EKS-SUS-00150
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00150
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC435.97.2E-131349602254
StatusUnreviewed
Ensembl ProteinENSSSCP00000026618
UniProt AccessionI3LR85;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCD
Gene Synonyms/Alias PRKCD;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000023503ENSSSCP00000026618ENSSSCT00000026074
OrganismSus scrofa
Functional Description
Protein Length675
Protein Sequence
(FASTA)
MAPFLRISFN SYELGSLKTA DEASQPFCAV RMKEALSTER GKTLVQKKPT MYPEWKSTFD 60
AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120
FLEDIDCKQS MRGEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCRDFVW 180
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVYNYMS 240
PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCQMKVANLC GINQKLLAEA LNQVTQRPVR 300
KSESEVAETV GIYQNFEKKP GVSGDDVSAG TGTYGKIWES STKCSIDNFI FIKVLGKGSF 360
GKVLLAELKG KKEFFAIKAL KKDVVLIDDD VECTMVEKRV LALAGENPFL THLFCTFQTK 420
DHLFFVMEFL NGGDLMYHIQ DKGRFELYRA TFYAAEIICG LQFLHQKGII YRDLKLDNVM 480
LDRDGHIKIA DFGMCKENML GDKQASTFCG TPDYIAPEIL QGLKYSFSVD WWSFGVLLYE 540
MLIGQSPFHG DDEDELFESI RVDSPYYPRW ITRESKDILE KLLERDTGKR LGVTGNIRTH 600
PFKTINWTLL EKRAVEPPFK PKVRSPGDYS NFDQEFLNEK PRLSFSDKNL IDSMDQTAFA 660
GFSFLNPKFE RLLEN 675
Nucleotide Sequence
(FASTA)
ATGGCACCGT TCCTGCGCAT CTCCTTCAAC TCCTATGAGC TGGGCTCCCT GAAGACCGCG 60
GACGAGGCCA GCCAGCCCTT CTGTGCTGTG AGGATGAAGG AGGCGCTCAG CACTGAGCGT 120
GGGAAGACGC TGGTGCAGAA GAAACCCACT ATGTATCCTG AGTGGAAGTC CACGTTCGAT 180
GCCCACATTT ATGAGGGCCG CGTCATCCAG ATCGTGCTGA TGCGAGCGGC AGAGGAGCCA 240
GTGTCCGAGG TGACAGTGGG CGTGTCAGTG CTGGCCGAGC GCTGCAAGAA GAACAATGGC 300
AAGGCCGAGT TCTGGCTGGA CCTGCAACCC CAGGCCAAGG TGTTGATGTC TGTGCAGTAT 360
TTCCTGGAAG ACATAGATTG CAAGCAGTCT ATGCGGGGTG AAGACGAGGC CAAGTTCCCA 420
ACAATGAACC GCCGTGGAGC CATCAAACAG GCCAAAATCC ACTACATCAA GAACCACGAG 480
TTTATCGCCA CCTTCTTTGG GCAGCCCACC TTCTGCTCTG TGTGCAGAGA CTTTGTTTGG 540
GGTCTCAACA AGCAAGGCTA CAAGTGCAGG CAATGCAATG CTGCCATCCA CAAGAAATGC 600
ATCGACAAGA TCATCGGCCG GTGTACGGGA ACTGCGGCCA ACAGCCGGGA CACCATATTT 660
CAGAAAGAAC GTTTCAACAT CGACATGCCA CACCGGTTCA AGGTTTATAA CTACATGAGC 720
CCCACCTTCT GTGACCACTG TGGCAGCCTG CTCTGGGGGC TGGTGAAGCA GGGATTAAAG 780
TGTGAAGATT GTGGCATGAA CGTGCACCAT AAGTGCCAGA TGAAGGTGGC CAACCTCTGT 840
GGCATCAACC AGAAGCTCTT GGCAGAAGCC TTGAACCAAG TCACCCAGAG ACCTGTCCGA 900
AAGTCAGAGT CGGAGGTTGC AGAGACGGTT GGGATCTATC AGAATTTCGA GAAGAAGCCA 960
GGAGTCTCTG GAGATGATGT CTCAGCAGGC ACTGGGACCT ATGGCAAGAT CTGGGAGAGC 1020
AGCACCAAGT GCAGCATTGA CAACTTCATC TTCATCAAGG TCCTGGGCAA AGGCAGCTTC 1080
GGGAAGGTGC TGCTTGCAGA GCTGAAGGGC AAGAAGGAAT TCTTCGCCAT CAAGGCCCTC 1140
AAGAAGGACG TGGTTCTGAT CGATGATGAC GTGGAGTGCA CCATGGTAGA GAAGCGGGTG 1200
CTGGCGCTCG CCGGGGAGAA TCCCTTTCTC ACCCACCTCT TTTGCACCTT CCAGACCAAG 1260
GACCACCTGT TCTTCGTGAT GGAGTTCCTC AACGGGGGGG ACCTGATGTA CCACATCCAG 1320
GACAAAGGCC GTTTCGAGCT CTACCGTGCC ACGTTTTATG CGGCTGAGAT AATCTGTGGG 1380
CTACAGTTTC TACACCAGAA AGGGATCATT TACAGGGACC TCAAGCTGGA CAACGTGATG 1440
CTGGACCGGG ATGGCCACAT CAAGATTGCT GACTTCGGCA TGTGCAAGGA GAACATGCTG 1500
GGGGACAAAC AGGCCAGCAC CTTCTGCGGC ACTCCTGACT ACATCGCCCC AGAGATCCTA 1560
CAGGGCCTGA AGTACTCATT CTCTGTGGAC TGGTGGTCCT TCGGAGTCCT TCTCTATGAA 1620
ATGCTCATCG GTCAGTCCCC CTTCCACGGT GATGATGAGG ACGAACTCTT CGAGTCCATC 1680
CGTGTGGACT CACCGTATTA TCCCCGCTGG ATCACTAGGG AGTCCAAGGA CATCCTGGAG 1740
AAGCTGCTTG AACGAGACAC AGGCAAGAGG CTGGGAGTGA CAGGGAACAT CAGAACCCAC 1800
CCCTTCAAGA CCATCAACTG GACTCTGCTG GAGAAACGTG CAGTGGAGCC ACCCTTCAAG 1860
CCCAAAGTGA GGTCCCCTGG AGACTACAGC AACTTCGACC AGGAGTTCCT GAATGAGAAG 1920
CCACGTCTCT CCTTCAGCGA CAAGAATCTC ATCGACTCCA TGGACCAAAC AGCATTTGCT 1980
GGCTTCTCCT TCCTGAACCC CAAATTCGAG AGGCTCCTGG AAAATTGA 2028
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f ++kvlGkGsfgkvllaelk+++e++aik lkkdvvl dddve+t+vekrvlala ++p
Q: 349   FIFIKVLGKGSFGKVLLAELKGKKEFFAIKALKKDVVLIDDDVECTMVEKRVLALAGENP  408
         88**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl++lf++fqt+d+lffv+e++nGGdlm+hiq++++++  ra+fyaaeii++l+flh+kg
Q: 409   FLTHLFCTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIICGLQFLHQKG  468
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld++Ghik+adfG+cke++l +k++stfcGtPdyiaPeil++ +y++s
Q: 469   IIYRDLKLDNVMLDRDGHIKIADFGMCKENMLGDKQASTFCGTPDYIAPEILQGLKYSFS  528
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP+++++e+++il++ll++d+ 
Q: 529   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDSPYYPRWITRESKDILEKLLERDTG  588
         ************************************************************
S: 241   krlGvkeegeedikehaf  258
         krlGv  +g  +i++h+f
Q: 589   KRLGV--TG--NIRTHPF  602
         ****9..55..7888887
Domain Sequence
(FASTA)
FIFIKVLGKG SFGKVLLAEL KGKKEFFAIK ALKKDVVLID DDVECTMVEK RVLALAGENP 60
FLTHLFCTFQ TKDHLFFVME FLNGGDLMYH IQDKGRFELY RATFYAAEII CGLQFLHQKG 120
IIYRDLKLDN VMLDRDGHIK IADFGMCKEN MLGDKQASTF CGTPDYIAPE ILQGLKYSFS 180
VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDSPYYP RWITRESKDI LEKLLERDTG 240
KRLGVTGNIR THPF 254
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00166
EKS-ANC-00168
EKS-BOT-00176
EKS-CAE-00133
EKS-CAJ-00179
EKS-CAF-00183
EKS-CAP-00173
EKS-CIS-00207
EKS-DAR-00469
EKS-DRM-00086
EKS-EQC-00174
EKS-FEC-00164
EKS-GAM-00094
EKS-GAG-00150
EKS-GAA-00213
EKS-GOG-00175
EKS-HOS-00182
EKS-ICT-00169
EKS-LAC-00183
EKS-LOA-00173
EKS-MAM-00172
EKS-MEG-00108
EKS-MOD-00172
EKS-MUM-00180
EKS-MYL-00181
EKS-NOL-00169
EKS-OCP-00109
EKS-ORN-00221
EKS-ORC-00160
EKS-ORL-00208
EKS-OTG-00181
EKS-PES-00154
EKS-PEM-00089
EKS-POA-00169
EKS-RAN-00172
EKS-SAH-00166
EKS-TAG-00204
EKS-TAR-00227
EKS-TEN-00221
EKS-XET-00163
EKS-XIM-00214
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0016363; C:nuclear matrix
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0008047; F:enzyme activator activity
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0006915; P:apoptotic process
GO:0042100; P:B cell proliferation
GO:0090398; P:cellular senescence
GO:0016064; P:immunoglobulin mediated immune response
GO:0032613; P:interleukin-10 production
GO:0032615; P:interleukin-12 production
GO:0035556; P:intracellular signal transduction
GO:0030837; P:negative regulation of actin filament polymerization
GO:0051490; P:negative regulation of filopodium assembly
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0043407; P:negative regulation of MAP kinase activity
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331; P:negative regulation of platelet aggregation
GO:0042119; P:neutrophil activation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:2000304; P:positive regulation of ceramide biosynthetic process
GO:2000753; P:positive regulation of glucosylceramide catabolic process
GO:1900163; P:positive regulation of phospholipid scramblase activity
GO:0035307; P:positive regulation of protein dephosphorylation
GO:2001022; P:positive regulation of response to DNA damage stimulus
GO:2000755; P:positive regulation of sphingomyelin catabolic process
GO:0032930; P:positive regulation of superoxide anion generation
GO:0023021; P:termination of signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013