EKS-ICT-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	532.9	1.2E-160	975	1242	268

Status

Unreviewed

Ensembl Protein

ENSSTOP00000000977

UniProt Accession

I3LXY7;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSR

Gene Synonyms/Alias

INSR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000001089	ENSSTOP00000000977	ENSSTOT00000001095

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1334

Protein Sequence
(FASTA)

VCPGMDIRNN LTRLHELENC SVIEGHLQIL LMFKTRPEDF RDLSFPKLII ITDYLLLFRV 60

YGLESLKDLF PNLTVIRGSR LFFNYALVVF EMVHLKELGL YSLMNITRGS VRIEKNNELC 120

YLATIDWSRI LDSVEDNYIV LNKDDNEECG DICPGTAKGK TNCPATVING QFVERCWTHS 180

HCQKVCPTIC KSHGCTAEGL CCHSECLGNC SEPDDPTKCV ACRNFYLDGR CVETCPPPYY 240

HFQDWRCVNF SFCQELHNRC KNSRRPGCHQ YVIHNNKCIP ECPSGYTMNS SNLMCTPCLG 300

PCPKVCHLLE GEKTIDSVTS AQELRGCTVV NGSLIINIRG GNNLAAELEA NLGLIEEISG 360

YLKIRRSYAL VSLSFFRKLR LIRGETLEIG NYSFYALDNQ NLRQLWDWSK HNLTITQGKL 420

FFHYNPKLCL SEIHKMEEVS GTKGRQERND IALKTNGDQA SCENELLKFS FIKTSFDKIL 480

LKWEPYWPPD FRDLLGFMLF YKEASPYQNV TEFDGQDACG SNSWTVVDID PPQRSNDPKP 540

QHHPGWLMRG LKPWTQYAIF VKTLVTFSDE RRTYGAKSDI IYVQTDATNP SVPLDPISVS 600

NSSSQIILKW KPPSDPNGNI THYLVYWERQ EEDSELYELD YCLKGLKLPS RTWSPPFESD 660

DSQKHNQSEY EDSAGECCTC PKTDSQILKE LEESSFRKTF EDYLHNVVFV PRPSRKRRSL 720

GVEANVTEPV PSAPALPSSS PSTPASQEEH RPFEKVVNKE SLVISGLRHF TGYRIELQAC 780

NQDTPEARCS VAAYVSARTM PEAKADDIVG PVTHEIFENN VVHLMWQEPK EPNGLIVLYE 840

VSYRRYGDET QELHLCVSRK HFALERGCRL RGLSPGNYSV RIRATSLAGN GSWTEATYFY 900

VTDYLDVPSN IAKIIIGPLI FVFLFSVVIG SIYLFLRKRQ PDGPMGPLYA SSNPEYLSAS 960

DVYVPDEWEV PREKITLLRE LGQGSFGMVY EGNAKDIIKG EAETRVAVKT VNEAASLRER 1020

IEFLNEASVM KGFTCHHVVR LLGVVSKGQP TLVVMELMAH GDLKSYLRSL RPEAENNPGR 1080

PPPTLQEVIQ MAAEIADGMA YLNAKKFVHR DLAARNCMVA HDFTVKIGDF GMTRDIYETD 1140

YYRKGGKGLL PVRWMAPESL KDGVFTASSD MWSFGVVLWE ITSLAEQPYQ GLSNEQVLKF 1200

VMDGGYLEQP DNCPDTVTEL MRMCWQFNPK MRPTFLEIVN MLKDDLHPSF PEVSFFHSDE 1260

NKAPETEELE MEFEDMENVP LDRSSHCQRE EAGGREGGSS LGIKRNYEDH IPYTHMNGGK 1320

KNGRILTLPR SSPS 1334

Nucleotide Sequence
(FASTA)

GTGTGTCCCG GCATGGACAT CCGGAACAAC CTCACCAGGC TGCATGAACT GGAGAACTGC 60

TCCGTCATCG AGGGACACCT GCAGATCCTG CTGATGTTCA AAACCAGGCC CGAGGACTTC 120

CGGGACCTCA GCTTCCCCAA GCTCATCATC ATCACCGACT ACCTGCTGCT CTTCCGCGTC 180

TACGGGCTGG AGAGCCTCAA GGACCTGTTC CCCAACCTCA CGGTCATCCG CGGCTCCCGC 240

CTCTTCTTCA ACTACGCGCT GGTCGTCTTC GAGATGGTCC ACCTGAAGGA GCTGGGGCTC 300

TACAGCCTCA TGAACATCAC CCGGGGCTCC GTGCGCATCG AGAAGAACAA CGAGCTCTGC 360

TACCTGGCCA CCATCGACTG GTCCCGGATC CTCGACTCCG TGGAGGACAA CTACATTGTG 420

CTGAACAAAG ACGACAACGA GGAGTGCGGA GACATCTGCC CGGGCACCGC CAAGGGCAAG 480

ACCAACTGCC CCGCCACCGT CATCAATGGG CAGTTTGTCG AGCGGTGCTG GACGCACAGC 540

CATTGCCAGA AAGTTTGCCC GACCATCTGT AAGTCGCACG GCTGTACCGC CGAAGGGCTC 600

TGCTGCCACA GCGAATGCTT GGGCAACTGT TCCGAGCCCG ACGATCCCAC CAAGTGTGTT 660

GCCTGCCGCA ACTTCTACCT GGACGGCAGG TGCGTGGAGA CCTGCCCGCC CCCGTACTAC 720

CACTTCCAGG ACTGGCGCTG CGTAAACTTC AGCTTCTGCC AGGAGCTGCA CAACAGATGC 780

AAGAACTCGC GGCGCCCGGG CTGCCACCAG TACGTCATCC ACAACAACAA ATGCATCCCC 840

GAATGTCCTT CCGGCTACAC CATGAACTCC AGCAACTTGA TGTGTACCCC GTGCCTGGGC 900

CCCTGTCCCA AGGTCTGTCA CCTCCTAGAA GGCGAGAAGA CCATCGACTC GGTGACGTCG 960

GCCCAGGAGC TCCGAGGCTG CACCGTGGTC AACGGGAGCC TGATCATCAA CATCCGCGGG 1020

GGCAACAATC TGGCGGCTGA GCTGGAGGCC AACCTCGGCC TCATTGAAGA AATTTCAGGG 1080

TATCTCAAAA TCCGCCGATC CTACGCTCTG GTGTCCCTCT CCTTCTTCCG GAAGTTGCGT 1140

CTGATTCGAG GAGAGACGCT GGAGATCGGG AATTACTCTT TCTACGCCTT GGACAACCAG 1200

AACCTAAGGC AGCTCTGGGA CTGGAGCAAG CACAACCTCA CCATCACTCA GGGGAAACTC 1260

TTCTTCCACT ACAATCCCAA ACTCTGCCTG TCGGAAATTC ACAAGATGGA AGAAGTCTCC 1320

GGAACCAAGG GGCGCCAGGA GAGGAATGAC ATTGCCCTGA AGACCAACGG CGACCAGGCA 1380

TCTTGTGAAA ATGAATTACT TAAATTTTCT TTCATTAAGA CATCTTTTGA CAAGATCTTG 1440

CTGAAATGGG AGCCGTACTG GCCCCCTGAC TTCCGGGACC TCTTGGGATT TATGCTCTTC 1500

TACAAAGAGG CAAGCCCTTA TCAGAACGTG ACCGAGTTTG ACGGGCAGGA TGCCTGTGGC 1560

TCCAACAGCT GGACCGTGGT GGACATCGAC CCCCCTCAGA GGTCTAACGA CCCCAAGCCC 1620

CAACACCACC CCGGATGGCT GATGCGGGGT CTCAAGCCCT GGACACAGTA CGCCATCTTT 1680

GTCAAGACCT TGGTCACCTT TTCTGATGAG CGCCGGACCT ACGGGGCCAA GAGTGACATC 1740

ATCTATGTGC AGACGGATGC CACCAATCCT TCCGTCCCGC TGGATCCCAT CTCGGTTTCG 1800

AATTCCTCGT CTCAGATCAT CTTGAAGTGG AAGCCCCCCT CGGACCCCAA CGGCAACATC 1860

ACGCACTACC TGGTTTACTG GGAAAGGCAG GAGGAAGACA GTGAGCTGTA CGAGTTGGAT 1920

TATTGTCTCA AAGGCTTGAA GCTGCCTTCG CGCACATGGT CCCCGCCGTT CGAGTCGGAC 1980

GATTCTCAGA AGCACAATCA GAGCGAGTAC GAGGACTCGG CCGGGGAGTG CTGCACCTGC 2040

CCCAAGACCG ACTCGCAGAT TCTGAAGGAG CTGGAGGAGT CCTCGTTTCG GAAGACCTTT 2100

GAGGATTACC TGCACAACGT CGTCTTCGTC CCCAGACCGT CTCGGAAACG CAGGTCCCTG 2160

GGTGTGGAGG CGAACGTGAC GGAGCCCGTG CCCTCGGCCC CGGCGCTCCC CAGCAGCTCC 2220

CCCAGCACGC CCGCCAGCCA GGAGGAGCAC AGGCCCTTTG AGAAGGTGGT CAACAAGGAG 2280

TCGCTGGTCA TCTCGGGTCT GCGCCACTTC ACCGGCTACC GCATCGAGCT GCAGGCCTGC 2340

AACCAGGACA CGCCCGAGGC CAGGTGCAGC GTGGCCGCCT ACGTGAGCGC GCGCACCATG 2400

CCCGAAGCCA AGGCAGATGA CATCGTCGGC CCTGTGACCC ACGAAATCTT CGAGAACAAC 2460

GTTGTTCACT TGATGTGGCA AGAGCCCAAG GAGCCCAACG GTCTGATCGT GCTGTACGAA 2520

GTGAGCTACC GGCGCTACGG CGACGAGACA CAGGAGCTGC ATCTCTGTGT CTCCCGGAAG 2580

CACTTTGCTC TGGAGAGGGG CTGCAGGCTG CGTGGGCTGT CACCAGGGAA CTACAGCGTG 2640

CGCATCCGGG CCACCTCCCT GGCAGGCAAC GGCTCCTGGA CAGAAGCCAC GTATTTCTAC 2700

GTGACTGATT ATCTAGATGT GCCATCAAAT ATTGCCAAAA TCATCATTGG CCCCCTCATC 2760

TTTGTCTTTC TCTTCAGTGT TGTGATTGGA AGCATTTACC TATTCCTGAG AAAAAGGCAG 2820

CCAGACGGGC CGATGGGACC TCTCTATGCT TCTTCAAACC CTGAGTACCT CAGCGCCAGT 2880

GACGTGTATG TGCCGGACGA ATGGGAGGTG CCTCGGGAGA AGATCACCCT CCTGCGGGAG 2940

CTGGGGCAGG GCTCCTTCGG CATGGTGTAC GAGGGCAATG CCAAGGACAT CATCAAGGGC 3000

GAGGCGGAGA CCCGGGTGGC AGTGAAGACC GTCAACGAGG CAGCCAGTCT CCGGGAGCGG 3060

ATCGAGTTCC TCAACGAGGC CTCGGTCATG AAGGGCTTCA CCTGCCATCA TGTGGTCCGC 3120

CTCCTGGGGG TGGTGTCCAA GGGCCAGCCC ACGCTGGTGG TGATGGAGCT GATGGCTCAC 3180

GGAGACCTGA AGAGCTACCT CCGCTCTCTG AGGCCGGAGG CTGAGAATAA CCCCGGTCGC 3240

CCTCCCCCAA CCCTGCAAGA GGTGATTCAG ATGGCAGCAG AGATCGCAGA TGGGATGGCA 3300

TACTTGAATG CCAAGAAGTT TGTGCACCGG GACCTGGCAG CTCGAAACTG CATGGTCGCT 3360

CACGATTTTA CTGTCAAAAT TGGAGATTTT GGAATGACCA GAGACATCTA CGAAACGGAT 3420

TACTACCGGA AAGGGGGCAA GGGCCTGCTG CCCGTGCGGT GGATGGCACC CGAGTCCCTG 3480

AAGGACGGGG TCTTTACCGC TTCTTCTGAC ATGTGGTCCT TCGGTGTGGT CCTCTGGGAG 3540

ATCACCAGCC TGGCGGAACA GCCCTACCAA GGCCTATCTA ACGAGCAGGT GCTGAAGTTC 3600

GTCATGGACG GCGGGTACCT GGAGCAGCCC GACAACTGTC CAGATACAGT CACCGAGCTG 3660

ATGCGCATGT GCTGGCAGTT CAACCCCAAG ATGCGGCCCA CCTTCCTGGA AATCGTCAAC 3720

ATGCTCAAGG ATGACCTGCA CCCCAGCTTT CCAGAAGTTT CCTTCTTCCA CAGTGATGAG 3780

AACAAGGCTC CTGAGACTGA GGAGCTGGAG ATGGAGTTTG AGGACATGGA GAATGTCCCC 3840

TTGGATCGGT CCTCCCACTG TCAGAGGGAG GAGGCCGGGG GCCGGGAGGG AGGGTCCTCT 3900

CTGGGCATCA AGCGGAACTA TGAGGACCAC ATCCCCTACA CCCACATGAA CGGGGGCAAG 3960

AAGAACGGGC GGATTCTGAC CTTGCCCCGG TCCAGTCCCT CCTAA 4005

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+llrelGqGsfGmvyeG+akd++kge+etrva+ktvneaas reriefl+easvmk f+

Q: 975   ITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNEAASLRERIEFLNEASVMKGFT  1034

         789*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrpe+en+++++pp+l+++iqmaae

Q: 1035  CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEVIQMAAE  1094

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1095  IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1154

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+le+p+ncp

Q: 1155  MAPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLEQPDNCP  1214

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         +++telmr+cwq+npk+rp+fleiv++l

Q: 1215  DTVTELMRMCWQFNPKMRPTFLEIVNML  1242

         *************************976

Domain Sequence
(FASTA)

ITLLRELGQG SFGMVYEGNA KDIIKGEAET RVAVKTVNEA ASLRERIEFL NEASVMKGFT 60

CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEVIQMAAE 120

IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTASSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLEQPDNCP 240

DTVTELMRMC WQFNPKMRPT FLEIVNML 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 2.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013