EKS-ICT-00009

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00009

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	491.1	5.0E-148	613	870	258

Status

Unreviewed

Ensembl Protein

ENSSTOP00000002767

UniProt Accession

I3M1N8;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA2

Gene Synonyms/Alias

EPHA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000003080	ENSSTOP00000002767	ENSSTOT00000003096

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

889

Protein Sequence
(FASTA)

MEHRTVGACL ALLWGCALVA AAAQGKEVVL LDFEAAKGEL GWLTHPYGKG WDLMQSIMDD 60

KPIYMYSVCN VVAGDQDNWL RTNWVYRGEA ERIFIELKFT VRDCNSFPGG ASSCKETFNL 120

YYAESDVDYG TNFQKRQFTK IDTIAPDEIT VSSDFEARNV KLNLEERSVG PLRRKGFYLA 180

FQDIGACVAL LSVRVYYKKC PELLQGLARF PETIAGSEAP SLATVAGTCV DHAVVPPGGE 240

EPRMHCAVDG EWLVPIGQCL CQEGYEKVED ACQACSPGFF KPEASERPCL PCPAHTLPSP 300

EGASSCECEE GYFRAPEDPL SMPCTRPPSA PHYLTAVGMG ANVELRWTPP QDSGGRDDIV 360

YSVTCEQCWP ESGQCGPCEA SVRYSEPPHA LKRTSVTVSD LEPHMNYTFA VEARNGVSDL 420

VTSRSFRTAS VSINQTEPPK VRLEGRSTTS LSVTWSIPPP QQSRVWKYEV TYRKKGDSNS 480

YNVRRTEGFS VTLDDLVPDT TYLVQVQALT QEGQGAGSKV HEFQTLSTEG SSNMAVISGV 540

AVGVFLLLVL AGIGFFIHRR RRSLRARQSA EDVYFSKSEQ LKPLKTYVDP HTYEDPNQAV 600

LKFTTEIHPS CVTRQKVIGA GEFGEVYKGT LKASSGKKEV PVAIKTLKAG YTEKQRVDFL 660

SEASIMGQFS HHNIIRLEGV VSKYKPMMII TEYMENGALD KFLREKDGEF SVLQLVGMLR 720

GIASGMKYLA NMNYVHRDLA ARNILVNSNL VCKVSDFGLS RVLEDDPEAT YTTSGGKIPI 780

RWTAPEAISY RKFTSASDVW SYGIVMWEVM AYGERPYWEL SNHEVMKAIN DGFRLPTPMD 840

CPSAIYQLMM QCWQQDRARR PKFADIVSIL DKLIRAPDSL KTLADFDPR 889

Nucleotide Sequence
(FASTA)

ATGGAGCACC GGACAGTCGG CGCCTGCCTC GCCCTGCTGT GGGGCTGCGC GTTGGTGGCC 60

GCGGCGGCTC AGGGCAAGGA AGTTGTCCTG TTGGATTTTG AGGCTGCAAA AGGAGAACTT 120

GGCTGGCTCA CACATCCCTA TGGCAAAGGG TGGGACCTGA TGCAGAGCAT AATGGACGAC 180

AAGCCCATCT ACATGTACTC CGTGTGCAAC GTGGTGGCCG GCGACCAGGA CAACTGGCTG 240

CGCACCAACT GGGTGTACCG CGGCGAGGCG GAGCGCATCT TCATCGAGCT CAAGTTCACG 300

GTGCGCGACT GCAACAGCTT CCCCGGTGGC GCCAGCTCCT GCAAGGAGAC CTTCAACCTC 360

TACTACGCCG AGTCGGACGT GGACTACGGC ACCAACTTCC AGAAGCGCCA GTTCACCAAG 420

ATCGACACCA TCGCGCCCGA TGAGATCACG GTCAGCAGCG ACTTCGAGGC GCGCAACGTG 480

AAGCTGAACT TGGAGGAGCG CTCCGTGGGG CCGCTGAGAC GCAAGGGCTT CTACCTGGCC 540

TTCCAGGACA TCGGTGCCTG CGTGGCTCTG CTGTCTGTCC GCGTCTACTA CAAGAAGTGT 600

CCCGAGCTGC TGCAGGGCCT GGCTCGCTTC CCCGAGACCA TCGCAGGTTC CGAAGCACCC 660

TCCCTGGCCA CCGTGGCCGG CACCTGCGTG GACCATGCTG TGGTGCCGCC AGGGGGCGAA 720

GAGCCCCGCA TGCACTGCGC GGTGGATGGC GAGTGGCTGG TGCCCATTGG GCAGTGCCTG 780

TGCCAGGAGG GCTACGAGAA GGTGGAGGAC GCCTGTCAGG CCTGTTCACC GGGATTCTTC 840

AAGCCCGAGG CCTCCGAGAG ACCCTGCTTG CCGTGCCCGG CACACACGCT GCCGTCCCCC 900

GAGGGTGCCA GCTCCTGCGA GTGCGAGGAG GGCTACTTCC GGGCACCCGA GGACCCGCTG 960

TCCATGCCCT GCACACGCCC GCCCTCCGCC CCCCACTACC TCACCGCCGT GGGCATGGGC 1020

GCCAACGTGG AGCTGCGGTG GACACCACCC CAGGACAGCG GGGGCCGCGA CGACATCGTC 1080

TACAGTGTCA CCTGTGAACA GTGCTGGCCG GAGTCCGGCC AGTGCGGGCC CTGCGAGGCC 1140

AGCGTGCGCT ACTCAGAGCC CCCCCACGCG CTGAAGCGGA CCAGCGTGAC GGTCAGCGAC 1200

CTGGAGCCCC ACATGAACTA CACCTTTGCC GTCGAGGCCC GCAATGGTGT CTCGGACCTT 1260

GTGACCAGCC GCAGCTTCCG CACGGCCAGT GTCAGCATCA ACCAGACAGA GCCCCCCAAG 1320

GTGAGGCTGG AGGGCCGCAG CACCACGTCA CTCAGCGTCA CCTGGAGCAT CCCCCCGCCA 1380

CAGCAGAGCC GAGTGTGGAA GTACGAGGTC ACCTACCGCA AGAAGGGGGA CTCCAACAGC 1440

TACAATGTGC GCCGCACTGA GGGCTTCTCT GTGACCCTGG ATGACCTGGT TCCTGACACC 1500

ACCTACCTGG TCCAGGTGCA GGCGCTGACG CAGGAGGGCC AGGGGGCTGG TAGCAAGGTG 1560

CACGAGTTCC AGACGCTGTC CACAGAAGGT TCTAGCAACA TGGCAGTGAT TAGCGGTGTG 1620

GCTGTTGGCG TCTTCTTGCT TCTGGTGCTG GCAGGAATCG GCTTCTTCAT CCACCGCAGG 1680

AGGAGGAGTC TGCGCGCTCG CCAGTCCGCA GAGGACGTCT ACTTCTCCAA GTCAGAGCAG 1740

CTGAAGCCCC TGAAGACGTA CGTGGACCCT CACACATATG AAGACCCCAA TCAGGCTGTG 1800

CTCAAGTTCA CCACGGAGAT CCACCCGTCC TGTGTCACCC GGCAGAAGGT GATCGGAGCA 1860

GGAGAGTTTG GGGAGGTGTA CAAGGGGACC CTGAAGGCGT CCTCGGGGAA GAAAGAGGTG 1920

CCCGTGGCCA TCAAGACCCT GAAGGCAGGC TACACAGAGA AGCAGCGCGT GGACTTCCTG 1980

AGCGAGGCCA GCATCATGGG CCAGTTCAGC CACCACAATA TCATCCGTCT GGAGGGCGTG 2040

GTCTCTAAAT ACAAACCCAT GATGATCATC ACGGAGTACA TGGAGAACGG GGCCCTCGAC 2100

AAGTTCCTCC GGGAGAAGGA CGGCGAGTTC AGCGTGCTGC AGCTGGTGGG CATGCTGCGG 2160

GGCATCGCGT CGGGCATGAA GTACCTGGCC AACATGAACT ACGTCCACCG TGACCTGGCT 2220

GCCCGCAACA TCTTGGTCAA CAGCAACCTG GTCTGCAAGG TGTCCGACTT TGGCCTGTCC 2280

CGCGTGCTGG AGGATGACCC CGAGGCCACC TACACCACCA GTGGTGGCAA GATCCCGATC 2340

CGGTGGACGG CCCCCGAGGC CATCTCCTAC CGCAAGTTCA CCTCGGCCAG CGACGTGTGG 2400

AGCTACGGCA TTGTCATGTG GGAGGTCATG GCCTACGGCG AGCGGCCCTA CTGGGAGCTG 2460

TCCAACCATG AGGTGATGAA AGCCATCAAC GATGGCTTCC GGCTGCCCAC GCCCATGGAT 2520

TGCCCCTCGG CCATCTATCA GCTCATGATG CAGTGCTGGC AGCAGGACCG CGCCCGGCGC 2580

CCCAAGTTCG CGGACATCGT CAGCATCCTC GACAAGCTCA TCCGCGCCCC CGACTCCCTC 2640

AAGACCCTGG CTGACTTCGA CCCCCGGTGA 2670

Domain Profile

S: 2     kiekviGaGefGevcsGrlkl.pgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         + +kviGaGefGev++G+lk+ +gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+

Q: 613   TRQKVIGAGEFGEVYKGTLKAsSGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHH  672

         6789****************9678************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvv+k kp+mi+teymengald+flr+kdg+f+v+qlvgmlrGiasgmkyl++m

Q: 673   NIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLANM  732

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         +yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrk

Q: 733   NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK  792

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++c

Q: 793   FTSASDVWSYGIVMWEVMAYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQC  852

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wq+dra+rpkf++ivsil

Q: 853   WQQDRARRPKFADIVSIL  870

         ***************985

Domain Sequence
(FASTA)

TRQKVIGAGE FGEVYKGTLK ASSGKKEVPV AIKTLKAGYT EKQRVDFLSE ASIMGQFSHH 60

NIIRLEGVVS KYKPMMIITE YMENGALDKF LREKDGEFSV LQLVGMLRGI ASGMKYLANM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEATYT TSGGKIPIRW TAPEAISYRK 180

FTSASDVWSY GIVMWEVMAY GERPYWELSN HEVMKAINDG FRLPTPMDCP SAIYQLMMQC 240

WQQDRARRPK FADIVSIL 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013