EKS-ICT-00381
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00381
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR601.45.5E-181591926336
StatusUnreviewed
Ensembl ProteinENSSTOP00000000677
UniProt AccessionI3LXA5;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000000752ENSSTOP00000000677ENSSTOT00000000756
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length978
Protein Sequence
(FASTA)
VRAQPASYFV FIFRILLILA PGSSQPSVSP EEPSPPSIDP AQSELIVRAG DQLQLVCTDP 60
DFVKWTFETL DKRSESRHNE WVREKAEAAD TGKYTCTNRG GLSSSIYVFV KDPDKLFLVG 120
LPLYGKEDND TLVRCPVTDP EVTSYSLMEC EGKPLPKDLT FVPDPKAGIT IRNVKRTYHR 180
LCFRCAAIWK GKLVQSDRLI LKVRAAIKAI PVVSVSKTNY LLREGEEFSV TCTIKDVSTS 240
VGSMWLKDNS LQTKAQVKRN SWHQGDFNYE RQETLTISSA RVNDSGVFMC YANNTFGSAN 300
VTTTLKVVGL DKGFINIFSM MNSTIFVNDG ENVDLIVEYE AFPKPEHQQW MYMNSTTANK 360
WDDYPKSEND SNIRYVSELH LTRLKGTEGG TYTFLVSNPD VDASMTFNVY VNTKPEILTY 420
DRLTNGMLQC VAAGFPEPTI DWYFCTGTEQ RCSVPVQAVD VQIQNSSVPP FGKLVVQSSI 480
DSSMFRHNGT VECKAHNDVG KSSAYFNFAF KGNNKEQTHP HTLFTPLLIG FVITAGMMCI 540
IVMILTYKYL QKPMYEVQWK VVEEINGNNY VYIDPTQLPY DHKWEFPRNR LSFGKTLGAG 600
AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG NHMNIVNLLG 660
ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDQV DAALYKNLLH SKESSCNDSS 720
NEYMDMKPGV SYVVPTKADK RRSARIGSYI EREVTPAIME DDELALDLED LLSFSYQVAK 780
GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN ARLPVKWMAP 840
ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR MLSPEHAPAE 900
MYDIMKTCWD ADPLKRPTFK QIVQLIEKQI SESTNHIYSN LANFNPNPEN PVVDHSVRVN 960
SVGSSASSTQ PLLVHEDV 978
Nucleotide Sequence
(FASTA)
GTCAGGGCCC AGCCTGCCTC TTACTTTGTC TTCATCTTCC GTATTTTACT TATTCTGGCA 60
CCAGGCTCTT CCCAACCATC TGTGAGTCCA GAGGAACCGT CTCCACCATC CATCGATCCA 120
GCACAATCAG AGTTAATAGT CAGGGCTGGC GACCAGCTCC AGCTGGTATG CACGGATCCA 180
GACTTTGTCA AATGGACCTT CGAGACCCTG GATAAGAGGA GTGAGAGTAG GCATAATGAA 240
TGGGTCAGGG AGAAGGCCGA GGCTGCCGAC ACCGGCAAGT ACACCTGCAC CAACCGAGGA 300
GGCCTGAGCA GCTCCATTTA TGTGTTTGTT AAAGATCCTG ATAAGCTTTT CCTCGTCGGC 360
CTTCCCCTGT ATGGGAAAGA AGACAATGAT ACGCTGGTCC GCTGTCCTGT GACGGACCCA 420
GAAGTGACCA GTTATTCCCT CATGGAATGT GAAGGGAAAC CTCTCCCCAA GGACCTGACA 480
TTTGTCCCTG ACCCCAAGGC TGGCATCACA ATCAGGAACG TGAAACGCAC CTACCATCGG 540
CTCTGTTTCC GCTGCGCTGC CATCTGGAAG GGCAAGTTGG TGCAGTCAGA TAGGTTGATC 600
CTGAAAGTGA GGGCAGCTAT CAAAGCTATT CCAGTTGTGT CTGTGTCCAA AACAAACTAT 660
CTTCTTAGGG AAGGGGAAGA ATTTTCAGTG ACATGCACAA TTAAAGATGT GTCCACATCC 720
GTGGGCTCAA TGTGGTTGAA GGACAACAGT CTGCAGACTA AAGCACAGGT AAAACGTAAT 780
AGCTGGCATC AGGGTGACTT CAATTATGAA CGTCAGGAAA CGTTGACTAT CAGCTCAGCA 840
AGAGTTAATG ATTCTGGAGT GTTCATGTGT TATGCCAATA ATACTTTTGG ATCAGCAAAT 900
GTCACAACAA CCTTGAAAGT TGTAGGATTA GATAAAGGAT TTATTAATAT CTTCTCCATG 960
ATGAATTCTA CGATATTTGT AAATGATGGA GAAAATGTAG ATTTGATTGT TGAATACGAA 1020
GCGTTCCCCA AACCGGAACA CCAGCAGTGG ATGTACATGA ACAGCACCAC CGCTAACAAG 1080
TGGGACGATT ACCCCAAGTC TGAGAATGAC AGCAATATCA GATATGTAAG TGAACTTCAC 1140
CTGACCAGGT TAAAAGGGAC TGAAGGAGGC ACGTACACAT TTCTCGTGTC CAACCCTGAC 1200
GTGGACGCTT CCATGACATT TAACGTTTAC GTGAACACAA AACCAGAAAT CCTGACTTAT 1260
GACAGGCTCA CAAATGGCAT GCTCCAGTGT GTGGCAGCAG GATTCCCAGA GCCCACAATA 1320
GATTGGTATT TTTGTACAGG AACGGAGCAG AGATGTTCCG TTCCTGTACA GGCTGTGGAT 1380
GTGCAGATTC AAAACTCATC TGTGCCACCG TTCGGAAAAC TCGTGGTTCA GAGCTCTATA 1440
GATTCTAGTA TGTTCCGGCA CAATGGCACA GTGGAGTGTA AGGCTCACAA CGATGTGGGC 1500
AAGAGTTCTG CCTATTTTAA CTTTGCATTT AAAGGTAACA ACAAAGAGCA AACCCATCCC 1560
CACACGTTGT TCACGCCCTT GCTGATTGGT TTCGTGATCA CAGCTGGTAT GATGTGCATC 1620
ATTGTGATGA TTCTGACCTA CAAATATTTA CAGAAACCTA TGTATGAAGT ACAGTGGAAG 1680
GTTGTCGAGG AGATAAATGG AAACAATTAT GTGTACATAG ACCCAACACA ACTTCCTTAT 1740
GATCACAAAT GGGAGTTTCC CAGAAACAGG CTGAGTTTTG GGAAGACCTT GGGTGCTGGC 1800
GCCTTCGGGA AGGTGGTGGA GGCCACTGCC TATGGCCTAA TTAAGTCGGA TGCGGCCATG 1860
ACCGTGGCTG TGAAGATGCT CAAACCGAGC GCCCACTTAA CGGAGCGAGA AGCCCTCATG 1920
TCGGAGCTGA AGGTCCTGAG CTACCTCGGC AATCACATGA ACATTGTCAA CCTCCTCGGA 1980
GCCTGTACCA TTGGAGGACC GACCCTGGTC ATTACAGAAT ATTGTTGCTA TGGTGATCTT 2040
TTGAATTTTT TGAGAAGAAA ACGTGATTCA TTTATTTGTT CCAAGCAGGA AGATCAGGTA 2100
GACGCAGCAC TTTATAAGAA TCTTCTGCAT TCAAAGGAGT CTTCCTGCAA TGACAGTAGT 2160
AATGAGTACA TGGACATGAA GCCTGGAGTT TCTTATGTTG TCCCAACCAA AGCAGACAAA 2220
AGGAGATCTG CAAGAATAGG CTCATATATA GAAAGAGAAG TGACCCCCGC CATCATGGAG 2280
GATGATGAAC TGGCCCTTGA CCTGGAAGAT TTGCTGAGCT TTTCTTACCA GGTGGCAAAG 2340
GGCATGGCTT TCCTCGCCTC AAAGAACTGT ATTCACAGAG ACTTGGCAGC CAGAAATATC 2400
CTCCTTACTC ATGGTCGAAT CACAAAGATT TGTGATTTTG GTCTAGCCAG AGACATCAAG 2460
AATGATTCTA ATTATGTGGT TAAAGGAAAT GCCCGGCTTC CTGTGAAGTG GATGGCCCCA 2520
GAAAGCATCT TCAACTGTGT GTACACATTT GAAAGCGATG TCTGGTCCTA TGGGATTTTT 2580
CTGTGGGAGC TCTTCTCTTT AGGAAGCAGC CCCTACCCTG GAATGCCTGT CGATTCCAAG 2640
TTCTACAAGA TGATCAAGGA AGGTTTTCGG ATGCTCAGCC CTGAGCATGC CCCTGCTGAA 2700
ATGTATGACA TTATGAAGAC TTGTTGGGAT GCTGATCCCC TGAAAAGGCC AACGTTCAAG 2760
CAGATTGTTC AGCTTATTGA GAAGCAGATT TCAGAGAGCA CCAATCATAT TTACTCCAAT 2820
TTAGCAAACT TCAACCCCAA CCCAGAGAAT CCCGTGGTGG ACCATTCCGT GAGGGTCAAT 2880
TCCGTCGGCA GCAGTGCTTC TTCTACCCAG CCCCTGCTTG TGCACGAAGA TGTCTGA 2937
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 591   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  650
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k++++  ++ +k+
Q: 651   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDQVDAALYKN  707
         ******************************************...899999999999999
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++ +ss+ey+d+k++vs+v ++kadk++s+++ s++erev++a++e+d
Q: 708   L-----LHSKESSCNDSSNEYMDMKPGVSYVVPTKADKRRSARIGSYIEREVTPAIMEDD  762
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 763   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  822
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 823   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  882
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 883   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  926
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDQV DAALYKNLLH 120
SKESSCNDSS NEYMDMKPGV SYVVPTKADK RRSARIGSYI EREVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013