EKS-ICT-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	548.7	1.9E-165	479	757	279

Status

Unreviewed

Ensembl Protein

ENSSTOP00000001054

UniProt Accession

I3LY43;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000001175	ENSSTOP00000001054	ENSSTOT00000001180

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

825

Protein Sequence
(FASTA)

SLWLASLPLS LPSFLSPLGS SSRPPWVAAA QPWGAPVEVE SLLVHPGDLL QLRCRLRDDV 60

QSINWLRDGV QLVESNRTRI TGEEVEVRDS VPADSGLYTC VTSSPSGSDT TYFSVNVSDA 120

LPSSEDDDDD DDSSSEEKET DNTKPNRMPV APYWTSPEKM EKKLHAVPAA KTVKFKCPSS 180

GTPNPTLRWL KNGKEFKPDH RIGGYKVRYA TWSIIMDSVV PSDKGNYTCI VENEYGSINH 240

TYQLDVVERS PHRPILQAGL PANKTVALGS NVEFMCKVYS DPQPHIQWLK HIEVNGSKIG 300

PDNLPYVQIL KHSGINSSDA EVLTLFNVTE AQSGEYVCKV SNYIGEANQS AWLTVTRPVA 360

KALEERPAVM TSPLYLEIII YCTGAFLISC MVGSVIIYKM KSGTKKSDFH SQMAVHKLAK 420

SIPLRRQVTV SADSSASMNS GVLLVRPSRL SSSGTPMLAG VSEYELPEDP RWELPRDRLV 480

LGKPLGEGCF GQVVLAEAIG LDKDKPNRVT KVAVKMLKCE ADATEKDLSD LISEMEMMKM 540

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREFLQARR PPGLEYCYNP SHNPEEQLSS 600

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 660

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 720

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI VALTSNQEYL DLSMPLDQYS 780

PSFPDTRSST CSSGEDSVFS HEPLPEEPCL PRHPTQLANG GLKRR 825

Nucleotide Sequence
(FASTA)

TCGCTGTGGC TAGCGTCACT CCCTTTGTCT CTCCCCTCCT TCCTCTCCCC TCTTGGTTCC 60

TCTTCCCGGC CCCCATGGGT GGCTGCAGCT CAGCCCTGGG GAGCCCCTGT GGAAGTGGAG 120

TCCCTCCTGG TCCACCCTGG TGACCTGCTG CAGCTTCGCT GTCGGCTGCG GGACGATGTG 180

CAGAGCATCA ACTGGCTGCG AGACGGGGTA CAGCTGGTGG AAAGCAACCG TACCCGCATC 240

ACAGGGGAGG AGGTGGAGGT GCGGGATTCC GTGCCCGCGG ACTCTGGCCT CTACACCTGT 300

GTGACCAGCA GCCCCTCTGG CAGCGACACC ACCTACTTCT CCGTCAATGT CTCAGATGCA 360

CTCCCCTCCT CGGAGGATGA CGATGACGAT GATGACTCCT CTTCAGAGGA GAAAGAGACA 420

GACAACACCA AACCAAACCG TATGCCCGTA GCTCCATATT GGACATCCCC AGAAAAGATG 480

GAAAAGAAAT TGCATGCCGT GCCAGCTGCC AAGACAGTGA AGTTCAAATG CCCTTCCAGT 540

GGGACACCTA ACCCCACACT GCGCTGGTTG AAAAATGGGA AAGAATTCAA ACCTGACCAC 600

AGGATTGGAG GCTACAAGGT CCGTTATGCC ACCTGGAGCA TCATAATGGA CTCTGTGGTA 660

CCTTCAGACA AAGGCAACTA CACCTGTATT GTGGAGAATG AGTATGGCAG CATTAACCAC 720

ACCTATCAGC TCGACGTCGT GGAGCGGTCC CCACATCGGC CTATCCTACA GGCAGGATTG 780

CCTGCCAACA AGACAGTGGC CCTGGGCAGC AATGTGGAGT TCATGTGTAA GGTGTACAGT 840

GACCCACAGC CCCACATCCA GTGGCTGAAG CACATCGAGG TGAATGGGAG TAAGATTGGT 900

CCAGACAACC TGCCTTATGT CCAGATCTTG AAGCATTCGG GGATTAATAG CTCGGATGCG 960

GAGGTGCTGA CCCTGTTCAA TGTGACAGAG GCCCAGAGCG GGGAGTATGT GTGTAAGGTT 1020

TCCAATTATA TTGGTGAAGC TAACCAGTCT GCGTGGCTCA CTGTCACCAG ACCTGTGGCA 1080

AAAGCCCTGG AAGAGAGACC GGCAGTGATG ACCTCGCCCC TGTACCTGGA GATCATCATC 1140

TACTGCACAG GGGCCTTCCT CATCTCCTGC ATGGTGGGCT CTGTCATCAT CTACAAGATG 1200

AAGAGTGGTA CCAAGAAGAG TGACTTCCAT AGCCAGATGG CCGTGCACAA GCTGGCCAAG 1260

AGCATCCCTC TGCGCAGACA GGTAACAGTG TCAGCTGACT CCAGTGCATC CATGAACTCT 1320

GGGGTACTTC TGGTTCGACC CTCTCGTCTC TCCTCCAGTG GGACCCCCAT GCTAGCTGGG 1380

GTCTCTGAAT ATGAGCTTCC TGAAGATCCC CGATGGGAGC TACCCAGAGA CAGACTGGTC 1440

TTAGGTAAAC CTCTGGGAGA AGGCTGCTTT GGGCAGGTGG TATTGGCAGA GGCCATTGGG 1500

CTGGACAAGG ACAAACCCAA CCGTGTGACC AAAGTGGCCG TGAAGATGTT GAAGTGTGAA 1560

GCGGATGCAA CAGAGAAGGA CCTGTCAGAC CTGATCTCAG AGATGGAAAT GATGAAGATG 1620

ATTGGGAAAC ACAAGAACAT CATCAACCTG CTGGGGGCCT GCACTCAAGA TGGTCCTTTG 1680

TACGTCATTG TGGAGTATGC TTCTAAGGGT AACCTGCGGG AGTTCCTGCA GGCCCGGAGG 1740

CCCCCGGGTC TGGAATACTG TTACAACCCC AGCCACAACC CAGAGGAACA GCTTTCCTCC 1800

AAGGACCTGG TATCCTGTGC CTATCAGGTG GCCCGAGGCA TGGAGTATCT TGCCTCCAAG 1860

AAGTGCATCC ACCGAGATCT AGCTGCCAGG AATGTCCTGG TGACAGAGGA CAATGTCATG 1920

AAGATTGCAG ACTTTGGCCT AGCTAGGGAC ATTCACCACA TCGACTACTA TAAAAAGACA 1980

ACCAACGGCC GGCTACCTGT TAAGTGGATG GCTCCTGAGG CACTGTTTGA CCGGATCTAT 2040

ACCCATCAGA GTGATGTGTG GTCTTTTGGG GTGCTCCTGT GGGAAATCTT CACTCTGGGT 2100

GGTTCCCCGT ATCCTGGTGT GCCTGTGGAG GAGCTTTTCA AGCTGCTGAA GGAAGGTCAT 2160

CGAATGGACA AACCCAGTAA CTGCACCAAC GAGCTGTACA TGATGATGCG GGACTGCTGG 2220

CATGCGGTGC CCTCTCAGAG ACCTACCTTC AAGCAGCTGG TGGAAGACCT GGACCGCATT 2280

GTGGCTTTGA CCTCCAATCA GGAGTATCTG GATCTGTCAA TGCCCCTAGA CCAGTACTCG 2340

CCCAGCTTTC CTGACACCCG AAGCTCTACC TGCTCCTCGG GGGAGGATTC CGTCTTCTCT 2400

CATGAGCCGT TGCCTGAGGA GCCCTGTCTG CCCCGACACC CTACCCAACT TGCCAATGGT 2460

GGACTCAAAC GACGCTGA 2478

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlk..edatdkdladlvsemevl  58

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk   dat+kdl+dl+seme++

Q: 479   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKceADATEKDLSDLISEMEMM  538

         79*************************************9444789**************

S: 59    kliGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeql  118

         k+iGkhkniinllGactq+Gplyviveya+kGnlrefl+arrp+g e+++++s+++eeql

Q: 539   KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREFLQARRPPGLEYCYNPSHNPEEQL  598

         ************************************************************

S: 119   tekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyyk  178

         ++kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyyk

Q: 599   SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK  658

         ************************************************************

S: 179   kttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllke  238

         kttnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllke

Q: 659   KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKE  718

         ************************************************************

S: 239   Ghrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         Ghrm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 719   GHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  757

         *************************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK CEADATEKDL SDLISEMEMM 60

KMIGKHKNII NLLGACTQDG PLYVIVEYAS KGNLREFLQA RRPPGLEYCY NPSHNPEEQL 120

SSKDLVSCAY QVARGMEYLA SKKCIHRDLA ARNVLVTEDN VMKIADFGLA RDIHHIDYYK 180

KTTNGRLPVK WMAPEALFDR IYTHQSDVWS FGVLLWEIFT LGGSPYPGVP VEELFKLLKE 240

GHRMDKPSNC TNELYMMMRD CWHAVPSQRP TFKQLVEDL 279

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013