EKS-ICT-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	246.6	2.3E-73	49	311	263

Status

Unreviewed

Ensembl Protein

ENSSTOP00000002339

UniProt Accession

I3M0R8;

Protein Name

Protein Synonyms/Alias

Gene Name

STK11

Gene Synonyms/Alias

STK11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000002617	ENSSTOP00000002339	ENSSTOT00000002615

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

439

Protein Sequence
(FASTA)

MDVADPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY 60

GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHRNV IQLVDVLYNE 120

EKQKCPTYMV MEYCVCGMQE MLDSVPEKRF PVCQAHGYFC QLIDGLEYLH SQGIVHKDIK 180

PGNLLLTTSG TLKISDLGVA EALHPFAADD TCRTSQGSPA FQPPEIANGL DTFSGFKVDI 240

WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGDYTIPGDC GPPLSDLLKG MLEYEPTKRF 300

SIRQIRQHSW FRKKHPLAEA LVPIPPSPDT KDRWRSMTVV PYLEDLHGRT DEDEDEDLFD 360

IEDGIIYTQD FTVPGQVPEE EASQNGQSHS LPKAVCMNGT ESAQLSSKTK VECRASATNP 420

ARKACSSSKI RRLSACKQQ 439

Nucleotide Sequence
(FASTA)

ATGGACGTGG CGGACCCGCA GCAGCTGGGC ATGTTCACGG AGGGCGAGCT GATGTCCGTG 60

GGCATGGACA CCTTCATCCA CCGCATCGAC TCCACGGAGG TCATCTACCA GCCCCGCCGC 120

AAGCGGGCCA AACTCATCGG CAAGTACCTG ATGGGGGACT TGCTGGGGGA GGGCTCCTAC 180

GGCAAGGTGA AGGAGGTGCT GGACTCGGAG ACGCTGTGCC GGAGGGCCGT CAAGATCCTC 240

AAGAAGAAGA AGTTGCGGCG GATCCCCAAC GGGGAGGCCA ACGTGAAGAA GGAGATCCAG 300

CTCCTGAGGC GTCTGCGGCA CAGAAACGTC ATCCAGCTGG TAGACGTGCT GTACAACGAG 360

GAGAAGCAAA AGTGCCCCAC GTATATGGTG ATGGAGTACT GCGTGTGTGG CATGCAGGAG 420

ATGCTGGACA GTGTGCCCGA GAAGCGCTTC CCTGTGTGCC AAGCCCACGG GTACTTCTGC 480

CAGCTCATCG ACGGACTGGA GTACCTGCAC AGCCAGGGTA TCGTGCACAA GGACATCAAA 540

CCCGGTAATC TGCTGCTCAC CACCAGTGGC ACACTCAAGA TCTCTGACCT GGGTGTCGCG 600

GAGGCCCTGC ACCCTTTTGC TGCGGATGAC ACTTGCCGGA CAAGCCAGGG CTCCCCAGCA 660

TTCCAGCCAC CTGAAATTGC CAATGGCCTG GACACCTTCT CTGGCTTCAA GGTGGACATC 720

TGGTCAGCTG GAGTCACACT CTACAACATC ACAACGGGCC TGTACCCATT TGAAGGGGAC 780

AACATCTACA AGCTGTTCGA GAACATTGGG AAGGGGGACT ACACGATCCC GGGTGACTGT 840

GGCCCCCCGC TCTCTGACCT GCTCAAAGGG ATGCTGGAGT ACGAGCCCAC CAAGAGGTTC 900

TCCATACGGC AGATCCGGCA GCACAGCTGG TTCCGGAAGA AGCATCCACT GGCAGAGGCC 960

TTGGTGCCCA TCCCGCCCAG CCCAGACACC AAGGACCGCT GGCGCAGCAT GACAGTCGTG 1020

CCCTACCTGG AGGACCTACA TGGCCGCACT GATGAGGATG AGGATGAGGA CCTCTTTGAC 1080

ATTGAGGATG GCATCATCTA CACCCAGGAC TTCACCGTGC CTGGACAGGT CCCAGAAGAG 1140

GAGGCCAGTC AGAATGGACA GAGCCACAGC TTGCCCAAGG CTGTGTGCAT GAACGGCACA 1200

GAGTCCGCGC AGCTGAGCTC CAAGACCAAG GTGGAGTGCC GGGCCAGTGC CACCAACCCT 1260

GCCCGCAAAG CCTGCTCCAG CAGCAAGATC CGCCGACTCT CAGCCTGCAA GCAGCAGTGA 1320

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+

Q: 49    YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHR  108

         778999******************************965334567***************

S: 59    niikllevi..etkkk..lylvleyasgg..eLfdyieekgrlkekearklfkqlvsavk  112

         n+i+l++v+  e+k+k  +y+v+ey+  g  e++d +  ++r++  +a+ +f ql+++++

Q: 109   NVIQLVDVLynEEKQKcpTYMVMEYCVCGmqEMLDSV-PEKRFPVCQAHGYFCQLIDGLE  167

         ********95533333347******998888*****6.8899******************

S: 113   YlhskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPell  169

         Ylhs+givH+D+Kp Nlll++++++ki+D+G+a+    f  +++++t++Gsp++++Pe+

Q: 168   YLHSQGIVHKDIKPGNLLLTTSGTLKISDLGVAEalhPFAADDTCRTSQGSPAFQPPEIA  227

         *********************************955556778******************

S: 170   kg.kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesL  228

         +g ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg+++ip  + + l++L

Q: 228   NGlDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYTIPGDCGPPLSDL  287

         99899*******************************************************

S: 229   lrklLvvdpekRatieeilkhewl  252

         l+ +L+ +p+kR++i++i++h+w+

Q: 288   LKGMLEYEPTKRFSIRQIRQHSWF  311

         ***********************7

Domain Sequence
(FASTA)

YLMGDLLGEG SYGKVKEVLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHR 60

NVIQLVDVLY NEEKQKCPTY MVMEYCVCGM QEMLDSVPEK RFPVCQAHGY FCQLIDGLEY 120

LHSQGIVHKD IKPGNLLLTT SGTLKISDLG VAEALHPFAA DDTCRTSQGS PAFQPPEIAN 180

GLDTFSGFKV DIWSAGVTLY NITTGLYPFE GDNIYKLFEN IGKGDYTIPG DCGPPLSDLL 240

KGMLEYEPTK RFSIRQIRQH SWF 263

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013