EKS-SUS-00241

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00241

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.3	2.2E-140	190	477	288

Status

Unreviewed

Ensembl Protein

ENSSSCP00000022940

UniProt Accession

I3LFU7;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000023995	ENSSSCP00000022940	ENSSSCT00000022448

Organism

Sus scrofa

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

LFSNGLANAY LNVNEITSLQ CFCHLCTKDN FTCVTDGLCF VSVTETTDKV IHNSMCIAEI 60

DLIPRDRPFV CAPSSKTGSV TTTYCCNQDH CNKIELPTVG KPPSGLGPVE LAAVIAGPVC 120

FVCISLMLMV YICHNRTVIH HRVPNEEDPS LDRPFISEGT TLKDLIYDMT TSGSGSGLPL 180

LVQRTIARTI VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR 240

HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL ALSTASGLAH 300

LHMEIVGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT 360

KRYMAPEVLD DSINMKHFES FKRADIYAMG LVFWEIARRC SIGGIHEDYQ LPYYDLVPSD 420

PSVEEMRKVV CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTLSQL 480

SQQEGIKM 488

Nucleotide Sequence
(FASTA)

CTTTTTTCAA ATGGGTTAGC AAATGCTTAT CTTAATGTTA ATGAAATTAC ATCATTACAG 60

TGTTTCTGCC ACCTTTGCAC AAAAGACAAT TTTACTTGTG TCACAGATGG GCTCTGCTTT 120

GTCTCCGTCA CAGAGACCAC AGACAAAGTT ATACACAATA GCATGTGTAT AGCTGAAATT 180

GACCTAATTC CGCGAGACAG GCCATTTGTA TGTGCACCTT CTTCAAAAAC TGGGTCTGTT 240

ACTACAACAT ATTGCTGCAA TCAGGACCAT TGCAATAAAA TAGAACTCCC AACTGTTGGA 300

AAGCCACCAT CTGGCCTTGG TCCTGTTGAA CTGGCAGCTG TCATTGCTGG ACCAGTCTGC 360

TTTGTCTGCA TCTCACTCAT GTTGATGGTC TATATCTGCC ATAACCGTAC AGTCATTCAC 420

CATCGAGTGC CAAATGAAGA GGATCCTTCA TTAGATCGCC CTTTTATTTC AGAGGGTACT 480

ACATTAAAAG ATTTAATTTA TGATATGACA ACATCAGGTT CTGGATCAGG TTTACCATTG 540

CTTGTTCAGA GAACAATTGC AAGAACTATT GTGCTACAAG AAAGTATTGG CAAAGGTCGA 600

TTTGGAGAGG TTTGGCGAGG AAAATGGAGA GGAGAGGAAG TTGCTGTTAA AATATTCTCC 660

TCCAGGGAAG AACGTTCATG GTTCCGTGAG GCAGAGATTT ATCAGACTGT TATGTTACGT 720

CATGAAAACA TCTTGGGATT TATAGCAGCA GACAATAAAG ATAATGGTAC ATGGACTCAG 780

CTTTGGTTGG TGTCAGATTA TCATGAACAT GGATCCCTTT TTGATTACTT GAATAGATAC 840

ACAGTTACTG TGGAAGGAAT GATAAAACTT GCTCTGTCCA CAGCAAGTGG ACTTGCCCAT 900

CTTCACATGG AGATAGTTGG TACCCAAGGA AAACCAGCTA TTGCTCATAG AGATTTGAAA 960

TCAAAGAATA TCTTGGTAAA AAAGAATGGA ACTTGCTGTA TTGCAGACTT AGGACTGGCA 1020

GTAAGACATG ATTCAGCCAC AGATACAATT GATATTGCTC CAAACCACAG AGTGGGAACA 1080

AAAAGGTACA TGGCCCCTGA AGTTCTAGAT GATTCCATAA ATATGAAACA CTTTGAATCC 1140

TTCAAACGTG CTGACATCTA TGCAATGGGC TTAGTATTCT GGGAAATAGC TCGACGATGT 1200

TCCATTGGTG GAATTCATGA AGATTACCAG CTGCCTTATT ATGATCTTGT ACCTTCTGAT 1260

CCATCAGTTG AAGAAATGAG AAAAGTTGTT TGTGAACAGA AGTTAAGGCC AAATATTCCT 1320

AACAGATGGC AGAGCTGTGA AGCCTTAAGA GTAATGGCTA AAATTATGAG AGAATGTTGG 1380

TATGCCAATG GAGCAGCCAG GCTCACAGCT TTGCGGATTA AGAAAACATT GTCACAACTC 1440

AGTCAGCAGG AAGGCATCAA AATGTAA 1467

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 190   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  249

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 250   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  309

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 310   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  367

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 368   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  426

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 427   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  477

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013