EKS-SUS-00109

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00109

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	480.9	1.2E-144	257	517	261

Status

Unreviewed

Ensembl Protein

ENSSSCP00000017621

UniProt Accession

F1SJC6;

Protein Name

Protein Synonyms/Alias

Hepatocyte growth factor receptor;

Gene Name

LOC100739745

Gene Synonyms/Alias

LOC100739745; MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000024351	ENSSSCP00000017621	ENSSSCT00000018111

Organism

Sus scrofa

Functional Description

Protein Length

560

Protein Sequence
(FASTA)

MLDGIHSKYF DLIYVHNPVF KPFEKPVMIS IGNENVLEIK GNDIDPEAVK GEVLKVGNKS 60

CENIHSHSEA VLCTVPNDLL KLNSELNIEW KQAISSTVLG KVIVQPDQNF TGLIVGVVSI 120

SIILLLLLGL FLWLKKRKQI KDLGSELVRY DARVHTPHLD RLVSARSVSP TTEMVSSEPV 180

DYRATFPEDQ FPNSSQNGSC RQVQYPLTDL SPILTSGDSD ISSPLLQNTV HIDLSALNPE 240

LVQAVQHVVI GPSSLIVHFN EVIGRGHFGC VYHGTLLDND DKKIHCAVKS LNRITDIGEV 300

SQFLTEGIIM KDFSHPNVLS LLGICLRSEG SPLVVLPYMK HGDLRNFIRN ETHNPTVKDL 360

IGFGLQVAKG MKYLASKKFV HRDLAARNCM LDEKFTVKVA DFGLARDVYD KEYYSVHNKT 420

GAKLPVKWMA LESLQTQKFT TKSDVWSFGV LLWELMTRGA PPYPDVNTFD ITVYLLQGRR 480

LLQPEYCPDP LYEVMLKCWH PRAELRPSFS ELVSRISAIF STFIGEHYVH VNATYVNVKC 540

VAPYPSLLSS QDNVDGEGDT 560

Nucleotide Sequence
(FASTA)

ATGTTAGATG GGATTCATTC CAAATACTTT GATCTCATTT ATGTACATAA TCCTGTGTTT 60

AAGCCTTTTG AAAAGCCAGT GATGATCTCA ATAGGCAATG AAAACGTACT GGAAATTAAG 120

GGAAATGATA TTGACCCTGA AGCAGTTAAA GGTGAAGTGT TAAAAGTTGG AAATAAGAGT 180

TGTGAGAATA TACATTCACA TTCTGAAGCC GTTTTATGTA CAGTCCCCAA TGACCTGCTG 240

AAATTGAACA GCGAGCTAAA TATAGAGTGG AAGCAAGCAA TTTCTTCAAC TGTCCTTGGA 300

AAAGTAATAG TTCAACCAGA TCAGAATTTC ACAGGATTGA TTGTTGGTGT TGTCTCAATA 360

TCAATAATAC TCTTATTACT GCTCGGGCTT TTCCTGTGGC TGAAAAAGAG AAAGCAAATT 420

AAAGATCTAG GCAGTGAACT AGTTCGCTAT GATGCAAGAG TACACACTCC TCATTTGGAT 480

AGGCTTGTAA GTGCCCGAAG TGTAAGCCCA ACTACAGAAA TGGTTTCAAG TGAACCTGTA 540

GACTACCGAG CTACTTTTCC AGAAGACCAG TTCCCTAACT CATCTCAGAA TGGATCATGC 600

AGACAAGTGC AGTATCCTCT GACAGACCTA TCCCCCATCC TAACTAGTGG AGACTCTGAT 660

ATATCTAGTC CATTACTGCA AAATACCGTC CACATTGACC TCAGTGCTCT AAATCCAGAG 720

CTGGTCCAGG CAGTTCAGCA TGTAGTGATT GGGCCAAGCA GCCTGATTGT GCATTTCAAT 780

GAAGTCATAG GAAGAGGACA TTTTGGGTGT GTATACCATG GGACTTTATT GGATAATGAT 840

GATAAGAAAA TTCACTGTGC TGTGAAATCC TTGAATAGAA TCACTGACAT AGGAGAAGTT 900

TCCCAATTTC TGACTGAGGG AATCATCATG AAAGATTTTA GTCATCCCAA TGTTCTCTCG 960

CTCTTGGGAA TCTGCCTTCG AAGTGAGGGG TCTCCACTGG TGGTCCTACC ATACATGAAA 1020

CATGGGGATC TTCGAAATTT CATTAGAAAT GAGACTCATA ACCCAACTGT AAAAGATCTT 1080

ATTGGCTTTG GCCTTCAAGT GGCCAAAGGC ATGAAATATC TTGCAAGCAA AAAGTTTGTC 1140

CACAGAGACT TGGCTGCAAG AAACTGTATG CTGGATGAAA AATTCACTGT CAAGGTTGCT 1200

GATTTTGGAC TTGCCAGGGA TGTGTATGAT AAAGAATACT ATAGTGTACA CAACAAAACA 1260

GGTGCAAAAC TGCCAGTGAA GTGGATGGCT TTAGAAAGCC TGCAAACTCA GAAGTTTACC 1320

ACCAAGTCAG ATGTGTGGTC CTTTGGCGTG CTCCTCTGGG AACTGATGAC AAGAGGAGCA 1380

CCACCTTATC CTGACGTCAA CACCTTTGAT ATAACAGTGT ACTTGTTGCA AGGCAGAAGG 1440

CTCCTACAAC CTGAATACTG CCCAGATCCC TTGTACGAAG TGATGCTGAA ATGCTGGCAT 1500

CCTAGAGCTG AACTTCGCCC ATCCTTTTCT GAACTGGTCT CCAGGATATC AGCTATCTTC 1560

TCTACTTTCA TTGGGGAGCA CTATGTCCAC GTGAATGCTA CTTACGTGAA TGTCAAATGT 1620

GTTGCTCCAT ATCCTTCTCT TTTGTCATCA CAAGATAATG TTGATGGCGA GGGGGACACA 1680

TGA 1683

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 257   VHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  316

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 317   NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  376

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlardv+dke+y+v+++++a+lpvkw+aleslqt

Q: 377   KKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT  436

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 437   QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  495

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++ ++ rp+fs+lvs+is

Q: 496   LKCWHPRAELRPSFSELVSRIS  517

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDDKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DVYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPRAELR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00429	; IPT; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013