EKS-ICT-00164
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00164
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC473.12.5E-142243503261
StatusUnreviewed
Ensembl ProteinENSSTOP00000023470
UniProt AccessionI3M1P9;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCA
Gene Synonyms/Alias PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000003118ENSSTOP00000002786ENSSTOT00000003118
ENSSTOG00000003118ENSSTOP00000023470ENSSTOT00000027733
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length578
Protein Sequence
(FASTA)
DPRSKHKFKI HTYGSPTFCD HCGSLLYGLI HQGMKCDTCD MNVHKQCVIN VPSLCGMDHT 60
EKRGRIYLKA EVTDEKLHVT VRDAKNLIPM DPNGLSDPYV KLKLIPDPKN ESKQKTKTIR 120
STLNPQWNES FTFKLKPSDK DRRLSVEIWD WDRTTRNDFM GSLSFGVSEL MKMPASGWYK 180
LLNQEEGEYY NVPIPEGDEE GNVELRQKFE KAKLGPAGNK VISPSEDRKQ PSNNLDRVKL 240
TDFNFLMVLG KGSFGKVMLA DRKGTEELYA IKILKKDVVI QDDDVECTMV EKRVLALLDK 300
PPFLTQLHSC FQTVDRLYFV MEYVNGGDLM YHIQQVGKFK EPQAVFYAAE ISIGLFFLHK 360
RGIIYRDLKL DNVMLDSEGH IKIADFGMCK EHMMDGVTTR TFCGTPDYIA PEIIAYQPYG 420
KSVDWWAYGV LLYEMLAGQE QPPFDGEDED ELFQSIMEHN VSYPKSLSKE AVSICKGLMT 480
KHPAKRLGCG PEGERDVREH AFFRRIDWEK LENREIQPPF KPKVCGKGAE NFDKFFTRGQ 540
PVLTPPDQLV IANIDQSDFE GFSYINPQFV HPILQSAV 578
Nucleotide Sequence
(FASTA)
GACCCCAGGA GCAAGCACAA GTTTAAAATC CACACTTATG GGAGCCCTAC CTTCTGTGAT 60
CACTGTGGGT CACTGCTGTA TGGACTTATC CACCAAGGGA TGAAATGTGA CACCTGCGAC 120
ATGAATGTTC ACAAGCAGTG TGTGATCAAC GTCCCCAGCC TCTGCGGGAT GGATCACACA 180
GAGAAGAGGG GGCGGATTTA CCTGAAGGCA GAGGTCACCG ATGAAAAGCT CCATGTCACA 240
GTACGAGATG CAAAAAATCT AATCCCTATG GATCCCAATG GACTCTCTGA TCCTTACGTG 300
AAGCTGAAAC TTATTCCCGA CCCTAAGAAT GAAAGCAAAC AGAAAACCAA AACCATCCGC 360
TCCACGCTGA ACCCCCAGTG GAATGAATCC TTCACGTTCA AACTAAAACC TTCAGACAAA 420
GATCGACGGC TGTCCGTAGA AATCTGGGAC TGGGATCGAA CAACAAGGAA TGACTTCATG 480
GGATCCCTTT CCTTTGGAGT CTCGGAGCTC ATGAAGATGC CGGCCAGCGG ATGGTACAAG 540
TTGCTTAACC AAGAAGAAGG TGAGTACTAC AACGTGCCCA TTCCAGAAGG GGACGAAGAA 600
GGAAACGTGG AGCTCAGGCA GAAATTCGAG AAAGCCAAGC TTGGCCCTGC GGGTAACAAA 660
GTGATCAGTC CTTCTGAGGA CAGGAAACAA CCTTCCAACA ACCTGGACAG AGTGAAGCTC 720
ACCGACTTCA ATTTCCTCAT GGTGCTGGGG AAGGGGAGCT TTGGGAAGGT GATGCTTGCT 780
GACCGGAAGG GAACAGAAGA ACTGTATGCC ATCAAAATCC TGAAGAAGGA TGTGGTGATT 840
CAGGACGACG ACGTGGAGTG CACCATGGTG GAGAAGCGGG TCCTGGCCCT GCTTGACAAG 900
CCCCCGTTCC TAACACAGCT GCACTCCTGC TTCCAGACGG TGGATCGGCT GTACTTTGTC 960
ATGGAGTACG TCAATGGCGG GGACCTCATG TACCACATTC AGCAAGTAGG AAAATTTAAG 1020
GAGCCACAAG CAGTATTCTA CGCAGCAGAG ATTTCCATTG GATTGTTCTT TCTTCATAAA 1080
AGAGGCATCA TTTATAGGGA CCTGAAGTTA GATAATGTCA TGCTGGATTC CGAAGGACAT 1140
ATCAAAATCG CTGACTTTGG GATGTGCAAA GAACACATGA TGGATGGAGT CACGACCAGG 1200
ACCTTCTGTG GGACTCCAGA TTACATCGCC CCGGAGATAA TCGCTTACCA GCCGTATGGG 1260
AAGTCTGTGG ACTGGTGGGC CTATGGCGTG CTGCTGTATG AAATGCTGGC TGGCCAGGAA 1320
CAGCCTCCAT TTGATGGTGA GGATGAAGAT GAGCTGTTCC AGTCGATCAT GGAGCACAAC 1380
GTCTCCTATC CCAAGTCCTT GTCCAAAGAG GCCGTCTCTA TCTGCAAAGG GCTGATGACC 1440
AAGCACCCAG CCAAGCGGCT GGGCTGTGGG CCTGAGGGGG AGAGGGATGT GAGAGAGCAC 1500
GCCTTCTTCC GCAGGATCGA CTGGGAAAAG CTGGAGAACA GGGAGATCCA GCCGCCCTTC 1560
AAGCCCAAAG TGTGTGGCAA AGGAGCAGAA AACTTTGACA AGTTCTTCAC ACGAGGGCAA 1620
CCCGTCTTAA CACCGCCAGA TCAGCTGGTC ATCGCGAACA TAGACCAGTC TGATTTTGAA 1680
GGGTTCTCAT ACATCAATCC CCAGTTTGTG CACCCAATCT TGCAAAGTGC GGTATGA 1737
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 243   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  302
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 303   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  362
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks
Q: 363   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  422
         ************************************************************
S: 181   vdwwalGvllyemlagq..sPfegededelfesilekevlyPkslskeaveilkglltkd  238
         vdwwa+Gvllyemlagq  +Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+
Q: 423   VDWWAYGVLLYEMLAGQeqPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKH  482
         ***************96448****************************************
S: 239   pekrlGvkeegeedikehaff  259
         p+krlG+ +ege+d++ehaff
Q: 483   PAKRLGCGPEGERDVREHAFF  503
         ********************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQEQP PFDGEDEDEL FQSIMEHNVS YPKSLSKEAV SICKGLMTKH 240
PAKRLGCGPE GERDVREHAF F 261
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-ANC-00165
EKS-BOT-00169
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-DAR-00460
EKS-DRM-00084
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-LAC-00179
EKS-LOA-00168
EKS-MAM-00167
EKS-MEG-00134
EKS-MOD-00168
EKS-MUM-00174
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-ORN-00213
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-OTG-00175
EKS-PAT-00160
EKS-PES-00149
EKS-POA-00171
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-SUS-00151
EKS-TAG-00197
EKS-TAR-00221
EKS-TEN-00212
EKS-XIM-00209
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013