EKS-SUS-00390

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00390

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	470.4	2.0E-141	76	338	263

Status

Unreviewed

Ensembl Protein

ENSSSCP00000022815

UniProt Accession

I3LCJ1;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000021893	ENSSSCP00000021766	ENSSSCT00000029907
ENSSSCG00000021893	ENSSSCP00000022815	ENSSSCT00000026467

Organism

Sus scrofa

Functional Description

Protein Length

1355

Protein Sequence
(FASTA)

MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK 60

DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 120

FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180

EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY 240

ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 300

DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS 360

SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY SNRRYLSAAN PNDNRASSNV 420

DKSLLKQENL QKTIYKLEEQ LHNEMQLKDE MEQKCRTSNI KLDKIMKELD EEGNQRRNLE 480

STLSQIEKEK MLLQHRINEY QRKAEQENEK RRNVENEVST LKDQLEDLKK VSQNSQLANE 540

KLAQLQKQLE EANDLLRTES DTAVRLRKSH TEMSKSITQL ESLNRELQER NRILENSKSQ 600

TDKDYYQLQA VLEAERRDRG RDSEMIGDLQ ARITSLQEEV KHLKHNLERV EGERKDAQDM 660

LNHSEKEKNN LEIDLNYKLK SLQQRLEQEV NEHKVTKARL TDKHQSIEEA KSVAMCEMEK 720

KLKEEREARE KAENRVVQIE KQCSMLDVDL KQSQQKLEHL TENKERMEDE VKNLTLQLEQ 780

ESNKRLLLQN ELKTQAFESD NLKGLQKQMK QEINTLLEAK RLLEFELAQL TKQYRGNEGQ 840

MRELQDQLEA EQYFSTLYKT QVKELKEEIE EKNRENLKKI QELQNEKETL ATQLDLAETK 900

AESEQLARGL LEEQYFELTQ ESKKAASRNR QEITDKDHIV SRLEETNSML TKDIDLLRKE 960

NEELTDKMRK AEEEYKLKKE EEISNLKAAF EKNINTERTL KTQAVNKLAE IMNRKDFKID 1020

RKKANTQDLR KKEKENRKLQ LELNQEREKF NQMVVKHQKE LNDMQAQLVE ECTHRNELQM 1080

QLASKESDIE QRAKLLDLSD STSVASFPSA DETDGNLPES RIEGWLSIPN RGNIKRYGWK 1140

KQYVVVSSKK ILFYNDEQDK EQSNPSMVLD IDKLFHVRPV TQGDVYRAET EEIPKIFQIL 1200

YANEGECRKD VEMEPVQQAE KTNFQNHKGH EFIPTLYHFP ANCEACAKPL WHVFKPPPAL 1260

ECRRCHVKCH RDHLDKKEDL ISPCKVSYDV TSARDMLLLA CSQDEQKKWV THLVKKIPKN 1320

PPSSFVRASP RTLSTRSTAN QSFRKVVKNT SGKTR 1355

Nucleotide Sequence
(FASTA)

ATGTCGACTG GGGACAGTTT TGAGACTCGG TTTGAAAAAA TCGACAACTT GCTGCGGGAT 60

CCCAAATCGG AAGTGAATTC AGATTGTTTG CTGGATGGAT TGGATGCTTT GGTGTATGAT 120

TTGGATTTTC CTGCCTTAAG AAAAAACAAA AATATTGACA ACTTTTTAAG CAGATATAAA 180

GACACAATAA ATAAAATTAG AGATTTACGA ATGAAAGCTG AAGATTATGA AGTAGTGAAA 240

GTGATTGGTA GAGGTGCATT TGGAGAAGTT CAATTGGTAA GGCATAAATC CACAAGGAAG 300

GTATATGCTA TGAAGCTTCT CAGCAAATTT GAAATGATTA AGAGATCTGA TTCTGCTTTT 360

TTCTGGGAAG AAAGGGACAT CATGGCTTTT GCTAATAGTC CTTGGGTTGT GCAGCTGTTT 420

TATGCATTCC AAGATGATCG TTATCTCTAC ATGGTAATGG AATACATGCC AGGTGGAGAT 480

CTTGTAAACT TAATGAGCAA CTATGATGTG CCTGAAAAAT GGGCCCGATT CTATACTGCA 540

GAAGTAGTCC TTGCATTGGA TGCAATCCAC TCCATGGGTT TTATTCATAG AGATGTGAAG 600

CCTGATAATA TGCTGCTGGA TAAATCTGGA CATTTGAAGT TAGCAGATTT TGGTACTTGT 660

ATGAAGATGA ATAAGGAAGG TATGGTACGA TGTGATACAG CAGTTGGAAC ACCTGATTAT 720

ATTTCCCCTG AAGTATTAAA GTCTCAAGGT GGCGATGGTT ATTATGGACG AGAATGTGAC 780

TGGTGGTCAG TTGGAGTATT TTTATATGAA ATGCTTGTTG GTGATACACC ATTTTATGCA 840

GATTCTTTGG TTGGAACTTA CAGTAAGATT ATGAATCATA AAAATTCACT TACCTTCCCT 900

GATGATAATG ATATATCAAA AGAAGCAAAA AATCTTATTT GTGCCTTCCT TACTGACAGG 960

GAGGTGAGAT TAGGGCGAAA TGGTGTAGAA GAAATCAAGC GACATCTCTT CTTCAAAAAT 1020

GACCAGTGGG CTTGGGAAAC ACTCCGAGAC ACTGTGGCAC CAGTTGTACC TGATTTAAGT 1080

AGTGACATTG ACACAAGTAA CTTTGATGAC TTGGAAGAAG ATAAAGGAGA TGAAGAAACA 1140

TTCCCTATAC CTAAAGCTTT TGTTGGCAAT CAACTACCTT TTGTAGGATT TACATATTAT 1200

AGCAATCGTA GATACTTATC TGCCGCAAAT CCTAACGATA ACAGAGCTAG TTCTAATGTG 1260

GATAAAAGCT TGTTAAAGCA GGAAAATTTG CAAAAAACAA TTTATAAGTT GGAAGAACAG 1320

CTGCATAATG AAATGCAATT AAAAGATGAA ATGGAGCAGA AGTGCAGAAC TTCAAACATA 1380

AAGCTAGACA AGATAATGAA AGAATTGGAT GAAGAGGGGA ATCAAAGAAG AAATCTAGAA 1440

TCTACATTGT CTCAGATCGA AAAGGAGAAA ATGTTGCTAC AGCACAGAAT TAATGAGTAC 1500

CAAAGAAAAG CAGAACAGGA AAATGAGAAG AGGAGGAATG TAGAAAATGA AGTTTCTACA 1560

TTAAAGGATC AGTTGGAAGA CTTAAAGAAA GTCAGTCAGA ATTCACAGCT TGCGAATGAG 1620

AAGCTGGCAC AGTTACAAAA GCAGCTAGAA GAAGCCAATG ACTTACTTAG GACAGAATCA 1680

GACACAGCTG TAAGGTTAAG GAAGAGTCAC ACTGAGATGA GCAAGTCAAT TACTCAGCTG 1740

GAGTCCCTTA ACAGAGAACT GCAGGAGAGA AATAGAATTT TAGAGAATTC AAAATCACAA 1800

ACAGACAAGG ATTATTACCA GCTGCAAGCT GTATTAGAAG CTGAACGAAG AGACAGAGGT 1860

CGTGATTCTG AGATGATTGG AGACCTACAA GCTCGAATTA CATCTTTACA AGAGGAGGTG 1920

AAGCATCTCA AACATAATCT TGAAAGAGTG GAAGGAGAAA GAAAAGATGC TCAAGACATG 1980

CTTAATCATT CAGAAAAGGA AAAGAATAAT TTAGAAATAG ATTTAAACTA TAAGCTTAAA 2040

TCATTACAGC AACGGTTAGA ACAAGAGGTA AATGAACATA AAGTAACCAA AGCTCGTTTA 2100

ACTGACAAAC ATCAATCTAT TGAAGAAGCA AAGTCTGTTG CAATGTGTGA GATGGAGAAA 2160

AAGCTTAAGG AAGAGAGAGA AGCTCGAGAG AAAGCTGAAA ATAGGGTTGT TCAAATTGAG 2220

AAGCAGTGCT CCATGTTAGA CGTTGATCTA AAACAATCTC AGCAGAAACT AGAGCATTTG 2280

ACCGAAAATA AAGAAAGAAT GGAGGATGAA GTTAAGAATC TAACCCTCCA ACTGGAGCAG 2340

GAATCAAATA AGCGACTATT GTTACAAAAT GAATTGAAGA CTCAAGCATT TGAGTCAGAC 2400

AATTTAAAAG GTTTACAAAA GCAGATGAAA CAGGAAATAA ATACATTATT GGAAGCAAAA 2460

AGATTGTTAG AATTTGAGTT AGCTCAGCTT ACAAAACAAT ACAGAGGAAA TGAAGGGCAG 2520

ATGCGGGAGC TACAAGATCA GCTTGAAGCA GAGCAATATT TCTCGACACT TTATAAAACC 2580

CAGGTAAAGG AACTTAAGGA AGAAATTGAA GAAAAAAACA GAGAAAATTT AAAGAAAATA 2640

CAGGAACTGC AAAATGAAAA AGAAACTCTT GCAACTCAGT TGGATCTAGC AGAAACAAAA 2700

GCTGAGTCTG AGCAGTTAGC TCGAGGACTT CTGGAAGAAC AGTATTTTGA ATTGACTCAA 2760

GAAAGCAAGA AAGCTGCTTC AAGAAATAGG CAAGAGATTA CGGATAAAGA TCACATAGTT 2820

AGTCGGCTCG AAGAAACGAA CAGCATGCTA ACCAAAGATA TTGATTTACT AAGAAAAGAA 2880

AATGAAGAGC TAACTGATAA AATGAGGAAG GCAGAGGAAG AATATAAATT GAAGAAGGAG 2940

GAGGAGATCA GTAATCTTAA GGCCGCCTTT GAAAAGAATA TCAATACTGA ACGAACTCTT 3000

AAAACACAGG CTGTTAACAA GTTGGCAGAA ATAATGAATC GGAAAGATTT TAAAATTGAT 3060

AGAAAGAAAG CTAATACACA GGATTTGAGA AAGAAAGAAA AGGAAAATCG AAAGCTACAA 3120

CTTGAACTCA ACCAAGAGAG AGAGAAATTC AACCAGATGG TCGTGAAACA TCAGAAGGAA 3180

TTGAATGACA TGCAAGCGCA ATTGGTAGAA GAATGTACAC ATAGGAATGA GCTTCAGATG 3240

CAGTTGGCTA GCAAAGAGAG TGATATTGAA CAACGGGCGA AACTTTTGGA CCTTTCGGAT 3300

TCTACAAGTG TTGCGAGTTT TCCTAGTGCT GATGAAACTG ATGGAAACCT TCCAGAATCA 3360

AGAATTGAAG GTTGGCTTTC AATACCAAAT AGAGGAAATA TCAAACGATA TGGCTGGAAG 3420

AAACAGTATG TTGTGGTAAG CAGCAAAAAA ATCTTGTTCT ATAATGATGA ACAAGATAAG 3480

GAACAATCCA ATCCGTCTAT GGTGTTGGAC ATTGATAAAT TGTTTCATGT TCGACCTGTA 3540

ACCCAAGGAG ATGTGTATAG AGCTGAAACT GAAGAAATTC CTAAGATATT CCAGATACTA 3600

TATGCAAACG AAGGTGAATG TAGAAAAGAC GTAGAGATGG AACCAGTACA ACAAGCTGAA 3660

AAAACTAATT TTCAAAACCA CAAAGGCCAT GAGTTCATCC CTACCCTCTA CCACTTTCCT 3720

GCCAACTGTG AGGCCTGTGC CAAACCTCTC TGGCATGTTT TTAAGCCACC CCCTGCCCTA 3780

GAATGTCGAA GATGCCACGT TAAGTGCCAC AGAGATCACT TAGATAAGAA GGAGGACTTA 3840

ATTTCTCCTT GTAAAGTAAG TTATGATGTA ACATCAGCAA GAGATATGCT GCTCTTAGCA 3900

TGTTCTCAGG ATGAACAAAA AAAATGGGTA ACTCATTTAG TAAAGAAGAT CCCTAAGAAT 3960

CCACCATCTA GTTTTGTTCG TGCATCCCCT CGAACACTTT CTACAAGATC CACTGCAAAT 4020

CAGTCTTTCC GAAAAGTGGT CAAAAATACA TCTGGAAAAA CTAGGTAA 4068

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k+t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 76    YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 136   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  193

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldksGh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+

Q: 194   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  252

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l

Q: 253   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL  312

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 313   ICAFLTDREVRLGRNGVEEIKRHLFF  338

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSTRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKSGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA 240

FLTDREVRLG RNGVEEIKRH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0003383	; P:apical constriction
GO:0032060	; P:bleb assembly
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0050901	; P:leukocyte tethering or rolling
GO:0022614	; P:membrane to membrane docking
GO:0016525	; P:negative regulation of angiogenesis
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0032970	; P:regulation of actin filament-based process
GO:0045616	; P:regulation of keratinocyte differentiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013