EKS-ICT-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	431.3	1.7E-129	204	490	287

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000427

UniProt Accession

I3LWQ1;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVRL1

Gene Synonyms/Alias

ACVRL1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000000477	ENSSTOP00000000427	ENSSTOT00000000475

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

MGFEFTLGEL CPEWLNFLCL PGDPVKPSRG PLVTCTCKNP HCRGPTCEGA WCTVVLVREQ 60

GRHPQEHRGC GNLHQELCRG RPTDFVNHYC CFSPFCNRNV SLVLNATKPP PEQPGIDGQL 120

PLILGPVLAL LVLVALGALG LWHIRQRQEK QRGLHSDLGE SSLILKASEQ GDSMLGDFLD 180

SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG LWHGESVAVK IFSSRDEQSW 240

FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300

LKLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQGS 360

DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIVNGIVE 420

DYRPPFYDVV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPTPSAR 480

LTALRIKKTL QKLSHGPEKP KVIH 504

Nucleotide Sequence
(FASTA)

ATGGGTTTTG AGTTCACCTT GGGAGAGCTC TGCCCAGAGT GGCTGAACTT CCTGTGTCTC 60

CCAGGTGACC CTGTGAAGCC CTCTCGGGGC CCGCTGGTGA CCTGCACATG CAAGAACCCA 120

CACTGCAGGG GGCCTACCTG CGAGGGGGCC TGGTGCACAG TAGTGCTGGT CCGTGAGCAG 180

GGCAGGCACC CCCAGGAACA TCGAGGCTGT GGGAACCTGC ACCAGGAGCT CTGCAGGGGA 240

CGCCCCACTG ACTTTGTCAA TCATTACTGC TGCTTCAGCC CCTTCTGTAA CCGCAATGTG 300

TCCCTGGTGC TGAATGCCAC TAAACCTCCT CCGGAGCAGC CTGGAATAGA TGGTCAGCTT 360

CCTCTGATCC TGGGCCCCGT GCTGGCCTTG CTGGTCCTGG TGGCCTTGGG TGCTCTGGGC 420

CTGTGGCATA TCCGGCAGAG GCAAGAGAAA CAGCGGGGCC TGCACAGCGA CCTGGGCGAG 480

TCCAGTCTCA TCCTGAAGGC ATCCGAGCAG GGAGATAGCA TGTTGGGGGA CTTCTTGGAC 540

AGTGACTGTA CTACCGGCAG TGGCTCTGGG CTCCCCTTTC TGGTGCAGAG GACCGTGGCA 600

CGACAGGTTG CCCTGGTGGA GTGTGTGGGA AAGGGACGCT ATGGTGAGGT GTGGCGAGGC 660

TTGTGGCATG GTGAGAGCGT CGCGGTCAAG ATTTTCTCCT CAAGGGATGA ACAGTCCTGG 720

TTTCGGGAGA CAGAAATCTA CAACACTGTG TTGCTCAGAC ACGACAACAT CCTAGGCTTC 780

ATCGCCTCGG ACATGACTTC CCGCAATTCA AGCACGCAGC TGTGGCTCAT CACGCACTAC 840

CATGAGCACG GCTCCCTCTA TGACTTTCTG CAGAGGCAAA CGCTTGAGCC CCAGCTGGCC 900

CTGAAGTTAG CTGTGTCCGC GGCCTGCGGC CTGGCGCACC TGCATGTGGA AATCTTTGGC 960

ACGCAGGGTA AACCGGCCAT CGCCCACCGT GACCTCAAGA GTCGCAACGT GCTGGTCAAG 1020

AGCAACTTGC AATGCTGCAT TGCCGACCTG GGCCTGGCTG TGATGCATTC CCAGGGCAGC 1080

GACTACCTGG ACATCGGCAA TAACCCAAGA GTGGGCACCA AGCGGTACAT GGCACCCGAG 1140

GTGCTGGATG AGCAGATCCG CACTGACTGC TTCGAGTCCT ACAAGTGGAC TGACATCTGG 1200

GCCTTTGGTC TAGTGCTGTG GGAAATTGCT CGACGAACCA TTGTCAATGG CATTGTGGAG 1260

GACTACAGGC CACCCTTCTA TGATGTGGTG CCCAATGACC CCAGCTTTGA AGACATGAAG 1320

AAGGTGGTGT GTGTTGATCA GCAAACCCCC ACCATCCCCA ACCGGCTGGC TGCAGACCCG 1380

GTCCTCTCGG GCCTGGCTCA GATGATGCGG GAGTGCTGGT ACCCCACGCC CTCCGCCCGC 1440

CTCACCGCGC TGCGCATCAA GAAGACACTA CAGAAACTCA GCCATGGTCC AGAGAAGCCC 1500

AAAGTGATTC ACTAA 1515

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+

Q: 204   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  263

         689*********************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +l+la s+a+GlahLH ei+gt+g

Q: 264   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALKLAVSAACGLAHLHVEIFGTQG  323

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv

Q: 324   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  381

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l+e++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+mk

Q: 382   LDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  440

         ********************************99.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+++++ P+ip+++ ++++l+ l+++++ecW+  p+aRltalr+kk+l

Q: 441   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPTPSARLTALRIKKTL  490

         ************************************************97

Domain Sequence
(FASTA)

ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60

DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALKL AVSAACGLAH LHVEIFGTQG 120

KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLD 180

EQIRTDCFES YKWTDIWAFG LVLWEIARRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240

CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPTPSARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013