EKS-ICT-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	3.7E-137	209	496	288

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000433

UniProt Accession

I3LWQ4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000000480	ENSSTOP00000000433	ENSSTOT00000000482

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

MPERGDGLIL APRNPECVCL CVCVGGCLLS SVALLCACTS CLQANYTCET DGACMVSIFN 60

LDGMEHHVRT CIPKVELVPA GKPFYCLSSE DLRNTHCCYT DFCNKIDLRV PSGHLKEPEH 120

PSVWGPVELV GIIAGPVFLL FLIIIIVFLV INYHQRVYHN RQRLDMEDPS CEMCLSKDKT 180

LQDLVYDLST SGSGSGLPLF VQRTVARTIV LQEIIGKGRF GEVWRGRWRG GDVAVKIFSS 240

REERSWFREA EIYQTVMLRH ENILGFIAAD NKDNGTWTQL WLVSDYHEHG SLFDYLNRYT 300

VTIEGMIKLA LSAASGLAHL HMEIVGTQGK PGIAHRDLKS KNILVKKNGM CAIADLGLAV 360

RHDAVTDTID IAPNQRVGTK RYMAPEVLDE TINMKHFDSF KCADIYALGL VYWEIARRCN 420

SGGVHEEYQL PYYDLVPSDP SIEEMRKVVC DQKLRPNIPN WWQSYEALRV MGKMMRECWY 480

ANGAARLTAL RIKKTLSQLS VQEDVKI 507

Nucleotide Sequence
(FASTA)

ATGCCTGAGA GAGGAGATGG CTTGATTCTG GCTCCAAGGA ACCCTGAGTG TGTGTGTCTG 60

TGTGTGTGTG TAGGGGGGTG CCTCCTATCT TCTGTAGCTC TGCTATGTGC ATGCACCAGC 120

TGCCTACAGG CCAACTACAC GTGTGAAACA GATGGGGCCT GCATGGTTTC CATCTTCAAC 180

CTGGATGGGA TGGAGCACCA TGTGCGTACC TGCATCCCCA AAGTGGAGCT GGTCCCTGCC 240

GGGAAGCCCT TCTACTGCCT GAGCTCAGAG GATCTGCGCA ACACCCACTG CTGCTATACT 300

GACTTCTGCA ACAAGATCGA CCTGAGGGTG CCCAGTGGTC ACCTCAAGGA GCCTGAGCAC 360

CCTTCCGTGT GGGGCCCTGT GGAGCTGGTA GGCATTATTG CTGGCCCAGT CTTCCTTCTG 420

TTTCTCATCA TCATCATTGT TTTCCTTGTT ATTAACTATC ATCAGCGTGT CTATCACAAC 480

CGCCAGAGAC TGGACATGGA AGATCCCTCA TGTGAGATGT GTCTTTCCAA AGACAAGACG 540

CTTCAGGATC TTGTCTACGA TCTCTCCACA TCAGGGTCTG GCTCAGGGTT ACCTCTCTTT 600

GTCCAGCGCA CAGTGGCCCG CACCATTGTT TTACAGGAGA TTATCGGCAA AGGCCGGTTT 660

GGGGAAGTAT GGCGTGGCCG CTGGAGGGGT GGTGATGTAG CTGTAAAAAT TTTCTCTTCT 720

CGTGAAGAAC GGTCTTGGTT CCGGGAAGCC GAGATATACC AGACAGTCAT GTTGCGGCAT 780

GAAAACATCC TTGGATTTAT TGCTGCTGAC AATAAAGATA ATGGCACCTG GACACAGCTA 840

TGGCTCGTCT CTGACTACCA TGAACATGGC TCCTTGTTTG ATTATCTTAA CCGCTACACA 900

GTAACCATTG AGGGCATGAT TAAGTTGGCC CTCTCTGCTG CCAGTGGCTT GGCACACCTA 960

CATATGGAGA TTGTGGGCAC TCAAGGGAAG CCTGGAATTG CTCATCGAGA CTTAAAGTCA 1020

AAGAACATCC TGGTGAAGAA AAATGGCATG TGTGCCATCG CAGACCTGGG CCTGGCTGTC 1080

CGTCATGATG CAGTCACTGA CACCATTGAC ATTGCCCCAA ATCAGAGGGT GGGAACCAAA 1140

AGATACATGG CCCCTGAAGT ACTCGATGAA ACTATTAATA TGAAACACTT TGACTCCTTT 1200

AAATGTGCTG ATATCTATGC CCTTGGGCTT GTATATTGGG AGATTGCTCG AAGGTGCAAT 1260

TCTGGAGGAG TCCATGAAGA ATATCAGCTG CCATATTACG ACTTAGTGCC CTCCGACCCT 1320

TCCATTGAGG AAATGCGAAA GGTTGTCTGT GACCAGAAGC TACGTCCCAA TATCCCCAAC 1380

TGGTGGCAGA GTTACGAGGC ATTACGGGTG ATGGGGAAGA TGATGCGGGA GTGCTGGTAC 1440

GCCAACGGCG CAGCCCGTCT GACTGCGCTG CGCATAAAGA AGACCCTATC ACAACTCAGT 1500

GTGCAGGAAG ATGTGAAGAT CTAG 1524

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 209   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  268

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 269   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  328

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 329   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  386

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 387   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  445

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 446   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  496

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013