EKS-ICT-00353

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00353

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	418.6	7.6E-126	235	484	250

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000574

UniProt Accession

I3LX27;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000000630	ENSSTOP00000000574	ENSSTOT00000000630

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MGLLSSKRQV TEKGKGWSPL KIGTQSKDPP PLPPLVVFNH LTPPPPEEHP DREEHFVVAL 60

YDYAAVNDRD LQMLKGEKLQ VLKETGDWWL AKSLVTGREG YVPSNFVAPL ETLEVEKWFF 120

RSISRKEAER QLLAPMNKAG AFLIRESETN RGAFSLSVKD VTSQGEMVKH YKIRSLDEGG 180

YYISPRITFP SLQALVQHYS KKGDGLCQRL TLPCVSPASQ NPWVQDEWEI PRQSLKLVRK 240

LGSGQFGEVW MGYYKNNLKV AIKTLKEGAM SPEAFLAEAN LMKALQHERL VRLYAVVTKE 300

PIFIVTEYMA RGCLLDFLKS EEGSRLSLPR LIDMSAQIAE GMAYIEHMNS IHRDLRAANI 360

LVSETLCCKI ADFGLARIID SEYTVQEGAK FPIKWTAPEA IHFGVFTIKA DVWSFGVLLM 420

EIVTYGRVPY PGMSNPEVIR SLERGYRMPR PDTCPPELYR QVIAECWRSR PEERPTFEFL 480

QSVLEDFYTA TEGQYELQP 499

Nucleotide Sequence
(FASTA)

ATGGGTCTGC TCAGCAGCAA GAGGCAGGTC ACTGAGAAGG GCAAGGGCTG GAGCCCCTTG 60

AAGATCGGCA CCCAGAGCAA AGACCCCCCA CCACTGCCAC CCCTGGTGGT CTTCAATCAC 120

CTCACCCCTC CACCACCCGA GGAGCACCCC GACCGCGAGG AGCATTTTGT GGTGGCCCTG 180

TATGACTATG CCGCTGTGAA TGACCGGGAC CTGCAGATGC TGAAGGGCGA GAAGCTGCAG 240

GTCTTGAAGG AAACTGGAGA CTGGTGGTTG GCCAAGTCAC TCGTCACAGG GAGAGAAGGC 300

TATGTGCCCA GCAACTTTGT GGCCCCCCTG GAGACCCTGG AAGTGGAAAA GTGGTTCTTT 360

AGGTCGATCA GCCGGAAGGA GGCGGAGAGG CAGCTGCTGG CTCCAATGAA CAAGGCGGGT 420

GCCTTCCTCA TCAGAGAGAG CGAGACCAAT AGAGGTGCCT TTTCCCTGTC TGTGAAGGAT 480

GTCACCTCCC AGGGGGAGAT GGTCAAGCAC TATAAGATCC GCTCTCTGGA TGAAGGGGGC 540

TACTACATCT CCCCCAGGAT CACCTTCCCC TCCCTCCAGG CCCTGGTGCA GCACTATTCT 600

AAGAAAGGGG ATGGCTTATG CCAGAGGCTG ACCCTGCCCT GTGTGAGCCC GGCATCGCAG 660

AACCCCTGGG TCCAGGACGA ATGGGAAATC CCCCGGCAGT CCCTCAAGCT GGTCCGGAAA 720

CTCGGGTCTG GGCAGTTTGG TGAAGTGTGG ATGGGTTATT ACAAAAACAA CTTGAAGGTG 780

GCCATCAAGA CCTTGAAGGA GGGAGCCATG TCTCCAGAAG CCTTCCTGGC TGAGGCCAAC 840

CTGATGAAGG CCCTGCAGCA TGAGAGGCTG GTCCGTCTGT ATGCCGTGGT CACCAAGGAG 900

CCCATCTTCA TCGTCACCGA GTACATGGCC AGAGGATGCC TACTGGACTT CTTAAAGTCA 960

GAGGAGGGCA GCAGGTTGTC CCTCCCACGA CTGATCGACA TGTCAGCCCA GATCGCGGAA 1020

GGGATGGCGT ACATCGAGCA CATGAATTCC ATCCACCGAG ACCTGAGGGC GGCCAACATC 1080

CTGGTGTCTG AGACCTTGTG CTGCAAAATC GCGGACTTCG GCTTGGCCCG GATCATTGAC 1140

AGTGAATACA CTGTCCAAGA GGGAGCCAAG TTCCCCATCA AGTGGACCGC CCCGGAAGCC 1200

ATCCACTTTG GGGTGTTCAC CATCAAAGCA GACGTGTGGT CATTCGGGGT CCTCCTGATG 1260

GAGATCGTCA CCTACGGGCG CGTGCCCTAC CCAGGCATGA GCAATCCCGA GGTCATCCGC 1320

AGCCTGGAGC GAGGCTACCG CATGCCAAGG CCGGACACGT GCCCACCCGA GCTGTACCGC 1380

CAGGTCATTG CTGAGTGCTG GCGAAGTCGG CCCGAGGAGC GGCCCACCTT TGAGTTCCTG 1440

CAGTCGGTGC TTGAGGACTT CTACACGGCC ACTGAGGGCC AGTATGAGCT GCAGCCCTAG 1500

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv+klG+GqfGevw+g++k+++kva+ktlkeg +speafl+ea+++k l+he+lv+ly

Q: 235   LKLVRKLGSGQFGEVWMGYYKNNLKVAIKTLKEGAMSPEAFLAEANLMKALQHERLVRLY  294

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePi+ivte+ma+G+lldflk+eeg++l+lp+l+d++aq+aeGmay+e++n ihr

Q: 295   AVVTK-EPIFIVTEYMARGCLLDFLKSEEGSRLSLPRLIDMSAQIAEGMAYIEHMNSIHR  353

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlar+i d+eyt +egak+PikWtaPeai++g+ftik+dv

Q: 354   DLRAANILVSETLCCKIADFGLARII-DSEYTVQEGAKFPIKWTAPEAIHFGVFTIKADV  412

         **************************.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfG+ll+eivt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe

Q: 413   WSFGVLLMEIVTYGRVPYPGMSNPEVIRSLERGYRMPRPDTCPPELYRqVIAECWRSRPE  472

         ***********************************************98***********

S: 240   erPtfetlqevl  251

         erPtfe+lq+vl

Q: 473   ERPTFEFLQSVL  484

         ********9986

Domain Sequence
(FASTA)

LKLVRKLGSG QFGEVWMGYY KNNLKVAIKT LKEGAMSPEA FLAEANLMKA LQHERLVRLY 60

AVVTKEPIFI VTEYMARGCL LDFLKSEEGS RLSLPRLIDM SAQIAEGMAY IEHMNSIHRD 120

LRAANILVSE TLCCKIADFG LARIIDSEYT VQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGVLLMEIVT YGRVPYPGMS NPEVIRSLER GYRMPRPDTC PPELYRQVIA ECWRSRPEER 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013