EKS-SUS-00094
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00094
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec489.52.2E-147402652251
StatusUnreviewed
Ensembl ProteinENSSSCP00000025530
UniProt AccessionF1S1L0;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000026742ENSSSCP00000025530ENSSSCT00000025835
OrganismSus scrofa
Functional Description
Protein Length659
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKS VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180
HRKTKKPLPP TPEEDQILKK PLPPEPTAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE 240
YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF AKATGEPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360
YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420
WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480
CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540
GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FTNSETAEHI AQGLRLYRPH LASERVYTIM YSCWHEKADE RPTFKILLSN ILDVMDEES 659
Nucleotide Sequence
(FASTA)
ATGGCTGCGG TGATACTGGA GAGCATCTTT CTGAAACGAT CTCAGCAGAA AAAGAAAACA 60
TCACCTTTGA ACTTCAAGAA GCGCCTCTTT CTCTTGACCG TGCAAAAACT TTCCTACTAT 120
GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAGAAG 180
ATCACCTGCG TTGAAACAGT TGTTCCTGAG AAAAATCCTC CCCCTGAAAG ACAGATTCCG 240
AGAAGGGGTG AAGAGTCCAG TGAAATGGAG CAGATTTCAA TTATTGAAAG GTTCCCTTAC 300
CCCTTCCAGG TTGTATATGA TGAAGGGCCT CTCTACGTCT TCTCCCCAAC TGAAGAACTG 360
AGAAAGCGTT GGATTCACCA GCTCAAAAGT GTAATCCGGT ACAACAGTGA TCTGGTACAG 420
AAATACCACC CTTGCTTCTG GATTGATGGG CAGTATCTCT GCTGCTCTCA GACAGCCAAA 480
AATGCTATGG GCTGCCAAAT TTTGGAGAAC AGAAATGGAA GCTTAAAACC TGGGAGTTCA 540
CACCGAAAGA CGAAAAAGCC TCTTCCTCCC ACACCTGAGG AGGACCAGAT CTTAAAAAAG 600
CCACTGCCCC CTGAGCCAAC AGCAGCACCG GTCTCGACAA GTGAGCTGAA AAAGGTTGTA 660
GCCCTTTATG ATTACATGCC AATGAATGCA AATGATCTAC AGCTGCGGAA GGGCGACGAG 720
TATTTTATCC TGGAGGAGAG CAACTTACCC TGGTGGCGAG CCCGGGACAA AAATGGGCAG 780
GAAGGCTACA TCCCTAGTAA CTATGTAACC GAAGCAGAAG ACTCCATAGA AATGTATGAG 840
TGGTATTCCA AACACATGAC TCGGAGTCAA GCTGAGCAAC TGCTAAAGCA AGAGGGCAAA 900
GAAGGAGGCT TCATTGTCAG AGACTCCAGC AAAGCTGGAA AATATACTGT GTCTGTGTTT 960
GCTAAAGCCA CAGGGGAACC TCAAGGGGTG ATACGTCATT ATGTTGTGTG TTCCACACCT 1020
CAGAGCCAGT ATTATCTGGC TGAGAAGCAC CTTTTCAGCA CCATCCCTGA GCTCATTAAC 1080
TACCACCAGC ATAATTCTGC AGGACTCATA TCTAGGCTCA AATATCCAGT GTCTCAACAA 1140
AACAAGAATG CGCCGTCCAC TGCAGGCCTG GGCTACGGAT CATGGGAAAT TGATCCAAAA 1200
GACCTGACCT TCTTGAAGGA GCTGGGGACT GGACAATTTG GAGTAGTGAA GTATGGGAAA 1260
TGGAGGGGCC AGTATGATGT GGCCATCAAG ATGATCAAAG AAGGCTCCAT GTCTGAGGAT 1320
GAGTTCATTG AAGAAGCCAA AGTCATGATG AATCTTTCCC ACGAGAAGCT GGTGCAGCTG 1380
TATGGTGTCT GCACCAAACA GCGCCCCATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440
TGCCTCCTGA ACTACCTGAG GGAGATGCGC CACCGCTTCC AGACTCAGCA GCTGCTGGAG 1500
ATGTGCAAGG ATGTCTGTGA AGCTATGGAA TACCTGGAGT CAAAGCAGTT CCTCCACCGA 1560
GACCTGGCGG CTCGGAACTG TTTGGTGAAT GACCAAGGAG TTGTTAAAGT ATCAGACTTT 1620
GGCCTATCCA GGTATGTTCT GGATGATGAA TACACAAGCT CAGTAGGCTC CAAATTTCCA 1680
GTCCGGTGGT CTCCACCAGA AGTCCTCATG TATAGCAAGT TCAGCAGCAA ATCTGATATT 1740
TGGGCTTTTG GGGTGTTGAT GTGGGAAATT TACTCTCTGG GGAAGATGCC ATATGAGAGA 1800
TTTACCAACA GCGAAACAGC TGAACACATT GCCCAAGGCC TACGTCTCTA CAGGCCTCAT 1860
CTAGCTTCAG AGAGGGTCTA TACCATCATG TACAGCTGCT GGCATGAGAA AGCAGATGAA 1920
CGTCCCACTT TCAAAATTCT TCTGAGCAAC ATTCTAGATG TCATGGATGA AGAATCCTGA 1980
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly
Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  461
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er
Q: 582   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADER  641
         ************************************************************
S: 241   ptfkellsale  251
         ptfk lls++ 
Q: 642   PTFKILLSNIL  652
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYTIMY SCWHEKADER 240
PTFKILLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CIS-00119
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
ssc:100517988;
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013