EKS-SUS-00141
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00141
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb429.64.9E-129415674260
StatusUnreviewed
Ensembl ProteinENSSSCP00000026900
UniProt AccessionI3LS09;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000028806ENSSSCP00000026900ENSSSCT00000026232
OrganismSus scrofa
Functional Description
Protein Length771
Protein Sequence
(FASTA)
MGDEDEDEGC AVELRITEAN LTGHEEKVGV ENFQLLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVNG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKSGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PKKRLGAGPQ GAQEVKNHPF 300
FQGLDWAALA ARKIPAPFRP QIRSELDVGN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMTDVLE AAGAGDRPGR AAVARSAMMQ DSPFFQQYEL DLREPALGQG 420
SFSVCRRCRQ RQSGQEFAVK ILSRRLEANT QREVAALRLC QSHPNVVKLH EVHHDQLHTY 480
LVLELLQGGE LLEHIRKKRH FSESEASQIL RSLVSAVSFM HEEAGVVHRD LKPENILYAD 540
DTPGAPVKII DFGFARLRPQ SPAGPMQTPC FTLQYAAPEL LAQQGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGQGGQSQ AAEIMCKIRE GRFSLDGEAW QGVSEEAKEL VRGLLTVDPA 660
KRLKLEGLRG SSWLQDGSAR SSPPLRTPDV LESSGPAVRS GLNATFMAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSAAT SRRVSPAPAA PGRAPAAKGA PRRANGPLPP S 771
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGACGAGGA CGAAGGCTGT GCGGTGGAGC TGCGGATCAC CGAAGCCAAC 60
CTGACCGGGC ACGAGGAGAA GGTGGGCGTG GAGAACTTCC AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAGGCAG GCGGGCACGA CGCGGGGAAG 180
CTGTATGCCA TGAAGGTGCT GCGCAAGGCG GCTCTGGTGC AGCGGGCCAA GACGCAGGAG 240
CACACACGCA CGGAGCGCTC CGTGCTGGAG CTGGTGCGCC AGGCACCCTT CCTGGTCACG 300
CTGCACTACG CCTTCCAGAC TGATGCCAAG CTGCACCTCA TCCTGGACTA TGTGAACGGC 360
GGAGAGATGT TCACCCACCT CTACCAGCGC CAGTACTTCA AGGAGGCCGA GGTGCGCGTG 420
TACGGGGGCG AGATCGTGCT GGCCCTGGAG CACCTGCATA AGCTGGGCAT CATCTACCGA 480
GATCTGAAGC TGGAGAACGT GCTGCTGGAC TCCGAGGGCC ATATCGTCCT CACGGACTTT 540
GGGCTTAGCA AGGAGTTCCT GACGGAGGAG AAAGAGCGGA CCTTCTCCTT CTGTGGCACC 600
ATTGAGTACA TGGCTCCTGA AATCATCCGC AGCAAGTCAG GCCACGGCAA GGCTGTGGAC 660
TGGTGGAGCC TAGGCATCCT GCTCTTTGAG CTGCTGACAG GGGCCTCGCC CTTCACCCTG 720
GAGGGTGAGC GGAATACACA GGCAGAGGTG TCTCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCTC GGATTGGGCC AGTGGCACAG GACCTACTGC AGCGGCTACT TTGCAAGGAT 840
CCCAAGAAAC GGCTGGGTGC GGGACCCCAG GGGGCACAGG AAGTTAAGAA TCACCCCTTC 900
TTCCAGGGTC TGGATTGGGC TGCTCTGGCT GCCAGGAAGA TTCCAGCCCC CTTCCGACCC 960
CAGATCCGCT CCGAGCTGGA TGTGGGCAAC TTTGCAGAGG AATTTACCCG GCTGGAGCCT 1020
GTCTACTCAC CCCCTGGCAG CCCCCCACCT GGGGACCCTC GCATCTTCCA GGGATACTCC 1080
TTCGTGGCGC CCTCCATCCT GTTTGACCAC AACAACGCGG TGATGACAGA TGTACTGGAG 1140
GCGGCTGGTG CTGGAGACCG GCCCGGCCGG GCAGCGGTGG CCAGGAGCGC CATGATGCAG 1200
GACTCGCCTT TCTTCCAGCA GTATGAGCTG GACCTGCGGG AGCCCGCGCT GGGCCAGGGT 1260
AGCTTTTCCG TGTGTCGCCG CTGCCGGCAG CGCCAGAGCG GCCAGGAGTT CGCGGTCAAG 1320
ATCCTCAGCC GCAGGCTGGA GGCGAATACG CAGCGCGAAG TGGCCGCCCT GCGGCTGTGC 1380
CAGTCGCACC CCAACGTAGT GAAGCTGCAC GAAGTGCATC ACGACCAGCT GCACACGTAC 1440
CTGGTCTTGG AGCTGCTGCA GGGTGGGGAG TTGCTGGAGC ACATCCGCAA GAAGCGACAC 1500
TTCAGCGAGT CCGAGGCGAG CCAGATCCTG CGCAGCCTTG TGTCGGCCGT GAGCTTCATG 1560
CACGAGGAGG CGGGAGTGGT GCACCGCGAC CTCAAGCCCG AGAACATCCT TTACGCCGAT 1620
GACACGCCTG GAGCCCCAGT TAAGATAATC GACTTCGGGT TCGCGCGGCT GCGCCCGCAG 1680
AGCCCCGCGG GGCCCATGCA GACGCCCTGC TTCACGCTGC AGTACGCGGC CCCCGAGCTG 1740
CTGGCGCAGC AAGGCTACGA CGAATCCTGC GACCTCTGGA GTCTCGGCGT CATTCTGTAC 1800
ATGATGCTGT CAGGCCAGGT CCCCTTCCAG GGGGCCTCAG GCCAGGGCGG GCAGAGCCAG 1860
GCGGCCGAGA TCATGTGCAA GATCCGCGAG GGGCGCTTCT CCCTTGACGG GGAGGCCTGG 1920
CAGGGCGTGT CTGAGGAAGC CAAGGAGCTG GTCCGAGGGC TCCTGACTGT GGACCCCGCC 1980
AAGCGGCTGA AGCTCGAGGG GCTGCGGGGC AGCTCGTGGC TGCAGGACGG CAGCGCGCGC 2040
TCCTCGCCCC CGCTCCGGAC GCCGGACGTG TTGGAGTCCT CGGGGCCCGC CGTGCGCTCT 2100
GGGCTCAACG CCACCTTCAT GGCATTCAAC CGGGGCAAAC GCGAGGGTTT CTTCCTGAAG 2160
AGCGTGGAGA ACGCGCCTCT GGCCAAGCGG CGGAAGCAGA AGCTGCGGAG CGCAGCCACA 2220
TCCCGCCGCG TCTCCCCCGC GCCCGCCGCC CCGGGCCGCG CTCCCGCCGC CAAGGGAGCC 2280
CCCCGACGAG CCAACGGTCC TCTGCCCCCT TCCTAG 2316
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l++v++
Q: 415   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQSHPNVVKLHEVHH  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLQGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 535   NILYADDTPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  593
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  653
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+ +swl
Q: 654   LLTVDPAKRLKLEGLRGSSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQSHP NVVKLHEVHH 60
DQLHTYLVLE LLQGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAE-00125
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00155
EKS-FEC-00154
EKS-GAG-00140
EKS-GAA-00194
EKS-GOG-00163
EKS-HOS-00170
EKS-ICT-00159
EKS-LAC-00173
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MEG-00130
EKS-MOD-00162
EKS-MUM-00169
EKS-MUP-00168
EKS-MYL-00173
EKS-NOL-00157
EKS-ORN-00204
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-POA-00160
EKS-RAN-00161
EKS-SAH-00158
EKS-TAG-00191
EKS-TAR-00211
EKS-TEN-00204
EKS-XET-00152
EKS-XIM-00199
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
ssc:100626270;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013