EKS-SUS-00331
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00331
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK342.22.3E-10299357259
StatusUnreviewed
Ensembl ProteinENSSSCP00000027280
UniProt AccessionI3LT36;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K10
Gene Synonyms/Alias MAP3K10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000028036ENSSSCP00000027280ENSSSCT00000022919
OrganismSus scrofa
Functional Description
Protein Length929
Protein Sequence
(FASTA)
MEEEEGGAAK EWGTTPAGPV WTAVFDYEAA GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPGT PAAPAGLRLP QEIPFHELQL EEIIGVGGFG KVYRALWRGE 120
EVAVKAARLD PERDPAVTAE QVRQEARLFG ALQHPNIIAL RGACLSPPHL CLVMEYARGG 180
ALSRVLAGRR VPPHVLVNWA VQVARGMNYL HNDAPVPIIH RDLKSINILI LEAIENHNLA 240
DTVLKITDFG LAREWHKTTK MSAAGTYAWM APEVIRLSLF SKSSDVWSFG VLLWELLTGE 300
VPYREIDALA VAYGVAMNKL TLPIPSTCPE PFARLLEECW DPDPHGRPDF GSILKQLEVI 360
EQSALFQMPL ESFHSLQEDW KLEIQHMFDD LRTKEKELRS REEELLRAAQ EQRFQEEQLR 420
RREQELAERE MDIVERELHL LMCQLSQEKP RVRKRKGNFK RSRLLKLREG SSHISLPSGF 480
EHKITVQASP TLDKRKGSNG ASPPASPSII PRLRAIRLTP VDGGGGSSSG SSSGGSGTWG 540
RGSGPPKKEE LVGGKKKGRT WGPSSTLQKE RAGGEERLKA LGEGSKQWSS SAPNLGKSPK 600
HTPIAPGFAS LNEMGVGNRG SRGYGGHSQG QGRLRCKDSR TTLSGTWRSR CWRGPWGPRG 660
PGPAPELTES SDGPLPVAEE FAEADGGGGS VPPSPYTTPS YLTVPLPAQP SPGDDAAPGP 720
GLAPSATLVS LSSVSDCNST RSLLRSDSDE AAPAAPSPPP SPPAPPPQPS TNPLVDLELE 780
SFKKDPRQSL TPTHVTAARA VSRGHRRTPS DGALGQRGAP EPSGLVPGPR DPLDFPRLPD 840
PQALFPTRRR PPEFPGRPTT LTFAPRPRPA ASRPRLDPWK LVSFGQILSI SPPSRPDTPE 900
SPGPPSMQPT LLDMDMEGQS QDSTVPLCG 929
Nucleotide Sequence
(FASTA)
ATGGAGGAGG AGGAAGGGGG GGCGGCCAAG GAGTGGGGCA CGACCCCCGC GGGGCCTGTC 60
TGGACCGCAG TGTTCGACTA CGAAGCGGCG GGCGACGAGG AGCTGACCCT GCGGAGGGGT 120
GACCGCGTCC AGGTGCTTTC CCAGGACTGT GCCGTGTCTG GCGACGAGGG CTGGTGGACC 180
GGGCAGCTAC CCAGCGGCCG TGTGGGCGTC TTCCCCAGCA ATTACGTGGC CCCCGGCACC 240
CCCGCCGCGC CCGCGGGCCT CCGGCTGCCC CAGGAGATCC CCTTCCACGA GCTGCAGCTA 300
GAAGAGATCA TCGGTGTAGG GGGCTTTGGC AAGGTCTATC GGGCCCTGTG GCGTGGCGAG 360
GAGGTGGCGG TCAAGGCCGC CCGGCTGGAC CCTGAACGGG ACCCGGCAGT GACAGCAGAG 420
CAGGTGCGCC AGGAGGCCCG GCTCTTCGGA GCCCTGCAGC ACCCCAACAT CATTGCCCTC 480
AGGGGCGCCT GCCTCAGCCC CCCACACCTC TGCCTGGTGA TGGAGTATGC CAGGGGGGGT 540
GCACTGAGCA GGGTGCTGGC AGGGCGCCGC GTGCCCCCTC ACGTGCTGGT CAACTGGGCC 600
GTGCAGGTGG CCCGGGGCAT GAACTACCTA CACAATGATG CCCCCGTGCC CATCATCCAC 660
CGGGACCTCA AGTCCATCAA CATCCTTATT CTGGAGGCCA TCGAGAACCA CAACCTCGCA 720
GACACGGTGC TCAAGATCAC GGACTTCGGC CTCGCCCGTG AGTGGCACAA GACCACTAAA 780
ATGAGCGCCG CGGGGACCTA CGCCTGGATG GCTCCGGAGG TTATCCGTCT CTCCCTCTTC 840
TCCAAAAGCA GTGACGTCTG GAGCTTCGGG GTACTGCTCT GGGAGCTGCT GACGGGTGAG 900
GTCCCCTACC GTGAAATCGA CGCCTTGGCT GTGGCATATG GCGTGGCTAT GAACAAGCTG 960
ACGCTGCCCA TCCCCTCCAC GTGCCCCGAG CCCTTTGCCC GCCTACTGGA GGAATGCTGG 1020
GACCCAGACC CCCATGGGCG GCCAGATTTT GGTAGCATCT TGAAGCAACT TGAAGTCATC 1080
GAACAGTCAG CCCTGTTCCA GATGCCGCTG GAGTCTTTCC ACTCACTGCA GGAAGACTGG 1140
AAGCTGGAGA TTCAGCACAT GTTCGATGAC CTCCGGACCA AGGAGAAGGA GCTCCGGAGC 1200
CGCGAGGAGG AGCTGTTGCG GGCGGCGCAG GAGCAACGCT TCCAGGAGGA ACAGCTGCGG 1260
CGGCGGGAGC AGGAGCTGGC TGAGCGCGAG ATGGACATCG TGGAGCGTGA GCTGCACCTG 1320
CTCATGTGCC AGCTGAGCCA GGAGAAGCCC CGGGTCCGCA AACGCAAGGG CAACTTCAAG 1380
CGTAGCCGCC TGCTTAAGCT GCGGGAAGGC AGCAGCCACA TCAGCCTGCC CTCCGGCTTT 1440
GAACATAAGA TCACAGTCCA GGCCTCTCCA ACCCTGGACA AGCGGAAAGG ATCCAATGGG 1500
GCCAGCCCCC CCGCCAGCCC CAGCATCATC CCTCGGCTGA GGGCCATCCG CCTGACTCCT 1560
GTGGATGGTG GTGGTGGTAG CAGCAGTGGC AGCAGCAGCG GTGGCAGTGG GACATGGGGC 1620
CGTGGCAGTG GACCCCCCAA GAAGGAAGAA CTGGTTGGTG GCAAGAAGAA GGGCCGGACC 1680
TGGGGGCCCA GCTCCACCCT GCAGAAGGAG CGGGCTGGAG GAGAGGAGAG GCTGAAGGCC 1740
CTGGGAGAAG GAAGCAAGCA GTGGTCATCA AGTGCCCCCA ACCTGGGCAA GTCCCCCAAA 1800
CATACACCCA TCGCCCCCGG CTTTGCCAGC CTCAATGAGA TGGGCGTGGG AAACCGCGGC 1860
TCCCGCGGCT ATGGGGGCCA TTCCCAGGGG CAGGGGAGGT TGAGGTGCAA AGATTCCAGA 1920
ACCACGCTCA GTGGGACTTG GCGGTCCCGC TGCTGGCGGG GTCCCTGGGG GCCGCGGGGC 1980
CCGGGGCCAG CCCCGGAGCT GACGGAGTCC AGTGACGGCC CTCTCCCGGT TGCAGAGGAG 2040
TTCGCGGAGG CGGACGGCGG CGGCGGCAGC GTGCCCCCCT CTCCCTACAC CACCCCGTCC 2100
TACCTCACGG TGCCGCTGCC CGCCCAGCCC TCCCCGGGGG ACGACGCGGC CCCCGGCCCG 2160
GGCCTGGCGC CCTCGGCCAC CCTCGTGTCG CTGTCGTCCG TGTCCGACTG CAACTCCACG 2220
CGTTCGCTGC TGCGCTCCGA CAGCGACGAG GCCGCGCCGG CCGCGCCCTC CCCGCCGCCC 2280
TCCCCACCCG CGCCCCCGCC CCAGCCCAGC ACCAACCCCC TGGTGGACCT GGAGCTGGAG 2340
AGCTTCAAGA AGGACCCCCG CCAGTCGCTC ACGCCCACCC ACGTCACGGC CGCGCGCGCT 2400
GTGAGCCGCG GGCACCGCCG GACACCGTCG GATGGGGCGC TGGGGCAGCG GGGGGCGCCC 2460
GAGCCCTCGG GCCTCGTCCC TGGCCCTCGA GATCCCCTGG ACTTCCCTCG CCTGCCCGAC 2520
CCCCAGGCCC TGTTCCCCAC CCGCCGCCGG CCCCCCGAGT TCCCTGGCCG CCCCACCACC 2580
CTGACCTTCG CCCCAAGACC CCGGCCAGCC GCCAGCCGTC CCCGTCTGGA CCCCTGGAAA 2640
CTGGTCTCCT TTGGCCAGAT ACTCAGCATC TCGCCTCCCA GCAGGCCGGA CACTCCGGAG 2700
AGCCCCGGGC CCCCCAGCAT GCAGCCTACG CTGCTTGACA TGGACATGGA AGGGCAGAGC 2760
CAGGACAGCA CGGTGCCCCT GTGTGGG 2787
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         +lee+ig g fgkvy+a wr++evavK++r + e+  + ++e++++ea+l+ +l+hpnii
Q: 99    QLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERdpAVTAEQVRQEARLFGALQHPNII  158
         789*******************************988999********************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119
         +l+G+cl++p+l+lvmey++gg+Ls+vl++   r+++++vlv+wa+q+ArGm+YLh++ap
Q: 159   ALRGACLSPPHLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAP  215
         ******************************...9**************************
S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172
         ++iihrdLks n+L+       + ++++lki+dFG are++k+tkmsaagt+awmaPEv+
Q: 216   VPIIHRDLKSINILIleaienhNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVI  275
         ********************99999***********************************
S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232
         + + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L
Q: 276   RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARL  335
         ************************************************************
S: 233   mkecwnedpekRpsfseivksl  254
         ++ecw+ dp+ Rp+f +i+k+l
Q: 336   LEECWDPDPHGRPDFGSILKQL  357
         ******************9986
Domain Sequence
(FASTA)
QLEEIIGVGG FGKVYRALWR GEEVAVKAAR LDPERDPAVT AEQVRQEARL FGALQHPNII 60
ALRGACLSPP HLCLVMEYAR GGALSRVLAG RRVPPHVLVN WAVQVARGMN YLHNDAPVPI 120
IHRDLKSINI LILEAIENHN LADTVLKITD FGLAREWHKT TKMSAAGTYA WMAPEVIRLS 180
LFSKSSDVWS FGVLLWELLT GEVPYREIDA LAVAYGVAMN KLTLPIPSTC PEPFARLLEE 240
CWDPDPHGRP DFGSILKQL 259
KeywordComplete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00379
EKS-CAJ-00382
EKS-CAF-00377
EKS-CAP-00410
EKS-CIS-00134
EKS-DAR-00758
EKS-DIO-00059
EKS-DRM-00176
EKS-FEC-00366
EKS-GAG-00318
EKS-GAA-00461
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LAC-00393
EKS-LOA-00388
EKS-MAM-00376
EKS-MOD-00368
EKS-MUM-00411
EKS-MUP-00371
EKS-MYL-00376
EKS-NOL-00352
EKS-ORN-00485
EKS-ORC-00355
EKS-ORL-00447
EKS-OTG-00380
EKS-PAT-00359
EKS-POA-00368
EKS-PTV-00099
EKS-RAN-00393
EKS-TAR-00480
EKS-TEN-00479
EKS-TUT-00103
EKS-XET-00491
EKS-XIM-00474
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0003714; F:transcription corepressor activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046330; P:positive regulation of JNK cascade
GO:0043507; P:positive regulation of JUN kinase activity
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF07653; SH3_2; 1.
SMARTs
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013