EKS-ICT-00143

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00143

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	528.1	3.6E-159	467	743	277

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000387

UniProt Accession

I3LWL9;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000000431	ENSSTOP00000000387	ENSSTOT00000000432

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

801

Protein Sequence
(FASTA)

MQLLLALFGV LLGAPRAPAL NLEASEETEL EPCLAPNLEQ KEQELTVALG QPLRLCCGRA 60

ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPKDAGHYL CLARGSMTVL HNLTLVADDS 120

LTSSNDDKDP TAHRDSLNVH IYHQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPVP 180

TIRWLKDGQD FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENSL GSIRYSYLLD 240

VLERSPHRPI LQAGLPANTT AVAGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300

YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDLTWTA 360

TVPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHSQHS RQPATVQKLS RFPLGRQFSL 420

ESGSSGKSSS SLVRGVRLSS SGPPLLAGLV NLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 480

VVRAEAFGMD PAQPDQTSTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 540

TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPALV SCAYQVARGM 600

QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA 660

LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPNCPPELYG 720

LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPSSGD ASSTCSSNDS 780

VFSHEPLPLE PSPFSFPGVQ T 801

Nucleotide Sequence
(FASTA)

ATGCAGCTGC TGTTGGCCCT GTTTGGAGTC CTGCTGGGGG CACCCAGGGC TCCAGCCTTG 60

AACCTAGAGG CCTCTGAGGA AACGGAGCTG GAGCCCTGCC TGGCCCCCAA CCTGGAGCAG 120

AAAGAGCAGG AGCTGACAGT GGCACTTGGG CAGCCTCTGA GGCTGTGCTG TGGGAGGGCC 180

GAGCGTGGTG GCCACTGGTA TAAGGAGGGT AGTCGCCTGG CACCTGCTGG CCGAGTACGG 240

GGCTGGAGGG GCCGCCTGGA GATTGCCAGC TTTCTACCAA AGGATGCTGG CCACTACCTC 300

TGCCTAGCAC GTGGCTCTAT GACTGTCCTG CACAATCTCA CCTTGGTTGC AGATGACTCC 360

TTGACCTCCA GCAATGATGA CAAGGACCCC ACGGCCCACA GGGACTCCTT GAATGTGCAC 420

ATTTACCACC AGCAAGCACC CTACTGGACA CACCCCCAAC GCATGGAGAA GAAACTGCAT 480

GCAGTGCCTG CTGGGAACAC AGTCAAGTTC CGCTGTCCAG CTGCAGGCAA CCCCGTGCCC 540

ACCATCCGCT GGCTCAAAGA TGGACAGGAT TTCCATGGGG AAAATCGCAT AGGAGGCATT 600

CGACTGCGCC ACCAGCACTG GAGCCTGGTG ATGGAAAGTG TGGTGCCCTC GGACCGTGGC 660

ACATACACTT GCCTCGTAGA GAACTCTCTG GGCAGCATCC GCTACAGCTA TTTGCTGGAT 720

GTACTGGAGC GGTCCCCGCA CCGGCCCATC CTGCAGGCGG GGCTCCCAGC CAACACCACA 780

GCTGTGGCGG GCAGTGACGT GGAGCTGTTG TGCAAGGTGT ACAGCGATGC CCAGCCCCAC 840

ATCCAGTGGC TGAAGCACAT CGTCATCAAT GGCAGCAGCT TCGGAGCTGA CGGCTTCCCC 900

TATGTGCAAG TCCTCAAGAC AGCAGACATT AACAGCTCAG AGGTGGAGGT CCTTTACCTC 960

CGGAATGTGT CAGCTGAGGA CGCAGGCGAG TACACCTGCT TGGCAGGCAA CTCCATTGGC 1020

CTCTCCTACC AGTCAGCCTG GCTCACGGTG CTGCCAGAAG AGGACCTCAC GTGGACAGCA 1080

ACAGTGCCAG AGGCCAGGTA TACAGACATC ATCCTGTATG CATCAGGCTC CCTGGCTTTA 1140

GCTGTGCTCC TGCTGCTGGC CGGGCTGTAT CGCGGACAGG CACTCCACAG CCAGCACTCC 1200

CGCCAGCCTG CCACCGTGCA AAAGCTGTCC CGTTTCCCTT TGGGCCGACA GTTCTCCCTG 1260

GAGTCAGGCT CCTCAGGCAA ATCAAGCTCA TCCCTGGTGC GAGGCGTCCG GCTCTCCTCC 1320

AGCGGCCCTC CCTTGCTCGC TGGCCTCGTG AATCTAGACC TTCCTCTTGA TCCGCTGTGG 1380

GAGTTCCCCC GAGACAGGCT GGTGCTCGGG AAGCCCCTAG GCGAGGGCTG CTTTGGGCAG 1440

GTGGTGCGCG CAGAAGCCTT CGGCATGGAC CCTGCCCAGC CTGACCAAAC CAGCACTGTG 1500

GCTGTCAAGA TGCTCAAAGA CAATGCCTCC GACAAGGACT TGGCGGACCT GGTCTCTGAG 1560

ATGGAAGTGA TGAAGCTGAT CGGCCGACAC AAGAACATCA TAAATCTGCT GGGTGTCTGC 1620

ACCCAGGAAG GTCCCCTATA TGTGATCGTG GAGTGTGCTG CCAAAGGAAA CCTTCGGGAG 1680

TTCCTCCGGG CCCGACGCCC CCCAGGCCCT GACCTCAGCC CTGATGGGCC CCGGAGCAGT 1740

GAGGGGCCTC TCTCCTTCCC AGCTCTGGTC TCCTGCGCCT ATCAGGTGGC CCGAGGCATG 1800

CAGTATTTGG AGTCTCGGAA GTGCATCCAC CGGGACCTAG CTGCCCGTAA TGTTCTGGTA 1860

ACTGAGGACA ATGTGATGAA GATTGCCGAC TTTGGGCTAG CCCGCGGTGT GCACCACATT 1920

GACTACTATA AGAAAACCAG CAATGGCCGC CTGCCAGTAA AGTGGATGGC ACCAGAGGCC 1980

TTATTTGACC GAGTATACAC GCACCAGAGT GATGTGTGGT CATTCGGGAT CCTGCTGTGG 2040

GAGATCTTCA CACTTGGAGG CTCCCCATAT CCTGGTATCC CTGTAGAAGA ATTGTTCTCG 2100

TTGCTACGGG AAGGACATCG AATGGACCGG CCCCCAAACT GCCCCCCAGA GCTGTATGGA 2160

CTGATGCGTG AGTGCTGGCA CGCAGCACCT TCTCAGAGGC CCACTTTCAA GCAGCTGGTG 2220

GAAGCACTGG ATAAGGTCCT ACTGGCCGTC TCTGAGGAGT ACCTAGACCT TCGTCTGACC 2280

TTTGGACCCT ACTCCCCCTC CAGTGGGGAT GCCAGCAGCA CCTGCTCCTC CAATGACTCT 2340

GTTTTCAGCC ACGAACCCCT GCCACTGGAA CCGAGCCCCT TCTCCTTCCC TGGAGTGCAG 2400

ACATGA 2406

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl

Q: 467   LVLGKPLGEGCFGQVVRAEAFGMDPAQPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKL  526

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++

Q: 527   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  586

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt

Q: 587   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  646

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh

Q: 647   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  706

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm++p +c+ ely lmrecwha++s+rptfkqlve+l

Q: 707   RMDRPPNCPPELYGLMRECWHAAPSQRPTFKQLVEAL  743

         **********************************986

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVRAEA FGMDPAQPDQ TSTVAVKMLK DNASDKDLAD LVSEMEVMKL 60

IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120

PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180

SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240

RMDRPPNCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013