EKS-SUS-00438

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00438

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/BRD	N/A	N/A	N/A	N/A	N/A

Status

Unreviewed

Ensembl Protein

ENSSSCP00000019596

UniProt Accession

I3L6E5;

Protein Name

Protein Synonyms/Alias

Gene Name

BRD4

Gene Synonyms/Alias

BRD4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000022227	ENSSSCP00000019596	ENSSSCT00000027972

Organism

Sus scrofa

Functional Description

Protein Length

1372

Protein Sequence
(FASTA)

MSAESGPGTR LRNLPVMGDG LETTQMSTTQ AQAQPQQANT ASTNPPPPET SNPNKPKRQT 60

NQLQYLLKVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW 120

NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG 180

RGRKEAVSAK PGISTVPNTT QASTPPQTQT PQQNPPPVQA TPHPFPAVTP DLIVQTPVMT 240

VVPPQPLQTP PPVPPQPPPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI 300

DPIHEPPSLP PEPKTTKLGP RRESSRPVKP PKKDVPDSQQ HPAPDKSSKV SEQLKCCSGI 360

LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA 420

DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV 480

APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE 540

KDKKEKKKEK HKKKEEVEEN KKSKAKELPP KKTKKNNSSN SNTSKKEPAP LKNKPPPAYE 600

SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK 660

PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESTSESS SSDSEDSETE 720

MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APMPQQPPPP PQQPPPPPPP QQQQQQQQQQ 780

PPPPPPPPSM PQQAASAMKS SPPPFIAAQV PVLEPQLPGS VFDPIGHFTQ PILHLPQPEL 840

PPHLPQPPEH STPPHLNQHS VVSPPALHNA LPQQPSRPSN RAAALPPKTA RPPAVSPALA 900

QPPLIPQPPM AQPPQVLLQE DEDPPAPPLT SMQMQLYLQQ LQKVQPPTPL LPSVKVQSQP 960

PPPLPPPPHP SVQQQLQQQQ QQQPPPPPPQ PQPPPQQQHQ PPPRPVHMQP MQFPTHIQQP 1020

PPPPGQQPPH PPTGQQPPPP QPAKPQQVIQ HHPSPRHHKS DPYSTGHLRE APSPLMIHSP 1080

QMPQFQSLTH QSPPQQNVQP KKQELRAASV VQPQPLVVVK EEKIHSPIIR SEPFSPSLRP 1140

EPPKHPESIK APVHLPQRPE MKPVDVGRPV IRPPEQNAPP PGAPDKDKQK QEPKTPVAPK 1200

KDLKIKNMGS WASLVQKHPT TPSSTAKSSS DSFEQFRRAA REKEEREKAL KAQAEHAEKE 1260

KERLRQERMR SREDEDALEQ ARRAHEEARR RQEQQQQQQR QEQQQQQQQQ AAAVAAAAAP 1320

QARSSQPQSM LDQQRELARK QEQERRRREA MAATIDMNFQ SDLLSIFEEN LF 1372

Nucleotide Sequence
(FASTA)

ATGTCTGCGG AGAGCGGCCC TGGGACAAGA TTGAGAAATC TGCCAGTAAT GGGGGATGGA 60

CTAGAAACTA CCCAAATGTC TACAACGCAG GCCCAGGCCC AACCCCAGCA AGCCAATACA 120

GCCAGCACCA ACCCCCCACC CCCGGAGACT TCTAACCCCA ACAAGCCCAA GAGGCAGACC 180

AACCAACTGC AATATCTGCT CAAAGTGGTG CTCAAGACAC TATGGAAACA CCAGTTTGCG 240

TGGCCTTTCC AGCAGCCTGT GGATGCCGTC AAGCTAAACC TCCCTGATTA CTATAAAATC 300

ATTAAAACAC CTATGGATAT GGGAACAATA AAGAAGCGCT TGGAAAACAA CTATTACTGG 360

AATGCTCAGG AATGTATCCA GGACTTCAAC ACTATGTTTA CAAATTGTTA CATCTACAAC 420

AAGCCTGGAG ATGACATAGT CTTAATGGCA GAAGCTCTGG AGAAGCTCTT CTTGCAAAAA 480

ATCAACGAAC TGCCCACAGA AGAAACTGAG ATCATGATAG TCCAGGCAAA AGGAAGAGGA 540

CGTGGGAGGA AAGAAGCAGT GTCGGCAAAA CCTGGCATCT CTACGGTACC AAACACAACA 600

CAAGCATCGA CTCCTCCGCA GACCCAGACC CCTCAGCAGA ATCCTCCACC CGTGCAGGCC 660

ACTCCTCACC CCTTCCCTGC CGTCACCCCA GACCTCATCG TCCAGACCCC TGTTATGACA 720

GTGGTACCTC CCCAGCCACT GCAGACACCC CCGCCGGTGC CCCCTCAACC ACCACCCCCA 780

CCCGCTCCAG CCCCCCAGCC CGTGCAGAGC CACCCACCCA TCATTGCGGC CACCCCACAA 840

CCTGTGAAGA CAAAGAAGGG GGTTAAGAGG AAAGCAGACA CCACCACCCC CACCACCATC 900

GACCCCATTC ACGAGCCTCC CTCACTGCCC CCGGAGCCCA AGACCACCAA GCTGGGCCCC 960

CGGCGGGAGA GCAGCCGGCC TGTTAAGCCT CCGAAGAAGG ATGTGCCCGA CTCGCAGCAG 1020

CACCCAGCGC CAGATAAGAG CAGCAAGGTC TCAGAGCAGC TTAAGTGCTG TAGTGGCATC 1080

CTCAAGGAAA TGTTTGCCAA GAAGCATGCG GCTTACGCCT GGCCATTCTA CAAGCCCGTG 1140

GACGTGGAGG CGCTGGGCCT ACATGACTAC TGTGACATCA TCAAGCACCC CATGGACATG 1200

AGCACTATAA AGTCTAAACT GGAGGCCCGT GAGTACCGCG ATGCTCAGGA ATTTGGTGCC 1260

GATGTCCGAT TGATGTTCTC CAACTGCTAC AAGTACAACC CTCCTGACCA TGAGGTGGTG 1320

GCCATGGCCC GCAAGCTCCA GGATGTGTTT GAGATGCGCT TTGCCAAGAT GCCAGACGAG 1380

CCCGAAGAGC CTGTAGTGGC TGTGTCCTCC CCAGCGGTGC CACCACCCAC CAAGGTCGTG 1440

GCCCCACCCT CATCCAGTGA CAGCAGCAGT GATAGCTCCT CAGACAGTGA CAGCTCCACT 1500

GATGACTCCG AGGAGGAACG AGCCCAACGA CTGGCTGAGC TCCAGGAGCA GCTCAAAGCC 1560

GTGCACGAGC AGCTTGCAGC CCTTTCACAG CCCCAGCAGA ACAAACCAAA GAAAAAGGAG 1620

AAAGACAAAA AGGAAAAGAA AAAAGAAAAG CACAAAAAGA AAGAGGAGGT GGAGGAGAAT 1680

AAGAAAAGCA AAGCCAAGGA ACTTCCTCCC AAAAAGACCA AGAAAAATAA TAGCAGCAAC 1740

AGCAACACAA GCAAGAAGGA GCCAGCACCC TTGAAGAACA AGCCCCCTCC TGCATATGAG 1800

TCGGAAGAAG AGGACAAGTG CAAGCCCATG TCGTATGAGG AAAAGCGACA GCTTAGCTTG 1860

GACATCAACA AGCTCCCTGG CGAAAAGCTG GGCCGCGTGG TGCACATCAT TCAGTCTCGA 1920

GAGCCCTCGC TCAAGAACTC CAACCCTGAT GAGATTGAGA TTGACTTTGA GACCCTGAAG 1980

CCATCTACTC TGCGTGAACT GGAGCGCTAT GTCACCTCCT GTTTACGGAA GAAAAGGAAA 2040

CCTCAAGCTG AGAAAGTTGA CGTGATTGCT GGCTCCTCCA AGATGAAGGG CTTCTCATCC 2100

TCAGAGTCAG AAAGCACCAG CGAGTCCAGC TCCTCTGACA GCGAAGACTC TGAAACAGAG 2160

ATGGCTCCGA AGTCAAAAAA GAAGGGGCAC CCTGGGAGGG AGCAGAAGAA GCACCATCAC 2220

CACCACCATC AGCAGATGCA GCAGGCCCCG GCCCCCATGC CCCAGCAGCC CCCGCCGCCT 2280

CCCCAGCAGC CCCCACCGCC GCCGCCGCCG CAGCAGCAGC AGCAGCAGCA GCAACAGCAG 2340

CCCCCACCCC CGCCTCCCCC ACCGTCCATG CCACAGCAGG CAGCCTCTGC AATGAAGTCC 2400

TCGCCTCCGC CCTTCATCGC CGCGCAGGTG CCTGTCCTGG AACCCCAACT CCCAGGCAGC 2460

GTGTTCGACC CCATTGGTCA CTTCACCCAG CCCATCTTGC ACCTGCCGCA GCCTGAGCTG 2520

CCCCCTCACC TGCCCCAGCC TCCCGAGCAC AGCACTCCGC CTCATCTTAA CCAGCACTCG 2580

GTGGTCTCTC CTCCAGCTTT GCACAATGCG CTGCCTCAGC AGCCATCACG GCCCAGTAAC 2640

CGAGCTGCCG CCCTGCCCCC CAAGACTGCC CGTCCCCCAG CTGTATCACC TGCCCTGGCC 2700

CAGCCACCCT TGATCCCACA ACCCCCCATG GCTCAGCCCC CCCAAGTGCT ACTGCAGGAG 2760

GATGAAGATC CACCTGCTCC ACCCCTCACC TCCATGCAGA TGCAGCTCTA TTTGCAGCAG 2820

CTGCAGAAGG TGCAGCCCCC CACACCACTA CTCCCTTCCG TGAAGGTGCA GTCCCAGCCC 2880

CCGCCCCCTC TGCCACCCCC TCCTCACCCC TCTGTGCAGC AGCAGCTACA GCAGCAGCAG 2940

CAGCAGCAGC CACCTCCCCC ACCACCCCAG CCACAGCCAC CACCCCAGCA GCAGCACCAG 3000

CCACCGCCAC GGCCCGTGCA TATGCAGCCC ATGCAGTTCC CTACCCATAT CCAGCAGCCC 3060

CCACCTCCCC CAGGCCAGCA GCCTCCTCAC CCACCCACGG GCCAGCAGCC ACCTCCGCCG 3120

CAGCCTGCCA AGCCTCAGCA AGTCATCCAA CATCACCCTT CACCCCGGCA CCACAAGTCA 3180

GACCCCTACT CAACTGGTCA CCTCCGTGAA GCCCCCTCTC CGCTTATGAT ACATTCCCCC 3240

CAGATGCCAC AGTTCCAGAG CCTGACCCAC CAGTCACCAC CCCAGCAAAA TGTCCAGCCT 3300

AAGAAGCAGG AGCTGCGTGC GGCCTCTGTG GTCCAGCCCC AGCCCCTGGT GGTGGTGAAG 3360

GAGGAGAAGA TCCACTCACC CATCATCCGC AGTGAACCCT TCAGCCCCTC GCTGCGGCCG 3420

GAGCCCCCCA AGCACCCGGA GAGCATCAAG GCCCCCGTCC ATCTGCCCCA GCGGCCTGAG 3480

ATGAAGCCCG TGGATGTTGG GAGGCCCGTG ATTCGGCCCC CTGAGCAGAA TGCACCCCCA 3540

CCAGGGGCCC CTGACAAGGA CAAACAGAAA CAGGAGCCGA AGACACCAGT TGCACCCAAA 3600

AAGGATCTAA AAATCAAGAA CATGGGCTCC TGGGCTAGCC TGGTGCAGAA GCATCCCACC 3660

ACCCCGTCCT CCACAGCCAA GTCATCAAGC GACAGCTTTG AGCAGTTCCG CCGGGCGGCC 3720

CGGGAAAAGG AGGAGCGTGA GAAGGCCCTG AAGGCACAAG CTGAGCATGC AGAGAAGGAG 3780

AAGGAACGGC TTCGGCAGGA GCGCATGAGG AGCCGAGAGG ATGAGGATGC ACTGGAGCAG 3840

GCCAGGCGAG CCCACGAGGA GGCCCGCCGG CGCCAGGAGC AGCAGCAGCA GCAGCAACGA 3900

CAGGAGCAGC AGCAGCAGCA ACAACAACAG GCTGCTGCTG TAGCTGCTGC CGCCGCCCCC 3960

CAGGCCCGGA GCTCCCAGCC CCAGTCCATG TTGGACCAGC AGAGGGAGTT GGCCCGAAAG 4020

CAGGAGCAGG AGCGAAGGCG CCGGGAAGCG ATGGCAGCTA CCATTGACAT GAATTTCCAG 4080

AGTGATCTAT TGTCAATATT TGAAGAAAAT CTTTTCTGA 4119

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Bromodomain; Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000794	; C:condensed nuclear chromosome
GO:0005737	; C:cytoplasm
GO:0000790	; C:nuclear chromatin
GO:0003677	; F:DNA binding
GO:0007059	; P:chromosome segregation
GO:0044154	; P:histone H3-K14 acetylation
GO:0043983	; P:histone H4-K12 acetylation
GO:0001833	; P:inner cell mass cell proliferation
GO:0043388	; P:positive regulation of DNA binding
GO:0010971	; P:positive regulation of G2/M transition of mitotic cell cycle
GO:0032968	; P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0006468	; P:protein phosphorylation
GO:0000114	; P:regulation of transcription involved in G1 phase of mitotic cell cycle

KEGG

InterPros

IPR001487	; Bromodomain.
IPR018359	; Bromodomain_CS.

Pfam

PF00439

; Bromodomain; 2.

SMARTs

SM00297

; BROMO; 2.

Prosites

PS00633	; BROMODOMAIN_1; 1.
PS50014	; BROMODOMAIN_2; 2.

Prints

PR00503

; BROMODOMAIN.

Created Date

20-Feb-2013