EKS-SUS-00002

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00002

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	518.4	3.1E-156	622	879	258

Status

Unreviewed

Ensembl Protein

ENSSSCP00000023658

UniProt Accession

D3K5K5;

Protein Name

Protein Synonyms/Alias

EPH receptor A3;

Gene Name

EPHA3

Gene Synonyms/Alias

EPHA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000026130	ENSSSCP00000023658	ENSSSCT00000022760

Organism

Sus scrofa

Functional Description

Protein Length

984

Protein Sequence
(FASTA)

MDCHLSILLL LSCSVLNCFG ELILQPSNEV NLLDSKAIQG ELGWISYPSH GWEEISGVDE 60

HYTPIRTYQV CNVMDHSQNN WLRTNWVPRN SAQKIYVELK FTLRDCNSIP LVLGTCKETF 120

NLYYMESDDD HGVKFREHQF IKIDTIAADE SFTQMDLGDR ILKLNTEVRE VGPVNKKGFY 180

LAFQDVGACV ALVSVRVYFK KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNNSKEEDPP 240

RMYCSTEGEW LVPIGKCSCN AGYEERGFMC EACRPGFYKA SDGNMKCAKC PPHSSTHEDG 300

SVNCRCENNY FRADKDPPSM ACTRPPSAPR NVISNINETS VILDWSWPLD TGGRKDVTFN 360

IICKKCGWNV KQCEPCSPNV RFLPRQFGLT NTTVTVTDLL AHTNYTFEID AINGVSELSS 420

PPRQFAAVSI TTNQAAPSPV MTIKKDRTSR NSISLSWQEP EHPNGIILDY EVKYYEKQEQ 480

ETSYTILRAR GTNVTISSLK PDTTYVFQIR ARTAAGYGTN SRKFEFETSP DSFSISGENS 540

QVVMIAISAA VAIILLTVVT YVLIGRFCGY NKSKHGADEK RLHFGNGHLK LPGLRTYVDP 600

HTYEDPTQAV HEFAKELDAT NISIDKVVGA GEFGEVCSGR LKLPSKKEIS VAIKTLKVGY 660

TEKQRRDFLG EASIMGQFDH PNIIRLEGVV TKSKPVMIVT EYMENGSLDS FLRKHDAQFT 720

VIQLVGMLRG IASGMKYLSD MGYVHRDLAA RNILINSNLV CKVSDFGLSR VLEDDPEAAY 780

TTRGGKIPIR WTSPEAIAYR KFTSASDVWS YGIVLWEVMS YGERPYWEMS NQDVIKAVDE 840

GYRLPPPMDC PAALYQLMLD CWQKDRNNRP KFEQIVSILD KLIRNPGSLK IITSAAARPS 900

NLLLDQSNVD ITTFRTTGDW LNGVRTAQCK EIFTGVEYSS CDTIAKISTD DMKKVGVTVV 960

GPQKKIISSI KALETQSKNS PVPV 984

Nucleotide Sequence
(FASTA)

ATGGATTGTC ACCTCTCCAT CCTCCTCCTT CTCAGCTGCT CTGTTCTCAA CTGCTTCGGG 60

GAACTGATTC TCCAACCTTC CAATGAAGTC AATCTACTGG ATTCAAAAGC AATTCAAGGG 120

GAGCTGGGCT GGATCTCCTA CCCATCACAT GGGTGGGAAG AGATAAGTGG TGTTGATGAA 180

CATTATACAC CCATCAGGAC TTACCAGGTG TGCAATGTCA TGGATCATAG TCAAAATAAT 240

TGGCTGAGGA CAAACTGGGT CCCCAGGAAC TCAGCTCAGA AGATCTATGT GGAACTCAAG 300

TTTACCCTCC GAGACTGCAA TAGTATTCCT TTGGTTTTGG GAACTTGCAA GGAGACTTTC 360

AACCTATACT ACATGGAGTC CGACGATGAT CACGGGGTCA AATTCCGAGA ACATCAGTTT 420

ATAAAGATTG ATACCATTGC AGCTGATGAA AGTTTCACAC AAATGGATCT TGGGGACCGT 480

ATTCTTAAAC TCAACACAGA AGTTAGAGAA GTAGGTCCTG TCAACAAAAA AGGATTTTAT 540

TTGGCTTTTC AAGATGTTGG TGCTTGTGTT GCCTTAGTGT CTGTGAGAGT GTACTTCAAA 600

AAGTGTCCGT TTACAGTGAA GAATTTGGCT ATGTTTCCAG ACACAGTACC CATGGATTCC 660

CAATCTCTGG TGGAAGTTAG AGGTTCTTGT GTTAACAATT CTAAGGAGGA AGATCCTCCC 720

AGGATGTACT GCAGCACAGA AGGTGAATGG CTTGTACCCA TTGGCAAGTG TTCATGCAAT 780

GCTGGCTATG AAGAAAGAGG TTTTATGTGT GAAGCTTGTC GACCAGGTTT CTACAAGGCT 840

TCGGATGGTA ATATGAAGTG TGCTAAGTGC CCACCTCACA GTTCTACTCA CGAAGATGGT 900

TCAGTGAACT GCAGGTGTGA GAATAATTAC TTCCGAGCAG ACAAAGACCC TCCATCCATG 960

GCTTGTACCC GACCTCCATC TGCACCGAGA AATGTTATAT CTAATATAAA TGAGACCTCC 1020

GTTATCCTGG ACTGGAGTTG GCCCCTGGAC ACAGGAGGCC GGAAAGATGT TACCTTCAAC 1080

ATCATATGTA AAAAATGTGG GTGGAATGTA AAACAGTGTG AGCCATGCAG CCCAAATGTC 1140

CGCTTCCTCC CTCGACAGTT TGGACTCACC AACACCACGG TGACAGTGAC AGACCTCCTG 1200

GCACACACTA ACTACACCTT TGAAATTGAT GCCATTAACG GGGTGTCAGA GCTGAGCTCA 1260

CCACCAAGAC AATTTGCTGC AGTCAGTATC ACAACGAACC AGGCTGCTCC ATCACCTGTC 1320

ATGACAATTA AGAAAGACCG GACATCCAGA AACAGCATTT CTTTATCCTG GCAAGAACCT 1380

GAACACCCTA ATGGGATCAT ATTGGACTAT GAGGTCAAAT ACTACGAAAA GCAGGAACAA 1440

GAAACAAGTT ATACTATTCT CAGGGCAAGA GGCACGAATG TTACAATCAG TAGCCTCAAG 1500

CCTGATACTA CATATGTATT CCAAATCCGA GCCCGGACTG CAGCTGGATA TGGGACCAAC 1560

AGCCGCAAAT TTGAGTTCGA AACTAGCCCA GACTCTTTCT CTATCTCCGG GGAGAATAGC 1620

CAAGTGGTAA TGATCGCCAT TTCAGCAGCA GTGGCCATTA TTCTCCTCAC AGTCGTCACC 1680

TACGTTTTGA TTGGGAGGTT CTGTGGCTAT AACAAGTCAA AACATGGTGC AGATGAAAAA 1740

AGACTGCACT TTGGGAATGG ACATTTAAAA CTTCCAGGTC TTAGGACTTA TGTTGATCCA 1800

CACACATATG AAGACCCTAC CCAAGCAGTT CATGAGTTTG CTAAGGAATT GGATGCCACC 1860

AACATATCCA TTGATAAAGT TGTTGGAGCA GGTGAATTTG GAGAGGTCTG CAGTGGTCGC 1920

TTAAAACTTC CTTCAAAAAA AGAGATTTCA GTGGCTATCA AGACCCTGAA AGTGGGCTAC 1980

ACAGAAAAGC AGAGGAGAGA CTTCTTAGGA GAAGCAAGCA TTATGGGGCA ATTTGACCAT 2040

CCCAATATCA TTCGACTGGA GGGAGTTGTT ACTAAAAGTA AACCAGTTAT GATTGTCACA 2100

GAATACATGG AGAATGGATC CTTGGACAGT TTCTTACGTA AACATGATGC CCAGTTCACA 2160

GTCATCCAGC TGGTAGGGAT GCTTCGAGGA ATAGCATCTG GCATGAAGTA CCTCTCAGAC 2220

ATGGGCTATG TTCACCGAGA CCTTGCTGCT CGAAACATCT TGATAAACAG CAATTTGGTG 2280

TGTAAGGTTT CTGATTTTGG ACTTTCACGA GTTCTAGAAG ATGACCCAGA AGCTGCTTAC 2340

ACAACAAGGG GAGGAAAGAT CCCTATCCGG TGGACCTCAC CAGAAGCTAT AGCCTACCGC 2400

AAATTCACGT CAGCCAGCGA CGTATGGAGT TATGGGATTG TTCTCTGGGA GGTGATGTCC 2460

TATGGAGAGA GACCATACTG GGAGATGTCC AATCAGGATG TAATTAAAGC TGTGGATGAA 2520

GGCTATCGAC TGCCGCCCCC CATGGACTGC CCAGCTGCGT TGTATCAGCT GATGCTGGAC 2580

TGTTGGCAGA AAGACAGAAA CAACAGACCC AAGTTTGAGC AGATTGTCAG CATTCTGGAC 2640

AAGCTTATCC GGAACCCAGG CAGTCTGAAG ATCATCACAA GTGCGGCAGC AAGGCCATCA 2700

AACCTTCTTC TGGACCAAAG CAACGTTGAC ATTACTACCT TCCGCACAAC AGGTGACTGG 2760

CTTAACGGTG TCCGGACAGC ACAGTGCAAG GAAATCTTCA CGGGCGTAGA GTACAGTTCT 2820

TGTGACACCA TAGCCAAGAT TTCCACAGAT GACATGAAAA AGGTTGGTGT CACTGTGGTT 2880

GGGCCACAGA AGAAGATCAT CAGTAGTATT AAAGCTCTAG AAACACAATC AAAGAATAGT 2940

CCAGTCCCAG TGTAA 2955

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk g+tekqrrdfl easi+Gqfdhp

Q: 622   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  681

         689*********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm

Q: 682   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  741

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk

Q: 742   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  801

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc

Q: 802   FTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  861

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wqkdr++rpkfeqivsil

Q: 862   WQKDRNNRPKFEQIVSIL  879

         ***************986

Domain Sequence
(FASTA)

ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60

NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120

GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180

FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240

WQKDRNNRPK FEQIVSIL 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005769	; C:early endosome
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005004	; F:GPI-linked ephrin receptor activity
GO:0071300	; P:cellular response to retinoic acid
GO:0010976	; P:positive regulation of neuron projection development
GO:0032956	; P:regulation of actin cytoskeleton organization
GO:0051893	; P:regulation of focal adhesion assembly
GO:0070507	; P:regulation of microtubule cytoskeleton organization
GO:0032319	; P:regulation of Rho GTPase activity

KEGG

ssc:100337658

;

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013