EKS-ICT-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	330.4	8.9E-99	919	1189	271

Status

Unreviewed

Ensembl Protein

ENSSTOP00000002949

UniProt Accession

I3M210;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000003264	ENSSTOP00000002949	ENSSTOT00000003298

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1209

Protein Sequence
(FASTA)

LRSMPLCQKG AAAKGSKPHR DRAQPMADMG GLKVLLHWAG PRGGEPWVTF SKTSLTAEEV 60

CIHIAHKVGI TPPCFNLFAL FDAQAQVWLP PNHILEVSRD TSLTLYFRMR FYFRNWHGMN 120

PQEPAVYRCG LPGAETSSEP TEQGVQLLDP ASFEYLFEQV FLSLGNEIIL ILPFLPDSYS 180

QGKHEFVNDV VSLWELSSEE EIHHFKNESL GMAFLHLSHL ALQRGVPLEE VAKEISFKDC 240

IPLSFRQQIR QHNALTRLRL RNVFRKFLHA FQPGHLSQQM VMVKYIATLE HLAPRFGTER 300

IPVCHLELLS QAEGEPCYIQ DSRRASADHN LEPALGSPTH EVLVTGTGGI QWRPVQVEVS 360

SDVNDSSRNS QTHLSGKKAK AREAGGQPAN RPREPPWTYF CDFQDITHLV LKGCRVTIYQ 420

QDNKCLELRL PSRAAALSFV ALVDGYFRLT ADSSHYLCQE VAPPRLVMSI QEGIHGPLLE 480

PFVQAKLQPE EGLYLIHWST VHLHRLILTV AQPEPVGLEL GVQSLRIRKF PIEQQDGAFM 540

LEGWGRSFAS VQELRGALQG CSLRAGDDCF SLRRCCLPQP GEISNLIIMR GSRASSRPLN 600

LSQLSFHRIH QDEITQLSHL GQGTRTNVYE GLLRVGGPEE GKADGGDSPK PGGGCGQQLR 660

VVLKVLDPSH HDIALAFYET ASLMSQVSHA HLAFVHGVCV RGSENIMVTE YVENGPLDVW 720

LRREKGHVPM TWKVAVAQQL ASALSYLEDK NLVHGNVCGR NILLARLGLA EGTSPFIKLS 780

DPGVGLGALS REERVERIPW TAPECLPAGA TSLCTAADKW GFGATLLEIC FDGEAPLQGR 840

GPSEKERFYQ KQHRLPEPSC PELATITSQC LTYERALRPS FRTILRDLTQ LQPHDLVDVS 900

TINPDSPVSD PTVFHKRYLK KIRDLGEGHF GKVSLYCYDP TNDGTGEMVA VKALKADCGP 960

QLRSGWRREI DILRTLYHEH IVKYKGCCED QGEKSVQLVM EYVPLGSLRD YLPRHNVGLA 1020

QLLLFSQQIC EGMAYLHAQH YIHRDLAARN VLLDNDRLVK IGDFGLAKAV PEGHEYYRVR 1080

EDGDSPVFWY APECLKECKF YYASDVWSFG VTLYELLTYC DSSQSPPSKF LELIGLTQGQ 1140

ITVLRLTELL ERGERLPRPE RCPCEIYHLM KNCWEAESSF RPTFQNLIPI LKMVHEKYQG 1200

QAPSVFSVC 1209

Nucleotide Sequence
(FASTA)

TTGAGGAGCA TGCCTCTCTG TCAGAAAGGA GCTGCTGCAA AGGGCAGCAA GCCCCATAGG 60

GACAGAGCTC AGCCCATGGC TGACATGGGA GGTTTGAAGG TACTTCTGCA CTGGGCTGGC 120

CCTAGAGGTG GAGAGCCCTG GGTCACCTTT AGCAAGACCT CACTGACGGC CGAGGAAGTC 180

TGCATCCACA TCGCACACAA AGTCGGCATC ACTCCACCCT GCTTCAATCT CTTTGCCCTC 240

TTTGATGCCC AGGCCCAAGT CTGGCTGCCC CCAAACCACA TCCTAGAGGT CTCCAGAGAT 300

ACAAGTCTGA CACTGTATTT CCGTATGAGG TTTTATTTCC GAAACTGGCA TGGCATGAAT 360

CCTCAGGAGC CAGCTGTATA CCGCTGTGGA CTCCCAGGGG CTGAGACTTC CTCAGAACCG 420

ACAGAGCAGG GGGTGCAACT CTTGGACCCA GCCTCATTTG AGTACCTCTT TGAACAGGTG 480

TTTCTCTCAC TAGGGAATGA AATCATTCTC ATACTTCCCT TTCTGCCTGA TTCCTACTCT 540

CAGGGCAAGC ATGAGTTTGT GAATGATGTG GTATCACTGT GGGAGCTGTC AAGTGAGGAG 600

GAGATCCACC ACTTTAAGAA TGAGAGCCTG GGCATGGCCT TTCTGCACCT CTCCCACCTC 660

GCTCTCCAAC GTGGCGTCCC CCTGGAAGAG GTGGCCAAGG AGATCAGCTT CAAGGACTGC 720

ATCCCGCTCT CCTTCCGGCA GCAGATCCGG CAGCACAACG CCCTTACACG GCTGCGCCTG 780

CGCAATGTCT TCCGCAAGTT CCTGCATGCC TTCCAGCCAG GCCACCTCTC TCAGCAGATG 840

GTCATGGTCA AATACATAGC CACCCTGGAG CATCTGGCCC CCCGCTTTGG CACTGAACGC 900

ATACCTGTGT GTCACCTGGA GCTACTGTCC CAGGCCGAGG GAGAGCCCTG CTACATCCAG 960

GACAGCAGGC GGGCCTCCGC GGACCACAAC CTGGAGCCTG CCTTGGGATC CCCCACCCAC 1020

GAGGTACTGG TGACAGGCAC TGGTGGCATC CAGTGGCGGC CAGTACAGGT GGAGGTTTCT 1080

AGTGACGTCA ACGACAGCAG CAGGAATTCC CAAACCCACC TGTCTGGGAA GAAAGCCAAG 1140

GCCCGTGAGG CAGGTGGCCA GCCAGCAAAC AGGCCGAGGG AGCCACCCTG GACTTACTTC 1200

TGTGACTTCC AGGACATCAC GCACCTGGTG CTAAAAGGGT GCCGTGTCAC CATCTACCAG 1260

CAAGACAACA AGTGCCTGGA GCTGAGACTG CCTTCCCGGG CCGCGGCCCT GTCCTTCGTG 1320

GCGCTGGTGG ACGGCTACTT CCGCCTGACA GCAGACTCCA GCCATTACCT GTGCCAGGAG 1380

GTGGCTCCCC CACGGCTAGT GATGAGCATC CAGGAGGGTA TCCATGGGCC CCTGCTGGAG 1440

CCCTTTGTGC AAGCCAAGCT CCAGCCAGAG GAGGGCCTCT ACCTTATCCA CTGGAGCACC 1500

GTCCACCTGC ACCGCCTTAT CCTCACAGTG GCCCAGCCTG AGCCGGTGGG CCTGGAGCTG 1560

GGGGTGCAGA GCTTGCGCAT CCGGAAGTTC CCCATTGAGC AGCAGGACGG GGCCTTCATG 1620

CTGGAGGGCT GGGGCCGCTC CTTTGCCAGT GTGCAGGAGC TGCGGGGAGC CCTGCAGGGC 1680

TGCTCCTTGC GGGCTGGGGA CGACTGTTTC TCTCTGCGTC GCTGCTGCCT GCCCCAGCCC 1740

GGAGAAATCT CCAACCTCAT CATCATGCGC GGTTCTCGGG CCAGCTCCAG GCCACTTAAC 1800

CTCAGCCAGC TAAGCTTCCA CCGCATCCAC CAGGATGAGA TCACCCAGCT ATCCCACTTG 1860

GGCCAGGGCA CAAGGACCAA TGTATATGAG GGCCTCCTGA GAGTGGGGGG CCCTGAGGAG 1920

GGCAAAGCAG ATGGCGGAGA CTCCCCCAAA CCTGGAGGGG GCTGTGGGCA GCAGCTGCGA 1980

GTAGTGCTTA AAGTACTGGA CCCCAGTCAC CATGACATCG CCCTGGCCTT CTACGAGACA 2040

GCCAGCCTCA TGAGCCAGGT CTCCCACGCA CATCTGGCCT TCGTGCATGG TGTCTGTGTG 2100

CGCGGCTCCG AGAACATCAT GGTGACGGAG TATGTAGAAA ATGGGCCCCT AGACGTGTGG 2160

CTGCGGCGAG AGAAGGGCCA TGTACCCATG ACCTGGAAGG TGGCAGTGGC TCAGCAGCTG 2220

GCCAGCGCCC TCAGCTACCT GGAGGACAAG AACCTGGTTC ATGGTAATGT GTGTGGCCGG 2280

AACATCCTGC TGGCACGGCT AGGGCTGGCA GAGGGCACCA GCCCCTTCAT CAAGCTGAGT 2340

GATCCCGGTG TGGGCCTGGG TGCCCTGTCC AGGGAGGAGA GGGTGGAACG CATCCCCTGG 2400

ACGGCGCCCG AGTGCCTGCC TGCTGGGGCC ACCAGTCTGT GCACTGCCGC TGACAAGTGG 2460

GGCTTTGGTG CCACTCTTCT GGAGATCTGC TTTGATGGGG AGGCCCCCCT GCAGGGCCGC 2520

GGTCCCTCTG AGAAAGAGCG GTTCTACCAG AAGCAGCACC GCCTGCCAGA GCCCTCCTGC 2580

CCAGAACTGG CCACCATCAC CAGCCAGTGC CTGACCTATG AGCGGGCCCT GCGACCTTCT 2640

TTTCGCACCA TCCTGCGTGA CCTCACTCAG CTGCAGCCCC ACGATCTAGT GGACGTCTCC 2700

ACTATAAATC CAGACTCACC AGTGTCAGAC CCCACGGTTT TCCACAAGCG ATACTTGAAA 2760

AAGATCCGGG ATCTTGGCGA GGGTCACTTT GGCAAGGTCA GCCTGTACTG CTACGACCCG 2820

ACCAACGATG GCACAGGTGA GATGGTGGCC GTGAAAGCCC TCAAGGCGGA CTGCGGGCCC 2880

CAGCTCCGTT CTGGCTGGAG GCGGGAGATC GATATCCTGC GCACGCTCTA CCATGAGCAT 2940

ATCGTCAAGT ACAAGGGCTG CTGCGAGGAC CAAGGCGAGA AGTCAGTGCA GCTGGTTATG 3000

GAGTACGTGC CCCTGGGCAG CCTCCGAGAC TACCTGCCCC GGCACAATGT TGGGCTGGCT 3060

CAGCTGCTGC TGTTTTCTCA GCAGATCTGT GAGGGCATGG CCTACCTGCA CGCGCAGCAC 3120

TACATCCATC GAGATCTAGC TGCCCGCAAC GTGCTGCTGG ACAACGACAG GCTGGTCAAG 3180

ATTGGGGACT TTGGCCTAGC CAAAGCCGTG CCTGAAGGCC ACGAGTACTA CCGCGTGCGC 3240

GAGGATGGGG ACAGCCCTGT GTTCTGGTAT GCCCCAGAGT GCCTGAAGGA GTGTAAGTTC 3300

TACTATGCAT CTGACGTCTG GTCCTTTGGG GTCACCCTCT ATGAGCTGTT GACATACTGT 3360

GACTCCAGCC AGAGTCCCCC TTCCAAATTC CTGGAGCTTA TAGGCCTCAC CCAGGGACAG 3420

ATAACTGTGC TGAGGCTCAC TGAGTTGCTG GAACGAGGGG AGAGGCTACC ACGACCTGAG 3480

AGATGTCCCT GTGAGATCTA TCATCTCATG AAGAACTGCT GGGAGGCAGA GTCCTCCTTC 3540

CGCCCTACCT TCCAGAACCT CATACCCATC CTCAAGATGG TCCATGAGAA ATACCAAGGC 3600

CAGGCTCCTT CAGTGTTCAG CGTATGCTGA 3630

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk ++g++ ++++ re++il++l+h

Q: 919   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKaDCGPQLRSGWRREIDILRTLYH  978

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +++q++++m+YL

Q: 979   EHIVKYKGCCEDQGEKsvQLVMEYVPLGSLRDYLPRH--NVGLAQLLLFSQQICEGMAYL  1036

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 1037  HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1090

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219

         apecl+e+k +++asdvWsFgvtlyellt c++++sp         l     +

Q: 1091  APECLKECK-FYYASDVWSFGVTLYELLTyCDSSQSPpskfleligL-----Tqgqitvl  1144

         *********.******************************9555554.....45555599

S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         r++elle++erlp+p+ cp+e+++lm+nc+++e s+rp+F++++

Q: 1145  RLTELLERGERLPRPErCPCEIYHLMKNCWEAESSFRPTFQNLIP  1189

         *****************************************9975

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKADC GPQLRSGWRR EIDILRTLYH 60

EHIVKYKGCC EDQGEKSVQL VMEYVPLGSL RDYLPRHNVG LAQLLLFSQQ ICEGMAYLHA 120

QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEC 180

KFYYASDVWS FGVTLYELLT YCDSSQSPPS KFLELIGLTQ GQITVLRLTE LLERGERLPR 240

PERCPCEIYH LMKNCWEAES SFRPTFQNLI P 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013