EKS-SUS-00376

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00376

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	540.8	7.5E-163	98	355	258

Status

Unreviewed

Ensembl Protein

ENSSSCP00000026969

UniProt Accession

I3LS78;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000021443	ENSSSCP00000026969	ENSSSCT00000027054

Organism

Sus scrofa

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MTVKTEAARN TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HSEVQSILKI 60

SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 120

EAFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN 180

GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD 240

FGLCKENIEH NGTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 300

NTAEMYDNIL NKPLQLKPNI TNSARHVLEG LLQKDRTKRL GAKDDFMEIK NHVFFSVINW 360

DDLINKKITP PFNPNVSGPS DLRHFDPEFT EEPVPNSIGR SPDSILLTAS VKEAAEAFLG 420

FSYAPPVDSF L 431

Nucleotide Sequence
(FASTA)

ATGACAGTGA AAACCGAGGC TGCTAGGAAC ACACTCACTT ACTCCAGAAT GAGGGGAATG 60

GTAGCAATTC TCATCGCTTT CATGAAACAG AGAAGGATGG GCCTGAACGA CTTTATTCAG 120

AAGATTGCCA ATAATTCCTA TGCATGCAAA CACTCTGAAG TTCAGTCCAT TTTGAAAATC 180

TCTCAACCTC AGGAGCCTGA GCTTATGAAT GCCAACCCTT CTCCTCCTCC AAGTCCTTCT 240

CAGCAAATCA ACCTGGGCCC ATCTTCCAAT CCTCATGCTA AACCGTCTGA CTTTCACTTC 300

TTGAAAGTGA TTGGGAAGGG CAGTTTTGGA AAGGTTCTTC TAGCAAGACA CAAAGCAGAA 360

GAAGCATTCT ATGCAGTCAA AGTTTTACAA AAGAAGGCGA TCCTGAAAAA GAAGGAGGAA 420

AAGCACATTA TGTCGGAGCG GAATGTTCTC CTGAAGAATG TGAAACACCC TTTCCTGGTG 480

GGCCTTCATT TCTCTTTCCA GACTGCTGAC AAACTGTACT TTGTCCTAGA CTACATTAAC 540

GGTGGAGAGT TGTTCTACCA TCTCCAGAGG GAGCGATGCT TCCTGGAACC ACGGGCTCGG 600

TTCTATGCTG CTGAAATAGC CAGTGCCTTG GGTTACCTGC ACTCTCTGAA CATCGTTTAT 660

AGAGACTTAA AACCAGAGAA TATTTTGCTA GATTCACAGG GACACATTGT CCTTACCGAC 720

TTTGGACTCT GCAAGGAGAA CATTGAACAC AACGGCACGA CATCCACCTT CTGCGGCACA 780

CCTGAGTATC TTGCACCTGA GGTCCTTCAC AAGCAGCCTT ATGACAGGAC TGTGGACTGG 840

TGGTGCCTGG GGGCCGTCTT ATATGAGATG CTGTATGGTC TGCCTCCATT TTACAGCCGA 900

AACACAGCTG AGATGTACGA CAACATTCTG AACAAGCCCC TCCAGTTGAA ACCAAATATT 960

ACGAATTCTG CAAGACACGT CCTGGAGGGC CTTCTGCAGA AGGACAGGAC GAAGAGGCTG 1020

GGTGCCAAGG ATGACTTTAT GGAGATTAAG AATCATGTCT TCTTCTCCGT AATTAACTGG 1080

GATGATCTCA TTAATAAGAA GATTACTCCC CCTTTTAACC CAAATGTGAG CGGACCCAGC 1140

GACCTGCGGC ACTTTGACCC CGAGTTCACC GAAGAGCCGG TCCCCAATTC CATTGGCCGG 1200

TCCCCCGACA GCATCCTCCT CACCGCCAGC GTCAAGGAAG CAGCCGAGGC CTTCCTGGGC 1260

TTCTCCTACG CCCCTCCCGT GGACTCCTTC CTCTGA 1296

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 98    FHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  157

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 158   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  217

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie++ ttstfcgtpeylapevl+k+pydrt

Q: 218   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT  277

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a+++le+ll+kdr+

Q: 278   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHVLEGLLQKDRT  337

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eiknhvff

Q: 338   KRLGAKDDFMEIKNHVFF  355

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEAFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHV LEGLLQKDRT 240

KRLGAKDDFM EIKNHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006974	; P:response to DNA damage stimulus

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013