EKS-ICT-00269

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00269

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	388.9	1.3E-116	203	501	299

Status

Unreviewed

Ensembl Protein

ENSSTOP00000002111

UniProt Accession

I3M095;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000002359	ENSSTOP00000002111	ENSSTOT00000002360

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1038

Protein Sequence
(FASTA)

MTSSLQRPWR VPWLPWAILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60

SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 120

DLCNVNFTEN FPPPDTTPIS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 180

QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240

INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300

SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG 360

NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC 420

TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480

EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MTTAMQNERN LSHNRRVPKI 540

GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTVG EKNRNSINYE RQQAQARIPS 600

PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETNL HAINVAQSIG PTPVCLQLTE 660

EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ 720

QDYTQAANGQ ACLIPDVPPT QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN 780

LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRNHSVNSHA ATTQYANGAV PSGQTANMVT 840

HRAQEMLQNQ FISEDTRLNI NSSPDEHEPL LRRDQQAGHD ESVLDRLVDR RERPLEGGRT 900

NSNNNNSNPC SEQDVLTQVV SSTVTDPGPS KPRRAQRPNS LDLSATNVLD GGSIQIGEST 960

QDGKSGSGEK IKKRVKTPYS LKRWRPSTWV ISTEPLDCEV NNNGSDRAVH SKSSTAVYLA 1020

EGGTATTMVS KDIGMNCL 1038

Nucleotide Sequence
(FASTA)

ATGACTTCCT CGCTGCAGCG GCCCTGGCGG GTGCCCTGGC TACCGTGGGC CATCCTGCTG 60

GTCAGCACTG CGGCCGCTTC CCAAAATCAA GAACGGCTAT GTGCATTTAA AGATCCATAT 120

CAACAAGACC TTGGGATAGG CGAGAGTCGA ATCTCTCATG AAAATGGGAC AATATTATGC 180

TCAAAAGGTA GCACCTGCTA TGGCCTTTGG GAAAAATCAA AAGGGGACAT AAATCTTGTA 240

AAACAAGGAT GTTGGTCTCA CATTGGAGAT CCTCAAGAGT GTCACTACGA AGAATGTGTA 300

GTAACTACCA CCCCTCCCTC AATTCAGAAT GGAACATATC GTTTTTGCTG CTGTAGCACA 360

GATTTATGTA ATGTCAACTT TACTGAGAAT TTTCCACCTC CTGACACAAC ACCAATCAGT 420

CCACCTCATT CATTTAACCG AGATGAGACA ATAATCATTG CTTTGGCATC TGTCTCTGTC 480

TTAGCTGTTT TGATAGTTGC CTTATGCTTC GGATACAGAA TGTTGACAGG AGACCGTAAA 540

CAAGGTCTTC ATAGTATGAA CATGATGGAG GCAGCAGCGT CAGAGCCCTC TCTTGATCTA 600

GATAATCTGA AACTGCTGGA GCTGATTGGC CGGGGTCGAT ATGGAGCAGT ATATAAAGGT 660

TCCTTGGATG AACGTCCAGT AGCTGTAAAA GTATTTTCTT TTGCAAACCG TCAGAATTTT 720

ATCAACGAAA AAAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCTCGCTTT 780

ATAGTTGGAG ATGAGAGAGT CACTGCAGAT GGACGCATGG AGTATTTGCT TGTGATGGAG 840

TATTATCCCA ATGGATCTCT TTGCAAGTAT TTGAGTCTCC ATACAAGTGA CTGGGTAAGC 900

TCTTGCCGTC TGGCTCATTC TGTGACTAGA GGACTGGCTT ATCTTCACAC AGAATTACCA 960

CGAGGAGATC ATTATAAGCC TGCAATTTCC CACCGAGATT TAAACAGCAG AAATGTCCTG 1020

GTGAAAAATG ATGGAACCTG TGTTATTAGT GACTTTGGGT TGTCCATGAG ACTGACTGGA 1080

AACAGACTGG TGCGCCCAGG GGAAGAAGAT AATGCAGCCA TAAGTGAGGT TGGCACAATT 1140

AGATATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAATC TGAGGGACTG TGAATCAGCT 1200

TTGAAACAAG TAGACATGTA TGCTCTTGGA TTAATCTATT GGGAGATATT TATGAGATGT 1260

ACAGACCTCT TCCCAGGTGA ATCTGTACCA GAATATCAGA TGGCTTTTCA GACAGAAGTT 1320

GGAAATCATC CTACTTTTGA AGATATGCAG GTTCTTGTAT CTAGGGAAAA ACAGAGACCC 1380

AAGTTTCCAG AAGCCTGGAA AGAAAATAGC CTGGCGGTGA GGTCACTCAA GGAGACAATT 1440

GAAGACTGTT GGGACCAGGA TGCAGAGGCT CGTCTTACTG CGCAGTGTGC TGAGGAAAGG 1500

ATGGCTGAAC TTATGATGAT ATGGGAAAGA AACAAATCTG TGAGCCCAAC AGTCAATCCC 1560

ATGACTACTG CTATGCAGAA TGAGCGCAAC CTGTCACATA ATAGGCGTGT GCCAAAAATT 1620

GGCCCTTATC CAGATTATTC TTCTTCCTCA TACATTGAAG ATTCTATCCA TCACACTGAC 1680

AGCATTGTGA AGAATATTTC CTCTGAGCAC TCAATGTCCA GCACACCTTT GACTGTAGGG 1740

GAAAAGAACC GTAATTCAAT AAATTATGAA CGACAGCAAG CACAAGCTCG AATCCCCAGC 1800

CCTGAAACGA GTGTCACCAG TCTGTCCACC AACACAACAA CCACAAACAC CACTGGTCTC 1860

ACTCCAAGTA CTGGTATGAC CACTATATCT GAGATGCCAT ACCCAGATGA AACAAATCTC 1920

CATGCCATAA ATGTTGCACA GTCAATTGGG CCAACCCCTG TCTGCTTACA GCTGACAGAA 1980

GAAGACTTGG AGACTAACAA GCTAGACCCA AAAGAAGTTG ACAAGAACCT CAAAGAAAGC 2040

TCTGATGAGA ATCTGATGGA GCATTCTCTT AAACAGTTCA GTGGGCCAGA CCCACTGAGT 2100

AGTACCAGTT CTAGCTTGCT TTACCCACTC ATAAAGCTTG CAGTAGAAGT GACTGGTCAG 2160

CAGGACTACA CCCAGGCTGC AAATGGCCAA GCATGTTTAA TTCCTGATGT TCCACCCACT 2220

CAGATATACC CTCTCCCTAA ACAACAGAAC CTTCCTAAGA GACCTACTAG TTTGCCTTTG 2280

AACACCAAAA ATTCAACAAA GGAGCCCCGG CTAAAATTTG GCAGCAAGCA CAAATCTAAC 2340

TTGAAACAAG TAGAAACTGG AGTTGCCAAG ATGAATACAA TCAATGCAGC AGAACCTCAT 2400

GTGGTGACAG TCACCATGAA TGGAGTAGCA GGTAGAAACC ACAGTGTTAA CTCCCATGCT 2460

GCCACAACCC AGTATGCCAA TGGGGCAGTT CCATCAGGCC AGACAGCCAA CATGGTGACA 2520

CATAGGGCCC AAGAAATGCT GCAGAATCAA TTTATTAGTG AGGATACCCG GCTGAATATT 2580

AATTCCAGTC CTGATGAGCA TGAACCTTTG CTAAGACGAG ACCAACAAGC TGGCCATGAT 2640

GAAAGTGTTC TAGATCGTCT TGTGGACAGG AGGGAACGGC CACTAGAAGG TGGCCGAACT 2700

AATTCCAATA ACAACAACAG TAATCCATGT TCAGAACAAG ATGTTCTTAC ACAGGTTGTT 2760

TCAAGCACAG TAACAGATCC AGGGCCATCA AAGCCCAGAA GAGCACAGAG GCCCAATTCT 2820

CTGGATCTTT CAGCCACAAA TGTCCTAGAT GGCGGCAGTA TACAGATAGG TGAGTCAACA 2880

CAAGATGGCA AATCAGGATC AGGTGAAAAG ATCAAGAAGC GTGTGAAAAC TCCCTATTCT 2940

CTTAAGCGAT GGCGCCCTTC CACCTGGGTC ATCTCCACTG AACCACTGGA CTGTGAGGTC 3000

AACAACAATG GCAGTGATAG GGCAGTTCAT TCCAAATCCA GCACCGCCGT TTACCTTGCA 3060

GAAGGAGGCA CTGCCACAAC CATGGTGTCT AAAGATATAG GAATGAATTG TCTGTGA 3117

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  262

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 263   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 323   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  441

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 442   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  501

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013