EKS-ICT-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	496.0	2.1E-149	723	980	258

Status

Unreviewed

Ensembl Protein

ENSSTOP00000003374

UniProt Accession

I3M2X8;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000003748	ENSSTOP00000003374	ENSSTOT00000003767

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1259

Protein Sequence
(FASTA)

FDLSSWLRRG LGGRVSLQLP SGAVGTAVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ 60

GNLELTYLPA NASLSFLQDI QEVQGYMLIA HNQVRRVPLQ RLRIVRGTQL FEDSYALAVL 120

DNGDPLDSAT PAPGAFPGGL QELQLRSLTE ILKGGVLIQR NPQLCYQDTI LWKDIFHKNN 180

QLALTVIDTN RSRACQPCSP ACKANHCWGE GSQDCQSLTR TICASGCARC KGTLPTDCCH 240

EQCAAGCTGP KHSDCLACLH FNHSGICELH CPALVTYNTD TFESMPNPEG RYTFGASCVT 300

TCPYNYLSTD VGSCTLVCPL NNQEVTGEDG TQRCEKCSKP CARVCYGLGM EHLRAARAVT 360

SANIQEFAGC KKIFGSLAFL PESFDGDPAS NTAALQPEQL KVFETLEEIT GYLYISAWPD 420

SLPDLSVFQN LRVIRGRVLH DGAYSLTLQG LGISWLGLRS LRELGSGLAL IHRNTRLCFV 480

HTVPWDQLFR NPHQALLHSG NRPQNECAGE GLSCYPLCAN GHCWGPGPTQ CVNCSQFLRG 540

QECVEECRVL QGLPREYMRD RHCLPCHPEC QPQNGSVTCV GSKADQCVAC AHYKDPPSCV 600

ARCPSGVKAD VSYMPIWKFP DEEGVCQPCP INCTHSCVDL DDKGCPAEQR ASPVTSIIAA 660

VVGILLFVVM GLVFGILIKR RRQKIRKYTM RRLLQETELV EPLTPSGAMP NQAQMRILKE 720

TELRKVKVLG SGAFGTVYKG IWIPDGENVK IPVAIKVLRE NTSPKANKEI LDEAYVMAGV 780

GSPYVSRLLG ICLTSTVQLV TQLMPYGCLL DHVREHRGRL GSQDLLNWCV QIAKGMSYLE 840

DVRLVHRDLA ARNVLVKSPN HVKITDFGLA RLLDIDETEY HADGGKVPIK WMALESILRR 900

RFTHQSDVWS YGVTVWELMT FGAKPYDGIP AREIPDLLEK GERLPQPPIC TIDVYMIMVK 960

CWMIDSECRP RFRELVAEFS RMARDPQRFV VIQNEDLGPA SPLDSTFYRS LLEDDDMGDL 1020

VDAEEYLVPQ QGFFCPDPAP GAGGTAHRRH RSSSTRSGGG GELTLGLEPS EEDPPRSPLA 1080

PSEGAGSDVF DGDLGIGAAK GLQSLPTHDP NPLQRYSEDP TVPLPPETDG YVAPLTCSPQ 1140

PEYVNQPEVR PQPPSPLEGP LPPVCPAGAT LERPKTLSPG KNGVVKDVFA FGGTVENPEY 1200

LAPRGGAAPQ PHPPPAFSPA FDNLYYWDQD SSERGSPPGT FEGTPTAENP EYLGLDVPV 1259

Nucleotide Sequence
(FASTA)

TTTGACCTCT CCTCATGGCT CAGGAGGGGG CTTGGTGGGC GTGTCAGCCT CCAGCTCCCT 60

TCTGGGGCGG TTGGCACAGC AGTGTGCACG GGCACAGACA TGAAGCTGCG GCTCCCGGCC 120

AGTCCTGAGA CCCACCTTGA CATGCTCCGC CACCTCTACC AGGGTTGTCA GGTGGTGCAG 180

GGTAACTTGG AACTGACCTA CCTGCCTGCT AATGCCAGCC TCTCCTTCCT GCAGGACATC 240

CAGGAGGTGC AGGGCTACAT GCTCATTGCT CACAACCAAG TGAGGCGAGT CCCTCTGCAG 300

AGGCTGCGGA TTGTACGAGG CACCCAACTC TTCGAGGACA GCTATGCCTT GGCGGTGTTA 360

GACAATGGAG ACCCTCTGGA CAGTGCCACC CCTGCTCCGG GGGCTTTTCC TGGAGGGCTG 420

CAGGAGCTGC AGCTTCGAAG CCTCACAGAG ATCCTGAAGG GAGGGGTCTT GATCCAGCGG 480

AACCCCCAGC TCTGCTACCA GGACACGATT TTGTGGAAGG ACATCTTCCA CAAGAACAAC 540

CAGCTGGCAC TTACGGTGAT AGACACCAAC CGCTCACGGG CCTGCCAACC CTGTTCTCCA 600

GCCTGTAAAG CCAACCACTG CTGGGGAGAA GGTTCCCAGG ACTGTCAGAG CCTGACACGC 660

ACCATTTGTG CCAGTGGCTG TGCCCGCTGC AAGGGCACGC TGCCCACCGA CTGCTGCCAT 720

GAGCAGTGTG CTGCCGGCTG CACAGGCCCC AAGCATTCGG ACTGCCTGGC TTGCCTCCAC 780

TTCAACCATA GTGGCATCTG TGAGCTTCAC TGCCCAGCCC TGGTCACTTA CAACACAGAC 840

ACCTTTGAAT CCATGCCCAA CCCTGAGGGC CGTTATACCT TTGGCGCCAG CTGTGTGACC 900

ACCTGTCCCT ACAACTACCT CTCTACGGAT GTGGGATCCT GCACCCTGGT CTGCCCTCTG 960

AACAACCAAG AAGTGACAGG GGAGGACGGG ACCCAGCGGT GTGAGAAATG CAGCAAGCCC 1020

TGTGCTCGAG TGTGCTATGG TCTGGGCATG GAGCACCTGC GGGCGGCGAG GGCAGTGACC 1080

AGTGCCAATA TCCAGGAGTT TGCTGGCTGC AAGAAGATCT TTGGGAGCCT GGCATTTTTG 1140

CCAGAGAGCT TTGATGGGGA TCCTGCCTCC AACACGGCCG CTCTACAACC TGAGCAGCTC 1200

AAAGTGTTTG AGACCCTGGA GGAGATCACA GGTTACCTGT ACATCTCAGC GTGGCCAGAC 1260

AGCCTGCCTG ACCTCAGTGT CTTCCAGAAC CTGCGAGTCA TCAGGGGACG AGTTCTGCAT 1320

GATGGCGCCT ACTCATTGAC CCTGCAAGGG CTGGGCATCA GCTGGCTGGG ACTGCGTTCA 1380

CTGAGGGAGC TGGGCAGCGG GCTGGCCCTC ATTCACCGCA ACACCCGCCT CTGCTTTGTG 1440

CACACGGTGC CCTGGGACCA GCTCTTTCGG AACCCCCACC AGGCCCTGCT CCACAGTGGC 1500

AACCGGCCGC AGAATGAGTG TGCGGGTGAG GGCCTGTCCT GCTACCCACT GTGTGCCAAT 1560

GGGCACTGCT GGGGGCCAGG GCCCACCCAG TGTGTCAACT GCAGCCAGTT CCTTCGGGGC 1620

CAAGAGTGCG TGGAGGAATG CCGAGTCCTG CAGGGGCTCC CCAGGGAGTA TATGAGGGAC 1680

AGGCACTGTC TACCATGCCA CCCCGAGTGT CAGCCCCAGA ATGGCTCCGT GACCTGCGTT 1740

GGATCGAAGG CTGACCAGTG TGTGGCCTGT GCCCACTACA AGGACCCTCC CTCGTGTGTG 1800

GCTCGCTGCC CCAGTGGTGT TAAAGCTGAT GTCTCCTACA TGCCCATCTG GAAGTTCCCG 1860

GATGAGGAGG GCGTGTGCCA GCCCTGCCCA ATCAACTGCA CTCACTCCTG CGTGGACCTG 1920

GATGACAAAG GCTGCCCAGC TGAGCAGAGA GCCAGCCCTG TGACATCTAT CATTGCTGCT 1980

GTGGTGGGCA TTCTGCTGTT CGTGGTCATG GGACTCGTCT TTGGGATCCT AATCAAGCGA 2040

AGGCGACAGA AGATTCGGAA ATACACGATG CGGAGGCTGC TGCAGGAAAC CGAGCTGGTG 2100

GAGCCGCTGA CACCCAGTGG AGCCATGCCC AACCAGGCTC AGATGCGAAT CCTGAAAGAG 2160

ACAGAGCTAA GGAAGGTGAA AGTTCTTGGA TCCGGAGCTT TTGGCACAGT CTACAAGGGC 2220

ATCTGGATCC CTGATGGGGA GAATGTGAAA ATCCCTGTGG CCATCAAAGT GTTGAGAGAA 2280

AACACATCCC CCAAAGCCAA CAAGGAAATC TTGGATGAAG CGTATGTGAT GGCTGGTGTG 2340

GGCTCCCCCT ATGTGTCCCG ACTCCTGGGC ATCTGCCTGA CATCCACGGT ACAACTGGTG 2400

ACCCAGCTTA TGCCCTATGG CTGCCTCCTG GACCATGTCC GAGAACACCG TGGTCGCCTG 2460

GGCTCCCAGG ACCTGCTGAA CTGGTGTGTG CAGATTGCCA AGGGGATGAG CTACTTGGAG 2520

GATGTGCGGC TCGTGCATAG GGACCTAGCT GCCCGGAATG TGCTGGTCAA GAGTCCCAAC 2580

CATGTGAAGA TTACAGATTT TGGGTTGGCT CGGCTGTTGG ACATTGACGA GACAGAGTAC 2640

CATGCCGACG GGGGCAAGGT GCCCATCAAG TGGATGGCGT TGGAGTCCAT TCTTCGTCGG 2700

CGGTTCACCC ATCAGAGTGA TGTGTGGAGC TACGGTGTCA CTGTGTGGGA GCTGATGACT 2760

TTTGGGGCCA AACCCTATGA TGGGATCCCA GCCCGGGAGA TCCCTGACCT ACTGGAGAAA 2820

GGGGAGCGGC TGCCCCAGCC TCCCATCTGC ACCATTGATG TCTACATGAT CATGGTCAAA 2880

TGTTGGATGA TCGACTCTGA ATGTCGGCCA AGATTCCGGG AGCTGGTGGC TGAATTCTCC 2940

CGTATGGCCA GGGATCCCCA GCGCTTTGTG GTCATCCAGA ATGAGGACTT GGGTCCAGCC 3000

AGCCCCTTGG ACAGCACCTT TTACCGCTCG CTGCTGGAGG ATGATGACAT GGGGGACTTG 3060

GTGGATGCTG AGGAGTATCT GGTACCCCAA CAGGGCTTCT TCTGCCCAGA CCCTGCCCCA 3120

GGTGCTGGGG GCACAGCTCA CCGCAGGCAC CGAAGCTCAT CCACCAGGAG TGGTGGTGGT 3180

GGTGAGCTGA CACTGGGGCT GGAGCCCTCT GAAGAAGACC CCCCAAGGTC TCCTCTGGCC 3240

CCCTCAGAAG GGGCTGGCTC TGATGTGTTT GATGGTGACC TGGGAATAGG GGCAGCCAAG 3300

GGGTTGCAGA GCCTCCCCAC ACACGACCCC AACCCTCTAC AGCGGTACAG TGAGGACCCC 3360

ACAGTACCCC TGCCCCCCGA GACTGATGGC TACGTTGCTC CCTTGACCTG CAGCCCCCAG 3420

CCTGAATATG TGAACCAGCC AGAGGTTCGG CCACAGCCCC CCTCACCCTT AGAGGGTCCT 3480

CTGCCTCCTG TCTGCCCTGC TGGTGCCACT CTGGAAAGAC CCAAGACTCT CTCCCCTGGG 3540

AAAAATGGGG TTGTCAAAGA CGTTTTTGCC TTTGGGGGTA CTGTGGAGAA CCCTGAGTAC 3600

TTGGCACCCA GAGGAGGTGC TGCCCCTCAG CCCCATCCTC CTCCTGCCTT CAGCCCAGCC 3660

TTTGACAACC TCTATTACTG GGACCAGGAC TCATCAGAGC GGGGATCTCC GCCTGGCACC 3720

TTTGAAGGGA CCCCAACAGC AGAGAACCCT GAGTACCTGG GCCTGGATGT GCCAGTGTGA 3780

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 723   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  782

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+

Q: 783   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  842

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++

Q: 843   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  902

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw

Q: 903   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  962

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mid+e+rp+f+el++efs

Q: 963   MIDSECRPRFRELVAEFS  980

         ****************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180

THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240

MIDSECRPRF RELVAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013