EKS-SUS-00208

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00208

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	333.7	7.7E-100	60	311	252

Status

Unreviewed

Ensembl Protein

ENSSSCP00000021457

UniProt Accession

F1SPP7;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000027055	ENSSSCP00000021457	ENSSSCT00000029499

Organism

Sus scrofa

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MEGAAAAAAG DGPDLGLGTP GSPPEAGAGA TAAPAAAAPE PRKPHGVKRH HHKHNLKHRY 60

ELQETLGKGT YGKVKRATER FSGRVVAIKS IRKDKIKDEQ DMVHIRREIE IMSSLSHPHI 120

ISIYEVFENK DKIVIIMEYA SKGELYDYIS ERRRLSERET RHFFRQIVSA VHYCHKNGVV 180

HRDLKLENIL LDDNCNIKIA DFGLSNLYQK DKFLQTFCGS PLYASPEIVN GRPYRGPEVD 240

SWALGVLLYT LVYGTMPFDG FDHKNLIRQI SSGEYREPTQ PSDARGLIRW MLMVNPDRRA 300

TIEDIANHWW VNWGYKSSVC DCDALHSSES PLLARIIDWH HRSTGLQVEA DAKVKGLAKP 360

GAPEVVLERQ RSLKKSKKEN DFAQSGQDAV PESPSKLSSK RPKGILKKRS NSEHRSHSTG 420

FIEGVVSPAL PPTFKMEQDL CRTAVPLPSS PEAEVPGKLS PKQSATMPKK GILKKTQQRE 480

SGYYSSPERS ESSELLDTND GLGGPVPSPS PPDAARAPPH SLSCRRKGIL KHSSKYSAGT 540

MDPALASPEM PTLESLLEPG VPAEGISRSY SRPSSVISDD SVLSSDSFDL LDLQENRPAR 600

QRIRSCVSAE NFLQIQDFER LQNRPRPQYL KRYRNRLGDS SFSLLTDMDD VTQVYKKALE 660

ICNKLN 666

Nucleotide Sequence
(FASTA)

ATGGAGGGGG CCGCTGCGGC CGCGGCCGGG GACGGCCCGG ACTTGGGGCT GGGGACGCCG 60

GGCTCTCCCC CGGAGGCGGG GGCGGGGGCG ACCGCAGCCC CCGCGGCGGC GGCCCCGGAG 120

CCCAGGAAGC CGCACGGGGT GAAGCGGCAT CACCACAAGC ACAACTTGAA GCACCGCTAC 180

GAGCTGCAGG AGACCCTGGG CAAAGGCACC TACGGCAAAG TCAAGAGGGC CACCGAGAGG 240

TTTTCGGGCC GAGTGGTTGC TATAAAATCC ATCCGTAAGG ACAAAATTAA GGATGAACAA 300

GACATGGTTC ACATCAGACG AGAGATTGAG ATCATGTCAT CCCTCAGCCA TCCTCATATC 360

ATCAGTATTT ATGAAGTGTT CGAGAACAAA GATAAGATTG TGATCATCAT GGAGTACGCC 420

AGCAAAGGGG AGCTGTACGA TTACATCAGC GAGCGGCGCC GGCTCAGCGA GCGGGAGACC 480

AGGCACTTCT TCCGGCAGAT CGTCTCCGCC GTGCACTATT GTCACAAGAA CGGCGTGGTC 540

CACCGGGACC TGAAGCTGGA GAATATACTG CTCGATGACA ACTGTAATAT CAAGATTGCT 600

GACTTTGGGC TTTCCAACCT GTACCAGAAG GACAAGTTCT TGCAAACATT TTGCGGGAGC 660

CCACTCTACG CCTCTCCTGA AATCGTCAAC GGGAGACCTT ACCGAGGGCC AGAGGTGGAC 720

AGCTGGGCCC TGGGCGTGTT GCTTTACACT CTTGTTTATG GAACAATGCC CTTCGACGGT 780

TTCGATCACA AAAACCTCAT TCGTCAGATC AGCAGCGGAG AGTACCGGGA GCCCACCCAG 840

CCCTCAGATG CTCGAGGACT CATTCGGTGG ATGCTGATGG TGAACCCCGA CCGCCGGGCC 900

ACCATCGAGG ACATCGCCAA CCACTGGTGG GTAAACTGGG GCTACAAGAG CAGCGTCTGC 960

GACTGCGACG CCCTTCACAG CTCTGAGTCC CCGCTGCTGG CCCGCATCAT CGACTGGCAC 1020

CACCGCTCCA CGGGGCTGCA GGTGGAGGCA GATGCTAAAG TGAAGGGCTT GGCCAAACCC 1080

GGGGCCCCTG AGGTCGTGCT GGAGCGGCAG CGGTCGCTGA AGAAGTCCAA GAAAGAGAAC 1140

GACTTTGCTC AGTCCGGCCA GGACGCAGTG CCCGAAAGCC CATCCAAGTT GAGTTCCAAG 1200

CGGCCCAAAG GGATCCTGAA GAAGCGGAGC AACAGCGAGC ATCGCTCTCA CAGCACTGGC 1260

TTCATCGAAG GCGTCGTCAG CCCCGCCTTG CCCCCCACCT TCAAGATGGA GCAGGACCTG 1320

TGCCGGACAG CCGTGCCCCT GCCCAGCTCC CCCGAGGCGG AGGTGCCGGG CAAACTCAGC 1380

CCCAAGCAGT CGGCCACGAT GCCCAAGAAA GGCATCCTGA AAAAGACCCA GCAGAGAGAA 1440

TCGGGTTACT ACTCGTCCCC GGAGCGCAGC GAGTCTTCGG AGCTGTTAGA CACTAACGAT 1500

GGGCTGGGTG GCCCCGTCCC GTCCCCGAGC CCCCCGGACG CAGCCAGGGC GCCTCCCCAC 1560

AGCCTCTCCT GCCGCAGGAA GGGCATCTTG AAACACAGCA GCAAGTACTC AGCAGGCACC 1620

ATGGACCCGG CCCTGGCCAG CCCCGAAATG CCCACACTGG AATCCTTGCT GGAGCCCGGC 1680

GTCCCCGCCG AGGGCATCTC CCGGAGCTAC AGCCGGCCTT CCAGCGTCAT CAGCGACGAC 1740

AGCGTCCTGT CCAGCGACTC CTTTGACTTG CTCGACTTGC AGGAGAATCG CCCCGCCCGC 1800

CAGCGCATCC GCAGCTGCGT CTCTGCCGAG AACTTCCTCC AGATCCAGGA CTTTGAGAGG 1860

CTCCAGAACC GGCCCCGGCC CCAGTACCTG AAGCGGTACC GGAACCGGCT GGGAGACAGC 1920

AGCTTCTCCC TCCTCACAGA CATGGACGAT GTGACTCAGG TCTACAAGAA AGCGCTGGAG 1980

ATCTGTAACA AACTCAACTA G 2001

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 60    YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLSHPH  119

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 120   IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  179

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 180   VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  239

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+p++

Q: 240   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDR  298

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 299   RATIEDIANHWWV  311

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRATE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLSHPH 60

IISIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDNCNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPDRR 240

ATIEDIANHW WV 252

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

ssc:100523669

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013