EKS-ICT-00424

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00424

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	460.3	1.9E-138	1	255	255

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000687

UniProt Accession

I3LXB0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000000756	ENSSTOP00000000687	ENSSTOT00000000766

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1625

Protein Sequence
(FASTA)

VAVVKMKNTE RIYAMKILNK WEMLKRAETA CFREERDVLV KGDCQWITAL HYAFQDENYL 60

YLVMDYYVGG DLLTLLSKFE DKLPEDMARF YIGEMVLAID SIHQLHYVHS NRDIKPDNVL 120

LDVNGHIRLA DFGSCLKMND DGTVQSSVAV GTPDYISPEI LQAMEDGMGK YGPECDWWSL 180

GVCMYEMLYG ETPFYAESLV ETYGKIMNHE ERFQFPSHVT DVSEEAKDLI QRLICSRERR 240

LGQNGIEDFK KHAFFEGLNW ENIRNLEAPY IPDVSSPSDT SNFDVDDDVL RNAEILPPGS 300

HTGFSGLHLP FIGFTFTTES CFSDRGSLKS VMQSNTLTKD EDVQRDLENS LQVEAYERRI 360

RRLEQEKLEL SRKLQESTQT VQSLHAATRA LGNSNRDKEI KRLNEEIEHL RNKMADSNRL 420

ERQLEDTVTL RQEHEDSTHR LKGLEKQYRL ARQEKEDFHK QLIEASERLK SQTKELKDAH 480

QQRKRALQEF SDLNERMAEL RSQKQKVSRQ LRDKEEEMDG AMQKIDSLRQ EIRKSEKFRK 540

ELEVQLEDAL AEASKERKLR EHSESFCKQM ESELEALKVK QGGRGSGATL EHQQEISKIK 600

SELEKKVLFY EEELVRREAS HVLEVKTVKK EVHDSESHQL ALQKEILMLK DKLEKSKRER 660

HSEMEEAIGT VKDKYERERA ILSEENKKLT AENEKLCAFV DKLTAQNRQL EDELQDLAAK 720

KESVAHWEAQ IAEIIQWVSD EKDARGYLQA LASKMTEELE TLRSSSLGSR TLDPLWKVRR 780

SQKLDMSARL ELQSALEAEI RAKQLIQEEL RKVKDTNLSF ESKLKDSEAK NRELLEEMEI 840

LKKKMEEKFR ADTGLKLPDF QDSIFEYFNT APLAHDLTFR TSSASEQEAQ APKTEVSPSV 900

SVAAGTEQQE DTTRPPQRPP AVSLPTTQAL ALAGPKPKAH QFSIKSFSSP TQCSHCTSLM 960

VGLIRQGYAC EVCAFACHAS CRDSAPQVCP IPPEQSKRPL GVDVQRGIGT AYKGCVKVPK 1020

PTGVKKGWQR AYAVVCDCKL FLYDLPEGKS TQPGVVASQV LDLRDDEFSV SSVLASDVIH 1080

ATRRDIPCIF RVTASLLGSP AKNSSLLILT ENENEKRKWV GILEGLQSIL HKNRLRNQVV 1140

HVPQEAYDST LPLIKAILTA AIVDGDRIAV GLEEGLYVIE VTRDVIVRAA DCKKVYQIEL 1200

APKEKIVILL CGRNHHVHLC PWSSFDGAEG NFDIKLPETK GCQLIATATL RKSSSTCLFV 1260

AVKRLVLCYE IQRTKPFHRK FSELVAPGHV QWMAVFKDRL CVGYPSGFSL LSIQGDGPSL 1320

DLVNPTDPSL AFLSQQSFDA LCAVELKSEE YLLCFSHMGL YVDPQGRRSR MQELMWPAAP 1380

VACSCSGSHV TVYSEYGVDV FDVCTMEWVQ TIGLRRIRPL NSDGSLNLLG CEPPRLIYFK 1440

NKSSGTVLNV PDTSDSSKKQ MLRTRSKRRF VFKVPEEERL QQRREMLRDP ELRSKMISNP 1500

TNFNHVAHMG PGDGMQVLMD LPLSAAPLTQ EERPGPAPAS LARQPPCRSK PYVSWPSSGG 1560

PEPGGTVPLR SMSDPDQDFD KEPDSDSTKH STPSNSSNPS GPPSPNSPHR SQLPLEGLEQ 1620

PTCDA 1625

Nucleotide Sequence
(FASTA)

GTTGCTGTTG TTAAAATGAA GAACACTGAA CGAATTTACG CCATGAAAAT TCTCAACAAG 60

TGGGAGATGC TTAAAAGAGC AGAGACCGCC TGTTTCCGGG AGGAGCGTGA TGTGCTAGTG 120

AAGGGCGACT GCCAGTGGAT CACCGCGCTG CACTACGCCT TCCAGGACGA GAACTACCTG 180

TACCTGGTCA TGGATTACTA CGTGGGTGGT GATTTGCTGA CACTACTTAG TAAATTTGAA 240

GACAAGCTTC CAGAAGACAT GGCAAGGTTC TATATTGGTG AGATGGTGCT GGCCATTGAC 300

TCCATCCACC AGCTTCATTA TGTGCACAGT AACAGAGACA TTAAACCTGA CAATGTCCTT 360

TTGGATGTGA ATGGTCATAT CCGCCTGGCT GACTTTGGAT CCTGTTTGAA GATGAACGAT 420

GATGGAACTG TTCAGTCCTC TGTGGCGGTG GGCACACCTG ACTACATTTC ACCCGAGATC 480

CTGCAGGCCA TGGAGGATGG CATGGGCAAA TATGGGCCTG AATGTGACTG GTGGTCCCTG 540

GGCGTCTGCA TGTACGAGAT GCTTTATGGA GAAACACCGT TTTATGCAGA GTCACTTGTA 600

GAGACGTATG GGAAAATCAT GAACCATGAG GAGCGATTTC AATTCCCTTC CCATGTCACG 660

GATGTCTCTG AAGAAGCGAA AGACCTCATT CAGAGATTGA TCTGCAGCAG AGAGCGTCGG 720

CTAGGGCAGA ATGGAATAGA GGACTTTAAG AAACATGCGT TTTTTGAAGG TCTAAACTGG 780

GAAAATATAC GAAACCTAGA AGCACCTTAC ATTCCTGATG TGAGCAGCCC TTCTGACACA 840

TCCAACTTCG ACGTGGATGA CGATGTGCTG AGAAACGCTG AAATATTACC TCCCGGCTCT 900

CACACCGGCT TCTCTGGATT GCATTTGCCC TTCATTGGCT TCACATTCAC AACAGAAAGC 960

TGCTTTTCCG ACCGTGGCTC TCTGAAGAGC GTGATGCAAT CTAACACATT AACCAAAGAT 1020

GAGGATGTGC AGCGGGACTT GGAGAACAGC TTGCAAGTTG AAGCTTATGA GAGGAGGATA 1080

CGAAGACTGG AACAGGAAAA GCTGGAGCTG AGCCGGAAGC TGCAGGAGTC CACACAGACC 1140

GTGCAGTCCC TTCATGCTGC CACACGGGCC CTGGGCAACT CCAACCGAGA CAAGGAAATC 1200

AAAAGGCTAA ATGAAGAAAT TGAGCATCTG AGGAACAAAA TGGCAGATTC AAATAGGCTA 1260

GAACGACAGC TGGAGGACAC AGTGACACTT CGCCAAGAGC ACGAGGACTC CACACACCGG 1320

CTAAAGGGCC TAGAAAAGCA GTACCGACTG GCGCGGCAGG AGAAGGAGGA CTTCCACAAG 1380

CAATTGATTG AAGCTTCAGA AAGATTGAAA TCCCAGACCA AAGAACTCAA AGATGCCCAT 1440

CAGCAGCGAA AGCGGGCCCT GCAGGAGTTC TCGGACCTCA ATGAGCGCAT GGCAGAGCTC 1500

CGCTCCCAGA AACAGAAGGT GTCCCGGCAG CTCCGGGACA AAGAGGAGGA GATGGATGGG 1560

GCCATGCAGA AGATCGACTC CCTGAGGCAG GAGATCCGCA AATCTGAGAA GTTCAGGAAA 1620

GAGCTGGAAG TGCAGCTGGA AGACGCCCTA GCTGAGGCCT CCAAGGAGCG CAAGCTTCGC 1680

GAGCACAGTG AGAGTTTCTG CAAGCAGATG GAGAGCGAGC TCGAGGCCCT CAAGGTAAAG 1740

CAAGGAGGTC GAGGGTCAGG GGCCACTTTG GAACACCAGC AAGAGATTTC CAAAATCAAA 1800

TCAGAGCTGG AGAAGAAGGT CTTGTTTTAT GAGGAAGAGC TGGTCCGCCG GGAGGCGTCC 1860

CACGTGCTGG AAGTGAAGAC TGTGAAGAAG GAGGTGCATG ACTCCGAAAG TCACCAGCTG 1920

GCACTGCAGA AAGAAATTTT AATGTTAAAA GACAAATTGG AAAAATCAAA ACGAGAACGG 1980

CACAGTGAGA TGGAGGAGGC GATAGGCACT GTGAAAGACA AGTACGAGCG AGAACGGGCG 2040

ATACTGTCGG AGGAGAACAA GAAGCTAACT GCTGAGAATG AAAAGCTCTG TGCCTTTGTG 2100

GATAAGCTCA CAGCCCAGAA CAGACAGCTG GAGGATGAGC TGCAGGATCT GGCAGCCAAG 2160

AAGGAGTCAG TGGCACACTG GGAAGCTCAG ATTGCAGAGA TCATTCAGTG GGTTAGTGAC 2220

GAGAAAGATG CCCGGGGTTA TCTTCAAGCC CTGGCCTCTA AGATGACTGA AGAGCTCGAG 2280

ACTTTGAGGA GTTCTAGTCT GGGATCAAGA ACACTGGACC CACTTTGGAA AGTTCGCCGT 2340

AGCCAGAAAC TGGACATGTC TGCACGGCTA GAACTGCAGT CTGCCCTTGA GGCGGAGATC 2400

CGTGCCAAGC AGCTCATCCA GGAAGAACTG AGGAAGGTCA AAGACACCAA TCTCTCCTTT 2460

GAAAGTAAAC TAAAGGATTC TGAAGCCAAA AACAGAGAAT TACTAGAAGA AATGGAAATT 2520

CTGAAGAAAA AGATGGAAGA AAAATTTAGA GCAGATACCG GGCTCAAGCT TCCAGATTTT 2580

CAGGATTCCA TTTTCGAGTA TTTCAACACT GCACCTCTTG CACATGACCT GACATTTAGA 2640

ACTAGTTCAG CCAGTGAGCA AGAAGCACAG GCGCCAAAGA CAGAAGTATC CCCATCAGTT 2700

TCTGTGGCCG CAGGCACAGA GCAGCAAGAG GACACGACTC GGCCCCCACA GAGGCCACCT 2760

GCTGTGTCGC TGCCCACCAC ACAGGCCCTC GCCCTGGCTG GACCAAAGCC CAAAGCTCAT 2820

CAGTTCAGCA TCAAGTCCTT CTCCAGCCCC ACTCAGTGCA GCCACTGCAC CTCGCTGATG 2880

GTTGGACTGA TCCGCCAGGG ATACGCCTGT GAGGTGTGTG CGTTTGCCTG CCATGCGTCC 2940

TGCAGAGACA GTGCTCCCCA GGTGTGCCCC ATCCCACCTG AACAGTCCAA GAGGCCTCTT 3000

GGCGTGGATG TACAGAGAGG CATAGGAACG GCCTACAAGG GTTGTGTCAA GGTCCCAAAG 3060

CCCACGGGGG TGAAGAAGGG ATGGCAGCGG GCCTATGCTG TGGTCTGTGA CTGCAAGCTC 3120

TTTCTGTACG ACCTGCCTGA GGGAAAGTCC ACCCAGCCAG GCGTCGTCGC GAGCCAAGTC 3180

CTGGACCTCA GGGATGACGA GTTTTCAGTA AGCTCAGTCC TGGCCTCAGA TGTCATCCAC 3240

GCAACACGCC GAGACATTCC CTGTATATTC AGGGTGACAG CCTCTCTCTT AGGTTCACCT 3300

GCTAAGAACA GCTCGCTGCT CATTCTGACA GAGAATGAGA ACGAGAAGAG GAAGTGGGTA 3360

GGGATCCTGG AAGGACTCCA GTCCATCCTC CATAAAAACC GGCTCAGGAA CCAGGTCGTG 3420

CACGTCCCCC AGGAAGCCTA CGACAGCACA CTGCCACTCA TCAAGGCCAT CCTCACTGCT 3480

GCCATCGTGG ATGGAGACAG GATTGCTGTC GGCCTGGAAG AAGGGCTCTA TGTCATCGAG 3540

GTCACCCGGG ATGTGATCGT CCGTGCTGCT GATTGTAAAA AGGTGTACCA GATTGAGCTT 3600

GCACCCAAGG AGAAAATTGT CATCCTCCTC TGTGGGCGGA ACCACCACGT GCACCTCTGT 3660

CCATGGTCTT CCTTTGACGG AGCAGAAGGC AACTTTGACA TCAAGCTTCC GGAAACCAAG 3720

GGCTGCCAGC TTATAGCCAC CGCGACTCTA AGAAAGAGCT CCTCCACCTG TTTGTTTGTT 3780

GCGGTGAAGC GGCTGGTCCT CTGCTACGAG ATCCAGAGAA CTAAGCCTTT CCACAGGAAG 3840

TTCAGTGAGC TGGTGGCTCC GGGACATGTG CAGTGGATGG CCGTGTTCAA GGACAGGCTC 3900

TGTGTCGGCT ACCCTTCTGG GTTCTCTCTG TTGAGCATCC AGGGGGACGG GCCGTCTCTA 3960

GACCTGGTAA ATCCCACTGA CCCCTCGCTT GCGTTCCTCT CACAGCAGTC TTTCGATGCC 4020

CTTTGTGCTG TGGAGCTCAA AAGTGAGGAG TACCTGCTTT GCTTCAGCCA CATGGGACTG 4080

TACGTGGACC CTCAAGGCCG GAGGTCACGC ATGCAGGAGC TCATGTGGCC TGCGGCTCCT 4140

GTCGCCTGTA GCTGCAGCGG CTCCCACGTT ACCGTGTACA GTGAGTACGG CGTGGACGTC 4200

TTCGACGTGT GCACCATGGA GTGGGTGCAG ACCATCGGCC TGCGGAGGAT AAGGCCCCTG 4260

AACTCTGACG GCAGCCTCAA CCTCCTTGGT TGTGAGCCTC CGCGCCTTAT CTACTTCAAG 4320

AACAAGTCCT CAGGAACGGT CCTCAATGTG CCAGACACCT CAGACAGCAG CAAGAAGCAG 4380

ATGCTCCGGA CTCGAAGCAA ACGGCGTTTT GTCTTCAAGG TGCCAGAGGA GGAGAGGCTG 4440

CAGCAGAGGC GAGAGATGCT CAGAGACCCA GAATTGAGGT CCAAGATGAT ATCCAACCCC 4500

ACCAACTTCA ACCACGTGGC CCACATGGGC CCGGGCGACG GGATGCAGGT GCTCATGGAC 4560

CTGCCTCTGA GTGCTGCACC GCTCACCCAG GAGGAGAGGC CTGGCCCTGC CCCTGCCAGC 4620

CTGGCCCGGC AGCCTCCCTG CAGGAGCAAG CCCTACGTCT CCTGGCCCTC CTCAGGTGGT 4680

CCAGAGCCTG GAGGGACCGT ACCTCTGAGG AGCATGTCCG ACCCCGACCA GGACTTTGAC 4740

AAAGAGCCTG ACTCGGATTC CACCAAACAC TCAACTCCCT CAAACAGCTC CAACCCCAGC 4800

GGCCCGCCGA GCCCCAACTC GCCCCACAGG AGCCAGCTCC CCCTCGAAGG CCTGGAGCAG 4860

CCAACCTGTG ACGCCTGA 4878

Domain Profile

S: 15    vavvrekatekvyamkilkklellkraesaffreerdvlvkadsewivqlqyafqdekyl  74

         vavv++k+te++yamkil+k+e+lkrae+a+freerdvlvk+d++wi++l+yafqde+yl

Q: 1     VAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVKGDCQWITALHYAFQDENYL  60

         79**********************************************************

S: 75    ylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelgyvh..rdikpdnil  132

         ylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+yvh  rdikpdn+l

Q: 61    YLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHsnRDIKPDNVL  120

         *************************************************999********

S: 133   ldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegkgeygkecdwwsl  192

         ld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+g+yg+ecdwwsl

Q: 121   LDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSL  180

         ************************************************************

S: 193   Gvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakdlikklltsreer  251

         Gv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakdli++l++sre+r

Q: 181   GVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKDLIQRLICSRERR  240

         **************************************99********************

S: 252   lgregiedlkkhpff  266

         lg++gied+kkh+ff

Q: 241   LGQNGIEDFKKHAFF  255

         **************9

Domain Sequence
(FASTA)

VAVVKMKNTE RIYAMKILNK WEMLKRAETA CFREERDVLV KGDCQWITAL HYAFQDENYL 60

YLVMDYYVGG DLLTLLSKFE DKLPEDMARF YIGEMVLAID SIHQLHYVHS NRDIKPDNVL 120

LDVNGHIRLA DFGSCLKMND DGTVQSSVAV GTPDYISPEI LQAMEDGMGK YGPECDWWSL 180

GVCMYEMLYG ETPFYAESLV ETYGKIMNHE ERFQFPSHVT DVSEEAKDLI QRLICSRERR 240

LGQNGIEDFK KHAFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013