCCACAG CTGCTGCTCA ACTGGGGAGT ACAAATTGCC 180
AAGGGAATGT ACTACCTTGA GGAGCATGGC ATGGTGCACA GGAACCTGGC TGCCCGAAAT 240
GTGCTACTGA AGTCCCCCAG TCAGGTTCAG GTGGCAGATT TTGGGGTTGC TGACTTGCTG 300
CCCCCTGATG ATAAGCAGCT ACTGCACAGT GAGGCCAAGA CTCCAATTAA GTGGATGGCC 360
CTAGAGAGTA TCCACTTTGG GAAATACACA CACCAGAGTG ACGTCTGGAG CTATGGAGTG 420
ACAGTTTGGG AGCTGATGAC CTTTGGGGCA GAGCCCTATG CAGGGCTGCG ACTGGCTGAA 480
GTACCAGACC TGCTGGAGAA GGGGGAACGG TTGGCACAGC CCCAGATCTG TACCATTGAT 540
GTCTACATGG TCATGGTCAA GTGTTGGATG ATTGATGAGA ACATCCGCCC AACCTTTAAA 600
GAACTAGCCA ATGAGTTCAC CAGGATGGCC CGGGACCCAC CACGGTACCT GGTTATAAAG 660
AGAGAAAGTG GACCTGGGAT TCCCCCCGGG GCAGAGCCCC CTGCTCTAAC AAACAAGGAA 720
CTGGAGGAAG TAGAGCTGGA GCCGGAACTA GACCTGGATC TGGAGTTGGA GGCAGAGGAG 780
GACAACCTGG CCCCCACACT GGGCTCTGCC CTCAGTCTGC CACTTGGAAC ACTTAATCGG 840
CCACGTGCAA GCCAGAGCCT TGTAAGCCCA TCATCTGGAT ATATGCCTAT GAACCAGGGA 900
AATCTTGGGG AGGCTTGCCA GGAGCCTGCA GTTTGTAGGG GTAGTGAACG GTGCCCCCGT 960
CCAGCCTCTC TGCACCCAGT GCCACGGGGA CGCCTGACAT CAGAGTCATC GGAGGGCCAC 1020
GTGACAGGCT CTGAAGCTGA GCTCCAGGAG AAGGTATCGA TGTGTAGAAG CCGGAGCCGG 1080
AGCCCTCGGC CACGAGGAGA CAGTGCCTAC CATTCCCAGC GCCACAGCCT GCTCACTCCT 1140
GTCACCCCAC AGTCCCCACC AGGGTTAGAG GAAGAGGATG TCAATGGTTA TGTCATGCCA 1200
GACGCACACC TCAAAGGTAC CTCCTCCCGG GAAGGCACCC TTTCTTCAGT CGGTCTCAGT 1260
TCTGTCCTGG GGACCGAGGA AGAAGAAGAA GACGAGGAGT ATGAATACAT GAACCGGAGG 1320
AGAAGGTGCA GTCCAGCTCG TCCCCCAAGG CCAAGTTCCC TCGAGGAGCT GGGTTATGAG 1380
TACATGGATG TGGGATCAGA CCTCAGTGCT TCCCTGGGCA GCACACAGAG TTGCCCACTC 1440
AACCCTGTGC CCACCATGCC CAATGCCAGC ACAACTCCAG ATGAGGACTA TGAATATATG 1500
AATCGGCGAC GTGGTGGAGG GGGTCCTGGG GGGGATTATG CAGCCATGGA GGCCTGCCCA 1560
GCAGCTGAGC AAGGGTATGA AGAAATGAGA GCTTTCCAGG GGCCTGGACA CCATGGCCCT 1620
CAGGTCCATT ATGCCCGCCT CAAAACCCGT AGTTTAGAAG CCACTGACTC CGCCTTTGAT 1680
AACCCGGATT ACTGGCATAG CAGGCTTTTC CCCAAGGCTA ATGCCCAGAG AACATAA 1737
Domain Profile
S: 53    lvlasldhanlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiak  112
         l+++sldha++vrllglc  s+lqlvtq+lplG+lld+vr+h++ lG+q llnw+vqiak
Q: 2     LAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGVLGPQLLLNWGVQIAK  61
         7899********************************************************
S: 113   GmsyleekrlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlal  172
         Gm+ylee+ +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+al
Q: 62    GMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMAL  121
         ************************************************************
S: 173   esilkrkythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidv  232
         esi++ kythqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidv
Q: 122   ESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDV  181
         ************************************************************
S: 233   ymvlvkcwmidaesrpkfkelaeef  257
         ymv+vkcwmid+++rp+fkela+ef
Q: 182   YMVMVKCWMIDENIRPTFKELANEF  206
         ************************9
Domain Sequence
(FASTA)
LAIGSLDHAH IVRLLGLCPG SSLQLVTQYL PLGSLLDHVR QHRGVLGPQL LLNWGVQIAK 60
GMYYLEEHGM VHRNLAARNV LLKSPSQVQV ADFGVADLLP PDDKQLLHSE AKTPIKWMAL 120
ESIHFGKYTH QSDVWSYGVT VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV 180
YMVMVKCWMI DENIRPTFKE LANEF 205
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Pteropus vampyrus"; ?>Tursiops truncatus"; ?>
EKS-AIM-00281
EKS-BOT-00299
EKS-CAF-00306
EKS-EQC-00291
EKS-FEC-00285
EKS-HOS-00306
EKS-MOD-00294
EKS-MUP-00297
EKS-OCP-00048
EKS-ORC-00282
EKS-PTV-00063
EKS-TUT-00065
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0016328; C:lateral plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0030296; F:protein tyrosine kinase activator activity
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0014037; P:Schwann cell differentiation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013