EKS-SUS-00238
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00238
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK270.03.8E-80193363171
StatusUnreviewed
Ensembl ProteinENSSSCP00000023629
UniProt AccessionI3LHT2;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK2
Gene Synonyms/Alias HIPK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000026733ENSSSCP00000023629ENSSSCT00000028580
OrganismSus scrofa
Functional Description
Protein Length378
Protein Sequence
(FASTA)
MASHVQVFSP HTLQSSAFCS VKKLKVEPSS TWDMTGYGSH SKVYGQSKNA PPSQPAAAAT 60
VSASLPIPNP GLPYEQTIIF PGSAGHIVVT SASSTSVTGQ VLGGPHNLMR RSTVSLLDTY 120
QKCGLKRKSE EIENTSSVQI IEEHPPMIQN TASGATVATA TTSTATSKNS GSNSEGDYQL 180
VQHEVLCSMT NTYEVLEFLG RGTFGQVVKC WKRGTNEIVA IKILKNHPSY ARQGQIEVSI 240
LARLSTESAD DYNFVRAYEC FQHKNHTCLV FEMLEQNLYD FLKQNKFSPL PLKYIRPVLQ 300
QVATALMKLK SLGLIHADLK PENIMLVDPS RQPYRVKVID FGSASHVSKA VCSTYLQSRY 360
YRSTPKAYGA SQARGPIG 378
Nucleotide Sequence
(FASTA)
ATGGCCTCAC ATGTGCAAGT TTTCTCCCCT CACACCCTCC AATCAAGTGC CTTCTGTAGC 60
GTGAAGAAGC TGAAAGTAGA GCCGAGTTCC ACCTGGGACA TGACCGGGTA CGGCTCGCAC 120
AGCAAGGTGT ATGGCCAGAG CAAGAACGCG CCGCCTTCGC AGCCAGCCGC CGCCGCCACC 180
GTCAGCGCCT CCCTGCCCAT CCCGAACCCA GGCCTACCTT ACGAGCAGAC CATCATCTTC 240
CCAGGGAGCG CCGGGCACAT CGTCGTCACG TCCGCCAGCA GCACGTCTGT CACTGGGCAA 300
GTCCTCGGTG GCCCGCACAA CCTCATGCGT CGCAGCACTG TGAGCCTTCT CGACACCTAC 360
CAAAAATGCG GACTCAAGCG GAAGAGTGAG GAGATTGAGA ACACGAGCAG CGTGCAGATC 420
ATCGAAGAGC ACCCACCCAT GATTCAGAAC ACCGCGAGTG GGGCCACTGT CGCCACTGCC 480
ACCACCTCGA CTGCCACCTC CAAAAACAGT GGCTCCAACA GCGAGGGGGA CTACCAGCTG 540
GTCCAGCATG AGGTGCTGTG CTCCATGACC AACACGTACG AAGTTCTGGA GTTCCTGGGC 600
CGGGGGACGT TTGGGCAAGT GGTCAAGTGC TGGAAGCGGG GCACCAATGA GATCGTGGCC 660
ATCAAGATCC TGAAGAACCA CCCGTCCTAC GCCCGCCAAG GTCAGATCGA GGTGAGCATC 720
CTGGCGCGCC TGAGCACGGA GAGCGCCGAC GACTACAACT TCGTCCGCGC CTACGAGTGC 780
TTCCAGCACA AGAACCACAC GTGCTTGGTC TTCGAGATGC TGGAGCAGAA CCTCTATGAC 840
TTTCTGAAGC AGAACAAGTT CAGCCCCTTG CCCCTCAAAT ACATTCGCCC AGTCCTCCAG 900
CAGGTGGCCA CGGCCCTGAT GAAACTAAAA AGCCTCGGTC TTATCCACGC CGACCTCAAA 960
CCGGAGAACA TCATGCTGGT CGATCCCTCT AGACAGCCGT ACCGAGTCAA GGTCATCGAC 1020
TTTGGGTCAG CCAGTCACGT GTCCAAGGCT GTGTGCTCCA CCTACTTGCA GTCCAGGTAT 1080
TACAGGTCTA CACCCAAGGC ATATGGAGCT TCCCAGGCTA GGGGTCCAAT TGGA 1134
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 193   YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ESADD  251
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 252   YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS  311
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYra  170
         l++iHaDlKPeNi+lv+++r++  vkviDFGs+s+vs+++++ty+qsr+Yr+
Q: 312   LGLIHADLKPENIMLVDPSRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRS  363
         *********************999***************************8
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTESADDY 60
NFVRAYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPVLQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPSRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR S 171
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005813; C:centrosome
GO:0031965; C:nuclear membrane
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001105; F:RNA polymerase II transcription coactivator activity
GO:0003714; F:transcription corepressor activity
GO:0046790; F:virion binding
GO:0007628; P:adult walking behavior
GO:0009952; P:anterior/posterior pattern specification
GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030514; P:negative regulation of BMP signaling pathway
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182; P:neuron differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0008284; P:positive regulation of cell proliferation
GO:0043388; P:positive regulation of DNA binding
GO:0046330; P:positive regulation of JNK cascade
GO:0032092; P:positive regulation of protein binding
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0010842; P:retina layer formation
GO:0060395; P:SMAD protein signal transduction
GO:0007224; P:smoothened signaling pathway
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0050882; P:voluntary musculoskeletal movement
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013