EKS-ICT-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.2	1.1E-128	80	332	253

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000123

UniProt Accession

I3LW17;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000000137	ENSSTOP00000000123	ENSSTOT00000000138

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

683

Protein Sequence
(FASTA)

MELLRTITYQ PAASSKMCEQ ALGKACGGDS KKKRPQQPPE EPQPQAQVPP AASHHHHHHH 60

SHSGPEISRI IVDPTTGKRY CRGKVLGKGG FAKCYEMTDL TNNKVYAAKI IPHSRVAKPH 120

QREKIDKEIE LHRILHHKHV VQFYHYFEDK ENIYILLEYC SRRSMAHILK ARKVLTEPEV 180

RYYLRQIVSG LKYLHEQEIL HRDLKLGNFF INEAMELKVG DFGLAARLEP LEHRRRTICG 240

TPNYLSPEVL NKQGHGCESD IWALGCVMYT MLLGRPPFET TNLKETYRCI REARYTMPSS 300

LLAPAKHLIA SMLSKNPEDR PSLDDIIRHD FFLQGFTPDR LSSSCCHTVP DFHLSSPAKN 360

FFKKAAAALF GGKKDKARYI DTHNRVSKED EEIYKLRHDL KKTSITQQPS KHRTDEELQP 420

PTTTVAKSGT PAVENKQQIG DAIRMIVRGT LGSCSSSSEC LEDSTMGSVA DTVARVLRGC 480

LENMPEADCI PKEQLSTSFQ WVTKWVDYSN KYGFGYQLSD HTVGVLFNNG AHMSLLPDKK 540

TVHYYAELGQ CSVFPATDAP EQFISQVTVL KYFSHYMEEN LMDGGDIPSI TDIRRPRLYL 600

LQWLKSDKAL MMLFNDGTFQ VNFYHDHTKI IICSQNEEYL LTYINEDRIS TTFRLTTLLM 660

SGCSLELKNR MEYALNMLLQ RCN 683

Nucleotide Sequence
(FASTA)

ATGGAGCTCT TGCGGACTAT CACCTACCAG CCGGCCGCCA GCTCCAAGAT GTGTGAGCAG 60

GCACTGGGCA AGGCTTGCGG CGGGGACTCG AAGAAGAAGC GGCCGCAGCA GCCCCCCGAG 120

GAGCCGCAGC CCCAGGCCCA GGTGCCCCCG GCGGCCTCGC ACCACCACCA CCACCACCAC 180

TCGCACTCGG GACCCGAGAT CTCGCGGATT ATCGTCGACC CCACGACGGG GAAGCGCTAC 240

TGCCGGGGCA AAGTGCTGGG AAAGGGTGGC TTTGCAAAAT GTTATGAAAT GACAGATTTG 300

ACAAACAACA AAGTCTACGC TGCAAAAATT ATTCCTCACA GCAGAGTAGC TAAACCTCAT 360

CAAAGGGAAA AGATTGACAA AGAAATAGAG CTTCACAGAA TTCTTCATCA TAAGCATGTA 420

GTGCAGTTTT ACCACTACTT TGAAGACAAA GAAAACATTT ACATTCTCTT GGAATACTGT 480

AGTAGAAGGT CGATGGCTCA TATCTTAAAA GCAAGAAAGG TGTTGACAGA GCCAGAAGTT 540

CGATACTACC TCAGACAGAT TGTGTCTGGA CTGAAGTACC TTCATGAACA AGAAATCTTG 600

CACAGAGATC TCAAACTTGG GAACTTTTTT ATTAACGAAG CCATGGAACT AAAAGTTGGA 660

GACTTTGGTT TGGCAGCTAG GTTGGAACCT TTGGAACACA GAAGGAGAAC AATATGTGGT 720

ACCCCAAATT ATCTTTCTCC TGAAGTCCTT AACAAACAAG GACATGGCTG TGAATCAGAC 780

ATTTGGGCCT TGGGCTGTGT AATGTACACA ATGCTGCTAG GAAGGCCCCC ATTTGAAACT 840

ACAAACCTGA AAGAAACTTA CAGGTGTATA AGAGAAGCCA GGTATACAAT GCCATCTTCA 900

TTGCTGGCTC CTGCTAAGCA CCTAATAGCT AGCATGTTGT CCAAAAACCC AGAGGATCGT 960

CCCAGTTTAG ATGACATCAT TCGACATGAC TTTTTTTTGC AGGGCTTCAC TCCAGACAGA 1020

CTTTCTTCCA GCTGTTGTCA TACTGTTCCA GATTTCCATT TATCAAGCCC AGCTAAGAAT 1080

TTCTTTAAGA AAGCTGCTGC TGCTCTTTTT GGTGGCAAAA AGGACAAAGC AAGATATATT 1140

GACACTCACA ATAGAGTGTC TAAAGAAGAT GAAGAAATTT ACAAGCTTAG GCATGATTTG 1200

AAAAAGACTT CAATAACTCA GCAACCCAGC AAACATAGGA CAGATGAGGA GCTCCAGCCA 1260

CCTACCACTA CAGTTGCCAA ATCTGGAACC CCCGCAGTAG AAAACAAGCA GCAGATTGGA 1320

GATGCTATTC GGATGATAGT GAGAGGGACG CTTGGCAGCT GCAGCAGTAG CAGTGAATGC 1380

CTTGAAGACA GCACAATGGG AAGTGTTGCA GACACGGTGG CAAGAGTCCT TCGAGGATGT 1440

CTGGAAAACA TGCCAGAAGC TGACTGCATT CCCAAAGAGC AATTAAGCAC GTCATTTCAG 1500

TGGGTCACCA AATGGGTCGA TTACTCTAAC AAATATGGCT TTGGATACCA GCTCTCAGAC 1560

CACACTGTAG GTGTCCTTTT CAACAATGGT GCTCACATGA GCCTCCTTCC AGACAAAAAA 1620

ACAGTTCACT ATTATGCAGA GCTTGGCCAG TGCTCTGTTT TTCCAGCAAC AGATGCCCCT 1680

GAACAATTCA TTAGTCAAGT GACGGTGCTG AAATACTTTT CTCATTACAT GGAGGAGAAC 1740

CTCATGGATG GTGGGGATAT CCCTAGCATT ACTGATATTC GAAGACCTCG GCTCTACCTC 1800

CTTCAGTGGC TAAAATCTGA TAAAGCCTTA ATGATGCTTT TTAATGATGG CACCTTTCAG 1860

GTGAATTTCT ATCATGACCA TACAAAAATA ATCATCTGTA GCCAAAATGA AGAATACCTT 1920

CTCACTTATA TCAATGAAGA TAGGATATCT ACAACTTTCA GACTGACAAC TCTGCTGATG 1980

TCTGGCTGTT CATTAGAATT AAAAAATCGA ATGGAATATG CCCTGAACAT GCTCTTACAG 2040

AGATGTAACT GA 2052

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 80    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  139

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 140   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  199

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 200   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  259

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 260   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  319

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl+++++++f+

Q: 320   RPSLDDIIRHDFF  332

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPSLDDIIRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013