EKS-ICT-00141
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00141
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR553.85.2E-167480756277
StatusUnreviewed
Ensembl ProteinENSSTOP00000000735
UniProt AccessionI3LXE6;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000000815ENSSTOP00000000735ENSSTOT00000000821
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length806
Protein Sequence
(FASTA)
MGAPACALAL CVAAAVVAGV ASESPGTEQR VLPRAAEGPG PEPGQQEPLV FGSGDTMELS 60
CDPPGGGPVG PTIWVKDGSG LESSGRILVG PQQLQVLNAS REDTGAYSCR QRLTQRVLCH 120
FSVRVTDAPS SGDDEDGEDV AEDTASTVAS HPPAPTGAPY WTRPERMDKK LLAVPAANTV 180
RFRCPAAGNP TPSISWLKNG KEFRGEHRIG GIKLRHQQWS LVMESVVPSD RGNYTCVVEN 240
KFGSIRQTYT LDVLERSPHR PILQAGLPAN QTAVLGSDVE FHCKVYSDAQ PHIQWLKHVE 300
VNGSKVGPDG TPYVTVLKTA GANTTDKELE VLSLRNVTFE DAGEYTCLAG NSIGFSHHSA 360
WLAVLPAEEE LVEADEAGSV YAGVLSYGVG FFLFILLVAA VTLCRLRSPP KKGLGSPTVH 420
TVSRFPLKRQ VSLESNSSMN SNTPLVRIAR LSSGEGPTLA NVSELELPAD PKWELSRARL 480
TLGKPLGEGC FGQVVMAEAI GIDKDRAARP VTVAVKMLKD DATDKDLSDL VSEMEMMKMI 540
GRHKNIINLL GACTQGGPLY VLVEYAAKGN LREYLRARRP PGMDYSFHTC RLPEEQLTFK 600
DLVSCAYQVA RGMEYLASQK CIHRDLAARN VLVTEDNVMK IADFGLARDV HNLDYYKKTT 660
NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LLWEIFTLGG SPYPGIPVEE LFKLLKEGHR 720
MDRPANCTHD LYMIMRECWH AVPSQRPTFK QLVEDLDRIL TVTSTDEYLD LSVPFEQYSP 780
GGQDTPSSSS SGDDSVFTHD LLPPAP 806
Nucleotide Sequence
(FASTA)
ATGGGCGCCC CGGCCTGCGC CCTCGCACTG TGCGTGGCCG CAGCGGTTGT GGCGGGCGTC 60
GCCTCGGAGT CCCCGGGCAC AGAGCAGCGC GTCTTGCCGA GAGCAGCAGA GGGCCCAGGG 120
CCTGAGCCTG GCCAGCAGGA GCCGCTGGTC TTTGGGAGTG GGGACACCAT GGAGCTGAGC 180
TGTGACCCAC CCGGAGGTGG TCCTGTGGGT CCCACGATCT GGGTCAAGGA TGGCTCGGGA 240
CTGGAGTCCT CGGGCCGTAT CCTGGTGGGG CCCCAGCAGC TGCAGGTGCT AAACGCCTCT 300
CGTGAAGACA CTGGGGCCTA CAGTTGCCGG CAGCGGCTCA CACAGCGCGT GCTGTGCCAC 360
TTCAGTGTGC GTGTGACAGA TGCTCCATCC TCTGGAGACG ATGAAGACGG GGAGGATGTG 420
GCTGAGGACA CAGCCTCCAC TGTGGCCTCA CATCCACCTG CACCCACAGG GGCCCCTTAC 480
TGGACTCGGC CAGAGCGGAT GGACAAGAAA CTGCTGGCAG TACCGGCTGC CAACACAGTT 540
CGCTTCCGCT GCCCAGCTGC TGGCAACCCC ACTCCTTCCA TCTCCTGGCT GAAGAACGGC 600
AAGGAGTTCC GAGGGGAGCA TCGCATTGGG GGCATCAAGC TGCGTCATCA GCAGTGGAGC 660
CTGGTCATGG AGAGCGTGGT GCCCTCTGAC CGCGGCAACT ACACGTGCGT GGTGGAGAAC 720
AAGTTTGGCA GCATCCGGCA GACGTACACT CTGGACGTGC TGGAGCGCTC CCCGCACCGG 780
CCCATCCTGC AGGCGGGGCT GCCAGCCAAC CAGACAGCCG TACTGGGCAG CGACGTGGAG 840
TTCCACTGCA AGGTGTACAG TGACGCACAG CCCCACATCC AGTGGCTCAA GCACGTGGAG 900
GTGAATGGCA GCAAGGTGGG CCCTGACGGC ACGCCCTACG TCACCGTGCT CAAGACGGCG 960
GGCGCTAACA CCACCGACAA GGAGCTAGAG GTTCTATCCT TGCGCAATGT CACCTTTGAG 1020
GACGCGGGGG AGTACACCTG CCTGGCGGGC AATTCTATCG GGTTTTCCCA TCACTCTGCG 1080
TGGCTGGCGG TGCTGCCAGC GGAGGAGGAG CTGGTGGAGG CGGACGAGGC TGGCAGCGTG 1140
TATGCAGGCG TCCTCAGCTA CGGGGTGGGC TTCTTCCTCT TCATTCTGCT GGTGGCAGCT 1200
GTAACGCTGT GCCGCCTGCG CAGCCCTCCC AAGAAGGGGC TGGGCTCCCC CACTGTGCAC 1260
ACGGTCTCCC GCTTCCCGCT CAAGCGACAG GTGTCCTTGG AGTCCAACTC GTCCATGAAC 1320
TCCAACACAC CGCTGGTCCG CATTGCCCGG CTGTCCTCGG GAGAAGGTCC CACGCTGGCT 1380
AATGTTTCTG AGCTTGAGTT ACCTGCCGAC CCCAAATGGG AGCTGTCCCG GGCCCGACTG 1440
ACCTTGGGCA AGCCTCTTGG AGAGGGCTGC TTTGGCCAGG TGGTCATGGC AGAGGCCATT 1500
GGCATCGACA AGGACCGTGC TGCCAGACCT GTTACAGTGG CGGTGAAAAT GCTGAAAGAC 1560
GATGCCACTG ACAAGGACCT GTCGGACCTG GTGTCGGAGA TGGAGATGAT GAAGATGATT 1620
GGGAGGCACA AGAACATCAT CAACCTGCTG GGGGCCTGCA CGCAAGGCGG GCCTCTGTAC 1680
GTGCTGGTGG AGTACGCGGC CAAAGGCAAC CTGAGGGAGT ACCTTCGGGC GCGGAGGCCG 1740
CCGGGCATGG ACTACTCCTT CCACACCTGC AGGCTGCCTG AGGAACAGCT CACCTTCAAG 1800
GACCTGGTGT CATGTGCCTA CCAGGTGGCG CGGGGCATGG AGTATCTGGC ATCCCAGAAG 1860
TGCATCCACA GGGACCTGGC TGCCCGCAAC GTGCTGGTGA CTGAGGACAA CGTGATGAAG 1920
ATAGCCGACT TTGGCCTGGC CCGTGATGTG CACAATCTCG ACTACTATAA GAAGACCACC 1980
AATGGCCGGC TGCCTGTGAA GTGGATGGCC CCTGAGGCCC TGTTTGATCG GGTCTACACC 2040
CACCAGAGTG ATGTCTGGTC CTTTGGGGTC CTGCTCTGGG AGATCTTCAC CCTGGGGGGC 2100
TCACCGTACC CCGGCATACC CGTGGAGGAG CTCTTCAAGC TGCTGAAGGA GGGCCACCGC 2160
ATGGACAGGC CAGCCAACTG CACACACGAC CTGTACATGA TCATGCGTGA GTGCTGGCAC 2220
GCAGTGCCCT CCCAGAGGCC TACCTTCAAA CAACTGGTTG AGGACCTGGA TCGCATCCTC 2280
ACCGTGACGT CCACTGATGA GTACCTGGAC CTGTCAGTGC CCTTTGAGCA GTACTCGCCA 2340
GGTGGCCAAG ACACCCCCAG TTCCAGCTCC TCAGGGGACG ACTCTGTGTT TACCCATGAC 2400
CTGCTGCCCC CAGCCCCA 2418
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkd++++ vtvavkmlk+datdkdl+dlvseme++k+
Q: 480   LTLGKPLGEGCFGQVVMAEAIGIDKDRAARPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  539
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllGactq+Gplyv+veyaakGnlre+lrarrp+g+++s ++++ +eeqlt+
Q: 540   IGRHKNIINLLGACTQGGPLYVLVEYAAKGNLREYLRARRPPGMDYSFHTCRLPEEQLTF  599
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt
Q: 600   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  659
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 660   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  719
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++pa+ct++ly++mrecwha++s+rptfkqlvedl
Q: 720   RMDRPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  756
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDRAAR PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGRHKNIINL LGACTQGGPL YVLVEYAAKG NLREYLRARR PPGMDYSFHT CRLPEEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDRPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-CAE-00120
EKS-CAF-00155
EKS-CAP-00149
EKS-CII-00090
EKS-CIS-00182
EKS-DAR-00435
EKS-DRM-00072
EKS-EQC-00146
EKS-GAM-00077
EKS-GAG-00124
EKS-GAA-00174
EKS-GOG-00150
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-ORA-00127
EKS-ORL-00169
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PEM-00080
EKS-PTV-00141
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
EKS-XIM-00175
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013