EKS-SUS-00340

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00340

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.2	6.0E-109	654	908	255

Status

Unreviewed

Ensembl Protein

ENSSSCP00000028668

UniProt Accession

I3LST3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000020735	ENSSSCP00000029795	ENSSSCT00000036225
ENSSSCG00000020735	ENSSSCP00000028668	ENSSSCT00000036543
ENSSSCG00000020735	ENSSSCP00000027176	ENSSSCT00000024706

Organism

Sus scrofa

Functional Description

Protein Length

924

Protein Sequence
(FASTA)

MESGGGAPAA GALGAAAESP PGSQPPGGEG AAGPAGPLEP DGAAEGAGVG GESGGGPRRA 60

LRAVYVRSES PQGGAVGGPE EGARQCLLRA CEAEGAHLIS VPFGELDFGE TAVLDAFYDA 120

DVAVVDMSDV SRQPSLFYHL GVRESFDMAN NVILYHDTDA DTALSLKDMV TQKNTASSGN 180

YYFIPYIVTP CADYFCCESD AQRRASEYMQ PNWDTILGPL CVPLVDRFTS LLKDIHVTSC 240

AYYKETLLND IRRAREKYQG DELAKELARI KLRMDNTEVL TSDIIVNLLL SYRDIQDYDA 300

MVKLVETLEM LPTCDLADQH NIKFHYAFAL NRRNTTGDRE KALQVMLQVL QSCDHPAPDM 360

FCLCGRIYKD IFLDSDCKDD ASRDSAIEWY RKGFELQSSL YSGINLAVLL IVAGQQFETS 420

MELRKIGVRL NSLLGRKGSL EKMNNYWDVG QFFSVSMLAS DAGKAVQAAE RLFKLKPPVW 480

YLRSLVQNLL LIQRFKKPII EHSPRQERLN FWLDIIFEAT NEVTNGLRFP VLVIEPTKVY 540

QPSYVSINSE AEERTVSLWH VSPTEMKQIH EWNFTASSIR GISISKFDER CCFLYVHDNS 600

DDFQIYFSTE DQCSRFCSLV KEMITSAVGT TVELEGETDG DTLEYEYDHD ANGERVVLGK 660

GTYGVVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL HKYLKHRNIV QYLGSVSENG 720

YIKIFMEQVP GGSLSALLRS KWGPMKEPTI RFYTRQILEG LKYLHENQIV HRDIKGDNVL 780

VNTYSGVVKI SDFGTSKRLA GVNPCTETFA GTLQYMAPEI IDQGPRGYGA PADIWSLGCT 840

IIEMATSRPP FHELGEPQAA MFKVGMFKIH PEIPETLSAE ARAFIVSCFE PDPRKRVTAA 900

GLLQEGFLKQ VNKGKKIRMA FKPA 924

Nucleotide Sequence
(FASTA)

ATGGAGAGCG GCGGCGGGGC GCCCGCGGCT GGGGCACTCG GGGCGGCGGC CGAGTCCCCA 60

CCCGGCTCGC AGCCGCCGGG GGGCGAGGGC GCCGCGGGGC CGGCGGGGCC GCTGGAGCCC 120

GATGGAGCGG CCGAGGGCGC CGGGGTCGGA GGCGAGAGCG GGGGCGGGCC GCGGCGGGCT 180

CTGCGGGCAG TATACGTGCG CAGCGAGAGC CCCCAGGGCG GCGCGGTCGG CGGCCCCGAG 240

GAGGGAGCGC GGCAGTGCCT GCTGCGAGCC TGCGAGGCCG AGGGCGCCCA CCTTATCTCC 300

GTGCCCTTCG GGGAGCTTGA CTTCGGGGAG ACGGCGGTGC TCGACGCCTT CTACGACGCA 360

GATGTTGCCG TGGTGGACAT GAGCGATGTC TCCAGACAGC CTTCCCTCTT CTACCATCTT 420

GGGGTCCGCG AAAGCTTCGA CATGGCCAAT AACGTGATCC TGTACCACGA CACCGATGCT 480

GACACTGCCC TTTCATTGAA GGATATGGTA ACTCAAAAAA ACACAGCGTC TAGTGGAAAT 540

TATTATTTCA TCCCGTACAT CGTGACACCG TGCGCTGATT ATTTTTGCTG TGAGAGCGAT 600

GCCCAGAGGC GTGCCTCGGA GTACATGCAG CCCAACTGGG ACACCATCCT GGGTCCGCTG 660

TGTGTGCCCC TGGTGGACCG GTTTACTAGC CTCCTCAAGG ACATCCACGT GACCTCATGC 720

GCTTATTACA AAGAAACCCT GTTAAATGAC ATCCGGAGAG CCAGAGAGAA ATACCAGGGC 780

GATGAACTGG CCAAAGAACT GGCTCGGATC AAACTCCGCA TGGATAATAC TGAGGTTCTG 840

ACCTCAGACA TCATCGTTAA TTTACTGCTG AGCTACCGCG ATATCCAGGA CTATGATGCA 900

ATGGTGAAGC TGGTAGAAAC ACTGGAAATG CTGCCTACAT GTGACTTGGC GGACCAGCAT 960

AATATTAAAT TCCACTACGC ATTCGCCCTG AATAGGAGGA ACACCACAGG CGATCGTGAG 1020

AAGGCTCTGC AGGTCATGCT CCAGGTCTTG CAGAGCTGTG ACCACCCGGC CCCCGACATG 1080

TTCTGCCTGT GTGGGAGGAT CTACAAGGAC ATCTTCTTGG ATTCAGACTG CAAAGATGAT 1140

GCCAGCCGAG ACAGCGCCAT TGAGTGGTAT CGCAAAGGGT TTGAGCTCCA GTCCTCTCTC 1200

TATTCAGGAA TTAACCTTGC AGTTTTGCTG ATAGTTGCTG GACAACAATT TGAAACTTCC 1260

ATGGAACTAA GGAAAATAGG TGTCCGGCTG AACAGTTTAT TGGGAAGAAA GGGGAGCTTG 1320

GAAAAAATGA ACAATTACTG GGATGTGGGT CAGTTTTTCA GCGTCAGCAT GTTGGCCAGT 1380

GATGCTGGGA AGGCTGTCCA GGCGGCAGAG AGGTTGTTCA AACTGAAACC TCCAGTCTGG 1440

TACCTGCGAT CATTAGTTCA GAACTTGTTA TTAATTCAGC GCTTCAAGAA ACCTATTATT 1500

GAACATTCGC CCAGGCAAGA ACGGCTGAAC TTCTGGTTAG ATATCATTTT CGAGGCCACA 1560

AATGAAGTTA CTAATGGACT CAGATTTCCA GTCCTGGTGA TAGAACCAAC CAAAGTCTAC 1620

CAGCCTTCGT ATGTCTCTAT CAACAGTGAA GCTGAAGAGA GGACGGTTTC TCTGTGGCAT 1680

GTCTCACCCA CAGAAATGAA ACAAATTCAT GAATGGAATT TTACAGCCTC TTCCATTAGA 1740

GGAATAAGCA TATCCAAATT TGATGAACGG TGTTGTTTTC TTTATGTCCA TGATAATTCT 1800

GATGACTTTC AAATCTACTT TTCCACTGAA GACCAGTGTA GTAGGTTTTG CTCTTTGGTC 1860

AAAGAGATGA TAACCAGCGC GGTGGGCACT ACAGTGGAGC TGGAGGGAGA GACCGATGGG 1920

GACACCTTAG AGTATGAGTA CGACCATGAT GCGAATGGTG AGCGAGTCGT GCTGGGGAAG 1980

GGCACGTACG GGGTCGTGTA CGCCGGAAGA GATCTGAGCA ATCAAGTGCG AATAGCCATC 2040

AAAGAAATTC CAGAGAGAGA CAGCAGGTAC TCTCAGCCTC TGCACGAGGA GATAGCCCTG 2100

CACAAGTACC TCAAGCACCG CAACATCGTT CAGTACCTGG GCTCCGTTTC CGAGAATGGC 2160

TACATTAAGA TATTTATGGA GCAGGTGCCT GGGGGAAGCC TTTCTGCTCT TTTGCGATCA 2220

AAGTGGGGGC CGATGAAGGA GCCCACCATC AGGTTTTACA CCAGGCAGAT CCTGGAAGGC 2280

CTCAAGTATC TGCACGAAAA CCAGATTGTG CACAGAGACA TAAAGGGTGA TAACGTTCTG 2340

GTGAATACCT ACAGCGGAGT GGTGAAAATC TCCGATTTCG GAACCTCTAA ACGTCTTGCA 2400

GGAGTGAATC CATGCACGGA GACTTTTGCT GGCACGCTGC AGTACATGGC GCCTGAGATT 2460

ATCGATCAGG GACCTCGTGG GTATGGTGCT CCGGCTGATA TCTGGTCCCT GGGCTGCACC 2520

ATCATTGAAA TGGCCACCAG CAGGCCTCCG TTCCATGAGC TCGGTGAACC GCAGGCAGCA 2580

ATGTTCAAAG TGGGGATGTT TAAGATTCAC CCTGAGATTC CGGAAACCCT TTCCGCTGAA 2640

GCCAGAGCTT TCATTGTATC CTGTTTTGAG CCTGACCCCC GCAAACGCGT CACCGCCGCT 2700

GGCCTGCTCC AGGAGGGTTT CTTAAAGCAG GTGAACAAGG GCAAGAAGAT CCGAATGGCT 2760

TTCAAGCCGG CAG 2773

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 654   ERVVLGKGTYGVVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  708

         6899**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+++e +i++yt+qilegl+yLHe++

Q: 709   IVQYLGSVSENGYIKIFMEQVPGGSLSALLRsKWGPMKEPTIRFYTRQILEGLKYLHENQ  768

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e+++Gtl+ymaPE+i+++

Q: 769   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGVNPC---TETFAGTLQYMAPEIIDQGP  825

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+t+++Pf+el+e++a+mfkvg+ k++Peipe+ls+e+++f+

Q: 826   RGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPETLSAEARAFI  885

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

          +c+e dp+kr++a+ LL++ fl

Q: 886   VSCFEPDPRKRVTAAGLLQEGFL  908

         *******************9985

Domain Sequence
(FASTA)

ERVVLGKGTY GVVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNIVQYL 60

GSVSENGYIK IFMEQVPGGS LSALLRSKWG PMKEPTIRFY TRQILEGLKY LHENQIVHRD 120

IKGDNVLVNT YSGVVKISDF GTSKRLAGVN PCTETFAGTL QYMAPEIIDQ GPRGYGAPAD 180

IWSLGCTIIE MATSRPPFHE LGEPQAAMFK VGMFKIHPEI PETLSAEARA FIVSCFEPDP 240

RKRVTAAGLL QEGFL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013