EKS-SUS-00325
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00325
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src422.85.4E-127237486250
StatusUnreviewed
Ensembl ProteinENSSSCP00000020456
UniProt AccessionI3L8U5;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000027568ENSSSCP00000020456ENSSSCT00000025629
OrganismSus scrofa
Functional Description
Protein Length501
Protein Sequence
(FASTA)
MGVVSSKRQV KEKGKDGWSP VKASTYSKEP PPLPPLVVFN HLAPPPPNTT HPDQEEHFVV 60
ALYNYNAMND RDLQMLKGEK LQILKEAGDW WLAKSLTTGR EGYVPSNFVA RVETLEVEKW 120
FFRSICRRDA ERQLLAPVNK VGSFLIRESE TSKGTFSLSV KDVTSQGEVI KHYKIRSLDE 180
GGYYISPRNT FPTLQALVQH YSKKGDGLCQ RLTQPCVSLA PQNPWAQDEW EIPRQSLKLV 240
RKLGSGQFGE VWMGYYKNNI KVAIKTLKEG TMSPEAFLGE ANLMKTLQHE RLVRLYAVVT 300
KEPIYIVTEY MARGCLLDFL KTDEGSRLSL PRLIDMSAQI AEGMAYIEQM NSIHRDLRAA 360
NILVSETLCC KIGDFGLARI IDSEYTAQEG AKFPIKWTAP EAIHFGVFTI KADVWSFGIL 420
LMEMVTYGRV PYPGMSNPEV IRNLERGYRM PRPDSCPPEL YNGVIAECWR SRPEERPTFE 480
FLQSVLEDFH TATEAQYELQ P 501
Nucleotide Sequence
(FASTA)
ATGGGAGTGG TGAGCAGCAA AAGGCAGGTC AAGGAGAAGG GTAAGGACGG ATGGAGCCCT 60
GTAAAGGCCA GCACCTACAG CAAAGAGCCC CCACCGCTGC CGCCCCTGGT CGTGTTTAAT 120
CACCTGGCTC CCCCACCTCC CAACACCACG CACCCGGACC AAGAGGAGCA CTTCGTGGTA 180
GCCCTGTATA ACTACAATGC CATGAACGAC CGGGACCTGC AGATGCTGAA GGGGGAGAAG 240
CTGCAGATCC TGAAGGAAGC TGGAGACTGG TGGCTGGCCA AGTCTCTCAC CACAGGAAGA 300
GAAGGCTACG TGCCCAGCAA TTTTGTGGCC CGAGTGGAGA CCCTGGAAGT GGAAAAGTGG 360
TTCTTTAGAT CAATTTGCCG GAGAGATGCC GAGAGGCAGC TTCTGGCTCC AGTCAATAAG 420
GTCGGCTCCT TTCTTATTAG AGAGAGTGAA ACCAGCAAAG GTACCTTTTC TCTGTCTGTG 480
AAGGATGTGA CCAGCCAGGG GGAGGTGATC AAACACTATA AGATCCGTTC CCTGGATGAA 540
GGCGGCTATT ACATCTCCCC CCGAAACACG TTCCCGACTC TGCAGGCTTT GGTGCAGCAC 600
TATTCTAAGA AAGGGGATGG TTTATGCCAG AGGCTGACCC AACCCTGCGT GAGCCTTGCT 660
CCCCAGAACC CCTGGGCCCA GGACGAATGG GAAATCCCCC GGCAGTCCCT CAAGCTGGTC 720
AGGAAACTCG GGTCTGGGCA GTTTGGCGAA GTCTGGATGG GTTATTACAA AAACAACATC 780
AAGGTGGCCA TCAAGACCTT GAAGGAGGGA ACCATGTCTC CAGAGGCCTT CCTGGGTGAG 840
GCCAACCTGA TGAAAACTCT CCAGCACGAG AGGCTGGTCC GTCTCTACGC TGTGGTCACC 900
AAGGAGCCCA TCTACATTGT GACCGAGTAC ATGGCCAGAG GGTGCTTGCT GGATTTCTTG 960
AAGACGGATG AAGGTAGCCG ATTGTCCCTC CCCAGGCTGA TTGACATGTC GGCCCAGATT 1020
GCTGAAGGGA TGGCGTATAT CGAGCAGATG AACTCCATCC ACCGGGACCT GAGGGCAGCC 1080
AACATCCTGG TGTCTGAGAC CCTGTGCTGC AAAATTGGGG ACTTTGGCTT GGCCCGGATC 1140
ATTGACAGTG AATACACAGC CCAAGAGGGG GCCAAGTTCC CCATCAAGTG GACTGCCCCA 1200
GAGGCCATCC ATTTTGGGGT GTTCACCATC AAAGCGGATG TGTGGTCCTT TGGAATCCTC 1260
CTGATGGAAA TGGTCACTTA CGGGCGTGTG CCCTACCCAG GAATGAGCAA CCCCGAGGTC 1320
ATCCGCAACC TAGAGCGCGG ATATCGCATG CCGCGCCCGG ACTCTTGCCC GCCCGAGCTG 1380
TACAACGGGG TCATCGCCGA GTGCTGGCGG AGCCGTCCCG AGGAGCGGCC CACCTTCGAG 1440
TTCCTGCAGT CTGTGCTCGA GGACTTCCAC ACGGCCACCG AGGCCCAATA CGAGCTGCAG 1500
CCCTAG 1506
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv+klG+GqfGevw+g++k+++kva+ktlkegt+speafl ea+++k+l+he+lv+ly
Q: 237   LKLVRKLGSGQFGEVWMGYYKNNIKVAIKTLKEGTMSPEAFLGEANLMKTLQHERLVRLY  296
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d++aq+aeGmay+e++n ihr
Q: 297   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIEQMNSIHR  355
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e+l++k++dfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv
Q: 356   DLRAANILVSETLCCKIGDFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  414
         **************************.899******************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239
         WsfGill+e+vt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe
Q: 415   WSFGILLMEMVTYGRVPYPGMSNPEVIRNLERGYRMPRPDSCPPELYNgVIAECWRSRPE  474
         ************************************************************
S: 240   erPtfetlqevl  251
         erPtfe+lq+vl
Q: 475   ERPTFEFLQSVL  486
         ********9986
Domain Sequence
(FASTA)
LKLVRKLGSG QFGEVWMGYY KNNIKVAIKT LKEGTMSPEA FLGEANLMKT LQHERLVRLY 60
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IEQMNSIHRD 120
LRAANILVSE TLCCKIGDFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180
FGILLMEMVT YGRVPYPGMS NPEVIRNLER GYRMPRPDSC PPELYNGVIA ECWRSRPEER 240
PTFEFLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-DAR-00751
EKS-EQC-00363
EKS-FEC-00359
EKS-GAM-00225
EKS-GAG-00314
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LAC-00386
EKS-LOA-00381
EKS-MAM-00373
EKS-MEG-00304
EKS-MOD-00360
EKS-MUM-00404
EKS-MUP-00366
EKS-NOL-00339
EKS-ORN-00479
EKS-ORC-00351
EKS-ORL-00443
EKS-OTG-00375
EKS-PAT-00352
EKS-PES-00329
EKS-POA-00361
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-TAG-00443
EKS-TAR-00476
EKS-TUT-00099
EKS-XIM-00469
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
ssc:100623761;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013