EKS-ICT-00369

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00369

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	348.8	2.2E-104	1289	1547	259

Status

Unreviewed

Ensembl Protein

ENSSTOP00000002540

UniProt Accession

I3M176;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000002821	ENSSTOP00000002540	ENSSTOT00000002839

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1554

Protein Sequence
(FASTA)

RQAYTLGDSA CKSPESDPED FSDEANTEHP YGTSPPSTPR QMKRMSAKHQ RNNVGRPISR 60

SYLKEKANAS NQPPHKDTGK TVENVEEYSY KQDKKIRATL RTTERDHKKN VQCSFMLDSV 120

SGSLPKKSIP DVDLNKPYLS LGCSNAKLPV SVPMPIARTA RQTSRTDCPA DRLKFFETLR 180

LLLKLTSVSK KKDREQRGQE NTSAFWFNRS NELIWLELQA WHAGRTINDQ DLFLYTARQA 240

IPDIINEILT FKVNYGSFAF VRNGASFNGT SIEGQCKAPH GTKNMGYSTY HEHLQRQRVS 300

FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT KDLNQKLRIM 360

GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EDEGEDTEGE LKELESSADE SEEERISHPK 420

VPEVRPSVDS GFHVQSRDCV SKKLERLESE EESVGWGAAD YSTEAGFSRH CLTSIYRPFV 480

DKALKQMGLR KLILRLHKLM DGSLQRARLA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP 540

SSEQKHSAVS WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ 600

LVRECKEVLK GGLLMKQYYQ FMLQEVLNDL EKADCNIDAF EEDLHKMLMV YFDYMRSWIQ 660

MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL FCDIAGMLLK STGSFLEFGL 720

QESCAEFWTS ADDSSASDEI RRSVIEISRA LKELFHEARE RASKALGFAK MLRKDLEIAA 780

EFILSAPVRN LLDVLKAKQY VKVQIPGLEN LQVFVPDSLA EEKSIVLQLL NAAAGKDCAK 840

DPDDVLMDAY LLLTKPSDRA RDSDGGWGTW DAQPVKLVPQ VETVDTLRSM QVDNLLLVVM 900

QSAHLTMHRK SFQQSIEGLM TLRQEQTSSQ PVIARALQQL KNDALELCNR ISDAIDQVDH 960

MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV VRLMSGEFRQ KIGDKYISFA 1020

RKWMNYVLTK CESGRGTRPR WATQGFDFLQ AIEPAFISAL PEDDFLSLQA LMNECIGHVI 1080

GKPHSPVTAI HRNSPRPVKV PRCHSDPPNP HLIIPTPEGF SARSVTSDGR SHGSPAAAPV 1140

AATATTTTGR LAPCGSDSVP LKPISSAPDT RGSSVPENDR LASIAAELQF RSLSRHSSPT 1200

EERDEPAYPR GDSSGSTRRS WELRTLISQT KDSASKQGPI EAIQKSVRLF EERRYREMRR 1260

KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY GKVYTCISVD TGELMAMKEI 1320

RFQPNDHKTI KETADELKIF EGIKHPNLVR YFGVELHREE MYIFMEYCDE GTLEEVSRLG 1380

LQEHVIRLYS KQITIAINVL HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT 1440

MPGEVNSTLG TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI 1500

MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC TDEE 1554

Nucleotide Sequence
(FASTA)

AGGCAAGCAT ACACATTGGG AGATTCAGCT TGCAAGAGTC CTGAATCTGA TCCTGAGGAC 60

TTTTCTGATG AAGCAAACAC AGAACATCCG TATGGCACCT CTCCTCCCAG CACTCCTCGA 120

CAGATGAAAC GAATGTCAGC CAAACACCAG AGGAATAATG TAGGGAGGCC AATTAGTCGA 180

TCTTATTTGA AAGAAAAAGC GAATGCATCA AATCAGCCTC CACATAAAGA CACTGGGAAA 240

ACAGTGGAGA ATGTGGAAGA ATATAGCTAT AAGCAAGATA AAAAGATCCG AGCAACTCTT 300

AGAACAACAG AGCGTGATCA TAAGAAAAAT GTACAGTGCT CATTCATGTT AGACTCAGTG 360

AGTGGGTCTT TGCCAAAAAA ATCAATTCCA GATGTGGATC TCAACAAGCC TTACCTCAGC 420

CTTGGCTGTA GCAACGCCAA GCTCCCAGTT TCTGTGCCCA TGCCTATAGC CAGGACCGCA 480

CGCCAGACTT CCAGGACTGA CTGCCCTGCA GATCGTTTAA AGTTTTTTGA AACCCTACGA 540

CTTCTGCTAA AGCTTACCTC AGTCTCAAAG AAGAAGGATA GGGAGCAAAG AGGACAAGAA 600

AATACTTCTG CTTTTTGGTT TAACCGATCA AATGAACTGA TTTGGTTAGA GCTACAAGCC 660

TGGCATGCAG GACGGACCAT TAATGACCAG GACCTCTTTT TATATACAGC CCGTCAAGCC 720

ATCCCAGATA TTATCAATGA AATCCTTACT TTCAAGGTTA ATTATGGAAG CTTTGCCTTT 780

GTTAGAAATG GGGCTAGTTT CAATGGTACT TCAATAGAAG GGCAGTGCAA AGCTCCTCAT 840

GGAACAAAGA ATATGGGTTA CTCAACATAC CATGAGCACC TCCAGCGCCA GAGGGTCTCA 900

TTTGAGCAGG TAAAACGGAT AATGGAGCTG TTGGAATATA TAGAAGCACT TTATCCATCG 960

CTGCAGGCTC TCCAAAAGGA CTATGAAAAA TATGCTGCAA AAGACTTCCA GGACAGGGTG 1020

CAGGCACTCT GTTTGTGGTT AAACATCACA AAAGACTTAA ACCAGAAACT GCGGATTATG 1080

GGCACTGTTT TGGGTATCAA GAATTTATCC GACATTGGCT GGCCAGTGTT TGAAATCCCT 1140

TCCCCTCGAC CATCCAAAGG TAATGAGCCG GAAGATGAGG GCGAGGACAC AGAGGGAGAA 1200

TTGAAGGAAT TGGAAAGTAG TGCAGATGAA AGTGAAGAAG AGCGAATCTC CCACCCGAAG 1260

GTACCAGAAG TCAGGCCGTC TGTAGACAGC GGTTTCCATG TCCAGTCACG AGACTGTGTG 1320

TCCAAGAAGC TTGAGAGACT GGAATCTGAG GAGGAGTCTG TGGGCTGGGG AGCGGCAGAC 1380

TACAGCACCG AAGCGGGCTT CAGTAGACAT TGTCTGACTT CTATTTATAG GCCTTTTGTA 1440

GACAAAGCCC TGAAGCAGAT GGGGTTAAGA AAATTAATCT TAAGACTTCA CAAGCTGATG 1500

GATGGCTCCT TGCAAAGGGC ACGCCTAGCA CTGGTAAAGA ATGATCGTCC AGTGGAGTTT 1560

TCTGAATTTC CAGATCCCAT GTGGGGTTCA GATTACGTGC AACTATCAAG GACACCACCT 1620

TCCTCGGAGC AGAAACACAG TGCTGTGTCC TGGGAAGAGC TGAAGGCTAT GGACTTGCCC 1680

TCCTTCGAAC CTGCCTTTTT AGTACTTTGC CGAGTCCTGC TGAACGTCAT TCATGAGTGT 1740

CTGAAGCTGC GACTGGAACA GAGACCCGCT GGAGAGCCAT CTCTCCTGAG TATCAAGCAG 1800

CTGGTGAGGG AGTGTAAAGA GGTCCTCAAA GGTGGCCTTT TGATGAAGCA GTACTACCAG 1860

TTCATGCTGC AGGAGGTTCT AAATGACTTG GAGAAGGCCG ACTGCAACAT TGATGCCTTC 1920

GAAGAGGATC TGCATAAGAT GTTGATGGTA TATTTTGATT ACATGAGAAG CTGGATCCAA 1980

ATGCTACAGC AATTACCTCA AGCATCCCAT AGTTTAAAAA ATCTGTTAGA AGAAGAATGG 2040

AATTTCACCA AAGAAATAAC TCATTACATA CGGGGAGGAG AGGCACAGGC TGGAAAACTC 2100

TTCTGTGACA TCGCAGGGAT GCTGCTGAAA TCCACAGGGA GCTTTCTGGA ATTTGGCTTG 2160

CAGGAGAGCT GTGCCGAGTT TTGGACCAGT GCTGACGACA GCAGTGCCTC AGATGAAATA 2220

AGGAGGTCTG TTATAGAGAT CAGTCGGGCA CTCAAGGAGC TTTTCCACGA AGCCAGAGAA 2280

AGAGCCTCAA AAGCACTTGG ATTTGCTAAA ATGTTGAGGA AGGACCTGGA AATAGCAGCA 2340

GAATTTATCC TCTCAGCCCC GGTTAGAAAC CTACTAGATG TTCTAAAAGC AAAACAGTAC 2400

GTGAAGGTAC AGATTCCTGG CTTGGAGAAC TTGCAAGTGT TTGTTCCGGA CTCTCTGGCT 2460

GAGGAGAAGA GCATCGTCTT GCAGTTGCTC AACGCTGCTG CAGGGAAGGA CTGTGCAAAG 2520

GACCCAGACG ACGTGCTCAT GGATGCCTAC CTGCTTCTGA CCAAGCCCAG TGACCGGGCC 2580

CGGGACTCAG ACGGTGGCTG GGGCACCTGG GACGCACAGC CTGTTAAGCT AGTGCCTCAG 2640

GTGGAGACCG TGGATACCCT GAGAAGTATG CAGGTGGACA ATCTTTTACT AGTTGTCATG 2700

CAGTCAGCTC ATCTCACGAT GCACAGAAAA TCCTTCCAGC AGTCCATTGA GGGGCTTATG 2760

ACTCTACGCC AGGAACAAAC GTCCAGTCAG CCAGTCATTG CCAGAGCTTT GCAGCAGCTC 2820

AAGAATGACG CACTAGAGCT CTGCAACAGA ATAAGTGATG CCATTGACCA AGTAGACCAC 2880

ATGTTCACCT CCGAGTTTGA TGCCGAAGTT GATGAATCTG AATCTGTCAC CTTGCAGCAG 2940

TATTACCGAG AAGCAATGAT TCAGGGTTAC AATTTTGGGT TCGAGTACCA TAAAGAAGTT 3000

GTTCGTTTGA TGTCTGGAGA GTTCAGACAG AAGATAGGAG ACAAATACAT AAGCTTTGCC 3060

CGGAAATGGA TGAATTATGT CCTGACTAAA TGTGAGAGTG GTAGAGGTAC AAGACCCAGG 3120

TGGGCAACTC AAGGATTTGA TTTTCTGCAA GCCATTGAAC CTGCCTTTAT TTCAGCTCTG 3180

CCAGAAGATG ACTTCTTGAG CCTACAAGCC TTGATGAACG AATGCATCGG CCACGTCATA 3240

GGAAAGCCAC ACAGTCCTGT TACAGCTATT CATCGGAACA GCCCCCGTCC TGTGAAGGTA 3300

CCTCGATGCC ATAGTGACCC TCCTAACCCA CATCTAATTA TCCCAACGCC AGAGGGATTC 3360

AGCGCTCGGA GCGTGACTTC GGATGGGCGG AGCCATGGCA GCCCAGCTGC TGCTCCTGTT 3420

GCTGCCACTG CCACCACTAC CACCGGCCGC CTGGCTCCCT GTGGTAGCGA CTCTGTGCCA 3480

CTCAAACCCA TCAGCAGTGC CCCTGATACC AGGGGTTCCA GCGTCCCTGA AAATGATCGA 3540

CTGGCTTCCA TAGCTGCTGA ATTGCAGTTT AGGTCTCTGA GTCGTCACTC AAGCCCCACA 3600

GAGGAGCGAG ACGAACCAGC ATATCCAAGA GGTGATTCAA GTGGGTCAAC AAGAAGAAGT 3660

TGGGAACTTC GGACACTTAT TAGCCAGACC AAAGATTCTG CTTCTAAACA AGGACCCATA 3720

GAAGCTATCC AGAAATCAGT CCGATTGTTT GAAGAAAGGC GGTATCGAGA AATGAGGAGA 3780

AAAAATATCA TTGGTCAAGT TTGTGATACC CCTAAATCCT ATGATAATGT CATGCATGTT 3840

GGCTTGAGGA AGGTGACCTT CAAATGGCAA AGAGGAAACA AAATTGGAGA AGGACAGTAT 3900

GGGAAGGTTT ACACCTGCAT CAGTGTGGAC ACGGGGGAGC TGATGGCCAT GAAGGAGATT 3960

CGATTTCAGC CAAATGACCA TAAAACCATC AAGGAGACTG CAGACGAATT GAAGATATTT 4020

GAGGGCATCA AGCACCCCAA TCTGGTTCGG TACTTTGGTG TGGAGCTGCA CAGAGAAGAA 4080

ATGTACATCT TCATGGAGTA CTGTGACGAG GGCACATTAG AAGAGGTGTC AAGACTGGGG 4140

CTCCAGGAGC ATGTCATCAG GCTGTATTCA AAGCAGATCA CCATCGCCAT CAACGTCCTC 4200

CATGAGCATG GCATAGTTCA CCGTGACATT AAAGGTGCCA ATATCTTTCT TACCTCATCT 4260

GGACTCATCA AATTGGGAGA TTTTGGATGC TCAGTAAAGC TTAAAAACAA TGCCCAGACC 4320

ATGCCTGGTG AAGTGAATAG CACACTGGGG ACAGCAGCAT ACATGGCACC TGAAGTCATT 4380

ACCCGTGCTA AAGGAGAAGG CCACGGACGT GCAGCAGACA TCTGGAGTCT GGGCTGCGTT 4440

GTCATAGAGA TGGTGACAGG CAAGAGGCCT TGGCATGAAT ATGAACACAA TTTTCAGATT 4500

ATGTATAAAG TGGGAATGGG ACATAAGCCC CCAATTCCTG AAAGATTAAG CCCTGAGGGA 4560

AAGGACTTTC TCTCTCACTG CCTGGAAAGT GACCCGAAGA TGAGGTGGAC GGCCAGCCAG 4620

CTCCTCGACC ATTCTTTTGT CAAGGTTTGC ACAGATGAAG AGTGA 4665

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1289  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1345

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1346  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEH  1403

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1404  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1463

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd

Q: 1464  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1522

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle+dpk r++a++LL+h+f+

Q: 1523  FLSHCLESDPKMRWTASQLLDHSFV  1547

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITIAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240

ESDPKMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013