EKS-ICT-00216

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00216

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	380.7	3.6E-114	43	340	298

Status

Unreviewed

Ensembl Protein

ENSSTOP00000002113

UniProt Accession

I3M097;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000002366	ENSSTOP00000002113	ENSSTOT00000002362

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

371

Protein Sequence
(FASTA)

RANLVDLQKK LEELELDEQQ KKRLEAFLTQ KAKVGELKDD DFERISELGA GNGGVVTKVQ 60

HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ VLHECNSPYI VGFYGAFYSD GEISICMEHM 120

DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG LAYLREKHQI MHRDVKPSNI LVNSRGEIKL 180

CDFGVSGQLI DSMANSFVGT RSYMSPERLQ GTHYSVQSDI WSMGLSLVEL SIGRYPIPPP 240

DAKELEAIFG RPVGNGAEGE PHSTSPRPRP PGRPISVGHG MDSRPAMAIF ELLDYIVNEP 300

PPKLPSGVFS PHFQEFVHKC LIKNPAERAD LKMLMGHAFI KRSEAEEVDF AGWLCRTLRL 360

NQPSTPTRTA V 371

Nucleotide Sequence
(FASTA)

AGGGCAAACC TGGTGGACCT GCAGAAGAAG CTGGAGGAGC TGGAGCTAGA CGAGCAGCAA 60

AAGAAGCGGT TAGAGGCCTT CCTGACTCAG AAGGCCAAGG TTGGTGAGCT CAAGGACGAC 120

GACTTTGAAA GGATCTCAGA GCTGGGAGCT GGCAATGGCG GGGTGGTCAC GAAGGTCCAG 180

CACAGGCCAT CGGGCCTCAT CATGGCCAGA AAGCTGATCC ACCTGGAGAT CAAGCCAGCC 240

ATCCGGAACC AGATCATCCG CGAGCTTCAG GTCCTACATG AGTGCAACTC CCCGTACATC 300

GTGGGCTTCT ACGGCGCCTT CTACAGCGAC GGGGAGATCA GCATCTGCAT GGAGCACATG 360

GACGGGGGCT CCCTGGACCA GGTGTTGAAG GAGGCCAAGA GGATCCCCGA GGAGATCTTG 420

GGGAAGGTCA GCATTGCGGT TCTCCGGGGC CTGGCATACC TTCGAGAAAA GCATCAGATC 480

ATGCACCGAG ATGTGAAACC CTCCAACATC CTGGTCAACT CCAGAGGGGA GATCAAGCTG 540

TGCGACTTCG GGGTGAGCGG GCAGCTCATC GATTCCATGG CCAACTCCTT CGTGGGAACG 600

CGGTCCTACA TGTCTCCAGA GCGATTGCAA GGCACACACT ATTCGGTGCA GTCGGACATC 660

TGGAGCATGG GCCTGTCCTT GGTGGAGCTG TCTATCGGGA GGTACCCCAT TCCCCCACCC 720

GATGCCAAGG AGCTGGAGGC CATCTTCGGC AGGCCCGTGG GCAACGGTGC AGAAGGAGAG 780

CCCCACAGCA CCTCACCCCG GCCGAGACCC CCTGGGCGCC CCATCAGCGT AGGTCACGGG 840

ATGGACAGCC GGCCAGCCAT GGCCATCTTC GAGCTGCTGG ACTACATTGT GAATGAGCCA 900

CCTCCCAAGC TACCCAGTGG CGTGTTCAGC CCACACTTCC AGGAATTCGT GCATAAATGC 960

CTCATTAAGA ACCCAGCAGA ACGAGCAGAT CTGAAGATGC TCATGGGCCA TGCCTTCATC 1020

AAGCGCTCAG AGGCTGAAGA GGTGGACTTC GCCGGCTGGC TGTGCAGGAC CCTGCGGCTC 1080

AACCAGCCCA GCACACCCAC GCGCACCGCT GTG 1113

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+++elGaGnggvV+kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 43    ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  101

         789**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl+ek

Q: 102   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREK  157

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 158   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  216

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lvel +gryp++++++

Q: 217   QSDIWSMGLSLVELSIGRYPIPPPDAkeleaifgrpvgngaegephstsprprppgrpis  276

         ************************999*********************************

S: 208   ............ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellk  255

                     i+ell++ivne+ppklp+  fs++fqefv+kCl+k+++eR++lk+l+

Q: 277   vghgmdsrpamaIFELLDYIVNEPPPKLPSGVFSPHFQEFVHKCLIKNPAERADLKMLMG  336

         ************************************************************

S: 256   hafi  259

         hafi

Q: 337   HAFI  340

         **97

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVELSI GRYPIPPPDA KELEAIFGRP VGNGAEGEPH STSPRPRPPG RPISVGHGMD 240

SRPAMAIFEL LDYIVNEPPP KLPSGVFSPH FQEFVHKCLI KNPAERADLK MLMGHAFI 298

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013