EKS-SUS-00052

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00052

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	401.8	1.8E-120	4	286	283

Status

Unreviewed

Ensembl Protein

ENSSSCP00000019921

UniProt Accession

Q197W4;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 5;

Gene Name

CDK5

Gene Synonyms/Alias

CDK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000024070	ENSSSCP00000019921	ENSSSCT00000026829

Organism

Sus scrofa

Functional Description

Protein Length

292

Protein Sequence
(FASTA)

MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 60

KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 120

NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 180

TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPAM TKLPDYKPYP 240

MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP 292

Nucleotide Sequence
(FASTA)

ATGCAGAAAT ACGAGAAACT GGAGAAGATT GGGGAAGGCA CCTATGGAAC AGTGTTCAAG 60

GCCAAAAACC GGGAGACTCA TGAGATTGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 120

GATGAGGGAG TGCCAAGTTC TGCCCTTCGG GAAATCTGCC TCCTCAAAGA GCTGAAGCAC 180

AAGAACATTG TCAGGCTCCA TGATGTCCTG CATAGCGACA AGAAGCTGAC GTTGGTTTTC 240

GAGTTCTGTG ACCAGGATCT TAAGAAGTAT TTCGACAGCT GCAATGGTGA CCTAGATCCT 300

GAAATTGTGA AGTCATTCCT TTTCCAGCTG CTAAAAGGCC TGGGATTCTG TCACAGCCGA 360

AATGTGCTAC ACAGGGACCT GAAGCCTCAG AACCTGCTCA TAAACAGGAA CGGGGAGCTG 420

AAGTTGGCAG ATTTTGGTTT GGCTCGAGCC TTTGGCATCC CTGTTCGCTG TTACTCGGCT 480

GAGGTGGTCA CGCTGTGGTA CCGCCCGCCG GATGTCCTCT TTGGGGCCAA GCTCTACTCC 540

ACATCCATCG ACATGTGGTC GGCCGGCTGC ATCTTCGCAG AGCTGGCCAA TGCCGGCCGG 600

CCTCTCTTTC CCGGCAACGA CGTTGACGAC CAGCTCAAAA GGATCTTCCG ACTGCTGGGG 660

ACACCGACCG AGGAGCAGTG GCCCGCCATG ACCAAGCTGC CAGACTATAA GCCCTACCCG 720

ATGTACCCAG CCACAACGTC CCTGGTGAAC GTCGTGCCCA AGCTCAATGC CACAGGGAGG 780

GACCTGCTGC AGAACCTCCT GAAGTGTAAC CCGGTCCAGC GCATCTCCGC AGAAGAGGCC 840

TTGCAGCACC CCTACTTCTC TGACTTCTGC CCCCCCTAG 879

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklekigeGtyg+v+kak++et+e+vAlK++rl++++egvp++alrEi llkelkhkni

Q: 4     YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI  63

         99**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L++v++ ++kkl+Lvfef++qdLkk++++++  +l++e vks+l+qll+gl ++Hs++

Q: 64    VRLHDVLH-SDKKLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSRN  121

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlaraf+ p++ y+ evvTlwYr+P++L+gak Yst

Q: 122   VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST  181

         ************************************************************

S: 181   avDiWsvgcilaellt.rkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         ++D+Ws+gci+ael++  +plf+g++  dql+rif+llgtp+e++wp ++klp+yk  +p

Q: 182   SIDMWSAGCIFAELANaGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYK-PYP  240

         **************97369*************************************.555

S: 240   kkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          ++++ +l ++v+kl+ +++dll++ll+++p +Risa+ealqh+yf

Q: 241   MYPATtSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF  286

         5555559**************************************9

Domain Sequence
(FASTA)

YEKLEKIGEG TYGTVFKAKN RETHEIVALK RVRLDDDDEG VPSSALREIC LLKELKHKNI 60

VRLHDVLHSD KKLTLVFEFC DQDLKKYFDS CNGDLDPEIV KSFLFQLLKG LGFCHSRNVL 120

HRDLKPQNLL INRNGELKLA DFGLARAFGI PVRCYSAEVV TLWYRPPDVL FGAKLYSTSI 180

DMWSAGCIFA ELANAGRPLF PGNDVDDQLK RIFRLLGTPT EEQWPAMTKL PDYKPYPMYP 240

ATTSLVNVVP KLNATGRDLL QNLLKCNPVQ RISAEEALQH PYF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0005829	; C:cytosol
GO:0030175	; C:filopodium
GO:0030027	; C:lamellipodium
GO:0005634	; C:nucleus
GO:0030549	; F:acetylcholine receptor activator activity
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048148	; P:behavioral response to cocaine
GO:0070509	; P:calcium ion import
GO:0007160	; P:cell-matrix adhesion
GO:0021954	; P:central nervous system neuron development
GO:0021697	; P:cerebellar cortex formation
GO:0022038	; P:corpus callosum development
GO:0048813	; P:dendrite morphogenesis
GO:0021766	; P:hippocampus development
GO:0006886	; P:intracellular protein transport
GO:0021819	; P:layer formation in cerebral cortex
GO:0008045	; P:motor neuron axon guidance
GO:0045786	; P:negative regulation of cell cycle
GO:0046826	; P:negative regulation of protein export from nucleus
GO:0031397	; P:negative regulation of protein ubiquitination
GO:0031914	; P:negative regulation of synaptic plasticity
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0051402	; P:neuron apoptotic process
GO:0001764	; P:neuron migration
GO:0048709	; P:oligodendrocyte differentiation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0045956	; P:positive regulation of calcium ion-dependent exocytosis
GO:0032092	; P:positive regulation of protein binding
GO:0045860	; P:positive regulation of protein kinase activity
GO:0090314	; P:positive regulation of protein targeting to membrane
GO:0035418	; P:protein localization to synapse
GO:0032801	; P:receptor catabolic process
GO:0043113	; P:receptor clustering
GO:0030334	; P:regulation of cell migration
GO:0061001	; P:regulation of dendritic spine morphogenesis
GO:0060079	; P:regulation of excitatory postsynaptic membrane potential
GO:0014044	; P:Schwann cell development
GO:0019233	; P:sensory perception of pain
GO:0033136	; P:serine phosphorylation of STAT3 protein
GO:0007519	; P:skeletal muscle tissue development
GO:0007416	; P:synapse assembly
GO:0001963	; P:synaptic transmission, dopaminergic
GO:0035249	; P:synaptic transmission, glutamatergic
GO:0008542	; P:visual learning

KEGG

ssc:733700

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013