EKS-ICT-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	330.7	6.4E-99	24	283	260

Status

Unreviewed

Ensembl Protein

ENSSTOP00000002186

UniProt Accession

I3M0F6;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK3

Gene Synonyms/Alias

RIPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000002445	ENSSTOP00000002186	ENSSTOT00000002444

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

MSCVKLWPNG ASAPVLPLEE LINPKYVGEG GFGSVFRAQH RTWGYDVAVK IVNSEAISRE 60

VKAMASLRNQ YVLLLLGVTE NLEWGYVSGP ALVTRFMENG SLAGLLQPEC PRPWPLLCRL 120

MQEVVLGMCY LHSLNPVLLH RDLKPSNVLL DPELHVKLAD FGLSTFQGGS QLGAGSKEPG 180

GTVSYLAPEL LANVNRKASL ASDVYSFGIL MWAMLAGREA EFVGKISLVQ EVVCEKQIRP 240

PLNEIPLPSP ETPGLEDLKE LMQHCWRSEP KDRPSFQECR PKTDKAFFLV QGKIDAAVSK 300

VKKFLSEQGS NNRTLSAPET SQRGTEMDGP GGATGSQFSW TDSTISEQLN KMNLEESPSS 360

VPEKSTSPPE GSRTQEEQIQ HARTARRSSD STTQIPQTPE TLPFRNQTRN PIFTRIPGPE 420

PQGNQGSKRY DANWSSRDPK SNPTTGSIIL DNCSAVQIGS NNSLIIQERT TLPKQGPTPF 480

SMGRGEPPQK IDSKEGLPKL EDSSEPQSQH NHNGN 515

Nucleotide Sequence
(FASTA)

ATGTCTTGCG TCAAGCTTTG GCCCAACGGT GCCTCCGCCC CCGTGCTGCC TCTCGAGGAA 60

TTGATAAACC CAAAGTATGT CGGCGAAGGC GGCTTCGGCT CAGTGTTCCG GGCACAGCAC 120

AGGACGTGGG GCTATGATGT GGCAGTCAAG ATCGTGAACT CGGAGGCGAT ATCGAGGGAG 180

GTGAAAGCCA TGGCAAGTCT TCGTAATCAA TACGTGTTGC TCCTGCTGGG GGTCACCGAG 240

AACCTGGAGT GGGGCTACGT GTCCGGACCA GCTCTGGTGA CCCGATTCAT GGAGAATGGC 300

TCCCTGGCTG GGCTATTGCA GCCAGAGTGC CCTCGGCCCT GGCCACTCCT TTGCCGCCTG 360

ATGCAGGAAG TGGTGCTGGG AATGTGTTAT CTGCACAGCC TGAACCCAGT GCTCCTGCAC 420

CGGGACCTCA AGCCCTCCAA CGTCCTGCTG GACCCAGAGC TGCATGTCAA GCTGGCAGAT 480

TTTGGGCTGT CCACATTTCA GGGAGGGTCA CAGTTAGGGG CAGGGTCCAA GGAACCTGGA 540

GGTACGGTGT CATACTTGGC CCCAGAACTG CTTGCTAATG TAAACCGGAA GGCCTCCCTG 600

GCCAGTGATG TCTACAGCTT TGGAATCCTC ATGTGGGCAA TGCTAGCTGG AAGAGAAGCT 660

GAATTTGTGG GAAAGATATC ACTGGTGCAA GAAGTAGTAT GTGAGAAGCA GATCCGGCCC 720

CCATTGAATG AGATACCACT GCCCAGCCCT GAGACTCCTG GCTTGGAAGA TCTGAAGGAA 780

TTAATGCAGC ACTGCTGGAG ATCTGAGCCC AAGGACAGGC CATCCTTCCA GGAATGTCGA 840

CCAAAAACTG ATAAGGCCTT CTTCCTGGTC CAGGGAAAGA TAGATGCTGC TGTCTCCAAG 900

GTGAAGAAGT TTCTGTCTGA GCAAGGAAGC AACAACAGGA CGTTGTCTGC CCCAGAAACA 960

AGTCAAAGAG GGACAGAAAT GGATGGCCCT GGGGGAGCCA CAGGAAGCCA GTTCTCTTGG 1020

ACTGATTCCA CAATTTCTGA GCAGCTGAAC AAGATGAATC TGGAGGAGTC CCCCAGCTCA 1080

GTCCCTGAAA AATCCACAAG CCCTCCTGAG GGGAGTAGGA CACAGGAAGA GCAGATTCAG 1140

CATGCCAGGA CAGCAAGAAG ATCTTCAGAT TCAACGACTC AAATTCCCCA AACACCGGAG 1200

ACCTTACCTT TCAGAAACCA GACGCGCAAC CCTATCTTCA CTAGGATTCC AGGTCCTGAA 1260

CCACAAGGGA ATCAGGGATC TAAGAGATAT GATGCCAACT GGTCTTCCAG AGACCCAAAG 1320

TCAAATCCAA CAACAGGGTC TATTATCTTA GACAATTGCT CTGCGGTGCA GATTGGAAGC 1380

AACAATTCCT TGATCATACA AGAGAGAACT ACATTGCCTA AGCAGGGCCC AACACCCTTC 1440

AGCATGGGTA GGGGCGAACC CCCCCAAAAA ATAGATTCAA AAGAAGGCTT GCCAAAACTT 1500

GAAGACTCCA GTGAGCCACA GAGCCAGCAT AATCACAATG GGAATTAA 1548

Domain Profile

S: 4     lelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsyvlk  63

          ++vg+Ggfg vf+a+hr+w+++vavk         +++++++++e+k+m++lr++yvl

Q: 24    PKYVGEGGFGSVFRAQHRTWGYDVAVK---------IVNSEAISREVKAMASLRNQYVLL  74

         689************************.........999*********************

S: 64    llGvikeeek.....lglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyLhsl  118

         llGv+++ e+      +lv+++menGsL++lL+ e+++pwpl +R+++evvlgm+yLhsl

Q: 75    LLGVTENLEWgyvsgPALVTRFMENGSLAGLLQPECPRPWPLLCRLMQEVVLGMCYLHSL  134

         ************9999********************************************

S: 119   kPpllhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevsssaegGtlaYlaPelle  178

         +P+llh+DLkp+n+LlD+elhvk+aDfGls+f ++ sq    s+++ gGt++YlaPell

Q: 135   NPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQLGAGSKEP-GGTVSYLAPELLA  192

         ********************************.************9.*************

S: 179   evnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseelPre  238

         +vn+kas +sDvYsf+i++Wa+la++e++   k sl+ ++v++k+ RP l+e++  +P e

Q: 193   NVNRKASLASDVYSFGILMWAMLAGREAEFVGKISLVQEVVCEKQIRPPLNEIPLPSP-E  251

         **********************************************************.7

S: 239   vpq...lieLmkrcWeadpeeRPsFleieekt  267

         +p+   l+eLm++cW+++p++RPsF+e+++kt

Q: 252   TPGledLKELMQHCWRSEPKDRPSFQECRPKT  283

         787778**********************9986

Domain Sequence
(FASTA)

PKYVGEGGFG SVFRAQHRTW GYDVAVKIVN SEAISREVKA MASLRNQYVL LLLGVTENLE 60

WGYVSGPALV TRFMENGSLA GLLQPECPRP WPLLCRLMQE VVLGMCYLHS LNPVLLHRDL 120

KPSNVLLDPE LHVKLADFGL STFQGGSQLG AGSKEPGGTV SYLAPELLAN VNRKASLASD 180

VYSFGILMWA MLAGREAEFV GKISLVQEVV CEKQIRPPLN EIPLPSPETP GLEDLKELMQ 240

HCWRSEPKDR PSFQECRPKT 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>