EKS-ICT-00383
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00383
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR584.57.9E-176596929334
StatusUnreviewed
Ensembl ProteinENSSTOP00000002636
UniProt AccessionI3M1E7;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000002925ENSSTOP00000002636ENSSTOT00000002947
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length976
Protein Sequence
(FASTA)
IFSIMIFETI TNQDLPVIKC VLITHKNNDS SVEKSSSYPM VPESPEDLGC TLRPESRTGA 60
VYEAATVEVD VSSSITLQVL VNIPGNISCL WVFKHNSLSC QPHFDLHNRG VISMVIVKMT 120
ETQAGEYLLF IQSEATNYTI LFTVSIRNTL LYTLRRPYFR KMENQDALVC ISESVPEPIV 180
EWVFCDSQGE SCQEESPAVV KKEEKVLHEL FGTDIRCCAR NELGRECTKL FTIDLNQTPQ 240
TTLPQLFLKV GEPLWIRCKA IHVNHGFGLT WELENKVLEE GSYFEMSTYS RNRTMIRILF 300
AFVSSVGRND TGYYTCSSSE HPSQSALVTI LEKGFINVTN SSEDYEIDQY EDFCFSVRFK 360
AYPQIRCTWT FSRKSFPCEQ RGLEDGYSIS KFCNHKHQPG EYIFHAENDD AQFTKMFTLN 420
IKRKPQVLAE TSASQASCSS DGYPLPSWTW KKCLDKSPNC TEEITEGIWN KKANRKVFGQ 480
WISSSTLNMS EAVKGFLVKC CAYNSMGTSC ETILLNSPGP FPFIQDNISF YATIGLCLPF 540
IAVLTILICH KYKKQFRYES QLQMVQVTGS LDNEYFYIDF REYEYDLKWE FPRENLEFGK 600
VLGSGAFGKV MNATAYGISK TGVSIQVAVK MLKEKADSSE KEALMSELKM MTHLGHHENI 660
VNLLGACTLS GPIYLIFEYC CYGDLLNYLR NKREKFHRTW TEIFKEHNFS FYPTFQSHPN 720
SSMPGSREVQ IHQDSDQVSG FNGNSIHSED EVEYENQKRL EEEEDLNVLT FEDLLCFAYQ 780
VAKGMEFLEF KSCVHRDLAA RNVLVTHGKV VKICDFGLAR DILSDSNYVV RGNARLPVKW 840
MAPESLFEGI YTIKSDVWSY GILLWEIFSL GVNPYPGIPV DANFYKLIQS GFKMDQPFYA 900
TEEIYFIMQS CWAFDSRKRP SFPNLTSFLG CQLADAEEAM YQNMDGHISG RASVYQNKRP 960
LGREVDLEPP SPQAQV 976
Nucleotide Sequence
(FASTA)
ATTTTCTCCA TAATGATATT TGAGACTATT ACCAATCAAG ATTTGCCTGT GATTAAATGT 60
GTTTTAATCA CTCATAAGAA CAATGATTCA TCTGTTGAGA AGTCGTCATC GTATCCCATG 120
GTACCAGAAT CCCCAGAAGA CCTGGGGTGT ACCTTGAGGC CTGAGAGTCG GACAGGGGCA 180
GTGTATGAAG CTGCTACCGT GGAAGTAGAT GTATCTTCAT CCATCACGCT GCAAGTGTTG 240
GTCAACATCC CGGGGAACAT TTCCTGTCTC TGGGTCTTTA AACACAATTC CCTGAGTTGC 300
CAGCCACACT TTGATTTACA CAACAGAGGA GTTATTTCCA TGGTCATTGT GAAAATGACA 360
GAGACCCAAG CTGGAGAATA CCTACTTTTT ATTCAGAGTG AAGCTACCAA TTACACAATA 420
TTGTTTACAG TGAGTATAAG AAATACACTG CTTTACACAT TAAGAAGACC TTACTTTAGA 480
AAAATGGAAA ATCAGGATGC CTTGGTCTGT ATATCTGAGA GTGTTCCAGA ACCGATCGTG 540
GAATGGGTGT TCTGTGATTC GCAGGGTGAA AGCTGTCAAG AAGAAAGTCC GGCTGTTGTT 600
AAAAAGGAGG AAAAGGTACT TCATGAATTA TTTGGAACAG ATATAAGGTG TTGTGCAAGA 660
AATGAACTGG GCAGAGAATG TACCAAGCTG TTCACAATAG ATTTAAATCA AACTCCTCAG 720
ACCACACTTC CCCAGTTATT CCTGAAAGTG GGGGAACCCT TATGGATAAG GTGCAAAGCC 780
ATTCATGTGA ACCACGGATT TGGGCTCACC TGGGAATTAG AAAACAAAGT CCTCGAGGAG 840
GGCAGCTACT TTGAGATGAG TACCTATTCA AGAAACAGAA CGATGATCCG GATTCTGTTT 900
GCCTTTGTAT CATCAGTGGG AAGAAACGAC ACTGGATATT ACACTTGTTC CTCCTCTGAG 960
CATCCCAGTC AGTCAGCTTT GGTTACCATC CTGGAAAAGG GATTTATAAA TGTTACCAAT 1020
TCAAGTGAAG ATTATGAAAT TGATCAATAT GAAGACTTTT GCTTTTCTGT CAGGTTTAAA 1080
GCATACCCAC AAATCCGATG CACATGGACC TTCTCTCGAA AATCATTTCC ATGTGAACAA 1140
AGGGGTCTGG AAGATGGATA CAGCATATCT AAGTTTTGCA ACCATAAGCA CCAACCAGGA 1200
GAATATATAT TCCATGCAGA AAATGATGAT GCTCAGTTCA CCAAAATGTT TACGCTGAAT 1260
ATAAAAAGGA AACCTCAAGT GCTAGCTGAA ACATCAGCTA GTCAGGCGTC TTGCTCTTCG 1320
GATGGATATC CATTACCCTC TTGGACGTGG AAGAAGTGTT TGGACAAGTC TCCCAACTGC 1380
ACTGAAGAAA TCACAGAAGG AATTTGGAAT AAAAAGGCTA ACAGGAAAGT GTTTGGACAG 1440
TGGATATCGA GCAGTACCCT AAACATGAGT GAGGCTGTAA AAGGGTTCCT GGTCAAGTGC 1500
TGTGCGTACA ATTCCATGGG CACGTCTTGT GAAACAATCC TTTTAAACTC ACCAGGCCCC 1560
TTCCCCTTCA TCCAGGACAA CATCTCATTC TATGCAACGA TTGGGCTTTG TCTCCCCTTC 1620
ATTGCCGTTC TAACCATTTT AATTTGTCAC AAGTACAAAA AGCAATTTAG GTATGAAAGC 1680
CAGCTGCAAA TGGTACAGGT GACCGGCTCA TTGGACAATG AGTATTTCTA CATTGATTTC 1740
AGAGAATATG AGTATGACCT CAAATGGGAG TTTCCAAGAG AAAACTTAGA GTTTGGGAAG 1800
GTACTAGGAT CGGGTGCTTT TGGGAAAGTG ATGAATGCCA CAGCTTATGG AATTAGTAAA 1860
ACAGGAGTCT CAATCCAAGT TGCAGTCAAA ATGCTGAAAG AAAAGGCTGA CAGCTCTGAA 1920
AAAGAGGCAC TCATGTCAGA ACTCAAAATG ATGACTCACT TGGGACATCA TGAGAACATT 1980
GTGAATCTGC TGGGGGCATG TACACTGTCA GGACCAATTT ACTTGATTTT TGAATACTGT 2040
TGCTATGGTG ATCTCCTCAA CTACCTAAGA AATAAAAGAG AAAAATTCCA TAGGACATGG 2100
ACAGAGATTT TCAAGGAACA CAATTTCAGT TTTTATCCCA CTTTCCAATC ACATCCAAAT 2160
TCCAGTATGC CTGGTTCAAG AGAAGTTCAG ATACACCAGG ACTCGGATCA GGTCTCAGGA 2220
TTCAATGGGA ATTCAATTCA CTCTGAAGAT GAAGTTGAAT ATGAAAACCA GAAAAGACTG 2280
GAAGAAGAGG AGGACTTGAA TGTGCTTACA TTTGAAGATC TTCTTTGCTT TGCGTATCAA 2340
GTTGCCAAAG GAATGGAATT CCTAGAATTT AAGTCGTGTG TTCACCGCGA CCTGGCAGCC 2400
AGGAACGTGC TCGTCACCCA TGGCAAGGTG GTGAAGATTT GTGATTTTGG ATTGGCTCGA 2460
GATATCCTGA GCGATTCCAA CTACGTCGTC AGGGGCAATG CCCGTCTGCC TGTAAAGTGG 2520
ATGGCTCCTG AAAGCTTGTT TGAAGGGATC TACACAATTA AGAGTGATGT CTGGTCGTAC 2580
GGAATATTAC TCTGGGAAAT ATTCTCACTT GGTGTGAATC CTTACCCTGG CATTCCGGTT 2640
GATGCTAACT TCTATAAACT CATTCAGAGT GGATTTAAAA TGGACCAGCC ATTTTATGCT 2700
ACAGAAGAAA TATACTTCAT AATGCAATCC TGCTGGGCTT TTGACTCGAG GAAGCGGCCG 2760
TCCTTCCCTA ACCTGACTTC ATTTTTAGGA TGTCAGCTGG CAGATGCAGA AGAAGCGATG 2820
TATCAGAACA TGGATGGCCA TATTTCAGGA CGTGCTTCCG TCTACCAAAA CAAGCGACCT 2880
TTGGGCAGAG AGGTGGATTT GGAGCCACCC TCTCCACAGG CTCAGGTT 2928
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+ssekealmselk+++hlG
Q: 596   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEKEALMSELKMMTHLG  655
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 656   HHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRNKREKFHRTWTEIFKEHNFSFYPT-  714
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d+++vs ++ ++++se++ +++++++   +eeed
Q: 715   ------FQSHPNSSMPGSRE-VQIHQDSDQVSGFNGNSIHSEDEVEYENQKRL--EEEED  765
         ......9*************.***********************999999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardi++d
Q: 766   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSD  825
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 826   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  885
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 886   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  929
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEKEALM SELKMMTHLG 60
HHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRNKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPG SREVQIHQDS DQVSGFNGNS IHSEDEVEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDILSD SNYVVRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013