EKS-ICT-00443

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00443

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	405.4	1.2E-121	55	347	293

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000403

UniProt Accession

I3LWN3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK7

Gene Synonyms/Alias

MAPK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000000446	ENSSTOP00000000403	ENSSTOT00000000449

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

784

Protein Sequence
(FASTA)

MAEPLKEEDG EDGTGEPPGP VKAEPVHTSA SVAAKNLALL KARSFDVTFD VGDEYEIIET 60

IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL RELKILKHFK HDNIIAIKDI 120

LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH 180

RDLKPSNLLV NENCELKIGD FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT 240

QAIDLWSVGC IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPTVIQAVG AERVRAYIQS 300

LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY HDPDDEPDCA 360

PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR FQPSLQPVAS EPGCPDVEMP 420

SPWAPSGDCA MESPPPAPPL CPGPAPDTID LTLQPPPPAS EPAPPKKEGA ISDNTKAALK 480

AALLKSLRSR LKDGPSAPLE APEPRKPVTA QERQREREEK RRRRQERAKE REKRRQERER 540

KERGAGTSGG PSTDPLAGLV LTTRLSPAQP TSPPPGPIAQ PTGPPPQPAG STTGPAPQPP 600

CPPPCPASHP AGPPGPIPIP AALQTATSSS LLAPQSLVPP PGLPGSSAPG VLPYFSSGPP 660

PLDPGGGPQP STSESPDVNL VTQQLSKSQV EDPLPPVFSG TPKGSGAGYG VGFDLEEFLN 720

QSFDMGVADG PQDGQADSAS LSASLLADWL EGHGMNPADI ESLQREIQMD SPMLLADLPD 780

LQEP 784

Nucleotide Sequence
(FASTA)

ATGGCCGAGC CCCTAAAGGA GGAAGACGGC GAGGACGGCA CTGGGGAGCC CCCCGGGCCG 60

GTGAAGGCAG AACCCGTCCA TACCTCTGCC TCTGTTGCGG CCAAGAACCT AGCTCTGCTC 120

AAAGCCCGCT CCTTTGATGT GACCTTTGAC GTGGGGGATG AGTACGAGAT CATCGAGACC 180

ATAGGCAATG GAGCCTATGG GGTGGTGTCC TCTGCTCGCC GCCGCCTCAC GGGCCAGCAG 240

GTGGCCATCA AGAAGATCCC GAATGCTTTT GATGTGGTAA CCAACGCCAA ACGGACCCTC 300

AGGGAGCTGA AGATCCTCAA ACACTTCAAA CATGACAATA TCATTGCTAT CAAGGACATC 360

CTGAGGCCCA CTGTACCCTA TGGAGAATTC AAATCTGTCT ATGTAGTCCT GGACCTGATG 420

GAGAGCGACC TGCACCAGAT CATCCACTCC TCACAGCCAC TCACACTGGA GCATGTGCGC 480

TACTTCCTGT ACCAGCTGCT TCGGGGCCTC AAGTACATGC ACTCGGCTCA GGTCATCCAC 540

CGTGACCTCA AGCCCTCTAA CCTGTTGGTG AATGAGAACT GTGAGCTCAA GATTGGTGAC 600

TTTGGTATGG CCCGTGGCCT GTGTACCTCC CCTGCTGAAC ACCAGTACTT CATGACTGAG 660

TATGTGGCTA CTCGCTGGTA CCGGGCCCCT GAGCTCATGT TGTCCCTGCA TGAGTACACA 720

CAGGCTATCG ACCTCTGGTC TGTGGGCTGT ATCTTTGGTG AGATGCTTGC CCGGCGCCAG 780

CTCTTCCCAG GCAAAAACTA CGTGCACCAG CTTCAACTGA TTATGATGGT GTTGGGTACC 840

CCATCGCCAA CTGTGATTCA AGCTGTTGGG GCTGAAAGGG TGCGGGCCTA TATCCAGAGC 900

CTGCCACCAC GCCAGCCTGT GCCTTGGGAG ACAGTGTACC CAGGTGCTGA CCGCCAGGCT 960

CTTTCACTGC TGGGTCGCAT GCTGCGTTTC GAACCCAGTG CCCGCATCTC AGCAGCTGCT 1020

GCTCTTCGCC ATCCTTTCCT GGCCAAGTAC CATGACCCTG ATGATGAGCC TGATTGTGCC 1080

CCACCCTTTG ACTTTGCCTT TGACCGTGAA GCCCTTACCC GGGAACGCAT TAAGGAGGCC 1140

ATTGTGGCAG AGATTGAGGA CTTCCACGCA CGAAGGGAAG GCATCCGCCA ACAGATCCGC 1200

TTCCAGCCTT CCTTGCAGCC TGTGGCCAGT GAGCCTGGCT GTCCAGATGT TGAGATGCCC 1260

AGTCCCTGGG CTCCCAGTGG GGACTGTGCC ATGGAGTCAC CCCCACCAGC CCCACCACTA 1320

TGCCCTGGCC CTGCACCTGA TACCATTGAT CTGACCCTGC AGCCACCTCC ACCAGCCAGT 1380

GAGCCTGCCC CACCGAAGAA AGAGGGCGCC ATCTCAGACA ATACCAAGGC AGCCCTTAAA 1440

GCTGCCCTGC TCAAGTCCTT GCGGAGCCGG CTGAAAGATG GCCCTAGTGC ACCCTTGGAG 1500

GCTCCTGAGC CACGGAAGCC AGTGACGGCC CAGGAGCGAC AACGAGAACG TGAGGAGAAG 1560

CGGCGGAGGC GGCAGGAGAG AGCCAAGGAG CGGGAAAAGC GGCGGCAAGA GCGGGAGCGA 1620

AAGGAGCGGG GGGCTGGGAC CTCGGGGGGC CCTTCCACTG ACCCCCTGGC TGGACTGGTG 1680

CTTACAACAA GGCTATCCCC AGCCCAGCCC ACCAGTCCAC CCCCTGGTCC CATAGCCCAG 1740

CCCACGGGTC CTCCTCCACA ACCTGCAGGC TCCACCACAG GTCCTGCACC CCAGCCTCCC 1800

TGCCCACCTC CTTGTCCTGC TTCCCACCCT GCTGGCCCTC CGGGACCCAT ACCTATTCCT 1860

GCTGCACTCC AGACTGCCAC CTCCAGTAGC CTTCTGGCCC CCCAGTCACT TGTGCCACCC 1920

CCTGGGTTGC CTGGCTCCAG TGCTCCAGGA GTTTTGCCTT ACTTCTCATC TGGCCCACCA 1980

CCTCTAGACC CTGGGGGGGG ACCTCAGCCT TCTACATCAG AATCACCCGA TGTCAACTTG 2040

GTGACCCAGC AGCTGTCTAA GTCCCAGGTG GAGGACCCCC TGCCCCCTGT GTTCTCAGGC 2100

ACTCCAAAGG GCAGTGGGGC TGGCTATGGT GTTGGCTTTG ACCTGGAGGA ATTCTTAAAC 2160

CAATCTTTCG ATATGGGCGT GGCTGATGGG CCACAGGATG GCCAGGCAGA CTCTGCCTCC 2220

CTCTCAGCTT CTCTCCTTGC TGACTGGCTT GAGGGCCATG GCATGAACCC TGCTGATATC 2280

GAGTCCCTGC AGCGTGAAAT TCAGATGGAC TCCCCGATGC TTCTGGCTGA CCTGCCTGAC 2340

CTCCAGGAGC CCTAA 2355

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         ye ++++g+Gaygvv sa ++ t+++vaikk+ ++f+  t+akrtlRElk+lk++kh+Ni

Q: 55    YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI  114

         77899*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i + d+++p+  + e+k+vY+v +lme+dL+++i+s+  l+ eh++++lyq+lrglky+H

Q: 115   IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSqPLTLEHVRYFLYQLLRGLKYMH  174

         ***********************************9889*********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk...lteyvatrwYraPeill  176

         sa+viHrDlKPsNllvne+celki dFG+ar   ++  ++   +teyvatrwYraPe++l

Q: 175   SAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHqyfMTEYVATRWYRAPELML  234

         *******************************955444333489*****************

S: 177   slkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseea  236

         sl+eyt+a+D+WsvGCI++E+l++++lfpgk++++ql++i+ vlgtps  +++++  e++

Q: 235   SLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPTVIQAVGAERV  294

         ************************************************************

S: 237   rnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         r+yi+slp+++  ++e+++p a+++al Ll ++L ++p+ Ris++ aL+hp+l

Q: 295   RAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL  347

         ***************************************************97

Domain Sequence
(FASTA)

YEIIETIGNG AYGVVSSARR RLTGQQVAIK KIPNAFDVVT NAKRTLRELK ILKHFKHDNI 60

IAIKDILRPT VPYGEFKSVY VVLDLMESDL HQIIHSSQPL TLEHVRYFLY QLLRGLKYMH 120

SAQVIHRDLK PSNLLVNENC ELKIGDFGMA RGLCTSPAEH QYFMTEYVAT RWYRAPELML 180

SLHEYTQAID LWSVGCIFGE MLARRQLFPG KNYVHQLQLI MMVLGTPSPT VIQAVGAERV 240

RAYIQSLPPR QPVPWETVYP GADRQALSLL GRMLRFEPSA RISAAAALRH PFL 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013