EKS-SUS-00284

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00284

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	322.1	3.4E-96	325	572	248

Status

Unreviewed

Ensembl Protein

ENSSSCP00000022719

UniProt Accession

I3LF79;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK4

Gene Synonyms/Alias

PAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000030520	ENSSSCP00000022719	ENSSSCT00000022903

Organism

Sus scrofa

Functional Description

Protein Length

591

Protein Sequence
(FASTA)

MFGKKKKRVE ISAPSNFEHR VHTGFDQNEQ KFTGLPRQWQ SLIEESARRP KPLVDPACIT 60

SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR ARQENGMPAE 120

QAAMARGGPE KAGGQGRVAG RSETGGNSGD RRRAGPDKRL KSSREGSGGP QESSRDKRPL 180

SGPDVGTPDQ PAGLASGAKV AAGRPFNTYP RADTDHPPRG AQGEPHNVAP NGPSVGGLAV 240

PQSSRPPARA RGTPSPGVLG PHASEPQLAP PARTPAAPAA PPAPGPPGPR SPQREPQRVS 300

HEQFRAALQL VVDPGDPRSY LDNFIKIGEG STGIVCIATV RSSGRLVAVK KMDLRKQQRR 360

ELLFNEVVIM RDYQHENVVE MYNSYLVGDE LWVVMEFLEG GALTDIVTHT RMNEEQIAAV 420

CLAVLQALSV LHAQGVIHRD IKSDSILLTH DGRVKLSDFG FCAQVSKEVP RRKSLVGTPY 480

WMAPELISRL PYGPEVDIWS LGVMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPRLKNLHK 540

VSPSLKGFLD RLLVRDPAQR ATAAELLKHP FLAKAGPPAS IVPLMRQNRT R 591

Nucleotide Sequence
(FASTA)

ATGTTCGGGA AGAAGAAGAA GCGGGTTGAG ATCTCAGCGC CGTCGAACTT TGAACACCGT 60

GTGCACACGG GCTTCGACCA GAACGAGCAG AAGTTCACGG GGCTGCCCCG CCAGTGGCAG 120

AGCCTGATCG AGGAGTCGGC TCGCCGGCCC AAGCCCCTTG TTGACCCCGC CTGCATCACC 180

TCCATCCAGC CCGGGGCCCC CAAGACCATC GTGCGGGGCA GCAAAGGTGC CAAGGATGGG 240

GCCCTCACGC TGCTGCTCGA CGAATTTGAG AACATGTCGG TGACACGCTC CAACTCCCTG 300

CGGAGAGACA GCCCGCCGCC ACCTGCCCGT GCCCGCCAGG AAAACGGGAT GCCCGCGGAG 360

CAGGCCGCCA TGGCCAGAGG GGGCCCAGAG AAGGCGGGTG GCCAAGGCCG GGTGGCCGGT 420

CGCAGCGAGA CGGGTGGCAA CAGTGGTGAC AGGCGGCGGG CGGGGCCGGA CAAGAGGCTC 480

AAGTCTTCCA GGGAGGGCTC AGGGGGCCCC CAGGAGTCCT CCCGGGACAA GCGCCCCCTC 540

TCTGGGCCTG ACGTCGGCAC CCCCGACCAG CCTGCCGGGC TGGCCAGCGG GGCGAAAGTG 600

GCGGCTGGCC GGCCCTTTAA CACGTACCCG CGGGCTGACA CGGACCACCC ACCCCGGGGC 660

GCCCAGGGGG AGCCTCACAA CGTGGCCCCC AATGGGCCAT CGGTGGGGGG CCTGGCTGTC 720

CCGCAGTCCT CCCGGCCCCC CGCTCGAGCC CGCGGCACCC CCAGCCCAGG CGTGCTGGGC 780

CCCCACGCCT CCGAGCCCCA GCTGGCCCCT CCAGCCCGCA CCCCAGCCGC CCCTGCCGCA 840

CCCCCTGCCC CTGGGCCCCC TGGCCCTCGA TCGCCACAGC GGGAACCCCA GCGAGTGTCC 900

CATGAGCAGT TCCGGGCCGC CCTGCAGCTG GTGGTGGACC CCGGCGACCC GCGCTCCTAC 960

CTGGACAACT TCATCAAGAT CGGCGAGGGC TCCACAGGCA TCGTGTGCAT CGCCACCGTG 1020

CGCAGCTCGG GCAGGCTGGT GGCTGTCAAG AAGATGGACC TGCGCAAGCA GCAGAGGCGC 1080

GAGCTGCTCT TCAATGAGGT GGTGATCATG CGGGACTACC AGCACGAGAA CGTGGTGGAG 1140

ATGTACAACA GCTACCTGGT CGGCGACGAG CTCTGGGTGG TGATGGAGTT CCTGGAGGGA 1200

GGCGCCCTCA CCGACATTGT CACCCACACC AGGATGAACG AGGAGCAGAT CGCCGCCGTG 1260

TGCCTGGCCG TGCTGCAGGC CTTGTCCGTC CTCCACGCCC AGGGCGTCAT CCACCGCGAC 1320

ATCAAGAGCG ACTCCATCCT GCTGACCCAT GATGGCCGGG TGAAGCTGTC GGACTTTGGG 1380

TTCTGCGCCC AGGTGAGCAA GGAGGTGCCG CGGAGGAAGT CCCTGGTGGG CACGCCCTAC 1440

TGGATGGCCC CGGAGCTCAT CTCCCGCCTT CCCTACGGGC CAGAGGTGGA CATCTGGTCT 1500

CTGGGGGTGA TGGTGATCGA GATGGTGGAC GGGGAGCCCC CCTACTTCAA CGAGCCACCC 1560

CTCAAAGCCA TGAAGATGAT TCGGGACAAC CTGCCGCCCC GACTGAAGAA TCTGCACAAG 1620

GTGTCACCCT CCCTGAAGGG CTTCCTGGAC CGCCTGCTGG TGCGTGACCC GGCACAGCGG 1680

GCCACGGCGG CTGAGCTGCT CAAGCACCCG TTCCTGGCCA AAGCAGGCCC GCCTGCCAGT 1740

ATCGTGCCCC TCATGCGCCA GAACCGCACC AGATGA 1776

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ +++g+lva+kk++l+kq++ e+l++e+ ++++++h+n+ve+++s

Q: 325   IKIGEGSTGIVCIATVRSSGRLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNS  384

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++  vl+aL+ lH+++viHrdi

Q: 385   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI  441

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g+VkLsdfg++aq++k++ +rk++vgtpywmAPE+i+  +  Y  ++Diw

Q: 442   KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS--RLPYGPEVDIW  499

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slG+++ie+++gepP+++++plka+ +i +n pp+lk+ +k+s+++k f++++l ++p++

Q: 500   SLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ  559

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ellkh+Fl

Q: 560   RATAAELLKHPFL  572

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATVRSSG RLVAVKKMDL RKQQRRELLF NEVVIMRDYQ HENVVEMYNS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIAAVCLAV LQALSVLHAQ GVIHRDIKSD 120

SILLTHDGRV KLSDFGFCAQ VSKEVPRRKS LVGTPYWMAP ELISRLPYGP EVDIWSLGVM 180

VIEMVDGEPP YFNEPPLKAM KMIRDNLPPR LKNLHKVSPS LKGFLDRLLV RDPAQRATAA 240

ELLKHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ssc:100627936

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013