EKS-SUS-00306
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00306
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ack399.19.9E-120116377262
StatusUnreviewed
Ensembl ProteinENSSSCP00000026023
UniProt AccessionI3LPJ6;
Protein Name
Protein Synonyms/Alias
Gene NameTNK1
Gene Synonyms/Alias TNK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000026142ENSSSCP00000026023ENSSSCT00000024389
OrganismSus scrofa
Functional Description
Protein Length673
Protein Sequence
(FASTA)
MLPEADSLWL LRLLRDIQLA EFYRPILEAL NVTRPEHFDF VRPEDLDGIG MGRPAQRRLV 60
EALKRHRSGL KSKNWVYKIL GGFAPGQKES TPPSDSPPSL PEPEGGLKCL IPDGAVCRGE 120
LLGSGCFGVV HRGLWTLPSG QSIPVAVKSL RVGPEGPEGT ELGDFLREVS VMMNLEHPHV 180
LRLHGLVLGQ PLQMVMELAP LGSLHTRLTA PAPTPPLPVA LLCLFLRQVA GAMAYLGARG 240
LVHRDLATRN LLLASPRTVK VADFGLVRPL GGARGRYVMG GPRRIPFAWC APESLRHGAF 300
SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEKDR ARLPRPPLCS RALYALALRC 360
WAPHPADRPS FSNLEGLLQE AWPPEGRCVR DVTEPGALRM EPGDPITIIE GSPCTSASPH 420
SPDSTTWKGQ NGRTFKMGNF PASAVTLVDS GGSPASHLLP RGAPARGEHH QGNISGALGP 480
RLPAVFLFPP NTRATPRIAQ NRAGISKSLE SVLSLGPRPT GGGSSPPELR HARVGPQGAP 540
GLPPRPPVAA SSSSQPSQPP RERPPWPKRE LPHSQPTGAP GASKATVPSR GPLPDFELQR 600
RITEVELSVH GVTHQECQEA LRATGGDVVA AIRNLKVDQL FYLSSWSRAD CRRILERYQW 660
DLSAASRYVL ARS 673
Nucleotide Sequence
(FASTA)
ATGCTCCCCG AGGCGGACTC CCTTTGGCTG CTGCGGCTGC TCCGGGACAT CCAGCTGGCC 60
GAGTTTTACC GACCCATCCT TGAGGCGCTT AATGTGACCC GGCCAGAGCA CTTCGACTTT 120
GTAAGACCCG AGGATCTGGA TGGCATTGGC ATGGGCCGGC CTGCCCAGCG CAGACTGGTT 180
GAAGCCCTGA AGAGGCACCG TTCCGGGCTC AAGTCTAAGA ACTGGGTCTA TAAGATCCTT 240
GGAGGTTTTG CCCCTGGGCA AAAGGAGAGC ACCCCACCCT CAGACAGCCC TCCATCCCTC 300
CCTGAGCCAG AAGGGGGACT CAAGTGTCTG ATCCCAGATG GTGCCGTGTG CAGAGGGGAG 360
CTTCTGGGCT CCGGCTGCTT TGGCGTGGTG CACCGGGGGC TGTGGACCCT GCCCAGTGGC 420
CAGAGTATCC CAGTGGCTGT CAAGTCCCTC CGGGTGGGTC CCGAAGGCCC CGAGGGCACC 480
GAGCTAGGGG ACTTCCTGCG AGAAGTGTCC GTCATGATGA ACTTGGAGCA CCCACACGTG 540
CTGCGTCTGC ATGGCCTGGT ACTGGGCCAG CCTCTGCAGA TGGTGATGGA GCTGGCGCCC 600
CTGGGCTCCC TGCACACGCG CCTGACCGCC CCGGCCCCCA CACCCCCGCT GCCCGTGGCC 660
CTGCTCTGCC TCTTCCTGCG GCAGGTGGCA GGGGCCATGG CGTACCTGGG GGCCCGCGGG 720
CTGGTGCACC GAGACCTTGC CACGCGCAAC CTGCTGCTGG CCTCACCGCG CACGGTCAAG 780
GTGGCTGACT TCGGGCTGGT GCGGCCGCTG GGCGGCGCCC GGGGCCGCTA CGTCATGGGC 840
GGGCCCCGCC GCATCCCCTT TGCCTGGTGT GCGCCAGAGA GCCTGCGCCA CGGGGCCTTC 900
TCTTCTGCCT CGGACGTGTG GATGTTTGGG GTGACGCTGT GGGAGATGTT CTCCGGAGGC 960
GAGGAGCCCT GGGCGGGGGT CCCGCCGTAC CTCATCCTGC AGCGGCTGGA GAAGGACCGA 1020
GCCCGCCTGC CTAGGCCTCC CCTCTGCTCC AGGGCCCTCT ACGCCCTCGC CTTGCGCTGC 1080
TGGGCCCCCC ACCCTGCGGA CCGGCCCAGC TTTTCCAACC TGGAGGGGCT GCTCCAAGAG 1140
GCCTGGCCTC CTGAGGGACG TTGTGTGAGG GATGTCACAG AGCCAGGTGC CCTGAGGATG 1200
GAGCCTGGTG ACCCCATCAC TATCATCGAG GGCAGTCCCT GCACCAGTGC CTCTCCCCAC 1260
AGCCCCGACT CCACCACCTG GAAGGGCCAG AACGGTCGCA CATTCAAAAT GGGCAACTTC 1320
CCAGCCTCGG CAGTGACGCT GGTAGACTCA GGGGGCTCGC CAGCCAGCCA TCTGCTCCCC 1380
AGAGGCGCCC CTGCCCGAGG AGAGCACCAC CAGGGAAACA TCAGTGGCGC TTTGGGCCCT 1440
CGGCTGCCTG CTGTCTTCTT GTTCCCCCCT AACACGAGGG CCACCCCAAG GATAGCCCAG 1500
AACCGTGCAG GCATTTCCAA GAGCCTGGAG TCAGTTCTGT CCCTGGGCCC CCGCCCCACA 1560
GGAGGGGGGT CCAGCCCCCC TGAACTTCGA CATGCCAGAG TGGGGCCCCA GGGCGCCCCG 1620
GGCCTGCCAC CCCGCCCTCC CGTTGCCGCC AGCTCGTCTT CCCAGCCCAG CCAGCCTCCC 1680
AGGGAGCGGC CTCCCTGGCC CAAAAGAGAA CTCCCCCACA GTCAGCCCAC AGGAGCGCCG 1740
GGGGCCAGCA AAGCCACTGT CCCCTCCAGA GGACCCCTGC CTGACTTCGA GCTGCAGAGG 1800
AGGATTACAG AGGTGGAGCT GAGCGTGCAT GGAGTCACCC ACCAGGAGTG CCAGGAGGCC 1860
CTGAGAGCCA CTGGGGGAGA TGTGGTGGCC GCCATCCGGA ACCTCAAGGT GGACCAGCTC 1920
TTCTACCTCA GCAGCTGGTC CAGAGCAGAC TGCCGGCGCA TCCTGGAGCG CTACCAGTGG 1980
GACCTCTCAG CTGCCAGCCG CTACGTCCTG GCCCGGTCTT GA 2022
Domain Profile
S: 1     iklleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkl  58
         ++++e+lG+G+fgvv+rg W+ psg+s++vavk+l+  ++   +tel+dflrevsv+++l
Q: 116   VCRGELLGSGCFGVVHRGLWTLPSGQSIPVAVKSLRvgPEGPEGTELGDFLREVSVMMNL  175
         56889******************************9999*********************
S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118
         eh++++rl+G+vl+qpl++v+ela+lgsl++rl+++a +++l+vall+ +++q+a ++ay
Q: 176   EHPHVLRLHGLVLGQPLQMVMELAPLGSLHTRLTAPAPTPPLPVALLCLFLRQVAGAMAY  235
         ************************************************************
S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPesl  178
         l+++ lvhrdla+rnlllas+++vk++dfGlvr+lg ++++yv+  ++++PfaWcaPesl
Q: 236   LGARGLVHRDLATRNLLLASPRTVKVADFGLVRPLGGARGRYVMGGPRRIPFAWCAPESL  295
         ************************************************************
S: 179   rtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediys  238
         r+ +fssasdvW+fGvtlWemfs GeePW+g++++ il++++k+++rl++P++c++++y+
Q: 296   RHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDRARLPRPPLCSRALYA  355
         ************************************************************
S: 239   lllkcWakkpadrpkfsalkek  260
         l+l+cWa +padrp+fs+l++ 
Q: 356   LALRCWAPHPADRPSFSNLEGL  377
         *******************976
Domain Sequence
(FASTA)
VCRGELLGSG CFGVVHRGLW TLPSGQSIPV AVKSLRVGPE GPEGTELGDF LREVSVMMNL 60
EHPHVLRLHG LVLGQPLQMV MELAPLGSLH TRLTAPAPTP PLPVALLCLF LRQVAGAMAY 120
LGARGLVHRD LATRNLLLAS PRTVKVADFG LVRPLGGARG RYVMGGPRRI PFAWCAPESL 180
RHGAFSSASD VWMFGVTLWE MFSGGEEPWA GVPPYLILQR LEKDRARLPR PPLCSRALYA 240
LALRCWAPHP ADRPSFSNLE GL 262
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>
EKS-AIM-00324
EKS-BOT-00346
EKS-CAJ-00352
EKS-CAF-00351
EKS-CAP-00380
EKS-ECT-00058
EKS-EQC-00338
EKS-ERE-00047
EKS-FEC-00334
EKS-GOG-00343
EKS-HOS-00353
EKS-ICT-00327
EKS-LOA-00355
EKS-MAM-00347
EKS-MUM-00378
EKS-MUP-00341
EKS-MYL-00347
EKS-NOL-00316
EKS-OCP-00065
EKS-ORC-00325
EKS-OTG-00351
EKS-PAT-00328
EKS-POA-00336
EKS-PRC-00058
EKS-PTV-00087
EKS-RAN-00361
Gene Ontology
GO:0005829; C:cytosol
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030308; P:negative regulation of cell growth
GO:0046580; P:negative regulation of Ras protein signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013