EKS-ICT-00144

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00144

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	484.9	5.3E-146	498	777	280

Status

Unreviewed

Ensembl Protein

ENSSTOP00000003568

UniProt Accession

I3M3D7;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000003979	ENSSTOP00000003568	ENSSTOT00000003980

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

841

Protein Sequence
(FASTA)

MGLTSTWRYG RGLGIGTVTM VNWGRFICLV VVTMATLSRA RPSFNLVEDT TLEPEEPPTK 60

YQISQPEVYV AAPGEALELR CLLKDAAAIS WTKDGVHLGP SNRTVLIGEY LQVKSATPRD 120

SGLYACSAAR TVDSETWYFM VNVTDALSSG DDEDDTDASE DLVSESSNNK RAPYWTNTEK 180

MEKRLHAVPA ANTVKFRCPA GGSPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240

VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300

SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT 360

CLAGNSIGIS FHSAWLTVLP APVREKEITA SPDYLEIAIY CIGVFLIACM VVTVILCRMK 420

TTTKKPDFSS QPAVHKLTKR IPLRRQVSAE SSSSMNSNTP LVRITTRLSS AADTPMLAGV 480

SEYELPEDPK WEFPRDKLTL GKPLGEGCFG QVVMAEAVGI DKDKPKEAVT VAVKMLKDDA 540

TEKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQDAGPLYV IVEYASKGNL REYLRARRPP 600

GMEYSYDINR VPEEQMTFKD LVSCTYQLAR GMEYLASQKC IHRDLAARNV LVTENNVMKI 660

ADFGLARDIN NIDYYKKTTN QWKIPSRVPQ PSLSKEPPWS RKGDMGWSFG VLMWEIFTLG 720

GSPYPGIPVE ELFKLLKEGH RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI 780

LTLTTNEDYL DLSQPLEQYS PSYPDTRSSC SSGDDSVFSP DPMPYEPCLP QFPHINGSTK 840

T 841

Nucleotide Sequence
(FASTA)

ATGGGATTAA CGTCCACATG GAGATATGGA AGAGGACTGG GGATTGGCAC CGTAACCATG 60

GTCAACTGGG GTCGGTTCAT CTGCCTGGTC GTGGTCACCA TGGCAACCTT GTCCCGGGCC 120

CGGCCCTCCT TCAATTTAGT TGAGGATACC ACGTTAGAGC CGGAAGAGCC ACCAACCAAA 180

TACCAAATCT CCCAACCCGA AGTGTACGTG GCCGCGCCAG GGGAGGCGCT AGAGCTGCGC 240

TGCCTGTTGA AAGATGCCGC CGCCATCAGT TGGACTAAGG ATGGGGTTCA CTTGGGGCCC 300

AGCAATAGGA CAGTGCTTAT TGGGGAGTAC TTGCAGGTCA AAAGCGCCAC ACCTAGAGAC 360

TCCGGCCTCT ATGCTTGTTC TGCCGCTAGG ACTGTAGACA GTGAGACTTG GTACTTCATG 420

GTGAATGTCA CAGATGCCCT CTCGTCCGGA GATGACGAGG ACGACACAGA CGCCTCTGAA 480

GACTTGGTCA GTGAGAGCAG TAACAACAAG AGGGCGCCCT ACTGGACCAA CACGGAGAAG 540

ATGGAGAAGA GACTGCACGC AGTCCCCGCA GCCAACACGG TCAAGTTCCG CTGTCCAGCT 600

GGGGGGAGCC CAACACCCAC CATGAGGTGG TTGAAGAACG GGAAGGAGTT TAAGCAGGAA 660

CATCGCATTG GAGGCTACAA GGTACGAAAC CAGCATTGGA GTCTTATTAT GGAAAGCGTG 720

GTCCCGTCCG ACAAAGGCAA TTACACGTGT GTGGTGGAGA ACGAGTACGG GTCCATCAAC 780

CACACCTACC ACCTCGACGT CGTTGAGCGG TCGCCACACC GGCCCATCCT GCAGGCTGGG 840

CTGCCGGCGA ATGCCTCCAC GGTGGTCGGA GGGGATGTGG AGTTTGTGTG CAAGGTGTAC 900

AGCGATGCCC AGCCCCACAT CCAGTGGATC AAGCATGTCG AGAAGAACGG CAGTAAATAT 960

GGGCCTGACG GGCTGCCCTA CCTCAAGGTT CTAAAGGCTG CCGGTGTTAA CACCACGGAC 1020

AAAGAGATTG AGGTTCTCTA TATTCGGAAT GTAACTTTTG AGGATGCTGG GGAATATACG 1080

TGCTTGGCGG GTAATTCTAT TGGGATATCC TTTCACTCTG CATGGTTGAC AGTTCTGCCA 1140

GCTCCTGTAA GAGAAAAGGA GATCACAGCT TCCCCAGATT ACCTGGAGAT AGCCATTTAC 1200

TGCATAGGGG TCTTCCTCAT TGCCTGCATG GTGGTGACAG TCATCCTGTG CCGAATGAAG 1260

ACCACCACCA AGAAGCCAGA CTTCAGCAGC CAGCCTGCAG TGCACAAGCT GACCAAGCGC 1320

ATCCCCCTGC GGAGACAGGT TTCCGCAGAG TCCAGCTCCT CCATGAACTC CAATACCCCG 1380

CTGGTGAGGA TAACGACTCG TCTGTCCTCG GCCGCTGACA CCCCGATGCT GGCAGGGGTC 1440

TCGGAGTACG AGCTGCCAGA GGACCCAAAA TGGGAGTTCC CCAGAGATAA GCTGACGCTG 1500

GGCAAACCCC TGGGGGAAGG TTGCTTTGGG CAAGTGGTCA TGGCGGAAGC GGTGGGCATC 1560

GACAAAGACA AGCCCAAGGA GGCGGTCACC GTGGCAGTGA AGATGCTGAA AGATGATGCC 1620

ACGGAAAAGG ACCTTTCTGA TCTGGTGTCA GAGATGGAGA TGATGAAGAT GATTGGAAAA 1680

CACAAAAATA TCATCAACCT TCTTGGAGCT TGCACACAGG ACGCAGGGCC ACTCTATGTC 1740

ATAGTGGAGT ACGCTTCGAA AGGCAACCTC CGGGAGTACC TCCGAGCCCG CAGGCCGCCC 1800

GGCATGGAGT ACTCCTATGA CATCAACCGA GTGCCCGAAG AGCAGATGAC CTTCAAGGAC 1860

CTGGTGTCCT GCACCTACCA GCTGGCCAGA GGCATGGAGT ACTTGGCTTC CCAAAAATGC 1920

ATTCATCGGG ATTTAGCAGC CAGAAATGTA TTGGTAACAG AAAACAATGT GATGAAAATA 1980

GCAGACTTTG GACTGGCCAG AGACATCAAC AATATAGACT ATTACAAGAA GACCACGAAT 2040

CAATGGAAAA TTCCATCAAG AGTACCCCAG CCCTCCCTGT CCAAGGAGCC TCCTTGGAGC 2100

AGGAAGGGAG ACATGGGCTG GTCCTTCGGG GTGTTAATGT GGGAGATCTT CACCTTAGGG 2160

GGCTCGCCCT ACCCAGGGAT TCCCGTGGAG GAACTTTTTA AGCTGCTGAA GGAAGGACAC 2220

AGGATGGATA AGCCAGCCAA CTGCACCAAT GAGCTGTACA TGATGATGAG GGACTGCTGG 2280

CACGCCGTGC CCTCACAGAG ACCGACGTTC AAGCAGTTGG TGGAGGACCT GGATCGAATC 2340

CTCACTCTCA CAACCAATGA GGACTACTTG GACCTCAGTC AGCCTCTCGA GCAGTATTCT 2400

CCTAGTTACC CCGACACCAG GAGCTCTTGT TCTTCAGGGG ATGACTCTGT GTTTTCTCCG 2460

GACCCCATGC CTTACGAACC TTGCCTGCCT CAGTTTCCAC ACATAAACGG CAGCACTAAA 2520

ACATGA 2526

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 498   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  557

         79**********************************************************

S: 61    iGkhkniinllGactqe.GplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlt  119

         iGkhkniinllGactq+ Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t

Q: 558   IGKHKNIINLLGACTQDaGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT  617

         ***************9669*****************************************

S: 120   ekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykk  179

         +kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykk

Q: 618   FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK  677

         ************************************************************

S: 180   ttnG.rlpvkwmapealfdrvytsqsdv.wsfGvllweiltlGgspypgiaveelfkllk  237

         ttn  ++p +   p   ++  ++ + d+ wsfGvl+wei+tlGgspypgi+veelfkllk

Q: 678   TTNQwKIPSRVPQPSLSKEPPWSRKGDMgWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK  737

         **9658999999999889999*****977*******************************

S: 238   eGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         eGhrm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 738   EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  777

         **************************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDAGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT 120

FKDLVSCTYQ LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK 180

TTNQWKIPSR VPQPSLSKEP PWSRKGDMGW SFGVLMWEIF TLGGSPYPGI PVEELFKLLK 240

EGHRMDKPAN CTNELYMMMR DCWHAVPSQR PTFKQLVEDL 280

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013