EKS-SUS-00224
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00224
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl552.21.9E-166288539252
StatusUnreviewed
Ensembl ProteinENSSSCP00000025893
UniProt AccessionI3LP68;
Protein Name
Protein Synonyms/Alias
Gene NameABL2
Gene Synonyms/Alias ABL2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000024674ENSSSCP00000025893ENSSSCT00000027500
OrganismSus scrofa
Functional Description
Protein Length1174
Protein Sequence
(FASTA)
MGQQVGRVGE APGLQQSQPR GIRGSSAARP SGRRRDLAGR TTEAGFNIFT QHDHFASCVE 60
DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 120
SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR 180
SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTTDGKV YVTAESRFST 240
LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG 300
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV 360
TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN 420
HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT 480
YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE 540
TMFHDSSISE EVAEELGRAA SSSSVVPYLP RLPTLPSKTR TLKKQGENKE NIEGAQDATE 600
NSASSSAPGF IRSAQAPSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR 660
NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG FSFTSAQQEA NLVPPKCYGG 720
SFAQRNLCDD DSGGGGWSGI TGFFTPRLIK KTLGLRAGKP TASDDTSKPF PRSNSTSSMS 780
SGLPEQDRMA MTLPRNCQKS KLQLERTVST SSQPEENGDR ANDTLPKKPE EGAAPTRERP 840
KAKLLPRGAT ALPLKTPSGD PAITEKDSPG VGVAGVTAAP KSKERNGGAR LGMAGVPEDG 900
EQTGWSSPAK AAVVLPTTHN HKVPVLISPT LKHTPADVQL IGTDSQGNKF KLLSEHQVTS 960
SGDKDRPRRV KPKCAPPPPP VMRLLPHPSM CSDPTEEPTA PTAGQPMSET QEGGKKAAPG 1020
AVPISGKAGR PAMPPPQVPL PTSSISPAKM ANGTAGTKVA LRKTKQAAEK ISADKISKEA 1080
LLECADLLSS AITEPVPNSQ LVDTGHQLLD YCSGYVDCIP QTRNKFAFRE AVSKLELSLQ 1140
ELQVSSAAAG VPGANPVLNN LLSCVQEISD VVQR 1174
Nucleotide Sequence
(FASTA)
ATGGGGCAGC AGGTGGGCCG CGTTGGGGAG GCTCCGGGGC TTCAGCAGTC ACAACCCCGG 60
GGGATCCGGG GTAGCAGTGC AGCCAGGCCC TCCGGCCGCA GGCGGGACCT GGCGGGGCGC 120
ACCACAGAGG CCGGCTTCAA TATCTTCACC CAGCATGATC ACTTTGCCAG CTGTGTGGAG 180
GATGGATTTG AGGGAGACAA GACTGGAGGC AGTAGTCCAG AAGCCTTGCA CCGCCCCTAT 240
GGTTGTGATG TTGAACCCCA AGCCCTGAAT GAAGCCATCA GGTGGAGCTC TAAGGAGAAC 300
TTGCTTGGAG CCACTGAGAG TGACCCCAAT CTCTTTGTTG CACTTTATGA TTTTGTAGCA 360
AGTGGTGATA ACACACTTAG TATCACTAAA GGAGAAAAGC TACGAGTCCT TGGTTACAAC 420
CAGAATGGTG AGTGGAGTGA AGTTCGCTCT AAGAATGGCC AAGGCTGGGT GCCAAGCAAT 480
TACATCACCC CAGTGAACAG CCTGGAAAAA CATTCCTGGT ACCATGGGCC TGTGTCCCGC 540
AGCGCAGCAG AGTACCTACT CAGCAGTCTG ATCAATGGCA GCTTCCTGGT GCGAGAAAGT 600
GAGAGCAGCC CCGGGCAGCT ATCAATCTCG CTCAGGTACG AGGGGCGTGT ATATCACTAC 660
AGGATCAATA CCACCACAGA TGGCAAGGTG TATGTAACTG CTGAGAGCCG CTTTAGCACC 720
TTGGCCGAGC TTGTTCACCA TCACTCAACA GTGGCTGATG GGCTCGTGAC AACACTACAC 780
TACCCAGCAC CCAAGTGTAA TAAGCCTACC GTGTATGGTG TGTCCCCCAT CCATGACAAA 840
TGGGAAATGG AACGAACAGA TATTACCATG AAGCACAAAC TTGGGGGTGG TCAGTATGGA 900
GAGGTTTACG TTGGCGTCTG GAAGAAATAC AGCCTTACTG TTGCTGTGAA AACGCTGAAG 960
GAGGATACTA TGGAGGTGGA GGAATTCCTA AAAGAAGCTG CAGTGATGAA AGAAATCAAG 1020
CATCCTAATC TGGTACAACT ATTAGGTGTA TGTACTTTGG AGCCACCATT TTACATTGTG 1080
ACTGAGTACA TGCCTTATGG GAACCTGCTT GATTATCTCC GAGAATGCAA CCGAGAAGAG 1140
GTAACTGCAG TTGTACTGCT TTACATGGCC ACTCAGATTT CTTCTGCAAT GGAGTATTTA 1200
GAAAAGAAGA ATTTCATCCA TAGAGATCTT GCAGCTCGTA ACTGCCTCGT GGGAGAAAAC 1260
CATGTGGTAA AAGTGGCTGA CTTTGGCTTA AGTAGATTGA TGACTGGAGA CACCTATACT 1320
GCTCATGCTG GAGCCAAATT TCCTATTAAA TGGACAGCAC CAGAGAGTCT TGCCTACAAT 1380
ACCTTCTCAA TTAAATCTGA TGTCTGGGCT TTTGGGGTTC TCTTGTGGGA AATTGCTACA 1440
TATGGAATGT CACCATATCC AGGTATTGAC CTGTCTCAGG TCTATGATCT GCTGGAAAAA 1500
GGATATCGAA TGGAACAACC TGAAGGATGT CCTCCTAAGG TGTATGAACT TATGAGAGCA 1560
TGCTGGAAGT GGAGCCCTGC TGACAGGCCC TCTTTTGCTG AAACACATCA AGCTTTTGAA 1620
ACCATGTTTC ATGACTCCAG CATTTCTGAA GAGGTAGCTG AGGAGCTCGG GAGAGCAGCC 1680
TCCTCCTCAT CTGTTGTTCC ATATCTGCCT CGATTACCTA CACTTCCTTC CAAGACCCGG 1740
ACGCTGAAGA AACAGGGGGA GAACAAGGAG AATATCGAAG GGGCACAAGA TGCCACAGAA 1800
AATTCTGCTT CCAGTTCAGC ACCAGGGTTC ATTAGAAGTG CACAGGCCCC CAGTGGGTCC 1860
CCGGCACTGC CTCGAAAGCA AAGAGACAAG TCACCCAGCA GCCTCTTGGA AGATGCCAAA 1920
GAGACTTGCT TCACCAGAGA TAGGAAGGGA GGCTTCTTCA GCTCCTTCAT GAAAAAGAGA 1980
AATGCTCCCA CACCCCCCAA ACGCAGCAGC TCCTTCCGAG AAATGGAGAA TCAGCCCCAC 2040
AAGAAATATG AACTCACGGG TAACTTCTCA TCTGTTGCTT CTCTGCAGCA TGCTGATGGG 2100
TTCTCTTTCA CTTCTGCCCA GCAAGAGGCG AATCTGGTGC CACCCAAGTG CTATGGGGGG 2160
AGCTTTGCAC AGAGGAACCT CTGTGATGAC GACAGTGGTG GGGGTGGGTG GTCTGGCATC 2220
ACAGGCTTCT TTACACCACG TTTAATCAAA AAGACACTGG GCTTACGAGC GGGTAAACCA 2280
ACAGCCAGTG ATGACACTTC CAAGCCTTTT CCAAGGTCAA ACTCTACATC TTCCATGTCC 2340
TCAGGGCTTC CAGAGCAGGA TAGGATGGCA ATGACCCTTC CCAGGAACTG CCAGAAGTCC 2400
AAACTCCAGC TGGAAAGGAC AGTGTCCACC TCTTCTCAGC CAGAAGAGAA TGGGGACAGG 2460
GCCAATGACA CGCTTCCAAA AAAACCAGAG GAAGGTGCTG CTCCAACCAG GGAGAGACCA 2520
AAAGCCAAAC TTTTGCCCAG AGGAGCCACA GCTCTTCCTC TCAAAACCCC CTCTGGGGAT 2580
CCAGCCATCA CAGAGAAGGA CTCTCCCGGG GTGGGGGTAG CTGGAGTGAC AGCTGCCCCA 2640
AAGAGCAAGG AGAGAAATGG TGGGGCACGG CTTGGCATGG CTGGAGTCCC AGAGGATGGC 2700
GAACAGACAG GCTGGTCTTC TCCAGCCAAG GCTGCAGTGG TCCTTCCAAC CACTCACAAC 2760
CACAAAGTGC CAGTCCTTAT CTCACCCACT CTAAAGCACA CTCCAGCTGA TGTGCAGCTC 2820
ATTGGCACAG ACTCTCAGGG GAATAAATTC AAGCTCTTAT CGGAGCATCA GGTCACTTCC 2880
TCTGGAGACA AGGACCGACC CCGCCGGGTA AAACCAAAGT GTGCCCCACC CCCACCACCA 2940
GTGATGAGAC TACTGCCGCA TCCGTCCATG TGCTCGGACC CGACGGAAGA GCCGACTGCC 3000
CCGACTGCAG GACAGCCCAT GTCAGAAACA CAGGAAGGAG GAAAAAAGGC AGCTCCAGGG 3060
GCAGTGCCCA TCAGTGGAAA AGCTGGGAGG CCTGCAATGC CTCCACCTCA AGTGCCTCTG 3120
CCCACATCTT CCATCTCGCC AGCCAAAATG GCCAACGGCA CAGCAGGTAC TAAAGTGGCT 3180
CTGAGAAAAA CCAAACAGGC AGCTGAGAAA ATCTCAGCTG ACAAGATCAG CAAGGAGGCC 3240
CTGCTGGAAT GTGCTGACCT ACTGTCGAGT GCAATCACGG AACCTGTGCC CAACAGCCAG 3300
CTGGTGGACA CTGGACACCA GCTGCTCGAC TACTGCTCAG GCTATGTGGA CTGCATCCCC 3360
CAGACTCGCA ACAAATTTGC CTTCCGAGAG GCCGTGAGCA AACTGGAACT CAGTCTGCAG 3420
GAGCTGCAGG TGTCTTCTGC AGCTGCTGGT GTGCCCGGGG CAAACCCTGT CCTTAACAAC 3480
CTACTGTCGT GCGTACAGGA AATCAGTGAT GTGGTGCAGA GGTAG 3525
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevy+gvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 288   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  347
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih
Q: 348   LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH  407
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd
Q: 408   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  467
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkwsp+
Q: 468   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA  527
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfae+hqa+
Q: 528   DRPSFAETHQAF  539
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVTAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWSPA 240
DRPSFAETHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00219
EKS-ANC-00229
EKS-BOT-00258
EKS-CAJ-00244
EKS-CAF-00246
EKS-CAP-00294
EKS-DAR-00594
EKS-EQC-00231
EKS-FEC-00245
EKS-GAG-00199
EKS-GOG-00257
EKS-HOS-00246
EKS-ICT-00226
EKS-LAC-00271
EKS-LOA-00269
EKS-MAM-00260
EKS-MEG-00205
EKS-MOD-00238
EKS-MUM-00243
EKS-MUP-00257
EKS-MYL-00238
EKS-NOL-00239
EKS-ORN-00336
EKS-ORA-00228
EKS-ORC-00245
EKS-ORL-00287
EKS-OTG-00265
EKS-PAT-00227
EKS-PES-00230
EKS-POA-00231
EKS-RAN-00273
EKS-SAH-00244
EKS-TAG-00254
EKS-TEN-00296
EKS-TUT-00027
EKS-XIM-00329
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0051017; P:actin filament bundle assembly
GO:0071300; P:cellular response to retinoic acid
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0010976; P:positive regulation of neuron projection development
GO:0051353; P:positive regulation of oxidoreductase activity
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013